Abstract: A fan for generating germicidal light is disclosed, which may be adapted to mount to a ceiling. The fan includes a hub connected to a plurality of fan blades. A motor is adapted to rotate the hub. A support is adapted to support the hub and motor from the ceiling. A lighting module may include a tray adapted to receive the support, the tray including one or more lights for providing ultraviolet germicidal light. The light may be provided by LEDs on a circuit board adapted for positioning around the support without dismounting the support from the ceiling, such as one comprised of wedge-shaped segments. The modular circuit board may form part of an uplight module supported by a housing for the motor.

Abstract: A fan for generating germicidal light is disclosed, which may be adapted to mount to a ceiling. The fan includes a hub connected to a plurality of fan blades. A motor is adapted to rotate the hub. A support is adapted to support the hub and motor from the ceiling. A lighting module may include a tray adapted to receive the support, the tray including one or more lights for providing ultraviolet germicidal light. The light may be provided by LEDs on a circuit board adapted for positioning around the support without dismounting the support from the ceiling, such as one comprised of wedge-shaped segments. The modular circuit board may form part of an uplight module supported by a housing for the motor.

Abstract: A fan is for improving air quality, such as in an indoor environment. The fan includes a motor and a rotatable hub coupled to the motor. At least one fan blade includes a first end portion coupled to the rotatable hub and a second end portion radially distant from the rotatable hub. At least one ion generator is carried by the second end portion of the at least one fan blade, such as by a winglet associated therewith. A stationary tube passes through the rotatable hub including a conduit for transmitting power. A rotary coupling is also provided for transmitting power from the conduit to the at least one ion generator.

Abstract: Described herein are methods directed to determining the carrier status or genotype of a subject. Described herein is a method that combines experimental and computational approaches to resolve the structure of genomic loci (i.e., the genotype) whose sequences are highly homologous to other sequences in the genome. In particular, the determination of carrier status and/or copy number of a gene in a subject, wherein the gene has a corresponding highly homologous homolog, e.g., gene or pseudogene, utilizes Next Generation Sequencing. Also described herein is a computer-assisted method for such determinations.

Abstract: An assembly having a positive locking device is provided. The assembly includes a solid body having a through hole arranged to receive a fastener. A fastener is disposed in the through hole of the solid body and secured to the solid body using a securing means. The locking plate positively locks the securing means onto the fastener. A generator including the assembly as well as a method to set a short circuit stop gap between the assembly and a support brace support the stator winding is also provided.

Abstract: The present disclosure relates to processes for determining the number of nucleic acid repeats in a DNA fragment comprising a nucleic acid repeat region. One example method may include receiving DNA size and abundance data generated by resolving DNA amplification products. A set of low-pass data may be generated by applying a low-pass filter to the DNA size and abundance data and a set of band-pass data may be generated by applying a band-pass filter to the DNA size and abundance data. A peak of the DNA size and abundance data representative of a number of nucleic acid repeats in the DNA may be identified based on peaks identified from the low-pass data and the band-pass data.

Abstract: The present disclosure relates to processes for determining the number of nucleic acid repeats in a DNA fragment comprising a nucleic acid repeat region. One example method may include receiving DNA size and abundance data generated by resolving DNA amplification products. A set of low-pass data may be generated by applying a low-pass filter to the DNA size and abundance data and a set of band-pass data may be generated by applying a band-pass filter to the DNA size and abundance data. A peak of the DNA size and abundance data representative of a number of nucleic acid repeats in the DNA may be identified based on peaks identified from the low-pass data and the band-pass data.

Abstract: An assembly having a positive locking device is provided. The assembly includes a solid body having a through hole arranged to receive a fastener. A fastener is disposed in the through hole of the solid body and secured to the solid body using a securing means. The locking plate positively locks the securing means onto the fastener. A generator including the assembly as well as a method to set a short circuit stop gap between the assembly and a support brace support the stator winding is also provided.

Abstract: A method of identifying and quantifying copy number variations in a gene of interest for a genomic DNA sample includes (i) fragmenting a genomic DNA sample to produce a plurality of polynucleotide fragments, (ii) isolating a plurality of target polynucleotide fragments, (iii) sequencing the plurality of target polynucleotide fragments, (iv) aligning fragment sequences to a reference sequence, (v) calculating read depths for base positions of the plurality of target polynucleotide fragments, (vi) calculating copy number likelihoods for each base position of the reference sequence, (vii) performing a breakpoint analysis on a set of fragment sequences to identify at least one sequence variation located between selected breakpoint regions of the target gene and calculate modified copy number likelihoods for base positions of the reference sequence based on the at least one sequence variation, and (viii) determining whether the target gene includes at least one copy number variation.

Abstract: A device for the controlled delivery of a single service portion of buttered flavored toppings is disclosed. The device comprises a three ounce plastic vessel or bottle, wherein the bottle has a top that screws on to the bottle and wherein the top has a restricted nipple with a covering cap, wherein the nipple is configured to allow the user to apply the butter topping when desired. A method for the controlled delivery of single service portion of buttered flavored toppings is also disclosed.

Abstract: Described herein are methods directed to determining the carrier status or genotype of a subject. Described herein is a method that combines experimental and computational approaches to resolve the structure of genomic loci (i.e., the genotype) whose sequences are highly homologous to other sequences in the genome. In particular, the determination of carrier status and/or copy number of a gene in a subject, wherein the gene has a corresponding highly homologous homolog, e.g., gene or pseudogene, utilizes Next Generation Sequencing. Also described herein is a computer-assisted method for such determinations.

Abstract: Provided herein are methods, systems, and devices for genetic screening. The genetic screening of two or more individuals can be utilized to predict the phenotype of a child from the group of individuals. Also disclosed is prediction of a phenotype of a child from a subset of biological relatives, such as a potential mother and father, before conception. In many instances, the methods, systems and devices herein are utilized to predict the probability of a child developing a rare genetic disease.

Abstract: The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged polynucleotides are sequenced simultaneously and sample sources are identified on the basis of barcode sequences. In some aspects, sequencing data are used to determine one or more genotypes at one or more loci comprising a causal genetic variant. In some aspects, systems and methods of detecting genetic variation are provided.

Abstract: The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged polynucleotides are sequenced simultaneously and sample sources are identified on the basis of barcode sequences. In some aspects, sequencing data are used to determine one or more genotypes at one or more loci comprising a causal genetic variant. In some aspects, systems and methods of detecting genetic variation are provided.

Abstract: The present disclosure relates to processes for determining the number of nucleic acid repeats in a DNA fragment comprising a nucleic acid repeat region. One example method may include receiving DNA size and abundance data generated by resolving DNA amplification products. A set of low-pass data may be generated by applying a low-pass filter to the DNA size and abundance data and a set of band-pass data may be generated by applying a band-pass filter to the DNA size and abundance data. A peak of the DNA size and abundance data representative of a number of nucleic acid repeats in the DNA may be identified based on peaks identified from the low-pass data and the band-pass data.

Abstract: The present disclosure provides for compositions and methods for the testing and analysis of genetic alterations of a sample comprising maternal and fetal polynucleotides. Generally, the composition and methods of this disclosure provide for the isolation of a mixture of maternal and fetal polynucleotides from a sample, generally from the mother. Polynucleotides are isolated and purified and further tested to determine the presence or absence of genetic alterations, such as copy number variation, or causal variants at one or more loci in the sample.

Abstract: The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged polynucleotides are sequenced simultaneously and sample sources are identified on the basis of barcode sequences. In some aspects, sequencing data are used to determine one or more genotypes at one or more loci comprising a causal genetic variant.

Abstract: The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged polynucleotides are sequenced simultaneously and sample sources are identified on the basis of barcode sequences. In some aspects, sequencing data are used to determine one or more genotypes at one or more loci comprising a causal genetic variant. In some aspects, systems and methods of detecting genetic variation are provided.

Abstract: The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged polynucleotides are sequenced simultaneously and sample sources are identified on the basis of barcode sequences. In some aspects, sequencing data are used to determine one or more genotypes at one or more loci comprising a causal genetic variant.

Abstract: The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged polynucleotides are sequenced simultaneously and sample sources are identified on the basis of barcode sequences. In some aspects, sequencing data are used to determine one or more genotypes at one or more loci comprising a causal genetic variant.