Patents by Inventor Edmond J. LaVoie

Edmond J. LaVoie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210094912
    Abstract: Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of formula I for use in treating or preventing bacterial infections.
    Type: Application
    Filed: March 9, 2018
    Publication date: April 1, 2021
    Applicant: RUTGERS, THE STATE UNIVERISTY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yi Yuan, Yongzheng Zhang, Yangsheng Sun
  • Publication number: 20210088525
    Abstract: The invention provides a compound of formula I: or a salt thereof, wherein Y, Z, L, and W have any of the values described in the specification, as well as compositions comprising a compound of formula I or a salt thereof. The compounds are useful as tools for visualizing FtsZ and monitoring cell division in a broad range of Gram-positive and Gram-negative bacterial pathogens of acute clinical importance and for identifying new FtsZ inhibitors.
    Type: Application
    Filed: September 21, 2020
    Publication date: March 25, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Daniel S. Pilch, Edgar Ferrer-González, Edmond J. LaVoie
  • Patent number: 10836706
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: November 17, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit Parhi, Gifty A. Blankson, Liping Wang, Xiao Chen, Yongzheng Zhang, Malvika Kaul, Daniel S. Pilch
  • Publication number: 20200325149
    Abstract: Provided herein are compounds of formula (I): and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating diseases such as cancer, a bacterial infection or a fungal infection using compounds of formula (I).
    Type: Application
    Filed: April 3, 2017
    Publication date: October 15, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit K. Parhi
  • Publication number: 20200325124
    Abstract: Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.
    Type: Application
    Filed: November 13, 2018
    Publication date: October 15, 2020
    Inventors: Edmond J. LaVoie, Hye Yeon Sagong, Ajit K. Parhi
  • Publication number: 20200197382
    Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: May 25, 2018
    Publication date: June 25, 2020
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yi Yuan, Yongzheng Zhang, Yangsheng Sun
  • Publication number: 20200155507
    Abstract: Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.
    Type: Application
    Filed: June 26, 2018
    Publication date: May 21, 2020
    Inventors: Edmond J. LaVoie, Ajit Parhi, Hye Yeon Sagong
  • Publication number: 20200140393
    Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: March 9, 2018
    Publication date: May 7, 2020
    Applicant: RUTGERS, THE STATE UNIVERISTY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Ajit Parhi, Yongzheng Zhang, Yi Yuan, Yangsheng Sun
  • Patent number: 10556854
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: February 11, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit Parhi, Malvika Kaul, Daniel S. Pilch
  • Publication number: 20190084919
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: February 23, 2017
    Publication date: March 21, 2019
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit Parhi, Malvika Kaul, Daniel S. Pilch
  • Publication number: 20190055188
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
    Type: Application
    Filed: February 23, 2017
    Publication date: February 21, 2019
    Inventors: Edmond J. LaVoie, Ajit Parhi, Gifty A. Blankson, Liping Wang, Xiao Chen, Yongzheng Zhang, Malvika Kaul, Daniel S. Pilch
  • Publication number: 20190031624
    Abstract: Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.
    Type: Application
    Filed: July 26, 2018
    Publication date: January 31, 2019
    Inventors: Edmond J. LaVoie, Ajit K. Parhi, Yangsheng Sun
  • Patent number: 10179789
    Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: January 15, 2019
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Wei Feng, Leroy F. Liu
  • Publication number: 20180338957
    Abstract: The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound:
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, TAXIS PHARMACEUTICALS, INC.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Patent number: 10071082
    Abstract: The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: September 11, 2018
    Assignees: Rutgers, The State University of New Jersey, Taxis Pharmaceuticals, Inc.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Publication number: 20180179225
    Abstract: The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
    Type: Application
    Filed: August 3, 2017
    Publication date: June 28, 2018
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, TAXIS PHARMACEUTICALS, INC.
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Patent number: 9950993
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 24, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit K. Parhi, Malvika Kaul, Daniel S. Pilch
  • Patent number: 9932323
    Abstract: The invention provides compounds of formula I: and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: April 3, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. Lavoie, Joseph David Bauman, Ajit Parhi, Hye Yeon Sagong, Disha Patel, Eddy Arnold, Kalyan Das, Suyambu Kesava Vijayan
  • Patent number: 9926261
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 27, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit K. Parhi, Gifty A. Blankson, Malvika Kaul, Daniel S. Pilch
  • Publication number: 20170355706
    Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
    Type: Application
    Filed: January 20, 2017
    Publication date: December 14, 2017
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Wei Feng, Leroy F. Liu