Patents by Inventor Edward Shaw

Edward Shaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclohexyl derivatives and their use as therapeutic agents
    Patent number: 6953792
    Abstract: The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: October 11, 2005
    Assignees: Merck Sharp & Dohme Limited, Merck & Co., Inc.
    Inventors: Jose Luis Castro Pineiro, Kevin Dinnell, Jason Matthew Elliot, Gregory John Hollingworth, Duncan Edward Shaw, Christopher John Swain, Lihu Yang
  • Cyclohexyl sulphones as gamma-secretase inhibitors
    Patent number: 6890956
    Abstract: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: May 10, 2005
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian Churcher, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Andrew Pate Owens, Duncan Edward Shaw, Joanne Thomson, Susannah Williams
  • Pilot operated valve
    Publication number: 20050087243
    Abstract: A valve assembly having a fluid switch and a main valve for controlling fluid pressure in a working volume in three control states wherein the main valve has three ports for fluid, flow of fluid through a first port and a second port being controlled by the fluid switch being provided with an electrical signal in a first state or a second state respectively, and flow of fluid through the third port being controlled by alternating said signal, preferably rapidly, between said first and second states.
    Type: Application
    Filed: April 12, 2004
    Publication date: April 28, 2005
    Inventors: Edward Shaw, Laurence Potter
  • Throttle plate having reduced air rush noise and method
    Patent number: 6824119
    Abstract: A throttle body for use in the air intake system of a motor vehicle comprising a throttle body defining a throttle bore. The throttle plate is rotatably mounted within the throttle bore, having an outside diameter smaller than an inside diameter of the throttle bore. A plurality of fins, located on the throttle plate, extend from the throttle plate in a direction generally perpendicular to a plane defined by said throttle plate. The fins are optimized in number, thickness, spacing, length, shape, and angle to reduce air-rush noise without impacting engine performance.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: November 30, 2004
    Assignee: Visteon Global Technologies, Inc.
    Inventors: David A. Conley, Christopher Edward Shaw, Stephen Joseph Hamby
  • Cyclic sulfonamides for inhibition of gamma-secretase
    Publication number: 20040230054
    Abstract: Compounds of formula I: 1
    Type: Application
    Filed: May 14, 2004
    Publication date: November 18, 2004
    Inventors: Kevin Dinnell, Timothy Harrison, Alan John Nadin, Andrew Pate Owens, Duncan Edward Shaw, Brian John Williams
  • Gem-disubstituted cyclohexane derivatives and their use as therapeutic agents
    Publication number: 20040171642
    Abstract: The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 represent a variety of substituents, ring A is a phenyl or pyridyl ring; d is zero, 1 or 2; and pharmaceutically acceptable salts and N-oxides thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
    Type: Application
    Filed: December 17, 2003
    Publication date: September 2, 2004
    Inventors: Jose Luis Castro Pineiro, Kevin Dinnell, Jason Matthew Elliott, Gregory John Hollingworth, Duncan Edward Shaw, Christopher John Swain
  • Cyclohexyl sulphones as gamma-secretase inhibitors
    Publication number: 20040121995
    Abstract: Compounds of formula I: 1
    Type: Application
    Filed: October 6, 2003
    Publication date: June 24, 2004
    Inventors: Ian Churcher, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Andrew Pate Owens, Duncan Edward Shaw, Joanne Thomson, Susannah Williams
  • Cyclohexyl sulphone derivatives as gamma-secretase inhibitors
    Publication number: 20040122050
    Abstract: Compounds of formula I: 1
    Type: Application
    Filed: October 6, 2003
    Publication date: June 24, 2004
    Inventors: Ian Churcher, Timothy Harrison, Sonia Kerrad, Paul Joseph Oakley, Duncan Edward Shaw, Martin Richard Teall, Susannah Williams
  • Sulphones which modulate the action of gamma secretase
    Publication number: 20040116404
    Abstract: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: October 1, 2003
    Publication date: June 17, 2004
    Inventors: Jose Luis Castro Pineiro, Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Andrew Pate Owens, Duncan Edward Shaw, Martin Richard Teall, Susannah William, Brian John Williams
  • Cyclohexane derivatives and their use as therapeutic agents
    Publication number: 20030236250
    Abstract: The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R17, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
    Type: Application
    Filed: November 13, 2002
    Publication date: December 25, 2003
    Inventors: Jose Luis Castro Pineiro, Kevin Dinnell, Jason Matthew Elliott, Gregory John Hollingworth, Duncan Edward Shaw, Christopher John Swain
  • Cyclohexyl derivatives and their use as therapeutic agents
    Publication number: 20030225059
    Abstract: The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
    Type: Application
    Filed: November 13, 2002
    Publication date: December 4, 2003
    Inventors: Jose Luis Castro Pineiro, Kevin Dinnell, Jason Matthew Elliott, Gregory John Hollingworth, Duncan Edward Shaw, Christopher John Swain, Lihu Yang
  • Novel cyclohexyl sulphones
    Publication number: 20030114496
    Abstract: Novel sulphones of formula I are disclosed: 1
    Type: Application
    Filed: August 20, 2002
    Publication date: June 19, 2003
    Inventors: Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Duncan Edward Shaw, Martin Richard Teall, Susannah Williams, Brian John Williams
  • Idle air bypass valve acoustic diverter passage
    Patent number: 6539917
    Abstract: An arrangement for reducing noise produced by an engine idle air bypass valve and passage includes positioning an acoustic diverter at the end of the air bypass passage to force the noise away from exterior surfaces of a downstream chamber and toward the internal cavities of the engine such as a cylinder head. The diverter of the present invention reduces noise without causing restriction of air flow through the air bypass passage.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: April 1, 2003
    Assignee: Visteon Global Technologies, Inc.
    Inventors: Christopher Edward Shaw, James T. Dumas, James John Kempf
  • Throttle plate having reduced air rush noise and method
    Publication number: 20030042448
    Abstract: A throttle body for use in the air intake system of a motor vehicle comprising a throttle body defining a throttle bore. The throttle plate is rotatably mounted within the throttle bore, having an outside diameter smaller than an inside diameter of the throttle bore. A plurality of fins, located on the throttle plate, extend from the throttle plate in a direction generally perpendicular to a plane defined by said throttle plate. The fins are optimized in number, thickness, spacing, length, shape, and angle to reduce air-rush noise without impacting engine performance.
    Type: Application
    Filed: August 20, 2002
    Publication date: March 6, 2003
    Inventors: David A. Conley, Christopher Edward Shaw, Stephen Joseph Hamby
  • 2-aryl indole derivative as antagonists of tachykinins
    Patent number: 6518273
    Abstract: The present invention relates to compounds of the formula (I): wherein R1a, R1b, R2, R3, R4, R5, X and n are defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis and postherpetic neuralgia.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: February 11, 2003
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Kevin Tyler Chapman, Kevin Dinnell, Jason Matthew Elliott, Gregory John Hollingworth, Steven Michael Hutchins, Duncan Edward Shaw, Christopher Alan Willoughby
  • Idle air bypass valve acoustic diverter passage
    Publication number: 20020162532
    Abstract: An arrangement for reducing noise produced by an engine idle air bypass valve and passage includes positioning an acoustic diverter at the end of the air bypass passage to force the noise away from exterior surfaces of a downstream chamber and toward the internal cavities of the engine such as a cylinder head. The diverter of the present invention reduces noise without causing restriction of air flow through the air bypass passage.
    Type: Application
    Filed: May 3, 2001
    Publication date: November 7, 2002
    Applicant: VISTEON GLOBAL TECHNOLOGIES, INC.
    Inventors: Christopher Edward Shaw, James T. Dumas, James John Kempf
  • Azaindole derivatives and their use as therapeutic agents
    Patent number: 6476045
    Abstract: The present invention relates to compounds of the formula (I): wherein: Het represents a heterocyclic residue selected from: where the dotted line in (b) represents an optional double bond; A completes a fused pyridine ring; and B completes a fused benzene or pyridine ring. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: November 5, 2002
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Kevin Dinnell, Jason Matthew Elliott, Gregory John Hollingworth, Duncan Edward Shaw
  • Azaindole derivatives and their use as therapeutic agents
    Publication number: 20020022624
    Abstract: The present invention relates to compounds of the formula (I): 1
    Type: Application
    Filed: July 11, 2001
    Publication date: February 21, 2002
    Inventors: Kevin Dinnell, Jason Matthew Elliott, Gregory John Hollingworth, Duncan Edward Shaw
  • 2-aryl indole derivatives and their use as therapeutic agents
    Publication number: 20010039286
    Abstract: The present invention relates compounds of the formula (I): 1
    Type: Application
    Filed: February 13, 2001
    Publication date: November 8, 2001
    Inventors: Kevin Dinnell, Jason Matthew Elliott, Gregory John Hollingworth, Mark Peter Ridgill, Duncan Edward Shaw
  • Tool holder
    Patent number: D449929
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: November 6, 2001
    Inventors: Robert Leon Rhoads, II, Thomas Edward Shaw, III