Patents by Inventor Ehud Gazit

Ehud Gazit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for treating amyloid associated diseases
    Patent number: 8889729
    Abstract: Indole derivatives, compositions including same, and methods utilizing same for the treatment of amyloid associated diseases, such as type II diabetes mellitus, Alzheimer's dementia or diseases, systemic and localized amyloidosis, and prion-related encephalopathies are provided.
    Type: Grant
    Filed: June 6, 2010
    Date of Patent: November 18, 2014
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventors: Ehud Gazit, Tomer Cohen
  • Vapor deposition of biomolecules
    Patent number: 8802193
    Abstract: A coating method is disclosed. The coating method comprises placing a substrate and a biomolecule in a chamber and applying a vapor deposition process within the chamber so as to form a solid deposition of the biomolecule on at least a portion of a surface of the substrate.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: August 12, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Lihi Adler-Abramovich, Daniel Aronov, Gil Rosenman
  • Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
    Patent number: 8796023
    Abstract: A nanostructure composed of a plurality of peptides, each peptide containing at least one aromatic amino acid, whereby one or more of these peptides is end-capping modified, is disclosed. The nanostructure can take a tubular, fibrillar, planar or spherical shape, and can encapsulate, entrap or be coated by other materials. Methods of preparing the nanostructure, and devices and methods utilizing same are also disclosed.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: August 5, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Meital Reches, Ehud Gazit
  • NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS
    Publication number: 20140213627
    Abstract: The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.
    Type: Application
    Filed: January 30, 2014
    Publication date: July 31, 2014
    Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Roni SCHERZER, Ehud GAZIT, Daniel SEGAL
  • Photocatalytic hydrogen production in cyanobacteria
    Patent number: 8741598
    Abstract: A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: June 3, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Nathan Nelson, Iftach Yacoby, Ehud Gazit, Itai Benhar
  • PHOTOCATALYTIC HYDROGEN PRODUCTION IN CYANOBACTERIA
    Publication number: 20140106428
    Abstract: A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.
    Type: Application
    Filed: October 17, 2013
    Publication date: April 17, 2014
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Nathan NELSON, Iftach Yacoby, Ehud Gazit, Itai Benhar
  • Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of diseases involving amyloidogenesis
    Patent number: 8697680
    Abstract: The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.
    Type: Grant
    Filed: September 6, 2009
    Date of Patent: April 15, 2014
    Assignee: Ramot At Tel Aviv University Ltd.
    Inventors: Roni Scherzer, Ehud Gazit, Daniel Segal
  • Peptides and methods using same for diagnosis and treatment of amyloid-associated disease
    Patent number: 8697634
    Abstract: Peptides having at least 2 amino acids and no more than 15 amino acids are provided. The peptides comprise amino acid sequence X—Y or Y—X, wherein X is an aromatic amino acid and Y is any amino acid other than glycine. Also provided are pharmaceutical compositions and kits including such peptides as well as methods using same for diagnosing and treating amyloid associated diseases.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: April 15, 2014
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventor: Ehud Gazit
  • METHOD OF FORMING A FIBER MADE OF PEPTIDE NANOSTRUCTURES
    Publication number: 20140044949
    Abstract: A method of forming a fiber made of peptide nanostructures is disclosed. The method comprises: providing peptide nanostructures in solution, and fiberizing the solution thereby forming at least one fiber of the peptide nanostructures. Also disclosed are methods of forming films and other articles using the peptide nanostructures.
    Type: Application
    Filed: October 24, 2013
    Publication date: February 13, 2014
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud GAZIT, Meital Reches
  • COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PHENYLKETONURIA (PKU)
    Publication number: 20130344079
    Abstract: A method of diagnosing Phenylketonuria (PKU) in a subject in need thereof is disclosed. The method comprises detecting phenylalanine fibrils in a tissue of the subject, wherein a presence or level above a predetermined threshold of said phenylalanine fibrils in said tissue, is indicative of PKU in the subject. Antibodies capable of detecting phenylalanine fibrils are also disclosed as well as additional uses.
    Type: Application
    Filed: March 8, 2012
    Publication date: December 26, 2013
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Lihi Adler-Abramovich, Ohad Carny, Ehud Gazit
  • PEPTIDES AND METHODS USING SAME FOR DIAGNOSIS AND TREATMENT OF AMYLOID-ASSOCIATED DISEASE
    Publication number: 20130338076
    Abstract: Peptides having at least 2 amino acids and no more than 15 amino acids are provided. The peptides comprise amino acid sequence X-Y or Y-X, wherein X is an aromatic amino acid and Y is any amino acid other than glycine. Also provided are pharmaceutical compositions and kits including such peptides as well as methods using same for diagnosing and treating amyloid associated diseases.
    Type: Application
    Filed: August 26, 2013
    Publication date: December 19, 2013
    Applicant: Tel Aviv University Future Technology Development L.P.
    Inventor: Ehud GAZIT
  • Method of forming a fiber made of peptide nanostructures
    Patent number: 8568637
    Abstract: A method of forming a fiber made of peptide nanostructures is disclosed. The method comprises: providing peptide nanostructures in solution, and fiberizing the solution thereby forming at least one fiber of the peptide nanostructures. Also disclosed are methods of forming films and other articles using the peptide nanostructures.
    Type: Grant
    Filed: June 5, 2005
    Date of Patent: October 29, 2013
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Meital Reches
  • Photocatalytic hydrogen production in cyanobacteria
    Patent number: 8563294
    Abstract: A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: October 22, 2013
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Nathan Nelson, Iftach Yacoby, Ehud Gazit, Itai Benhar
  • Method of screening for compounds that disaggregate amyloid aggregates
    Patent number: 8563273
    Abstract: A peptide comprising at least 5 amino acid residues and less than 15 amino acid residues, the peptide including an amino acid sequence as set forth in SEQ ID NO: 7 as well as pharmaceutical compositions, kits and methods for diagnosing and treating amyloid associated diseases.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: October 22, 2013
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventor: Ehud Gazit
  • Compositions and methods for treatment of neurodegenerative diseases
    Patent number: 8546330
    Abstract: Isolated peptides are provided, being less than 20 amino acids in length. The peptides comprising an amino acid sequence GVLYVGSKTREGV (SEQ ID NO: 12) AAATGLVKREE (SEQ ID NO: 13) or GVVAAAEKTKQG (SEQ ID NO: 14), mimetics and/or fragment thereof, the peptides being capable of inhibiting alpha synuclein aggregation. Pharmaceutical compositions comprising same are also provided as well as uses thereof.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: October 1, 2013
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ronit Shaltiel-Karyo, Ehud Gazit
  • COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20130244946
    Abstract: Isolated peptides are provided, being less than 20 amino acids in length. The peptides comprising an amino acid sequence GVLYVGSKTREGV (SEQ ID NO: 12) AAATGLVKREE (SEQ ID NO: 13) or GVVAAAEKTKQG (SEQ ID NO: 14), mimetics and/or fragment thereof, the peptides being capable of inhibiting alpha synuclein aggregation. Pharmaceutical compositions comprising same are also provided as well as uses thereof.
    Type: Application
    Filed: May 22, 2013
    Publication date: September 19, 2013
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ronit SHALTIEL-KARYO, Ehud Gazit
  • DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION
    Publication number: 20130225512
    Abstract: Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipeptide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.
    Type: Application
    Filed: November 15, 2011
    Publication date: August 29, 2013
    Applicant: Merz Pharma GmbH & Co. KGaA
    Inventors: Ehud Gazit, Yaniv Amir, Ludmila Buzhansky, Ulrich Abel, Anat Frydman-Marom
  • Peptide nanostructures encapsulating a foreign material and method of manufacturing same
    Patent number: 8501697
    Abstract: A composition comprising a material at least partially enclosed by a tubular, spherical or planar nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides includes no more than 4 amino acids and whereas at least one of the 4 amino acids is an aromatic amino acid.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: August 6, 2013
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Meital Reches
  • METHODS OF TREATING DIABETES AND COMPOSITIONS CAPABLE OF SAME
    Publication number: 20130071401
    Abstract: A composition of matter is disclosed which comprises isolated oligomers of human islet amyloid polypeptide (IAPP). Antibodies recognizing same are also disclosed. Use of the composition of matter and the antibodies are also disclosed.
    Type: Application
    Filed: June 2, 2011
    Publication date: March 21, 2013
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Yaron Bram, Ehud Gazit
  • Compositions and methods using same for treating amyloid-associated diseases
    Patent number: 8372880
    Abstract: Compounds having one or more phenol moieties, derivatives thereof, compositions containing same and uses thereof for the treatment of amyloid-associated diseases are provided.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: February 12, 2013
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventors: Ehud Gazit, Yair Porat