Abstract: This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by having a dispersion component value of the Hansen Solubility Parameter of less than or equal to about 17 MPa0.5. This invention also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.

Abstract: Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.

Abstract: Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition.

Abstract: Provided herein are a biarylsulfonamide, e.g., a compound of Formula (IA), and a pharmaceutical composition thereof. Also provided herein is a method of treating a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent. Additionally, provided herein is a method of slowing the rate of decline in pulmonary function in a subject having a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent.

Abstract: A magnetic recording head assembly is provided and is configured to read from and write to a magnetic media. The head assembly includes a first module having a first media facing surface (MFS), a first closure, and a first recessed portion disposed between the first MFS and the first closure. The first MFS includes AlTiC. A second module is provided having a second MFS, a second closure, and a second recessed portion disposed between the second MFS and the second closure. The second MFS includes AlTiC. An overcoat disposed within the first and second recessed portions includes an adhesive layer and a protective layer disposed within the first and second recessed portion.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: The present disclosure is generally related to a tape head assembly narrower than the width of a tape, wherein the tape head assembly comprises one or more heads, wherein each of the one or more heads comprise a curved surface comprising a first beveled wing, a second beveled wing, and a flat-lapped surface disposed between the first beveled wing and the second beveled wing. The first beveled wing and the second beveled wing each comprise outer corners recessed from a top surface of the flat-lapped surface such that there is no interaction between the outer corners of the beveled wings and the tape.

Abstract: The present disclosure generally relates to a head assembly in a data storage device. The data storage device may include magnetic media embedded in the device or magnetic media from an insertable cassette or cartridge (e.g., in an LTO drive), where the head assembly reads from and writes to the magnetic media. During device operation, the magnetic media moves across the head assembly. The magnetic media experiences higher contact stress at certain points or portions of the head assembly. A sensor guard is coupled to the head assembly. The sensor guard comprises at least one chamfered surface or at least one stepped surface to decrease the contact stress between the magnetic media and the head assembly during device operation. The at least one chamfered or stepped surface may be disposed on a leading edge of the sensor guard.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: A magnetic recording head assembly is provided and is configured to read from and write to a magnetic media. The head assembly includes a first module having a first media facing surface (MFS), a first closure, and a first recessed portion disposed between the first MFS and the first closure. The first MFS includes AlTiC. A second module is provided having a second MFS, a second closure, and a second recessed portion disposed between the second MFS and the second closure. The second MFS includes AlTiC. An overcoat disposed within the first and second recessed portions includes an adhesive layer and a protective layer disposed within the first and second recessed portion.

Abstract: Provided herein are RAS protein degraders, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RAS-mediated disorder, disease, or condition.

Abstract: A system and method for providing distributed on-street valet parking with the aid of a digital computer is provided. Parking spaces for valet services are reserved. One of the reserved parking spaces is designated as a valet drop-off parking space. A motor vehicle is detected in the valet drop-off parking space and a notification that the motor vehicle requires parking is provided to a valet of the detected motor vehicle. A search is conducted for the reserved parking spaces available for valet services for the motor vehicle. At least one of the reserved parking spaces available for the motor vehicle is identified and the motor vehicle is parked in the identified reserved parking space.

Abstract: A laundry care composition comprises a laundry care ingredient or adjunct and at least one compound that is capable of changing from a first color state (i.e., the initial color state in the composition) to a second color state that is perceptibly different from the first color state. A method for treating textile articles comprises the steps of: (a) providing a laundry care composition as described above; (b) adding the laundry care composition to a liquid medium; and (c) placing the textile articles in the liquid medium.

Abstract: A portable carrying case assembly for carrying a box of disposable gloves includes a container that has a plurality of intersecting sides such that the container has a rectilinear shape for containing a box of disposable gloves. A cover is positionable on the container for closing the container. The cover has an opening extending through the cover to facilitate the disposable gloves to be drawn outwardly therefrom when the cover is positioned on the container. A clip is coupled to the container to engage an article of clothing for carrying the container in a hands free manner.

Abstract: The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.

Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.

Abstract: The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.

Abstract: The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1?, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

Abstract: A system and method for managing a multiplicity of motor vehicle parking spaces through a server is provided. Smart parking devices and vehicle occupancy sensors that are each physically proximate to and which correspond to at least one of the parking spaces is interfaced with the server. Parking availability indicators that are each associated with at least one of the parking spaces is interfaced with the server. Street sweeping activity affecting the parking spaces is planned and comprising times and dates over which street sweeping of the parking spaces will occur. Any requests for reserving the use of the parking spaces during the street sweeping activity is denied. The parking availability indicators are activated associated with the parking spaces affected by the street sweeping activity. Occupancy of each of the parking spaces by a motor vehicle is sensed through the nearest vehicle occupancy sensor.

Abstract: The present application relates to an antimicrobial coated substrate with one or more surfaces and a TiO2 coating on at least one of the surfaces of the substrate, where the coating has a rhombohedral microstructure. Also disclosed is a process for preparing an antimicrobial coated substrate with one or more surfaces and methods of killing microbes.