Patents by Inventor Emmanuel Delamarche

Emmanuel Delamarche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180103884
    Abstract: A diagnostic patch apparatus has a sampling module that includes sampling means for sampling fluid from a patient's skin when the sampling module is placed against the patient's skin, and a sample chamber coupled in fluid communication with the sampling means. The apparatus also has an analysis module that includes a fluid conduit coupled in fluid communication with the sample chamber of the sampling module and a plurality of sensors coupled in fluid communication with the fluid conduit. The apparatus also may have a reader module that includes at least one optical sensor coupled in optical communication with the analysis module, a microcontroller coupled in electrical communication with the at least one sensor of the analysis module, and a wireless communication package coupled in electrical communication with the microcontroller.
    Type: Application
    Filed: October 18, 2016
    Publication date: April 19, 2018
    Inventors: Emmanuel Delamarche, James L. Hedrick, Minhua Lu, Vince S. Siu
  • Patent number: 9917148
    Abstract: The present invention is notably directed to a method of fabrication of a microfluidic chip (1), comprising: providing (S10-S20) a wafer (10, 12) of semiconductor material having a diamond cubic crystal structure, exhibiting two opposite main surfaces (S1, S2), one on each side of the wafer, and having, each, a normal in the <100> or <110> direction; and performing (S30) self-limited, anisotropic wet etching steps on each of the two main surfaces on each side of the wafer, to create a via (20, 20a) extending transversely through the thickness of the wafer, at a location such that the resulting via connects an in-plane microchannel (31) on a first one (S1) of the two main surfaces to a second one (S2) of the two main surfaces, the via exhibiting slanted sidewalls (20s) as a result of the self-limited wet etching. The invention further concerns microfluidic chips accordingly obtained.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: March 13, 2018
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Bilge Eker, Yuksel Temiz
  • Patent number: 9901926
    Abstract: The present invention is notably directed to a microfluidic chip (1, 1a) comprising: a flow path (22) defined by a hydrophilic surface; a liquid input (24, 24a, 24b) on one side of the flow path; at least one electrical circuit (62), hereafter DEP circuit, comprising at least one pair of dielectrophoretic electrodes (E21, E22), hereafter DEP electrodes, wherein: each of the DEP electrodes extends transverse to the flow path; and the DEP circuit is configured to generate a dielectrophoretic force, hereafter DEP force, at the level of the DEP electrodes. The chip may further include one or more electroosmotic circuits. The present invention is further directed to methods of operation of such a microfluidic chip.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: February 27, 2018
    Assignee: International Business Machines Corporation
    Inventors: Jaione Tirapu Azpiroz, Emmanuel Delamarche, Tobias Guenzler, Govind Kaigala, Yuksel Temiz, Tino Treiber
  • Patent number: 9879360
    Abstract: Disclosed herein is a microfluidic device comprising a chip; a flow channel being disposed in the chip; the flow channel being in communication with an entry port and an exit port; the flow channel being operative to permit the flow of a library from the entry port to the exit port; a substrate; the substrate being disposed upon the chip; the substrate being operative to act as an upper wall for the flow channels; and a plurality of receptors; the plurality of receptors being disposed on the substrate; the plurality of receptors being operative to interact with an element from the library.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: January 30, 2018
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Emmanuel Delamarche, Robert Lovchik, Daniel J. Solis
  • Publication number: 20170350821
    Abstract: A test device is configured for diagnostic testing and includes an optical readable medium, in turn including a pattern of spots of material arranged on a surface of the device. Several patterns may be provided. The patterns accordingly formed may be human and/or machine readable. They may notably encode security information, e.g., indicating whether the device has already been used. The spots may notably be inkjet spotted. In addition, a method is provided for decoding information encoded in a pattern of such a test device. In embodiments, liquid is introduced in the device, which comprises additional spots having a substantially different solubility than spots forming the actual pattern. Thus, the additional spots get solubilized in and flushed by the liquid as the latter wets them, and an initially hidden pattern may be read, which is formed of the remaining spots (not solubilized). Encoding methods are also provided.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Inventors: Emmanuel Delamarche, Onur Goekce, Yuksel Temiz
  • Patent number: 9770717
    Abstract: The present invention is notably directed to a microfluidic chip. The chip comprises a main microfluidic channel, on one side of the chip, and a bead integration system. The bead integration system is arranged on said one side of the chip. It comprises an auxiliary microfluidic channel transverse to and in fluidic communication with the main microfluidic channel, so as to form an intersection therewith. The intersection is delimited by structural elements arranged in the main microfluidic channel. The structural elements are configured to retain, at said intersection, beads flowed in a bead suspension liquid advancing in said auxiliary microfluidic channel and passing the intersection. In addition, such structural elements are configured to let liquid advancing in the main microfluidic channel pass the intersection through the structural elements. The invention is further directed to related devices and methods.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: September 26, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Emmanuel Delamarche, Michel Lim, Yuksel Temiz
  • Patent number: 9745949
    Abstract: The invention is directed to a microfluidic probe head (100) with a base layer (120) comprising: at least two processing liquid microchannel (123, 124) in fluid communication with a processing liquid aperture (121, 122) on a face of the base layer; and an immersion liquid microchannel (223, 224) in fluid communication with a immersion liquid aperture (221, 222) on a face of the base layer, wherein the microfluidic probe head is configured to allow, in operation, processing liquid provided through the processing liquid aperture to merge into immersion liquid provided through the immersion liquid aperture. An additional layer can be provided to close the microchannels. Such a multilayered head is compact and easier to fabricate than heads made with unitary construction. The head can further be interfaced with tubing using e.g. a standard fitting for tubing port.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: August 29, 2017
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Govind Kaigala, Robert Lovchik
  • Publication number: 20170184545
    Abstract: An assembly is provided for interfacing with a microfluidic chip having at least one microscopic channel configured to receive a liquid sample for analysis. The assembly includes a chip carrier, an electronics module, an optical module, and a mechanical module. The chip carrier includes a base and a cover defining a cavity to receive the microfluidic chip. The electronics module includes a signal generator which applies at least one electrokinetic signal electrode(s) of the chip. The optical module includes an excitation radiation source which causes excitation radiation to impinge on the sample, and an emission radiation detector which detects radiation emitted from the sample. The mechanical module includes a chip-carrier receiving structure, relatable with respect to the optical module for focus and at least one degree of translational freedom.
    Type: Application
    Filed: June 30, 2016
    Publication date: June 29, 2017
    Inventors: Jaione T. Azpiroz, Emmanuel Delamarche, Claudius Feger, Ricardo L. Ohta, Mathias B. Steiner, Yuksel Temiz
  • Publication number: 20170151563
    Abstract: A microfluidic device and method for fabrication includes a microfluidic channel that has a closed portion, which comprises: a liquid pathway formed by a wetting area; and an anti-wetting area extending along and contiguously with the liquid pathway. The anti-wetting area is configured so as to provide a vent to evacuate gas along the anti-wetting area.
    Type: Application
    Filed: February 13, 2017
    Publication date: June 1, 2017
    Inventors: Emmanuel Delamarche, Yuksel Temiz
  • Publication number: 20170151566
    Abstract: A microfluidic device and method for fabrication includes a microfluidic channel that has a closed portion, which comprises: a liquid pathway formed by a wetting area; and an anti-wetting area extending along and contiguously with the liquid pathway. The anti-wetting area is configured so as to provide a vent to evacuate gas along the anti-wetting area.
    Type: Application
    Filed: February 13, 2017
    Publication date: June 1, 2017
    Inventors: Emmanuel Delamarche, Yuksel Temiz
  • Publication number: 20170120240
    Abstract: A microfluidic chip comprising a microchannel fillable with a liquid, the microchannel comprises a pair of electrodes, and a liquid flow path defined between the electrodes, wherein each of the electrodes extends along the flow path and parallel to a direction of a liquid filling the microchannel, in operation, and an electrical circuitry connected to each of the electrodes and configured to continuously measure, via the electrodes, a capacitance of the electrodes being wet by a liquid continuously filling the flow path, as a function of time, in operation.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 4, 2017
    Inventors: Emmanuel Delamarche, Yuksel Temiz
  • Patent number: 9623407
    Abstract: A microfluidic device including one or more microchannels. Each microchannel comprising: a microchannel portion with a longitudinal liquid barrier that defines first and second regions. The device includes one or more first liquid passages at the level of the longitudinal barrier. A liquid inlet allows liquid to enter the first region and a liquid outlet allows liquid to leave the microchannel portion. A transverse liquid barrier between the microchannel portion and the liquid outlet holds liquid in the first region. The device includes one or more second liquid passages at the level of the transverse liquid barrier. A liquid pump displaces liquid through a microchannel portion. The first liquid passages allow excess liquid in the first region to flow into the second region, transversally to the longitudinal barrier. The second liquid passages allow excess liquid in the longitudinal portion to be discharged via the liquid outlet.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: April 18, 2017
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Onur Gökce
  • Publication number: 20170100717
    Abstract: A microfluidic probe is disclosed. The microfluidic probe includes a probe head, a liquid spacer supply and a spacer modulation unit. The probe head may include a processing liquid channel in fluid communication with a processing liquid aperture provided on a face of the probe head. The probe head is configured to transport, circulate, recirculate, or move some processing liquid in (or via) the processing liquid channel toward and/or from the processing liquid aperture. The spacer supply is fluidly connected, via a spacer insertion junction, to the processing liquid channel. The spacer supply is configured for inserting liquid spacers into the processing liquid channel, via the spacer insertion junction. Liquid volumes can be obtained, which are separated by inserted liquid spacers. The spacer modulation unit is configured to control the spacer supply, to modulate the insertion of spacers via the spacer supply. Related devices and methods of operation are disclosed.
    Type: Application
    Filed: October 9, 2015
    Publication date: April 13, 2017
    Inventors: Julien AUTEBERT, Julien CORS, Emmanuel DELAMARCHE, Govind KAIGALA, Xander Frank VAN KOOTEN
  • Patent number: 9604209
    Abstract: A microfluidic device and method for fabrication includes a microfluidic channel that has a closed portion, which comprises: a liquid pathway formed by a wetting area; and an anti-wetting area extending along and contiguously with the liquid pathway. The anti-wetting area is configured so as to provide a vent to evacuate gas along the anti-wetting area.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: March 28, 2017
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Yuksel Temiz
  • Patent number: 9594082
    Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: March 14, 2017
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Daniel J. Solis
  • Publication number: 20170008009
    Abstract: A microchannel for processing microparticles in a fluid flow comprises a first and second pairs of electrodes. The first pair of electrodes is configured for generating an asymmetric first electric field and for sorting the microparticles to provide sorted microparticles. The second pair of electrodes is configured for generating an asymmetric second electric field and for trapping at least some of the sorted microparticles.
    Type: Application
    Filed: July 12, 2015
    Publication date: January 12, 2017
    Inventors: Jaione Tirapu Azpiroz, Emmanuel Delamarche, Claudius Feger, Yuksel Temiz
  • Publication number: 20170007996
    Abstract: A device for trapping at least one microparticle in a fluid flow is suggested. The device comprises a trapping element and an electrode. The trapping element is configured for trapping the at least one microparticle and has at least one recess for receiving the at least one microparticle. The electrode is configured for generating an asymmetric electric field. In operation, at least one microparticle of a plurality of microparticles passing through the asymmetric electric field is forced into the at least one recess of the trapping element.
    Type: Application
    Filed: July 12, 2015
    Publication date: January 12, 2017
    Inventors: Jaione Tirapu Azpiroz, Emmanuel Delamarche, Claudius Feger, Yuksel Temiz
  • Publication number: 20160367984
    Abstract: The present invention is notably directed to methods of fabrication of a microfluidic chip package or assembly (1), comprising: providing (S1) a substrate (10, 30) having at least one block (14, 14a) comprising one or more microfluidic structures on a face (F) of the substrate; partially cutting (S2) into the substrate to obtain partial cuts (10c), such that a residual thickness of the substrate at the level of the partial cuts (10c) enables singulation of said at least one block (14, 14a); cleaning (S4) said at least one block; and applying (S5-S7) a cover-film (62) to cover said at least one block (14, 14a), whereby at least one covered block is obtained, the applied cover film still enabling singulation of each covered block, wherein each covered block corresponds to a microfluidic chip after singulation. The present invention is further directed to microfluidic chips, packing or assembly, obtainable with such methods.
    Type: Application
    Filed: June 18, 2014
    Publication date: December 22, 2016
    Inventors: Emmanuel Delamarche, Yuksel Temiz
  • Publication number: 20160367985
    Abstract: The present invention is notably directed to method of fabrication of a microfluidic chip (1), comprising: providing (S1-S7) a substrate (10), a face (F) of which is covered by an electrically insulating layer (30); obtaining (S8) a resist layer (40) covering one or more selected portions (P1) of the electrically insulating layer (30), at least a remaining portion (P2) of said electrically insulating layer (30) not being covered by the resist layer; partially etching (S9) with a wet etchant (E) a surface of the remaining portion (P2) of the electrically insulating layer (30) to create a recess (40r) and/or an undercut (40u) under the resist layer (40); depositing (S10) the electrically conductive layer (50) on the etched surface (35), such that the electrically conductive layer reaches the created recess (40r) and/or undercut (40u); and removing (S11) the resist layer (40) to expose a portion (P1) of the electrically insulating layer adjoining a contiguous portion (P2) of the electrically conductive layer (50
    Type: Application
    Filed: June 18, 2014
    Publication date: December 22, 2016
    Inventors: Emmanuel Delamarche, TOBIAS GUENZLER, Yuksel Temiz, Tino Treiber
  • Publication number: 20160367988
    Abstract: The present invention is notably directed to a microfluidic chip (1, 1a) comprising: a flow path (22) defined by a hydrophilic surface; a liquid input (24, 24a, 24b) on one side of the flow path; at least one electrical circuit (62), hereafter DEP circuit, comprising at least one pair of dielectrophoretic electrodes (E21, E22), hereafter DEP electrodes, wherein: each of the DEP electrodes extends transverse to the flow path; and the DEP circuit is configured to generate a dielectrophoretic force, hereafter DEP force, at the level of the DEP electrodes. The chip may further include one or more electroosmotic circuits. The present invention is further directed to methods of operation of such a microfluidic chip.
    Type: Application
    Filed: June 18, 2014
    Publication date: December 22, 2016
    Inventors: Jaione Tirapu AZPIROZ, Emmanuel DELAMARCHE, Tobias GUENZLER, Govind KAIGALA, Yuksel TEMIZ, Tino TREIBER