Patents by Inventor Edmond J. LaVoie

Edmond J. LaVoie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BACTERIAL EFFLUX PUMP INHIBITORS
    Publication number: 20190055188
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: February 23, 2017
    Publication date: February 21, 2019
    Inventors: Edmond J. LaVoie, Ajit Parhi, Gifty A. Blankson, Liping Wang, Xiao Chen, Yongzheng Zhang, Malvika Kaul, Daniel S. Pilch
  • THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION
    Publication number: 20190031624
    Abstract: Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.
    Type: Application
    Filed: July 26, 2018
    Publication date: January 31, 2019
    Inventors: Edmond J. LaVoie, Ajit K. Parhi, Yangsheng Sun
  • Methylenedioxybenzo [I] phenanthridine derivatives used to treat cancer
    Patent number: 10179789
    Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: January 15, 2019
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Wei Feng, Leroy F. Liu
  • ANTIMICROBIAL AGENTS
    Publication number: 20180338957
    Abstract: The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound:
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, TAXIS PHARMACEUTICALS, INC.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Antimicrobial agents
    Patent number: 10071082
    Abstract: The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: September 11, 2018
    Assignees: Rutgers, The State University of New Jersey, Taxis Pharmaceuticals, Inc.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • ANTIMICROBIAL AGENTS
    Publication number: 20180179225
    Abstract: The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
    Type: Application
    Filed: August 3, 2017
    Publication date: June 28, 2018
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, TAXIS PHARMACEUTICALS, INC.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Bacterial efflux pump inhibitors
    Patent number: 9950993
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 24, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit K. Parhi, Malvika Kaul, Daniel S. Pilch
  • Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones
    Patent number: 9932323
    Abstract: The invention provides compounds of formula I: and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: April 3, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. Lavoie, Joseph David Bauman, Ajit Parhi, Hye Yeon Sagong, Disha Patel, Eddy Arnold, Kalyan Das, Suyambu Kesava Vijayan
  • Bacterial efflux pump inhibitors
    Patent number: 9926261
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 27, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit K. Parhi, Gifty A. Blankson, Malvika Kaul, Daniel S. Pilch
  • METHYLENEDIOXYBENZO [I] PHENANTHRIDINE DERIVATIVES USED TO TREAT CANCER
    Publication number: 20170355706
    Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
    Type: Application
    Filed: January 20, 2017
    Publication date: December 14, 2017
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Wei Feng, Leroy F. Liu
  • Antimicrobial agents
    Patent number: 9822108
    Abstract: The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of X1 to X8 are N and the remaining of X1 to X8 are CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: November 21, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Malvika Kaul
  • THERAPEUTIC HYDROXYPYRIDINONES, HYDROXYPYRIMIDINONES AND HYDROXYPYRIDAZINONES
    Publication number: 20170204083
    Abstract: The invention provides compounds of formula I: and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.
    Type: Application
    Filed: January 13, 2017
    Publication date: July 20, 2017
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LAVOIE, Joseph David BAUMAN, Ajit PARHI, Hye Yeon SAGONG, Disha PATEL, Eddy ARNOLD, Kalyan DAS, Suyambu Kesava VIJAYAN
  • Therapeutic hydroxyquinolones
    Patent number: 9701638
    Abstract: The invention provides compounds of formula (I) and salts thereof wherein R4-R8 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: July 11, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. Lavoie, Joseph David Bauman, Hye Yeon Sagong, Eddy Arnold, Ajit Parhi, Kalyan Das, Suyambu Kesava Vijayan, Disha Patel
  • Therapeutic catechols
    Patent number: 9695135
    Abstract: The invention provides compounds of formula I: and salts thereof wherein R1-R4 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts, and methods for their use in therapy. The compounds have useful antiviral properties.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: July 4, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Eddy Arnold, Joseph D. Bauman, John E. Kerrigan, Ajit K. Parhi, Kalyan Das, Cody Kelley, Dishaben V. Patel
  • Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones
    Patent number: 9573938
    Abstract: The invention provides compounds of formula (I): and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: February 21, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. Lavoie, Joseph David Bauman, Ajit Parhi, Hye Yeon Sagong, Disha Patel, Eddy Arnold, Kalyan Das, Suyambu Kesava Vijayan
  • Methylenedioxybenzo [I] phenanthridine derivatives used to treat cancer
    Patent number: 9562051
    Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: February 7, 2017
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Edmond J. LaVoie, Wei Feng, Leroy F. Liu
  • ANTIMICROBIAL AGENTS
    Publication number: 20160367531
    Abstract: The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
    Type: Application
    Filed: August 31, 2016
    Publication date: December 22, 2016
    Applicants: Rutgers, The State University of New Jersey, Taxis Pharmaceuticals, Inc.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Antimicrobial agents
    Patent number: 9475783
    Abstract: The invention provides compounds of formula (I): wherein R1-R7 and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: October 25, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yongzheng Zhang, Daniel S. Pilch, Malvika Kaul
  • Antimicrobial agents
    Patent number: 9458150
    Abstract: The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: October 4, 2016
    Assignees: Rutgers, The State University of New Jersey, Taxis Pharmaceuticals, Inc.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • BACTERIAL EFFLUX PUMP INHIBITORS
    Publication number: 20160271081
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: March 11, 2016
    Publication date: September 22, 2016
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit K. Parhi, Malvika Kaul, Daniel S. Pilch