Patents by Inventor Edward B. McCauley

Edward B. McCauley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10008377
    Abstract: A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: June 26, 2018
    Assignee: Thermo Finnigan LLC
    Inventors: Scott T. Quarmby, Edward B. McCauley, Joshua T. Maze
  • Patent number: 9874546
    Abstract: A device for a gas chromatograph system includes an injector, a conduit assembly, a flow restrictor, and a pressure controller. The injector is connected to a carrier gas source and an auxiliary gas source. The conduit assembly surrounds the input end of an analytical column. A carrier gas is supplied at a constant pressure through a flow restrictor to the injector. A pressure controller is configured to control the pressure of an auxiliary gas supplied to the injector from the auxiliary source. The pressure controller is configured to operate in a first mode to provide a first auxiliary gas pressure sufficient to force a flow of the auxiliary gas and a sample onto the analytical column during an inject phase and to operate in a second mode to provide a second auxiliary gas pressure below a threshold necessary to flow auxiliary gas into the analytical column during a resolving phase.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: January 23, 2018
    Assignee: Thermo Finnigan LLC
    Inventor: Edward B. McCauley
  • Publication number: 20180019111
    Abstract: A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold.
    Type: Application
    Filed: August 16, 2017
    Publication date: January 18, 2018
    Inventors: Scott T. QUARMBY, Edward B. McCAULEY, Joshua T. MAZE
  • Publication number: 20170282113
    Abstract: A capillary column includes a fused silica tubing and a polyimide coating over the fusing silica tubing. Additionally, the capillary column further includes a first plurality of integrated ferrules positioned along at least a first portion of the fused silica tubing and spaced apart from one another by a first fixed interval.
    Type: Application
    Filed: March 29, 2016
    Publication date: October 5, 2017
    Inventor: Edward B. McCauley
  • Patent number: 9768006
    Abstract: A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: September 19, 2017
    Assignee: Thermo Finnigan LLC
    Inventors: Scott T. Quarmby, Edward B. McCauley, Joshua T. Maze
  • Publication number: 20170207075
    Abstract: A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold.
    Type: Application
    Filed: January 20, 2016
    Publication date: July 20, 2017
    Inventors: Scott T. QUARMBY, Edward B. McCAULEY, Joshua T. MAZE
  • Patent number: 9632064
    Abstract: An injection port for a gas chromatograph (GC) is operated such that, during an injection sequence, an inert gas is used for sample transfer to the analytical column while hydrogen is subsequently utilized for the majority of the analytical separation. This allows for a high degree of chromatographic efficiency, while also reducing unwanted chemical reactions involving hydrogen and/or reactive solvents in a hot injection port. Certain embodiments also provide an increased margin of safety when using hydrogen, since the total flow may be limited such that the concentration of hydrogen in the GC oven never exceeds a safety limit, such as the lower explosive limit.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: April 25, 2017
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Franco Ponciroli, Paolo Magni
  • Publication number: 20170023534
    Abstract: A device for a gas chromatograph system includes an injector, a conduit assembly, a flow restrictor, and a pressure controller. The injector is connected to a carrier gas source and an auxiliary gas source. The conduit assembly surrounds the input end of an analytical column. A carrier gas is supplied at a constant pressure through a flow restrictor to the injector. A pressure controller is configured to control the pressure of an auxiliary gas supplied to the injector from the auxiliary source. The pressure controller is configured to operate in a first mode to provide a first auxiliary gas pressure sufficient to force a flow of the auxiliary gas and a sample onto the analytical column during an inject phase and to operate in a second mode to provide a second auxiliary gas pressure below a threshold necessary to flow auxiliary gas into the analytical column during a resolving phase.
    Type: Application
    Filed: July 24, 2015
    Publication date: January 26, 2017
    Inventor: Edward B. McCAULEY
  • Patent number: 9244044
    Abstract: A method of operating a gas chromatograph-mass spectrometer (GC-MS) comprising a GC column for separating analytes of a sample, a GC oven and a mass spectrometer comprises: providing a conduit extending between the GC oven and the mass spectrometer such that a conduit interior volume is contiguous with an interior volume of the GC oven; routing the GC column through the GC oven and conduit interior volume to an ion source of the mass spectrometer; providing a flow of temperature regulated air or gas between a fan or blower of the gas chromatograph and the conduit interior volume; introducing the sample into the GC column; controlling the temperature of the GC oven interior volume and the conduit interior volume so as to facilitate analyte separation within the GC column and transfer of the separated analytes to the mass spectrometer; and analyzing the separated analytes with the mass spectrometer.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: January 26, 2016
    Assignee: Thermo Finnigan LLC
    Inventor: Edward B. McCauley
  • Patent number: 9212897
    Abstract: A column used for gas chromatography (GC) is fabricated from an open tubular light guiding capillary. The light guiding capillary is suitable for transmission of optical frequencies employed in commercially available hand held laser range finders.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: December 15, 2015
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, James M. Hitchcock
  • Publication number: 20150330953
    Abstract: An injection port for a gas chromatograph (GC) is operated such that, during an injection sequence, an inert gas is used for sample transfer to the analytical column while hydrogen is subsequently utilized for the majority of the analytical separation. This allows for a high degree of chromatographic efficiency, while also reducing unwanted chemical reactions involving hydrogen and/or reactive solvents in a hot injection port. Certain embodiments also provide an increased margin of safety when using hydrogen, since the total flow may be limited such that the concentration of hydrogen in the GC oven never exceeds a safety limit, such as the lower explosive limit.
    Type: Application
    Filed: July 17, 2014
    Publication date: November 19, 2015
    Inventors: Edward B. McCauley, Franco Ponciroli, Paolo Magni
  • Patent number: 9170241
    Abstract: A gas chromatography (GC) system comprises: a sample injector adapted to receive a liquid sample into an interior cavity thereof and to volatilize the liquid sample; a GC column configured to receive the volatilized sample from the sample injector; a carrier gas inlet line fluidically coupled to a gas inlet port of the sample injector; a septum purge vent line fluidically coupled to a first gas outlet port of the sample injector; a split-flow vent line fluidically coupled to a second gas outlet port of the sample injector; and a vacuum system configured to apply vacuum to the septum purge vent line, the split-flow vent line and the interior cavity of the sample injector. Alternatively, the vacuum system may be coupled to a vacuum port of the sample injector. A separate flow of helium gas may be supplied to an inlet of the GC column.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: October 27, 2015
    Assignee: Thermo Finnigan LLC
    Inventor: Edward B. McCauley
  • Publication number: 20140250978
    Abstract: A gas chromatography (GC) system comprises: a sample injector adapted to receive a liquid sample into an interior cavity thereof and to volatilize the liquid sample; a GC column configured to receive the volatilized sample from the sample injector; a carrier gas inlet line fluidically coupled to a gas inlet port of the sample injector; a septum purge vent line fluidically coupled to a first gas outlet port of the sample injector; a split-flow vent line fluidically coupled to a second gas outlet port of the sample injector; and a vacuum system configured to apply vacuum to the septum purge vent line, the split-flow vent line and the interior cavity of the sample injector. Alternatively, the vacuum system may be coupled to a vacuum port of the sample injector. A separate flow of helium gas may be supplied to an inlet of the GC column.
    Type: Application
    Filed: March 7, 2013
    Publication date: September 11, 2014
    Inventor: Edward B. McCauley
  • Patent number: 8740587
    Abstract: An apparatus and method for differential pumping of a mass spectrometer or other ion-optical device provides a transverse pressure drop introduced across a face of a primary rotor of a turbomolecular pump by placement of one or more partitions in close proximity to the face of the primary rotor. Thus, two or more regions of space within the vacuum chamber having respective different pressures is achieved with a single pump.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: June 3, 2014
    Assignee: Thermo Finnigan LLC
    Inventor: Edward B. McCauley
  • Publication number: 20140000341
    Abstract: A method of operating a gas chromatograph-mass spectrometer (GC-MS) comprising a GC column for separating analytes of a sample, a GC oven and a mass spectrometer comprises: providing a conduit extending between the GC oven and the mass spectrometer such that a conduit interior volume is contiguous with an interior volume of the GC oven; routing the GC column through the GC oven and conduit interior volume to an ion source of the mass spectrometer; providing a flow of temperature regulated air or gas between a fan or blower of the gas chromatograph and the conduit interior volume; introducing the sample into the GC column; controlling the temperature of the GC oven interior volume and the conduit interior volume so as to facilitate analyte separation within the GC column and transfer of the separated analytes to the mass spectrometer; and analyzing the separated analytes with the mass spectrometer.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 2, 2014
    Applicant: Thermo Finnigan LLC
    Inventor: Edward B. McCauley
  • Patent number: 8549893
    Abstract: A system for interfacing a gas chromatograph (GC) to a mass spectrometer the GC comprising a GC column partially contained within a GC oven, the mass spectrometer comprising a housing enclosing an interior having an ion source, the system comprising: a conduit extending from the GC oven to the mass spectrometer and comprising an interior volume that is contiguous with an interior volume of the GC oven; and a duct extending from a region of relatively high or relatively low pressure within the GC oven to the conduit interior volume and operable so as to transmit a flow of air or gas between the region of relatively high or relatively low pressure and the conduit interior volume, wherein a portion of the GC column extends through the conduit interior volume to the ion source.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: October 8, 2013
    Assignee: Thermo Finnigan LLC
    Inventor: Edward B. McCauley
  • Publication number: 20130199267
    Abstract: A column used for gas chromatography (GC) is fabricated from an open tubular light guiding capillary. The light guiding capillary is suitable for transmission of optical frequencies employed in commercially available hand held laser range finders.
    Type: Application
    Filed: February 8, 2012
    Publication date: August 8, 2013
    Inventors: Edward B. McCAULEY, James M. HITCHCOCK
  • Publication number: 20130118231
    Abstract: A device for conserving helium gas in a gas chromatograph system is characterized in that during the majority of an analytical separation, helium is used as the carrier gas while an auxiliary non-helium gas is used to pressurize the inlet and provide for septum purge and split vent flow. Prior an injection period, a coaxial helium flow is established at the column entrance wherein the coaxial helium flow is less than the column flow. Following the injection and sample transfer period, a coaxial helium flow is established wherein the flow is greater than the column flow.
    Type: Application
    Filed: January 7, 2013
    Publication date: May 16, 2013
    Inventors: Edward B. McCAULEY, Paolo MAGNI
  • Patent number: 8426805
    Abstract: A mass spectrometer and a technique for operating it involve setting an operating parameter that influences a rate of flow of electrons from an electron source into an ion volume so that ions produced from a material in the ion volume in response to electrons satisfy an ion production target, performing a plurality of analytical runs using the mass spectrometer with the electron source while monitoring an operational characteristic, and adjusting the operating parameter in response to the monitoring to compensate for a change over time in the operational characteristic in a manner so that the ion production target remains satisfied.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: April 23, 2013
    Assignee: Thermo Finnigan LLC
    Inventor: Edward B. McCauley
  • Patent number: 8371152
    Abstract: A device for conserving helium gas in a gas chromatograph system is characterized in that during the majority of an analytical separation, helium is used as the carrier gas while an auxiliary non-helium gas is used to pressurize the inlet and provide for septum purge and split vent flow. Prior an injection period, a coaxial helium flow is established at the column entrance wherein the coaxial helium flow is less than the column flow. Following the injection and sample transfer period, a coaxial helium flow is established wherein the flow is greater than the column flow.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: February 12, 2013
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Paolo Magni