Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.

Abstract: An immunomodulatory delivery system includes a hydrogel, a first immunomodulatory cargo encapsulated in the cargo, and a second immunomodulatory cargo encapsulated in the hydrogel. The hydrogel includes a polymer non-covalently crossed-linked with a plurality of nanoparticles. The first immunomodulatory cargo is smaller than the second immunomodulatory cargo. A ratio of a diffusivity of the first immunomodulatory cargo through the hydrogel to a diffusivity of the second immunomodulatory cargo through the hydrogel is less than 3.

Abstract: In implementations of systems for role classification, a computing device implements a role system to receive data describing a corpus of text that is associated with a user ID. Feature values of features are generated by a first machine learning model by processing the corpus of text, the features representing questions with respect to the corpus of text and the feature values representing answers to the questions included in the corpus of text. A classification of a role is generated by a second machine learning model by processing the feature values, the classification of the role indicating a relationship of the user ID with respect to a product or service. The role system outputs an indication of the classification of the role for display in a user interface of a display device.

Abstract: According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member.

Abstract: Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.

Abstract: Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.

Abstract: Techniques for producing a Brillouin laser are provided. According to some aspects, techniques are based on forward Brillouin scattering and a multimode acousto-optic waveguide in which light is scattered between optical modes of the waveguide via the Brillouin scattering. This process may transfer energy from a waveguide mode of pump light to a waveguide mode of Stokes light. This process may be referred to herein as Stimulated Inter-Modal Brillouin Scattering (SIMS). Since SIMS is based on forward Brillouin scattering, laser (Stokes) light may be output in a different direction than back toward the input pump light, and as such there is no need for a circulator or other non-reciprocal device to protect the pump light as in conventional devices.

Abstract: A method executed by a computing device includes obtaining a string of words and determining whether two or more words of the string of words are in a word group. When the two or more words are in the word group, the method further includes determining a set of identigens for each word of the word group to produce sets of identigens, where a set of identigens of the sets of identigens represents one or more different meanings of a word of the word group. The method further includes interpreting, using identigen pairing rules, the sets of identigens to produce an entigen group. The method further includes assigning a new entigen to represent the entigen group, where the new entigen represents a most likely meaning interpretation of the word group.

Abstract: In implementations of user interaction determination within a webinar system, a computing device implements a webinar system that exposes interactive elements on user devices during a webinar and monitors device interactions reflecting user interactions with webinar content on the user devices. The webinar system determines amounts of user interaction based on the device interactions, and can output the interactive elements based on the device interactions. The webinar system can receive user responses to the interactive elements, and maintain a pipeline that assigns levels to the users based on the user responses and the interactive elements. Users are determined as sales leads based on the levels for the users in the pipeline.

Abstract: A bracket is provided having a base and an arm. The base can be connected to a rear window hinge support of a hardtop with the hinge bolts used to secure a rear window hinge. The base has slots that provide for an increased flexibility of bolt patterns or widths. The top of the slots are open with necks to allow for easy insertion and removal of the brackets without removal of the rear window and allows the brackets to be used with multiple models. The base has a central void. An arm having an eye upstands from the base. A relief is provided at the area where the arm is connected to the base. Two brackets (a left and a right bracket) are secured to a hardtop before use. A hoist or lift can connect to the eyes to facilitate removal and storage of the hardtop.

Abstract: In implementations of user interaction determination within a webinar system, a computing device implements a webinar system that exposes interactive elements on user devices during a webinar and monitors device interactions reflecting user interactions with webinar content on the user devices. The webinar system determines amounts of user interaction based on the device interactions, and can output the interactive elements based on the device interactions. The webinar system can receive user responses to the interactive elements, and maintain a pipeline that assigns levels to the users based on the user responses and the interactive elements. Users are determined as sales leads based on the levels for the users in the pipeline.

Abstract: An apparatus and method of managing negative incidence of an airfoil are provided. The apparatus includes a row of vane pairs including a first row of main vanes extending radially inwardly from a stationary casing member and spaced circumferentially about a first axial location of the stationary casing member. The apparatus also includes a second row of auxiliary vanes extending radially inwardly from the stationary casing member and spaced circumferentially about a second axial location of the stationary casing member. The apparatus also includes a flow channel defined between a pressure side of each auxiliary vane and a suction side of an adjacent main vane proximate a leading edge of the adjacent main vane.

Abstract: Various embodiments provide for the consolidation of policies across multiple identities that are respectively associated with multiple active directory (AD) groups to which a user belongs. Present embodiments provide for dynamically generating a new identity in the resource provider environment that includes permissions to all of the resources that may otherwise be distributed across multiple identities. Specifically, in accordance with various embodiments, when a user login is detected, the active directory is queried to determine the AD groups to which the user belongs. As mentioned, the user's AD groups are mapped to respective identities in the resource provider environment, in which each identity includes policy defining access to one or more resources. The policies of all the respective identities are consolidated and assigned to a new identity. The user may assume the new identity and access all the resources in tandem.

Abstract: Systems and methods for performing non-parametric texture synthesis of arbitrary shape and/or material data taken from an exemplar object in accordance with embodiments of the invention are illustrated. Exemplar data is first analyzed. Based upon the analysis, new unique but similar data is synthesized in a myriad of ways.

Abstract: Methods, systems, and devices for a controllable irrigation and environment monitoring system, devices, and applications, are described. The irrigation system may use a valve on each spray head which may allow each spray head of the irrigation system to be independently controlled. The spray radius and the water flow of each of the spray heads may be individually adjusted. The irrigation system may include sensors which provide feedback and the system may individually adjust each of the spray heads of the irrigation system and may adjust the watering schedule, water flow, and spray radius based on the sensor feedback. The irrigation system may be automated and self-managed and may adjust watering schedules according to an algorithm. The algorithm may use data collected by the system and also may use user-defined parameters such as local watering restrictions.

Abstract: According to some aspects, a database system is provided. The database system may include at least one processor configured to execute a plurality of system components. The plurality of system components may include an interface component configured to receive a read commit command and provide a result, a snapshot component configured to generate a plurality of snapshots of data stored in a first data storage node of a plurality of data storage nodes and identify a committed snapshot representative of data that has been replicated on a majority of the plurality of data storage nodes, and a command processing component configured to read the committed snapshot responsive to receipt of the read commit command and generate the result.

Abstract: Various embodiments provide for the consolidation of policies across multiple identities that are respectively associated with multiple active directory (AD) groups to which a user belongs. Present embodiments provide for dynamically generating a new identity in the resource provider environment that includes permissions to all of the resources that may otherwise be distributed across multiple identities. Specifically, in accordance with various embodiments, when a user login is detected, the active directory is queried to determine the AD groups to which the user belongs. As mentioned, the user's AD groups are mapped to respective identities in the resource provider environment, in which each identity includes policy defining access to one or more resources. The policies of all the respective identities are consolidated and assigned to a new identity. The user may assume the new identity and access all the resources in tandem.

Abstract: Systems and methods perform non-parametric texture synthesis of arbitrary shape and/or material data mimicking input exemplar data in accordance with embodiments of the invention. Exemplar data is first analyzed and appearance vectors are generated based on geometric information determined for the exemplar data. Feature vector maps are generated for locations of the exemplar data based on the geometric information and the appearance vectors. Based upon the feature vector maps, outputs can be synthesized.

Abstract: According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member.

Abstract: According to some aspects, a database system comprising a processor configured to execute a plurality of system components is provided. The plurality of system components may include an interface component configured to receive a write commit command and provide a write commit confirmation, a snapshot component configured to generate a plurality of snapshots of data stored in a data storage node of a plurality of data storage nodes and identify a committed snapshot representative of data that has been replicated on a majority of the plurality of data storage nodes, and a command processing component configured to modify a data element based on the write commit command, determine whether the majority of the plurality of storage nodes have replicated the modification using the committed snapshot, and generate the write commit confirmation responsive to a determination that the majority of the plurality of data storage nodes have replicated the modification.