Abstract: The present invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).

Abstract: An optical sight comprises an elongate housing defining a light channel. A lens is provided at one end of the light channel and has a partially reflecting surface. A laser diode is energised by a pulsating electric current delivered by a battery powered energising circuit, and the energised laser diode emits light towards the reflecting surface to produce a light spot by direct imaging of the laser diode on the surface. The light spot shall be superimposed on the target when sighting through the light channel from the other end thereof.

Abstract: The present invention relates to the production of ethanol as a product of bacterial fermentation. In particular this invention relates to a novel method of gene inactivation and gene expression based upon homologous recombination. The method is particularly useful in connection with species of Bacillus such as B. stereothermophilus, B. calvodelox, B. caldotenax, B. thermoglucosidasius, B. coagulans, B. licheniformis, B. thermodenitrificans, and B. caldolyticus.

Abstract: Production of ethanol in a thermophilic bacterium can be achieved by transformation of the bacterium with a heterologous gene encoding pyruvate decarboxylase. The bacterium comprises native alcohol dehydrogenase function and does not comprise a gene encoding a functional lactate dehydrogenase. The bacterium may be grown at elevated temperatures to allow the ethanol to be conveniently removed in a vaporized form from the fermentation medium. Traditional mesophilic microorganisms are incapable of growth at the envisioned elevated temperatures.

Abstract: A machine based tool and associated logic and methodology are used in converting data from an input form to a target form using context dependent conversion rules. In particular, a frame-slot architecture is utilized where a frame represents an intersection between a contextual cue recognized by the machine tool, associated content and related constraint information to specific to that conversion environment, whereas a slot represents an included chunk of information. An exemplary conversion system (400) includes a parser (402) for use in parsing and converting an input stream (403) from a source (404) to provide an output stream (411) in a form for use by a target system (412). To accomplish the desired conversion, the parser (402) uses information from a public schema (406), a private schema (408) and a grammar (410). The public schema (406), private schema (408) and grammar (410) may include conversion rules applicable to less than the whole of a subject matter area including the input stream (403).

Abstract: The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly reduced bones mass, osteoporosis, osteopenia, or reduced muscle mass or strength, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof. X-17142.

Abstract: A method and apparatus are disclosed for transforming information from one semantic environment to another. In one implementation, a SOLx system (1700) includes a Normalization/Translation NorTran Workbench (1702) and a SOLx server (1708). The NorTran Workbench (1702) is used to develop a knowledge base based on information from a source system (1712), to normalize legacy content (1710) according to various rules, and to develop a database (1706) of translated content. During run time, the SOLx server (1708) receives transmissions from the source system (1712), normalizes the transmitted content, accesses the database (1706) of translated content and otherwise translates the normalized content, and reconstructs the transmission to provide substantially real-time transformation of electronic messages.

Abstract: The present invention is directed to a compound of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

Abstract: The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of formula (I).

Abstract: One embodiment of the invention provides a method of televising a card game. Each playing card in the card game has a value. The method includes providing the back surface of each playing card with a marking that is substantially invisible to the naked eye. The marking indicates the value of the playing card. An infrared detector is used to access the marking to identify the value of a playing card involved in the card game. Visual information indicative of the identified value of the playing card is generated and included in a broadcast of the card game.

Abstract: A semantic conversion system (1900) includes a self-learning tool (1902). The self-learning tool (1902) receives input files from legacy data systems (1904). The self-learning tool (1902) includes a conversion processor (1914) that can calculate probabilities associated with candidate conversion terms so as to select an appropriate conversion term. The self-learning tool (1902) provides a fully attributed and normalized data set (1908).

Abstract: A semantic conversion system (1900) includes a self-learning tool (1902). The self-learning tool (1902) receives input files from legacy data systems (1904). The self-learning tool (1902) includes a conversion processor (1914) that can calculate probabilities associated with candidate conversion terms so as to select an appropriate conversion term. The self-learning tool (1902) provides a fully attributed and normalized data set (1908).

Abstract: The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.

Abstract: A machine based tool and associated logic and methodology are used in converting data from an input form to a target form using context dependent conversion rules. In particular, a frame-slot architecture is utilized where a frame represents an intersection between a contextual cue recognized by the machine tool, associated content and related constraint information to specific to that conversion environment, whereas a slot represents an included chunk of information. An exemplary conversion system (400) includes a parser (402) for use in parsing and converting an input stream (403) from a source (404) to provide an output stream (411) in a form for use by a target system (412). To accomplish the desired conversion, the parser (402) uses information from a public schema (406), a private schema (408) and a grammar (410). The public schema (406), private schema (408) and grammar (410) may include conversion rules applicable to less than the whole of a subject matter area including the input stream (403).

Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).

Abstract: The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.

Abstract: The present invention is directed to a compound of formula I, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomer thereof, which are useful in treating Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to Syndrome X as well as cardiovascular diseases.

Abstract: Production of ethanol in a thermophilic bacterium can be achieved by transformation of the bacterium with a heterologous gene encoding pyruvate decarboxylase. The bacterium comprises native alcohol dehydrogenase function and does not comprise a gene encoding a functional lactate dehydrogenase. The bacterium may be grown at elevated temperatures to allow the ethanol to be conveniently removed in a vaporized form from the fermentation medium. Traditional mesophilic microorganisms are incapable of growth at the envisioned elevated temperatures.