Abstract: Methods, systems, and computer-readable media for generating a personalized virtual network. The method acquires a request for a service associated with a user and their preferences. The method then identifies one or more conditions of the user and their propensities based on a first set of machine learning models using stored past information of the user. The method next identifies a second set of machine learning models and evaluates the weightage of each model based on the determined propensities of the conditions. The evaluated weights are applied to the second set of models to generate a personalized virtual network for the user.

Abstract: This invention relates to graphical user-interactive analysis of data, including in particular, mass spectrographic data analysis, as well as methods and software for generating and using such. One aspect provides user-customizable reports, including methods and apparatuses for generating customizable pivot tables and graphs specific to mass spectrographic data.

Abstract: A method for providing and maintaining secure storage of data includes cloaking the data by retrieving, from a database and using a first set of user-specific cloaking sequences and a first mapping, a first set of hidden sequences, and applying the data and the first set of hidden sequences as inputs to a cloaking algorithm. The cloaked data is stored in a persistent memory. The method further includes, during a later, second time period, re-cloaking the cloaked data by uncloaking the cloaked data using the first set of hidden sequences, retrieving, from the database and using the first set of user-specific cloaking sequences and a different, second mapping, a second set of one or more hidden sequences, and applying the uncloaked data and the second set of hidden sequences as inputs to the cloaking algorithm. The re-cloaked data is stored in the persistent memory.

Abstract: Methods and apparatuses for the identification and/or characterization of properties of a macromolecule based on mass spectrometry data. Specifically, described herein are methods and apparatuses for converting peptide-level data into a pseudo-intact mass spectra. Also described herein are methods and apparatuses for converting peptide-level data into a pseudo-electropherogram. The methods may be well suited for analyzing proteins and protein complexes, including estimating properties of post-translational modifications of the proteins and protein complexes. Methods may include generating a theoretical graph or spectrum based on peptide-level mass spectrometry data. In some embodiments, the theoretical graph may be a theoretical intact mass spectrum or a theoretical charge distribution spectrum.

Abstract: This invention relates to graphical user-interactive analysis of data, including in particular, mass spectrographic data analysis, as well as methods and software for generating and using such. One aspect provides user-customizable reports, including methods and apparatuses for generating customizable pivot tables and graphs specific to mass spectrographic data.

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract: A hydraulic clutch system that enables automatic emergency braking (AEB) and remote start of a manual transmission vehicle. The hydraulic clutch system includes a piston-operated hydraulic cylinder or other accumulator to store a charge of hydraulic fluid that can be selectively routed to the clutch and discharged under electronic control to thereby disengage the clutch independently of any operator input via the clutch pedal. By doing so, the system can provide an improved AEB response that slows or stops the vehicle without stalling the engine. The system may also be used to provide remote start capability to the vehicle by automatically disengaging the clutch as part of a remote start sequence of operations.

Abstract: A method and apparatus for presenting timed media represented by data in a markup language (e.g., HTML) including examining a tag or metadata which is capable of specifying more than one form or representation of timed media, such as different versions of a video encoded according to different video codec standards.

Abstract: In a method for providing secure data storage, a user interface is provided to a user, and a user selection of a plurality of cloaking sequences is received via the user interface. The cloaking sequences include at least a first and second cloaking sequence. The method also includes cloaking data (e.g., one or more files). Cloaking the data includes retrieving a first hidden sequence associated with the first cloaking sequence, and retrieving a second hidden sequence associated with the second cloaking sequence. The second hidden sequence includes an ordered sequence of bit sets each including one or more bits. Cloaking the data also includes using the first hidden sequence to identify offset positions within the data, and using the ordered sequence of bit sets to perform one or more operations on the data at the identified offset positions. The method further includes storing the cloaked data in a database.

Abstract: A method for providing and maintaining secure storage of data includes cloaking the data by retrieving, from a database and using a first set of user-specific cloaking sequences and a first mapping, a first set of hidden sequences, and applying the data and the first set of hidden sequences as inputs to a cloaking algorithm. The cloaked data is stored in a persistent memory. The method further includes, during a later, second time period, re-cloaking the cloaked data by uncloaking the cloaked data using the first set of hidden sequences, retrieving, from the database and using the first set of user-specific cloaking sequences and a different, second mapping, a second set of one or more hidden sequences, and applying the uncloaked data and the second set of hidden sequences as inputs to the cloaking algorithm. The re-cloaked data is stored in the persistent memory.

Abstract: Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

Abstract: This invention relates to graphical user-interactive analysis of data, including in particular, mass spectrographic data analysis, as well as methods and software for generating and using such. One aspect provides user-customizable reports, including methods and apparatuses for generating customizable pivot tables and graphs specific to mass spectrographic data.

Abstract: Tinted lenses for attenuating ambient light, reducing glare, and improving color discrimination for a user are disclosed. In some embodiments, the lens has uniform transmittance across the visible spectrum with selective filtering of light at 480 nm and 580 nm. In some embodiments, the lens may reduce light in the blue region of the spectrum while maintaining color discrimination. In some embodiments, the level of attenuation provided by the lens may vary based on the intensity of light present while maintaining selective filtering at 480 nm and 580 nm.

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract: A hydraulic clutch system that enables automatic emergency braking (AEB) and remote start of a manual transmission vehicle. The hydraulic clutch system includes a piston-operated hydraulic cylinder or other accumulator to store a charge of hydraulic fluid that can be selectively routed to the clutch and discharged under electronic control to thereby disengage the clutch independently of any operator input via the clutch pedal. By doing so, the system can provide an improved AEB response that slows or stops the vehicle without stalling the engine. The system may also be used to provide remote start capability to the vehicle by automatically disengaging the clutch as part of a remote start sequence of operations.

Abstract: Provided herein are compounds and pharmaceutical compositions useful in modulating kinase activity, and related diseases. Also provided herein are methods of treating an eye disease or disorder in a subject. Also provided herein are methods of reducing intraocular pressure in a subject. Also provided herein are methods of modulating kinase activity in a cell. Also provided herein are methods of making the compounds provided herein, and compounds useful for the preparation of the compounds provided herein.

Abstract: This invention relates to graphical user-interactive analysis of data, including in particular, mass spectrographic data analysis, as well as methods and software for generating and using such. One aspect provides user-customizable reports, including methods and apparatuses for generating customizable pivot tables and graphs specific to mass spectrographic data.

Abstract: Compressed gas dispensing methods using cascade dispensing from a first plurality of storage vessels and a second plurality of storage vessels. A compressor is used to provide very high pressure compressed gas for the second plurality of pressure storage vessels. Various methods are described for different sources of the compressed gas. The methods are particularly suitable for dispensing hydrogen into storage vessels in vehicles.

Abstract: A method and apparatus for presenting timed media represented by data in a markup language (e.g., HTML) including examining a tag or metadata which is capable of specifying more than one form or representation of timed media, such as different versions of a video encoded according to different video codec standards.

Abstract: A prosthetic device configured to function as a joint has a first joint component configured to be fixed to a first bone and a second joint component configured to engage the first joint component. The second joint component has an anchoring base configured to be fixed to a second bone, and a cup configured to be connected to the anchoring base. The cup has a cylindrical wall defining an outer surface of the cup, a cavity formed by a spherical recess inside of a circular edge at a top of the cylindrical wall, and an attachment post extending away from the cavity and configured to connect to the anchoring base. The attachment post is aligned with a center of a circle defined by the circular edge and an axis of the attachment post is parallel to the cylindrical wall.