Abstract: This disclosure relates to compounds of Formula (A): Formula (A), or a pharmaceutically acceptable salt thereof, wherein DSM is a degradation signaling moiety that is covalently attached to the linker L, L is a linker that covalently attaches IRAK to DSM; and IRAK is an IRAK4 binding moiety represented by Formula (I) that is covalently attached to linker L; Formula (I) in which all of the variables are as defined in the application. Compounds or pharmaceutically acceptable salts thereof as described herein are capable of activating the selective ubiqitination of IRAK4 proteins via the ubiquitin-proteasome pathways (UPP) and cause degradation of IRAK4 proteins. The present disclosure also provides methods of treating disorders responsive to modulation of IRAK4 activity and/or degradation of IRAK4 with at least one compound described herein.

Abstract: A refuse vehicle has a Commercial and a Residential Mode whereby when in Commercial Mode, stops or fins, utilized in Residential Mode to assist in securing a residential container laterally at the front of the vehicle, are adjustable to prevent contact or interference with the cab protector or other portions of the vehicle when in Commercial Mode. The fins may be located and/or rotated, such as at least 30 degrees (from position to position) or above a horizontal or otherwise intermediate the residential and commercial configurations. The fins may preferably be located above a bottom of the crossbar when moving through the dumping cycle so as not to contact the cab protector in Commercial Mode. Preferably, the fins may also be housed on the residential refuse container rather than along the crossbar.

Abstract: The present disclosure relates to processes for determining the number of nucleic acid repeats in a DNA fragment comprising a nucleic acid repeat region. One example method may include receiving DNA size and abundance data generated by resolving DNA amplification products. A set of low-pass data may be generated by applying a low-pass filter to the DNA size and abundance data and a set of band-pass data may be generated by applying a band-pass filter to the DNA size and abundance data. A peak of the DNA size and abundance data representative of a number of nucleic acid repeats in the DNA may be identified based on peaks identified from the low-pass data and the band-pass data.

Abstract: A system for controlling the position of a vehicle seat is disclosed. The system includes in network communication, an input device, a detection system, at least one controller, and at least one controllable device. The detection system measures a current value of at least one of the recline, fore-aft, or swivel position of the seat. The input device communicates to the controllers a desired value for at least one of these seat positions. The controller compares the measured value to a limiting value and the desired value and calculates a movement factor value. The movement factor value determines the communication between the controller and the controllable device. If the movement factor value falls into a range where the seat can be moved to the desired value, the controller signals the at least one controllable device to control the adjustment of at least one of the recline position, the fore-aft position, or the swivel position to the desired value.

Abstract: A fan for generating germicidal light is disclosed, which may be adapted to mount to a ceiling. The fan includes a hub connected to a plurality of fan blades. A motor is adapted to rotate the hub. A support is adapted to support the hub and motor from the ceiling. A lighting module may include a tray adapted to receive the support, the tray including one or more lights for providing ultraviolet germicidal light. The light may be provided by LEDs on a circuit board adapted for positioning around the support without dismounting the support from the ceiling, such as one comprised of wedge-shaped segments. The modular circuit board may form part of an uplight module supported by a housing for the motor.

Abstract: A generator injection tool is provided. The generator injection tool injects an adhesive into a generator that includes a rotor positioned within a stator having a stator vent, the stator and rotor having a gap therebetween. The generator injection tool includes a first carriage sized to fit within the gap, a tube, a first motor, a controller, and an adhesive source. An end of the tube is movable between a first position in which the end is outside of the stator vent and a second position within the stator vent. The first motor is operable to move the tube between the first position and the second position. The controller is operable to selectively activate the first motor to position the end of the tube within the stator vent. The adhesive source moves the adhesive through the tube end to inject a portion of the adhesive into the stator vent.

Abstract: A refuse vehicle has a Commercial and a Residential Mode whereby when in Commercial Mode, stops or fins, utilized in Residential Mode to assist in securing a residential container laterally at the front of the vehicle, are adjustable to prevent contact or interference with the cab protector or other portions of the vehicle when in Commercial Mode. The fins may be located and/or rotated, such as at least 30 degrees (from position to position) or above a horizontal or otherwise intermediate the residential and commercial configurations. The fins may preferably be located above a bottom of the crossbar when moving through the dumping cycle so as not to contact the cab protector in Commercial Mode. Preferably, the fins may also be housed on the residential refuse container rather than along the crossbar.

Abstract: An apparatus includes a fan and a controller configured for controlling the fan to operate in a first mode limiting rotational speed of the fan within a first range of speeds between a first minimum speed and a first maximum speed. The controller is further configured to control the fan to operate in a second mode limiting rotational speed of the fan within a second range of speeds between a second minimum speed and a second maximum speed. The second range of speeds may be narrower than the first range of speeds. Related methods are also disclosed.

Abstract: A refuse vehicle has a Commercial and a Residential Mode whereby when in Commercial Mode, stops or fins, utilized in Residential Mode to assist in securing a residential container laterally at the front of the vehicle, are adjustable to prevent contact or interference with the cab protector or other portions of the vehicle when in Commercial Mode. The fins may be located and/or rotated, such as at least 30 degrees (from position to position) or above a horizontal or otherwise intermediate the residential and commercial configurations. The fins may preferably be located above a bottom of the crossbar when moving through the dumping cycle so as not to contact the cab protector in Commercial Mode. Preferably, the fins may also be housed on the residential refuse container rather than along the crossbar.

Abstract: A generator injection tool is provided. The generator injection tool injects an adhesive into a generator that includes a rotor positioned within a stator having a stator vent, the stator and rotor having a gap therebetween. The generator injection tool includes a first carriage sized to fit within the gap, a tube, a first motor, a controller, and an adhesive source. An end of the tube is movable between a first position in which the end is outside of the stator vent and a second position within the stator vent. The first motor is operable to move the tube between the first position and the second position. The controller is operable to selectively activate the first motor to position the end of the tube within the stator vent. The adhesive source moves the adhesive through the tube end to inject a portion of the adhesive into the stator vent.

Abstract: A system for controlling the position of a vehicle seat is disclosed. The system includes a component position detection device, a seat and component adjustment controller and at least one controllable actuator in network communication. The measured value of the absence of a seat operator is communicated to the seat and component adjustment controller as is the current value of at least one of the fore-aft position or height position of the seat. The seat and component adjustment controller compares the measured value of the absence of a seat operator to a set value to determine if an operator is present. If an operator is not present based on this comparison, the seat and position controller calculates a movement factor value wherein the movement factor value determines the communication between the seat and component adjustment controller and the at least one controllable actuator.

Abstract: A method for forming a planarization layer is provided that can include depositing an organic planarization layer on a deposition surface using a spin on deposition method; and treating the deposited organic planarization layer with a solvent anneal. In some embodiments, a vapor of solvent is passed over the deposited organic planarization layer to increase uniformity of the deposited organic planarization layer. The method may further include curing the deposited organic planarization layer with a thermal anneal.

Abstract: A fan for generating germicidal light is disclosed, which may be adapted to mount to a ceiling. The fan includes a hub connected to a plurality of fan blades. A motor is adapted to rotate the hub. A support is adapted to support the hub and motor from the ceiling. A lighting module may include a tray adapted to receive the support, the tray including one or more lights for providing ultraviolet germicidal light. The light may be provided by LEDs on a circuit board adapted for positioning around the support without dismounting the support from the ceiling, such as one comprised of wedge-shaped segments. The modular circuit board may form part of an uplight module supported by a housing for the motor.

Abstract: A computerized system and method for user interface management provides an augmented reality-based experience that delivers real-time visual cues to a cognitively impaired person, that monitors visual recognition performance, and that provides visual recognition training based on observed visual recognition performance. The system uses image/facial recognition to identify persons/places/objects encountered by a person/dementia sufferer and captured by a camera of a computing device, retrieves information associated with identified person/place/object, and displays retrieved information associated with identified person/place/object to the person/dementia sufferer via the device, e.g., in an augmented reality overlay to an image captured by the camera. The information may identify the identified person's relationship with dementia sufferer and other pertinent details. Accordingly, for example, a person with cognitive impairment can quickly assess who is approaching them, based on facial recognition.

Abstract: A refuse collection vehicle having a packer system, a hopper, and a storage compartment. A wall between the storage compartment and the hopper defines an opening that allows refuse to pass from the hopper to the storage compartment. The packer system includes an auger screw and a driver. The driver rotates the auger screw such that refuse is packed into the storage compartment through the opening. A door can be positioned to cover the opening in the wall to inhibit refuse from passing back through the opening. A door actuator system moves the door to selectively open and close the door on the opening. A packing actuator can push an ejector panel across the floor of the storage compartment while the door is closed on the opening in the wall to further compact refuse in the storage compartment or to eject refuse from the vehicle.

Abstract: A refuse collection vehicle includes a packer system with an auger screw, one or more refuse support panels, one or more sensing devices, and a refuse support panel actuator system. The refuse support panel(s) support refuse while characteristics of the refuse are sensed. The refuse support panel actuator system moves the refuse support panels such that refuse is released from the refuse support panels in to the packer system. A driver of the packer system rotates the auger screw such the refuse is packed into a storage compartment of the vehicle.

Abstract: A refuse vehicle body includes a tailgate coupled to the body. The tailgate is movable between closed and open positions. An ejector is deployed in the body and configured to translate between forward and rearward positions. An actuator is configured to translate the ejector between the forward and rearward positions and is further configured to provide an actuation force that moves the tailgate from the closed position towards the open position and thereby at least partially opens the tailgate.

Abstract: The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged polynucleotides are sequenced simultaneously and sample sources are identified on the basis of barcode sequences. In some aspects, sequencing data are used to determine one or more genotypes at one or more loci comprising a causal genetic variant. In some aspects, systems and methods of detecting genetic variation are provided.