Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Abstract: Methods and systems for assisting individuals (101) arrange meetings such as networking meeting with other individuals (101) at a specified time (or within a specified time range) and/or at a specified place (or within a specified geographic region). More specifically, methods and systems for allowing individuals (110) to post an invitation to for a meeting on an on-line network and for allowing one or more other individuals (101) to accept such invitation.

Abstract: Methods and systems for assisting individuals (101) arrange meetings such as networking meeting with other individuals (101) at a specified time (or within a specified time range) and/or at a specified place (or within a specified geographic region). More specifically, methods and systems for allowing individuals (110) to post an invitation to for a meeting on an on-line network and for allowing one or more other individuals (101) to accept such invitation.

Abstract: The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.

Abstract: An article of apparel comprising: a pocket, the pocket comprising an opening to permit insertion and removal of an electronic device, the pocket further comprising at least one raised portion, wherein when the electronic device is located in the pocket, at least one operational control button of the electronic device is positioned adjacent the at least one raised portion.

Abstract: Compounds of general formula (I): wherein R1, R2, R3 and R4 are independently hydrogen, halo, C1-C6 alkyl, —O(C1-C6 alkyl), —CON(R9)2, —SOR9, —SO2R9, —SO2N(R9)2, —N(R9)2, —NR9COR9, —CO2R9, —COR9, —SR9, —OH, —NO2 or —CN; each R9 is independently hydrogen or C1-C6 alkyl; R5 and R6 are each independently hydrogen, or C1-C6 alkyl or together with the carbon atom to which they are attached form a C3-C7 cycloalkyl group; R7 is hydrogen or C1-C6 alkyl n is 1 or 2; X is a bond or, when n is 2, X may also be a NR9 group; wherein R9 is as defined above; when X is a bond R8 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, biphenyl or a 9-14 membered bicyclic or tricyclic heteroaryl group; when X is a NR9 group R8 may additionally be phenyl, naphthyl or a 5-7 membered heteroaromatic ring; and the R8 group is optionally substituted with one or more substituents selected from halo, C1-C6 alkyl, —O(C1-C6)alkyl, aryl, —O-aryl, heteroaryl, —O-heteroaryl, —CON(R9)2, —SOR9, —SO2R9, SO2N(9)2, —N(9)2, —NR9COR9, —CO2

Abstract: An article of apparel is disclosed that includes a covered electronic device. The apparel is at least partially formed from a material element that defines an aperture. The electronic device is locatable within the aperture and secured to the material element. A material covers the electronic device such that the electronic device cannot be seen. Upon activation of the electronic device, the readout is seen through the material. The electronic device may be a timing device, such as a watch, or a global positioning system unit. The apparel may be a wristband formed from a textile material or any of a variety of other types of apparel.

Abstract: The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.

Abstract: One embodiment of the present invention provides a system for accommodating time-division multiplexing (TDM) traffic in an Ethernet passive optical network (EPON). During operation, the system receives data from an upstream TDM channel at a remote node and stores received data in a segmentation buffer. The system encapsulates the data stored in the segmentation buffer into a packet. The system receives a message from the central node granting a TDM transmission window starting at a designated time. The system further communicates the packet to an upstream transmission mechanism within the remote node before the designated time, and transmits to the central node an upstream frame containing the packet at the designated time.

Abstract: Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.

Abstract: The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

Abstract: One embodiment of the present invention provides a method for facilitating asymmetric line rates in an Ethernet passive optical network (EPON) which includes a central node and at least one remote node. During operation, the system provides a downstream code-group clock, wherein each cycle thereof corresponds to a code group transmitted from the central node to a remote node. The system also provides an upstream code-group clock, wherein each cycle thereof corresponds to a code group received at the central node from a remote node. In addition, the system provides a multi-point control protocol (MPCP) clock, wherein the frequency ratio of the MPCP clock to the downstream code-group clock is different from the frequency ratio of the MPCP clock to the upstream code-group clock, thereby allowing the downstream transmission to be performed at a faster line rate than the upstream transmission line rate.

Abstract: The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

Abstract: One embodiment of the present invention provides a system that accommodates different clock frequencies in an EPON. The system receives a signal from the OLT at the ONU and derives an OLT clock. The system also maintains a local clock. The system further receives from the OLT an assignment for an upstream transmission window, during which the ONU can transmit an upstream data burst to the OLT based on the local clock. The system adjusts the number of bits of the data burst without affecting the payload data carried in the data burst, thereby allowing the data burst to fit properly within the upstream transmission window and compensating for frequency differences between the local clock and the OLT clock. The system transmits the data burst based on the local clock in the upstream transmission window.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

Abstract: One embodiment of the present invention provides a system that accommodates multiple optical segments in an Ethernet passive optical network (EPON), wherein the EPON includes a central node and a number of remote nodes, and wherein the remote nodes reside in a number of optical segments. During operation, the system transmits downstream data from the central node to the remote nodes by broadcasting the data to the optical segments. In addition, the system selectively allows an optical segment to communicate with the central node during an upstream transmission period assigned to a remote node residing in that optical segment, thereby accommodating multiple optical segments and hence an increased number of remote nodes within the EPON.

Abstract: A manual release mechanism for disengaging a king pin on a truck trailer from a fifth wheel of a truck cab includes a substantially straight lever arm with a first end being pivotally attached to the fifth wheel and a second end being spaced away from the fifth wheel extending horizontally from the first end. A pair of flat disks and a pair of slide bars are provided for slideably coupling to a release rod of the fifth wheel, such that a manual movement of the second end of the lever arm will cause pivoting thereof horizontally about the first end, thereby causing the release rod to be pulled outwardly to disengage the king pin from the fifth wheel. The lever arm is provided with an adjustable extension arm so that the length of the lever arm can be adjusted to an extent desired to best facilitate manipulation thereof. A lock pin is provided for securing the extension arm to the lever arm. A flexible cable secures the extension arm to the frame of the truck cab.

Abstract: Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.