Patents by Inventor Edmond J. LaVoie

Edmond J. LaVoie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC COMPOUNDS
    Publication number: 20120238595
    Abstract: The invention provides compounds of formula (I) wherein u, d, v, m, n, R1, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.
    Type: Application
    Filed: November 5, 2010
    Publication date: September 20, 2012
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Joseph E. Rice, Suzanne G. Rzuczek, Daniel S. Pilch
  • TOPOISOMERASE INHIBITORS
    Publication number: 20120237531
    Abstract: The invention provides compounds of formula I: (I) wherein A, B, W, Y, Z, R1, R3 and R4 have any of the meanings defined in the specification and their salts as well as additional compounds and their salts. The invention also provides pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer, a bacterial infection or a fungal infection using compounds of the invention.
    Type: Application
    Filed: November 4, 2010
    Publication date: September 20, 2012
    Inventors: Edmond J. LaVoie, Ajit K. Parhi
  • METHYLENEDIOXYBENZO [I] PHENANTHRIDINE DERIVATIVES USED TO TREAT CANCER
    Publication number: 20120101117
    Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
    Type: Application
    Filed: March 5, 2010
    Publication date: April 26, 2012
    Inventors: Edmond J. LaVoie, Wei Feng, Leroy F. Liu
  • THERAPEUTIC COMPOUNDS
    Publication number: 20120071527
    Abstract: The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and - - - have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabilizers and as anti-proliferative agents.
    Type: Application
    Filed: November 30, 2011
    Publication date: March 22, 2012
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. Lavoie, Joseph E. Rice, Leroy F. Liu
  • ANTIMICROBIAL AGENTS
    Publication number: 20120059026
    Abstract: The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1-R12 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents.
    Type: Application
    Filed: April 30, 2010
    Publication date: March 8, 2012
    Applicants: University of Medicine and Dentistry of New Jersey, Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Daniel S. Pilch, Ajit Parhi, Malvika Kaul
  • THERAPEUTIC COMPOUNDS
    Publication number: 20120046234
    Abstract: The invention provides compounds of formula I, II, and III as defined herein, as well as salts thereof. The compounds may have activity as anti-proliferative agents.
    Type: Application
    Filed: August 1, 2008
    Publication date: February 23, 2012
    Inventors: Edmond J. LaVoie, Joseph E. Rice
  • BENZO [C] PHENANTHRIDINES AS ANTIMICROBIAL AGENTS
    Publication number: 20120022061
    Abstract: The present invention provides compounds of formula I: formula (I) wherein X1-X4 and R1-R12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The invention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacterial cell division and proliferation and to treat bacterial infections.
    Type: Application
    Filed: January 15, 2010
    Publication date: January 26, 2012
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Malvika Kaul
  • Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA
    Patent number: 8093235
    Abstract: The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabilizers and as anti-proliferative agents.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: January 10, 2012
    Assignees: Rutgers, The State University of New Jersey, University of Medicine and Dentistry of New Jersey
    Inventors: Edmond J. Lavoie, Joseph E. Rice, Leroy F. Liu
  • METHODS TO TREAT CANCER
    Publication number: 20120004235
    Abstract: The invention provides methods and pharmaceutical compositions for treating certain cancers with compounds of formula (I) wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts and prodrugs.
    Type: Application
    Filed: January 29, 2010
    Publication date: January 5, 2012
    Applicants: Rutgers, The State University of New Jersey, Genzyme Corporation, Old Queens Building, Somerset and George Streets
    Inventors: Edmond J. Lavoie, Beverly Teicher, Steven Schmid
  • THERAPEUTIC COMPOUNDS
    Publication number: 20110230531
    Abstract: The invention provides compounds of formula (I) wherein A, B, R1, F, G, n, n? and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.
    Type: Application
    Filed: August 1, 2008
    Publication date: September 22, 2011
    Inventors: Edmond J. LaVoie, Joseph E. Rice, Satyanarayana Mavurapu
  • SOLUBILIZED TOPOISOMERASE POISONS
    Publication number: 20110136812
    Abstract: The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
    Type: Application
    Filed: August 5, 2010
    Publication date: June 9, 2011
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
  • Topoisomerase-targeting agents
    Patent number: 7858627
    Abstract: The invention provides compounds of formula I or formula II: wherein: the bond represented by is a single bond or a double bond, and R1—R5, X, and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I or II, processes for preparing compounds of formula I or II, intermediates useful for preparing compounds of formula I or II, and therapeutic methods for treating cancer and other topoisomerase related conditions using compounds of formula I or II.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: December 28, 2010
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
  • SOLUBILIZED TOPOISOMERASE POISON AGENTS
    Publication number: 20100240664
    Abstract: The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
    Type: Application
    Filed: May 28, 2010
    Publication date: September 23, 2010
    Applicant: Rutgers, the State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman
  • Solubilized topoisomerase poisons
    Patent number: 7781587
    Abstract: The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: August 24, 2010
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
  • TOPOISOMERASE-TARGETING AGENTS
    Publication number: 20090258890
    Abstract: The invention provides compounds of formula I or formula II: wherein: the bond represented by is a single bond or a double bond, and R1-R5, X, and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I or II, processes for preparing compounds of formula I or II, intermediates useful for preparing compounds of formula I or II, and therapeutic methods for treating cancer and other topoisomerase related conditions using compounds of formula I or II.
    Type: Application
    Filed: April 13, 2009
    Publication date: October 15, 2009
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
  • SOLUBILIZED TOPOISOMERASE POISONS
    Publication number: 20090239871
    Abstract: The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
    Type: Application
    Filed: March 27, 2009
    Publication date: September 24, 2009
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
  • THERAPEUTIC COMPOUNDS
    Publication number: 20090156627
    Abstract: The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabilizers and as anti-proliferative agents.
    Type: Application
    Filed: October 24, 2008
    Publication date: June 18, 2009
    Inventors: Edmond J. Lavoie, Joseph E. Rice, Leroy F. Liu
  • Solubilized topoisomerase poisons
    Patent number: 7517883
    Abstract: The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
    Type: Grant
    Filed: August 24, 2005
    Date of Patent: April 14, 2009
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
  • Topoisomerase-targeting agents
    Patent number: 7517867
    Abstract: The invention provides compounds of formula I or formula II: wherein: the bond represented by — is a single bond or a double bond, and R1-R5, X, and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I or II, processes for preparing compounds of formula I or II, intermediates useful for preparing compounds of formula I or II, and therapeutic methods for treating cancer and other topoisomerase related conditions using compounds of formula I or II.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: April 14, 2009
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
  • Cytotoxic agents
    Patent number: 7468366
    Abstract: The invention provides compounds of the invention pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: December 23, 2008
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Sudhir K. Singh, Abhijit Ray, Leroy F. Liu