Abstract: According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member.

Abstract: This disclosure provides a biological sample processing system and methods for processing biological samples. The processing may include one or both of removing wax from wax-embedded biological samples and applying a reagent to biological samples. Aspects of the dewaxing technique and the technique for applying the reagent may be combined to achieve energy efficiencies. Additional efficiency may be achieved by recirculating heated reagent. A hybrid power system may use a source of stored power to supplement external power at times of peak demand. Uniform distribution of liquids across a surface of the biological samples may be achieved by self-leveling using an inclinometer.

Abstract: Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.

Abstract: According to some aspects, a database system is provided. The database system may include at least one processor configured to execute a plurality of system components. The plurality of system components may include an interface component configured to receive a read commit command and provide a result, a snapshot component configured to generate a plurality of snapshots of data stored in a first data storage node of a plurality of data storage nodes and identify a committed snapshot representative of data that has been replicated on a majority of the plurality of data storage nodes, and a command processing component configured to read the committed snapshot responsive to receipt of the read commit command and generate the result.

Abstract: Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.

Abstract: In an embodiment, a method for effecting thermal therapy using an in vivo probe includes positioning the probe in a volume in a patient, identifying an irregularly shaped three-dimensional region of interest and automatically applying thermal therapy to the region using the probe. Applying thermal therapy may include identifying a first emission level at a first rotational angle based in part on a depth of a radial portion of the region in the direction of probe emission, activating emission of the probe, causing rotation of the probe to a next rotational angle, identifying a next emission level at the next rotational angle based in part on a depth of a radial portion of the region in the direction of probe emission, activating emission to deliver therapeutic energy, and repeating rotation and emission until therapeutic energy has been delivered to the volume.

Abstract: According to some aspects, a database system comprising a processor configured to execute a plurality of system components is provided. The plurality of system components may include an interface component configured to receive a write commit command and provide a write commit confirmation, a snapshot component configured to generate a plurality of snapshots of data stored in a data storage node of a plurality of data storage nodes and identify a committed snapshot representative of data that has been replicated on a majority of the plurality of data storage nodes, and a command processing component configured to modify a data element based on the write commit command, determine whether the majority of the plurality of storage nodes have replicated the modification using the committed snapshot, and generate the write commit confirmation responsive to a determination that the majority of the plurality of data storage nodes have replicated the modification.

Abstract: A method of preventing tissue adhesion includes forming an incision in tissue, applying a hydrogel to tissue through the incision, and closing the incision with the hydrogel therein. The hydrogel includes a polymer non-covalently cross-linked with a plurality of nanoparticles and prevents a formation of adhesions between tissues and/or organs.

Abstract: According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member.

Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.

Abstract: This disclosure provides a biological sample processing system and methods for processing biological samples. The processing may include one or both of removing wax from wax-embedded biological samples and applying a reagent to biological samples. Aspects of the dewaxing technique and the technique for applying the reagent may be combined to achieve energy efficiencies. Additional efficiency may be achieved by recirculating heated reagent. A hybrid power system may use a source of stored power to supplement external power at times of peak demand. Uniform distribution of liquids across a surface of the biological samples may be achieved by self-leveling using an inclinometer.

Abstract: A system and method for determining consensus within a distributed database are provided. According to one aspect, a protocol is provided that reduces or eliminates heartbeat communication between nodes of a replica set. Nodes may communicate liveness information using existing database commands and metadata associated with the database commands. According to another aspect, improved systems and methods are provided for detection of node failures and election of a new primary node.

Abstract: A system and method for determining consensus within a distributed database are provided. According to one aspect, a protocol is provided that reduces or eliminates heartbeat communication between nodes of a replica set. Nodes may communicate liveness information using existing database commands and metadata associated with the database commands. According to another aspect, improved systems and methods are provided for detection of node failures and election of a new primary node.

Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.

Abstract: A height-adjustable display support is disclosed in which a carriage is fixed at a stationary elevation with respect to an external support surface, and a column is height-adjustable with respect to the carriage to change the height of a display attached to the column. In some embodiments the carriage is supported by an arm that is not height-adjustable.

Abstract: According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member.

Abstract: Battery holding and utilization systems wherein multiple, different disposable power sources, which can be rechargeable if desired, can be alternately held and used in a single battery bay.

Abstract: In one embodiment, a method includes accessing one or more content objects associated with a first user of an online social network; generating a set of tag candidates by extracting one or more n-grams from the content objects, wherein each tag candidate comprises one or more text strings or ideograms from the extracted n-grams; calculating, for each tag candidate of the set of tag candidates, a quality-score for the tag candidate based on an affinity coefficient between the first user and a respective content object from which the n-grams or ideograms comprising the tag candidate were extracted; and sending, to a client system for display, one or more of the tag candidates as suggested tags for the first user, wherein each suggested tag has a quality-score greater than a threshold quality-score.

Abstract: A method includes obtaining a string of words and determining whether two or more words of the string of words are in a word group. When the two or more words are in the word group, the method further includes retrieving a set of word group identigens for the word group and retrieving sets of word identigens for remaining words of the string of words. The method further includes determining whether a word group identigen of the set of word group identigens and word identigens of the sets of word identigens creates an entigen group that is a valid interpretation of the string of words. When the entigen group is the valid interpretation of the string of words, the method further includes outputting the entigen group.

Abstract: A method includes generating a new entigen group regarding trusted new information. The method further includes generating entigen groups from phrases of a document and determining whether an entigen group of the entigen groups has a most likely meaning similar to a most likely meaning of the new entigen group. When the entigen group has a most likely meaning similar to the most likely meaning of the new entigen group, the method further includes updating the entigen group based on the new entigen group. When the entigen groups do not include an entigen group having a most likely meaning similar to the most likely meaning of the new entigen group, the method further includes updating the entigen groups to include the new entigen group.