Patents by Inventor Edmond J. LaVoie

Edmond J. LaVoie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial efflux pump inhibitors
    Patent number: 11938114
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: March 26, 2024
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yongzheng Zhang
  • Therapeutic compounds and methods to treat infection
    Patent number: 11845742
    Abstract: Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: December 19, 2023
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Hye Yeon Sagong, Ajit K. Parhi
  • Bacterial efflux pump inhibitors
    Patent number: 11826357
    Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: November 28, 2023
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yi Yuan, Yongzheng Zhang, Yangsheng Sun
  • Therapeutic compounds and methods to treat infection
    Patent number: 11458121
    Abstract: Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: October 4, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Hye Yeon Sagong
  • Bacterial efflux pump inhibitors
    Patent number: 11180459
    Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: November 23, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yongzheng Zhang, Yi Yuan, Yangsheng Sun
  • Antimicrobial agents
    Patent number: 11129814
    Abstract: The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound:
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: September 28, 2021
    Assignee: TAXIS PHARMACEUTICALS, INC.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Topoisomerase poisons
    Patent number: 11091498
    Abstract: Provided herein are compounds of formula (I): and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating diseases such as cancer, a bacterial infection or a fungal infection using compounds of formula (I).
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 17, 2021
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit K. Parhi
  • BACTERIAL EFFLUX PUMP INHIBITORS
    Publication number: 20210137881
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: March 9, 2018
    Publication date: May 13, 2021
    Applicant: RUTGERS, THE STATE UNIVERISTY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yongzheng Zhang
  • INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS
    Publication number: 20210094912
    Abstract: Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of formula I for use in treating or preventing bacterial infections.
    Type: Application
    Filed: March 9, 2018
    Publication date: April 1, 2021
    Applicant: RUTGERS, THE STATE UNIVERISTY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yi Yuan, Yongzheng Zhang, Yangsheng Sun
  • Fluorescent Probes for the Visualization of FtsZ in Gram-Positive and Gram-Negative Bacterial Pathogens
    Publication number: 20210088525
    Abstract: The invention provides a compound of formula I: or a salt thereof, wherein Y, Z, L, and W have any of the values described in the specification, as well as compositions comprising a compound of formula I or a salt thereof. The compounds are useful as tools for visualizing FtsZ and monitoring cell division in a broad range of Gram-positive and Gram-negative bacterial pathogens of acute clinical importance and for identifying new FtsZ inhibitors.
    Type: Application
    Filed: September 21, 2020
    Publication date: March 25, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Daniel S. Pilch, Edgar Ferrer-González, Edmond J. LaVoie
  • Bacterial efflux pump inhibitors
    Patent number: 10836706
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: November 17, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit Parhi, Gifty A. Blankson, Liping Wang, Xiao Chen, Yongzheng Zhang, Malvika Kaul, Daniel S. Pilch
  • TOPOISOMERASE POISONS
    Publication number: 20200325149
    Abstract: Provided herein are compounds of formula (I): and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating diseases such as cancer, a bacterial infection or a fungal infection using compounds of formula (I).
    Type: Application
    Filed: April 3, 2017
    Publication date: October 15, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit K. Parhi
  • THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION
    Publication number: 20200325124
    Abstract: Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.
    Type: Application
    Filed: November 13, 2018
    Publication date: October 15, 2020
    Inventors: Edmond J. LaVoie, Hye Yeon Sagong, Ajit K. Parhi
  • BACTERIAL EFFLUX PUMP INHIBITORS
    Publication number: 20200197382
    Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: May 25, 2018
    Publication date: June 25, 2020
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yi Yuan, Yongzheng Zhang, Yangsheng Sun
  • THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION
    Publication number: 20200155507
    Abstract: Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.
    Type: Application
    Filed: June 26, 2018
    Publication date: May 21, 2020
    Inventors: Edmond J. LaVoie, Ajit Parhi, Hye Yeon Sagong
  • BACTERIAL EFFLUX PUMP INHIBITORS
    Publication number: 20200140393
    Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: March 9, 2018
    Publication date: May 7, 2020
    Applicant: RUTGERS, THE STATE UNIVERISTY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yongzheng Zhang, Yi Yuan, Yangsheng Sun
  • Bacterial efflux pump inhibitors
    Patent number: 10556854
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: February 11, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit Parhi, Malvika Kaul, Daniel S. Pilch
  • BACTERIAL EFFLUX PUMP INHIBITORS
    Publication number: 20190084919
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: February 23, 2017
    Publication date: March 21, 2019
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit Parhi, Malvika Kaul, Daniel S. Pilch
  • BACTERIAL EFFLUX PUMP INHIBITORS
    Publication number: 20190055188
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: February 23, 2017
    Publication date: February 21, 2019
    Inventors: Edmond J. LaVoie, Ajit Parhi, Gifty A. Blankson, Liping Wang, Xiao Chen, Yongzheng Zhang, Malvika Kaul, Daniel S. Pilch
  • THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION
    Publication number: 20190031624
    Abstract: Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.
    Type: Application
    Filed: July 26, 2018
    Publication date: January 31, 2019
    Inventors: Edmond J. LaVoie, Ajit K. Parhi, Yangsheng Sun