Abstract: The present invention provides methods of treating cancer by inhibiting MECP2 and identifying cancers that will respond to therapy using MECP2 as a biomarker.

Abstract: A urostomy bag carrying system includes a bag that may be carried. The bag has a pair of slots extending into an interior of the bag. A strap is coupled to the bag and the strap may be slung over a shoulder. Thus, the bag may be carried having the bag being positioned to cover a stoma on user. A urostomy bag is selectively positioned within the bag. At least one hose is fluidly coupled to the urostomy bag. The at least one hose is positioned in a selected one of the slots. Thus, the at least one hose may be fluidly coupled to the stoma.

Abstract: According to some embodiments, a railcar comprises a pair of trucks disposed near each end of the railcar. A well component supported by the pair of trucks is disposed between the pair of trucks. A pair of end sections are disposed at each end of the railcar. At least one end section of the pair of end sections comprises a well platform disposed near an end of the well. A step is coupled to the well platform and extends into the well component to facilitate operator egress from the well component to the well platform. A handrail is proximate the step, the handrail is sized to accommodate a hand of the operator. The handrail may be positioned above the step and below the well platform.

Abstract: According to some embodiments, a railcar comprises a well component disposed between a pair of trucks. A pair of end sections are disposed at each end of the railcar. An end section comprises a well platform disposed near an end of the well component; an end platform disposed near an end of the railcar; and a connecting platform extending between the end platform and the well platform. A pair of ladders may be coupled to each end of the end platform. A first handrail may extend between the ladders and along an outside edge of the end platform. A second handrail may extend from a ladder, along an inside edge of the end platform, along an edge of the connecting platform, and along an inside edge of the well platform. A third handrail may extend along an edge of the well platform adjacent to the well component.

Abstract: Embodiments generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incisions to form a top lenticular incision, a bottom lenticular incision of a lens in the subject's eye, an added shape between the top and bottom incisions where the added shape has no corrective power and a transition ring bisecting both the top and bottom lenticular incisions.

Abstract: According to some embodiments, a railcar comprises a railcar body comprising at least one end or side arranged in a generally vertical plane. The railcar comprises a staggered ladder coupled to the railcar body and extending in a generally vertical direction. The staggered ladder comprises a plurality of steps that are staggered such that at least one step proximate a bottom of the ladder is offset from the generally vertical plane of the railcar body by a greater distance than at least one step proximate a top of the ladder. The railcar further comprises a staggered handrail coupled to the rail car body and proximate the staggered ladder, wherein a bottom portion of the staggered handrail is offset from the vertical plane of the railcar body by a greater distance than a top portion of the staggered handrail.

Abstract: According to some embodiments, a method of improving weld fatigue performance in a railcar weld comprises identifying a railcar weld subject to dynamic loads; determining the railcar weld is prone to fatigue; applying an impact treatment to the railcar weld using transducer coupled to one or more pins, wherein the one or more pins are configured to contact the railcar weld without interference from other portions of the railcar. According to some embodiments, an impact treatment device for a railcar comprises a transducer coupled to one or more pins for imparting an impact to a railcar weld. The transducer and the one or more pins are configured to put the one or more pins in contact with the railcar weld without interference from other portions of the railcar. The transducer comprises one of an ultrasonic transducer, a piezoelectric transducer, or a pneumatic transducer.

Abstract: An apparatus and method for monitoring the productivity of a portable machine are provided. The method includes receiving motion data for at least one component of the portable machine from a multi-axis accelerometer, receiving position data for the at least one component from a process parameter sensor communicatively coupled to the at least one component, and determining, based on the received motion data and the received position data that the at least one component is oriented in a predetermined position for productive operation. The method also includes determining an area of productive operation using at least one physical dimension of the at least one component and the received motion data when the at least one component is oriented in the predetermined position for productive operation and incrementing a total area counter based on the determination.

Abstract: Embodiments generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incision. In an embodiment, an ophthalmic surgical laser system comprises a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye, an XY-scan device to deflect the pulsed laser beam, a Z-scan device to modify a depth of a focus of the pulsed laser beam, and a controller configured to form a top lenticular incision and a bottom lenticular incision of a lens in a corneal stroma.

Abstract: A dual action truck cover provides two modes, actions or ways to access contents in a truck bed. Side rails can be mountable to a cargo box so as to be pivotable between a raised position to provide a rear opening in an open pivot arrangement, and a lowered or closed pivot arrangement. The side rails can be spaced apart to define an inter-rail area therebetween. A door can include a plurality of elements hingedly coupled together and extending between the side rails and movable between a closed door arrangement wherein the elements cover the inter-rail area, and an open door arrangement in which the elements are positioned to permit access through the inter-rail area. The door can move between the open and closed arrangements by rolling up the hingedly coupled elements together or folding the elements together.

Abstract: A system is disclosed for providing retailer controllable access to consolidated inventory management services through a retail worker's personal smartphone. The system—operable largely within and through the retailer's private computing network—comprises data nodes, an enterprise service bus, and a device application. Inventory-related data is kept in the data nodes, with access thereto from suitably provisioned personal mobile devices moderated by the enterprise service bus pursuant to policies and parameters defined by the retailer. Provisioning the personal mobile device involves installation thereon of the device application. The device application launches a user interface for accessing the data nodes through the enterprise service bus, thus enabling the use on the worker's personal mobile device of retailer-specific, job-related inventory management tools.

Abstract: An enhanced septic system includes a storage tank having an inlet that receives liquid gray water from a standard septic system having at least one digester and a pump located in the storage tank. The pump is coupled to an actuator to selectively provide power to the pump from a power supply to pump the gray water from the storage tank when the gray water reaches a predetermined level within the storage tank. The system also includes an outlet pipe coupled to the storage tank and to receive gray water pumped from the storage tank by the pump, at least one ultraviolet light in communication with the outlet pipe, and a detector to determine when the pump is actuated and to turn on the at least one ultraviolet light upon actuation of the pump.

Abstract: A hovercraft includes a lift air supply source having a dynamic air flow area in communication with a central lift air chamber to provide continuous air flow to the central lift air chamber and a static air flow area in communication with an inflatable skirt extending around a periphery of the hovercraft. Air flow from the static air flow area enters the skirt to replenish air leaking from the skirt. The static air flow area has less air flow than the dynamic air flow area. The static air flow area is located at a higher position than the dynamic air flow area to reduce the likelihood of water entering the inflatable skirt when the hovercraft is operated on water.

Abstract: A well pump assembly has a number modules, including a pump and a motor, secured together. Each of the modules has a housing, and at least one of the modules has a neck of reduced diameter relative to the housing. A clamp is secured around the neck. The clamp has a dovetail groove extending around and within the outer surface of the clamp. An accessory member protrudes radially outward from the outer surface of the clamp and has an inner portion located in the groove. A threaded fastener secures the accessory member to the clamp. The accessory member is slidable along the groove to a selected orientation prior to tightening the fastener.

Abstract: Methods, systems, and treatment probes for delivering heating energy such as acoustic waves to a target tissue volume inside of a patient for medically treating the target tissue volume are disclosed. A method includes inserting a treatment probe into the patient through an exposed skin of the patient, the treatment probe including heating energy dispensing element. The method further includes applying heating energy to the target tissue volume via the dispensing element, the heating energy being applied so as to medically treat the target tissue volume. The method also includes monitoring an amount of energy absorbed by the target tissue as a result of applying the energy, and adjusting the heating energy being applied to the target tissue based on the amount of energy absorbed by the target tissue.

Abstract: Devices, systems, and methods for providing improved network performance in wireless communications networks using intelligent radiation selection are provided. A radio is communicatively coupled to an antenna and configured to provide a signal to the antenna for broadcast from a cell site. One or more input components are communicatively coupled to the radio to provide information on at least one of an internal or an external condition of the antenna, so that the radio can adjust or modify the signal provided to the antenna to change an emitted pattern of radiation from the antenna to reduce signal loss, or recover or help maintain an area of coverage provided by the antenna.

Abstract: A furnace system includes an air intake that includes a pipe portion and a seal component configured to couple with the pipe portion. The furnace system also includes an internal drain disposed internal to the air intake. The internal drain includes a trough configured to collect liquid flowing along an inner surface of the pipe portion. The internal drain also includes an opening in the trough configured to guide the liquid collected in the trough to a passage through the air intake to a location outside the air intake.

Abstract: A method of controlling electric fields created by a plurality of electrodes. The method includes repetitively applying multiple sets of voltages to at least some of a plurality of electrodes over a treatment period to achieve and maintain a target temperature, the at least some of the electrodes being treatment electrodes. The sets of voltages may be in patterns such that a unique current pattern between electrodes is created for each set of voltages, resulting in temperature averaging. The voltage at each electrode may be determined based on a temperature of an adjacent electrode. The voltage at each electrode may also or alternatively be determined based on an estimated voltage at the electrode.

Abstract: A remedial composition comprising a soluble silicate, a surfactant, a polyol and water is disclosed. The remedial composition of the present invention is generally intended for use in the treatment of soil, sand, water, fly ash and other mediums that may contain hazardous materials. In one embodiment of the present invention the soluble silicate of the remedial composition has a mole ratio of about 2.6 to about 3.9 moles silicate per mole of alkali metal oxide. In another embodiment of the present invention the remedial composition will have a pH level ranging from about 10.5 to about 11.9. In another embodiment the water component further comprises from about 0.5% to about 15% dissolved oxygen (O2). In another embodiment of the present invention the remedial composition may be further diluted by adding water to create various solutions comprising about 1 to 300 parts water to 1 part remedial composition.

Abstract: Antenna mount systems and methods for deploying small cells are disclosed. The antenna mount system may include an outer housing and an inner antenna enclosure at least partly positioned inside the outer housing, with the inner antenna enclosure movably coupled to the outer housing. The antenna mount system can include an orientation member that can aid in maintaining a particular orientation of an antenna so as to maintain a radiation pattern substantially on a defined area, independent of the position of the antenna mount system.