Abstract: Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

Abstract: Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

Abstract: Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

Abstract: Provided is a novel method of isolating and producing human antibodies with desired specificity from human B cells. In particular, a method of isolating human antibodies from memory B cells obtained from patients which suffer from a disease which is caused by or involves activation of the immune system, for example autoimmune and inflammatory disorders is described.

Abstract: Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

Abstract: Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

Abstract: Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

Abstract: Provided is a novel method of isolating and producing human antibodies with desired specificity from human B cells. In particular, a method of isolating human antibodies from memory B cells obtained from patients which suffer from a disease which is caused by or involves activation of the immune system, for example autoimmune and inflammatory disorders is described.

Abstract: A support stand assembly for a rod and reel combination comprises a horizontal base member with a vertical support member extending from the base member. A linear support arm member is pivotally secured at a first end to the vertical support member, with the support arm member extending horizontally in a support position and pivoting upwardly to a release position. A stop member is secured adjacent a second end of the support arm member with a portion of the arm member extending beyond the stop member. An attachment member is adapted for securement to the rod of a rod and reel combination. The attachment member engages with the portion of the arm member extending beyond the stop member to support the rod and reel combination. In use, the attachment member is secured at the balance point of the rod and reel combination and engaged with the portion of the arm member extending beyond the stop member to support the rod and reel combination in a horizontal position.

Abstract: A rigid drive axle assembly includes a support beam member having a substantially flat central plate section, a differential assembly module secured to the central plate section through at least two threaded studs extending from the central plate section. The differential assembly module includes a differential carrier frame member having two bearing hubs receiving differential bearings. A method for verifying a predetermined bearing preload of the differential assembly module comprises the steps of preloading the differential bearings to the predetermined bearing preload, inserting mounting bores in the bearing hubs of the frame member onto the mounting studs, and determining that the differential bearings are properly preloaded if the mounting studs are received in the mounting bores in the differential carrier frame member without substantial resistance, or determining that the differential bearings are not properly preloaded if the mounting studs may not be received in the mounting bores easily.

Abstract: A drive axle assembly for a motor vehicle comprises a support beam member, a differential assembly module secured to the support beam member and a cover member fastened to the support beam member to cover at least a portion the differential assembly module. The cover member includes two spaced access openings with adjustable sealing flange devices for sealing an interior cavity within the cover member between the access openings and corresponding axle shaft members. The sealing flange device is positionally adjustable relative to the cover member. A method for adjusting position of the sealing flange device relative to the cover member comprises the steps of securing the cover member to the axle support member, mounting the sealing flange device to the cover member, adjusting the position of the sealing flange device relative to the cover member and securing the sealing flange device to the cover member.

Abstract: A drive axle assembly for motor vehicles, includes a support beam member having a substantially flat, enlarged central plate section and two opposite arm sections, a differential assembly module secured to the central plate section and enclosed into a housing formed by a rear cover and a front cover secured to opposite surfaces of the central plate section. A method for assembling the drive axle assembly comprises the steps of securing the front cover to a front mounting surface of the support beam member, fastening the differential assembly module to the central plate section of the support beam member, and fastening the rear cover to the rear mounting surface of the support beam member.