Abstract: A system and method for offering customer priority parking reservations. Motor vehicle parking spaces are provided through a server. The server respectively interfaces with smart parking devices, vehicle occupancy sensors, and parking availability indicators that are each associated with the parking spaces. The parking spaces are reserved by accepting a request for a customer priority parking reservation from a merchant for a reservation period. Use of the parking space is managed through the server by activating the parking availability indicators associated with the reserved parking spaces, sensing occupancy of the parking spaces by a motor vehicle through the vehicle occupancy sensor, and retrieving and providing an identity of the driver of the motor vehicle through the nearest smart parking device to the server. The use of the parking space is validated from the merchant through the server.

Abstract: A system and method for providing distributed on-street valet parking with the aid of a digital computer is provided. Parking spaces for valet services are reserved. One of the reserved parking spaces is designated as a valet drop-off parking space. A motor vehicle is detected in the valet drop-off parking space and a notification that the motor vehicle requires parking is provided to a valet of the detected motor vehicle. A search is conducted for the reserved parking spaces available for valet services for the motor vehicle. At least one of the reserved parking spaces available for the motor vehicle is identified and the motor vehicle is parked in the identified reserved parking space.

Abstract: This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by having a dispersion component value of the Hansen Solubility Parameter of less than or equal to about 17 MPa0.5. This invention also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.

Abstract: This application relates to thiophene azo dyes for use as hueing agents, laundry care compositions comprising such thiophene azo dyes, processes for making such thiophene azo dyes, and laundry care compositions and methods of using the same. The thiophene azo dyes contain a formally charged moiety and are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. These thiophene azo dyes are advantageous in providing a hueing effect, for example, a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics. The thiophene azo dyes are also generally stable to bleaching agents used in laundry care compositions.

Abstract: A method for making a halosilane compound comprises the steps of: (a) providing a first halosilane compound, (b) providing a reaction vessel containing a halide source disposed inside, (c) feeding the halosilane compound into the reaction vessel, and (d) collecting a product stream from the reaction vessel, where the product stream contains a second halosilane.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1?, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

Abstract: The present disclosure provides compounds that modulate protein function and/or restore protein homeostasis. The disclosure provides methods of modulating protein-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other therapeutic agents, are provided.

Abstract: This application relates to thiophene azo dyes for use as hueing agents, laundry care compositions comprising such thiophene azo dyes, processes for making such thiophene azo dyes, and laundry care compositions and methods of using the same. The thiophene azo dyes contain a formally charged moiety and are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. These thiophene azo dyes are advantageous in providing a hueing effect, for example, a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics. The thiophene azo dyes are also generally stable to bleaching agents used in laundry care compositions.

Abstract: A cleaning composition comprises at least one surfactant and at least one colorant. The cleaning composition can have a pH of about 3 or less. The colorant exhibits one of several specified structures at a pH of about 7. A method for cleaning a surface utilizes the cleaning composition.

Abstract: A computer-implemented system and method for providing multi-locational curbside valet parking service is provided. A multiplicity of motor vehicle parking spaces are managed by a server. A plurality of smart parking devices and vehicle occupancy sensors are interfaced with the server. Use of a plurality of the parking spaces is reserved for a valet service. A reservation request for the use of the plurality of the parking spaces is accepted for use by the valet service for a period of time. Occupancy of the reserved parking spaces by a motor vehicle is sensed through the vehicle occupancy sensor. A valet drop-off location of at least one of the parking spaces that is reserved for the use of the valet service and is not occupied by a motor vehicle is identified. The valet drop-off location and a location of a lock box are provided to the motorist through a user interface.

Abstract: The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, TNF-alpha activity, CK1-alpha activity and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions, such as cytokine-mediated diseases, disorders, and conditions, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, organ transplant rejection, and cancer, are provided.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: A computer-implemented system and method for offering merchant and shopper-friendly parking reservations through tourist privileges is provided. A tourist identification card is issued to a tourist via an agency and is associated with one or more parking privileges. A presence of a motor vehicle in at least one parking space is identified and the tourist identification card is received via a smart parking meter that is associated with the parking space. The received tourist identification card is authenticated and parking privileges are provided upon the authentication of the received tourist identification card for the parking space. The parking privileges include one or more of extending parking limits, reserving tourist spaces, and reducing parking rates. An indicator for an unavailable status is displayed for the parking space.

Abstract: The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1?, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

Abstract: This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.

Abstract: A composition comprises a first siloxane compound comprising at least one cyclic siloxane moiety and a first salt, the first salt comprising a conjugate base of a volatile organic acid. A method for producing a cross-linked siloxane network comprises the steps of providing a first siloxane compound comprising at least one cyclic siloxane moiety, providing a first salt comprising a conjugate base of a volatile organic acid, combining the first siloxane compound and the first salt to produce a reaction mixture, heating the reaction mixture to a temperature sufficient for the first salt to open the ring of the cyclic siloxane moiety, and maintaining the reaction mixture at an elevated temperature so that at least a portion of the opened cyclic siloxane moieties react with each other to produce a cross-linked siloxane network.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: A computer-implemented system and method for offering merchant and shopper-friendly parking reservations through tourist privileges is provided. Motor vehicle parking spaces located in a tourist area of an urban environment are managed through a server. Smart parking devices and vehicle occupancy sensors are each proximate to at least one of the parking spaces. Tourist parking identification cards are issued to an agency authorized to provide tourist parking privileges, which are then provided to the visitors. The parking identification cards are activated by pairing each identification card with a digital ticket issued to the agency. The parking spaces are managed by sensing occupancy of one of the parking spaces by a motor vehicle through the nearest vehicle occupancy sensor and by determining an identity of the driver of the motor vehicle through the nearest smart parking device.

Abstract: The present application relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two constituents: at least one chromophore constituent and at least one polymeric constituent. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by the polymeric component comprising at least two repeating glycerol units. This disclosure also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.