Abstract: The present application relates to an antimicrobial coated substrate with one or more surfaces and a TiO2 coating on at least one of the surfaces of the substrate, where the coating has a rhombohedral microstructure. Also disclosed is a process for preparing an antimicrobial coated substrate with one or more surfaces and methods of killing microbes.

Abstract: This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.

Abstract: This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by having a dispersion component value of the Hansen Solubility Parameter of less than or equal to about 17 MPa0.5. This invention also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.

Abstract: The present disclosure generally relates to a head assembly in a data storage device. The data storage device may include magnetic media embedded in the device or magnetic media from an insertable cassette or cartridge (e.g., in an LTO drive), where the head assembly reads from and writes to the magnetic media. During device operation, the magnetic media moves across the head assembly. The magnetic media experiences higher contact stress at certain points or portions of the head assembly. A sensor guard is coupled to the head assembly. The sensor guard comprises at least one chamfered surface or at least one stepped surface to decrease the contact stress between the magnetic media and the head assembly during device operation. The at least one chamfered or stepped surface may be disposed on a leading edge of the sensor guard.

Abstract: The present disclosure is directed to devices and methods for synchronizing capturing of spectral images with the capturing of thermal images. A thermal imaging device of an aerial vehicle captures a sequence of thermal image of thermal images. Capturing of spectral images by a spectral imaging device of the aerial vehicle is synchronized with the capturing of the thermal images. Irradiance data indicative of a background temperature is sensed. A digital surface model of an area of interest is generated based on the sequence of spectral images. An emissivity of a target is estimated and a temperature of a pixel of the digital surface model of the target is estimated based on the sequence of thermal images, the irradiance data indicative of the background temperature and the estimated emissivity of the target.

Abstract: The present invention provides compounds that modulate protein function, specifically phosphodiesterase 4 (PDE4). The invention provides methods of treating, ameliorating, and/or preventing diseases, disorders, and conditions associated with PDE4. Compositions, including in combination with other inflammatory mediators, are also provided.

Abstract: This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by having a dispersion component value of the Hansen Solubility Parameter of less than or equal to about 17 MPa0.5. This invention also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.

Abstract: Aspects of the present disclosure generally relate to a base and related methods for write and read heads. In one example, the base and related methods are used as part of a magnetic storage device, for example a magnetic media drive such as a hard disk drive (HDD) or a magnetic tape drive (e.g., a tape embedded drive). The base includes one or more base bodies formed of a ceramic material. Each base body includes an inward surface, an outward surface opposing the inward surface, a lower surface, and an angled upper surface disposed above the lower surface. Each base body includes a vertical opening extending between the upper surface and the lower surface. In one example, two base bodies are bonded together. In one example, the two base bodies combine to form a single base body of the base that is monolithic and unitary.

Abstract: Aspects of the present disclosure generally relate to a base and related methods for write and read heads. In one example, the base and related methods are used as part of a magnetic storage device, for example a magnetic media drive such as a hard disk drive (HDD) or a magnetic tape drive (e.g., a tape embedded drive). The base includes one or more base bodies formed of a ceramic material. Each base body includes an inward surface, an outward surface opposing the inward surface, a lower surface, and an angled upper surface disposed above the lower surface. Each base body includes a vertical opening extending between the upper surface and the lower surface. In one example, two base bodies are bonded together. In one example, the two base bodies combine to form a single base body of the base that is monolithic and unitary.

Abstract: This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.

Abstract: The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK?, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: A computer-implemented system and method for facilitating rental of a private parking space by an urban resident are provided. Motor vehicle parking spaces located in a residential area are managed through a server. Smart parking devices that are each physically proximate to least one of the parking spaces are interfaced to the server. Vehicle occupancy sensors that are also each physically proximate to least one of the parking spaces are interfaced to the server. Parking availability indicators that are each associated with at least one of the parking spaces are interfaced to the server. The parking spaces are supplemented with a private parking space under legitimate control by a resident of the residential area. Use of the private parking space is managed through the server and the smart parking device nearest to the private parking space. Parking availability the parking spaces is indicated through the nearest parking availability indicator.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: Methods (and related apparatus) include obtaining data regarding a measured property. The measured property includes an amount of each of predetermined hydrocarbons in a gas sample extracted from drilling fluid exiting a wellbore having a hydrocarbon resource. An unknown characteristic of an investigated fluid property of the hydrocarbon resource is predicted utilizing the obtained input data and one or more predetermined models each built via statistical classification and regression analysis of a preexisting database containing records. Each record includes known characteristics of fluid properties of a different one of known reservoir fluids. The fluid properties include the investigated fluid property and the measured property. The investigated fluid property includes a fluid type of the hydrocarbon resource, an amount of at least one additional hydrocarbon, gas-oil ratio, or stock tank oil density.

Abstract: The present application relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two constituents: at least one chromophore constituent and at least one polymeric constituent. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by the polymeric component comprising at least two repeating glycerol units. This disclosure also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.

Abstract: The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1?, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

Abstract: Bis-azo colorants for use as bluing agents, laundry care compositions including bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally include at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.

Abstract: The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.