Abstract: Provided herein are estrogen receptor degraders, for example, a compound of Formula (I), RT-L-RE; and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms r of an estrogen receptor-mediated disorder, disease, or condition.

Abstract: An information handling system may include a backplane configured to couple at a first side thereof to a plurality of physical storage resources, an air mover configured to provide cooling to the information handling system, and a shelf coupled to the backplane at a second, opposite side thereof, wherein the shelf is disposed between the first side of the backplane and the air mover. The shelf may include an acoustically absorbent material.

Abstract: The present invention relates to a system for analyzing the insulation condition of an electrical machine (1), the electrical machine (1) comprising a housing (2), a plurality of supply conductors (3) and at least one grounding branch (5), in which it comprises: at least one scanning module (20) coupled to the plurality of conductors (3); at least one control module (9) coupled to the scanning module (20); and at least one analysis module (21) coupled to the control module (9); wherein the scanning module (20) is configured to inject and measure a plurality of high frequency voltage signals between the housing (2) of the electrical machine (1) and the plurality of conductors (3) and measure a plurality of high frequency currents circulating in the plurality of conductors (3) in response to the injection of each of the plurality of high frequency voltage signals; wherein the control module (9) is configured to control and synchronize the injections and measurements of the scanning module (20) and send the meas

Abstract: The present disclosure generally relates to a head assembly in a data storage device. The data storage device may include magnetic media embedded in the device or magnetic media from an insertable cassette or cartridge (e.g., in an LTO drive), where the head assembly reads from and writes to the magnetic media. During device operation, the magnetic media moves across the head assembly. The magnetic media experiences higher contact stress at certain points or portions of the head assembly. A sensor guard is coupled to the head assembly. The sensor guard comprises at least one chamfered surface or at least one stepped surface to decrease the contact stress between the magnetic media and the head assembly during device operation. The at least one chamfered or stepped surface may be disposed on a leading edge of the sensor guard.

Abstract: A method for making a halosilane compound comprises the steps of: (a) providing a first halosilane compound, (b) providing a reaction vessel containing a halide source disposed inside, (c) feeding the halosilane compound into the reaction vessel, and (d) collecting a product stream from the reaction vessel, where the product stream contains a second halosilane.

Abstract: The present disclosure generally relates to a head assembly in a data storage device. The data storage device may include magnetic media embedded in the device or magnetic media from an insertable cassette or cartridge (e.g., in an LTO drive), where the head assembly reads from and writes to the magnetic media. During device operation, the magnetic media moves across the head assembly. The magnetic media experiences higher contact stress at certain points or portions of the head assembly. A sensor guard is coupled to the head assembly. The sensor guard comprises at least one chamfered surface or at least one stepped surface to decrease the contact stress between the magnetic media and the head assembly during device operation. The at least one chamfered or stepped surface may be disposed on a leading edge of the sensor guard.

Abstract: The present disclosure is directed to devices and methods for synchronizing capturing of spectral images with the capturing of thermal images. A thermal imaging device of an aerial vehicle captures a sequence of thermal image of thermal images. Capturing of spectral images by a spectral imaging device of the aerial vehicle is synchronized with the capturing of the thermal images. Irradiance data indicative of a background temperature is sensed. A digital surface model of an area of interest is generated based on the sequence of spectral images. An emissivity of a target is estimated and a temperature of a pixel of the digital surface model of the target is estimated based on the sequence of thermal images, the irradiance data indicative of the background temperature and the estimated emissivity of the target.

Abstract: Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a SOS1-mediated disorder, disease, or condition.

Abstract: Provided herein are KRAS protein degraders, for example, a compound of Formula (A), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a KRAS-mediated disorder, disease, or condition.

Abstract: Provided herein are KRAS protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a KRAS-mediated disorder, disease, or condition.

Abstract: Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition.

Abstract: The present disclosure is generally related to a tape drive comprising a tape head assembly. The tape head assembly comprises a spring adaptor, the spring adaptor comprising a first hole, a second hole, and a spring member disposed between the first hole and the second hole, a beam disposed within the first hole of the spring adaptor, a first module disposed on the beam, the first module comprising a first plurality of write transducers and a first plurality of read transducers, a second module disposed on the beam adjacent to the first module, the second module comprising a second plurality of write transducers and a second plurality of read transducers, and an actuator disposed in the first hole. The actuator is controllable to move the beam in a direction transverse to a media movement direction. The spring adaptor stabilizes the beam while the beam is being actuated.

Abstract: This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by having a dispersion component value of the Hansen Solubility Parameter of less than or equal to about 17 MPa0.5. This invention also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.

Abstract: Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition.

Abstract: Provided herein are a biarylsulfonamide, e.g., a compound of Formula (IA), and a pharmaceutical composition thereof. Also provided herein is a method of treating a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent. Additionally, provided herein is a method of slowing the rate of decline in pulmonary function in a subject having a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent.

Abstract: A magnetic recording head assembly is provided and is configured to read from and write to a magnetic media. The head assembly includes a first module having a first media facing surface (MFS), a first closure, and a first recessed portion disposed between the first MFS and the first closure. The first MFS includes AlTiC. A second module is provided having a second MFS, a second closure, and a second recessed portion disposed between the second MFS and the second closure. The second MFS includes AlTiC. An overcoat disposed within the first and second recessed portions includes an adhesive layer and a protective layer disposed within the first and second recessed portion.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: The present disclosure is generally related to a tape head assembly narrower than the width of a tape, wherein the tape head assembly comprises one or more heads, wherein each of the one or more heads comprise a curved surface comprising a first beveled wing, a second beveled wing, and a flat-lapped surface disposed between the first beveled wing and the second beveled wing. The first beveled wing and the second beveled wing each comprise outer corners recessed from a top surface of the flat-lapped surface such that there is no interaction between the outer corners of the beveled wings and the tape.

Abstract: The present disclosure generally relates to a head assembly in a data storage device. The data storage device may include magnetic media embedded in the device or magnetic media from an insertable cassette or cartridge (e.g., in an LTO drive), where the head assembly reads from and writes to the magnetic media. During device operation, the magnetic media moves across the head assembly. The magnetic media experiences higher contact stress at certain points or portions of the head assembly. A sensor guard is coupled to the head assembly. The sensor guard comprises at least one chamfered surface or at least one stepped surface to decrease the contact stress between the magnetic media and the head assembly during device operation. The at least one chamfered or stepped surface may be disposed on a leading edge of the sensor guard.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.