Abstract: Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.

Abstract: This invention provides a crystalline azithromycin L-malate monohydrate for treating various microbial infections, which has high thermostability, solubility and non-hygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.

Abstract: The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.

Abstract: The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.

Abstract: A crystalline clopidogrel naphthalenesulfonate or a hydrate thereof, a method for preparing same, and a pharmaceutical composition containing same are provided.

Abstract: Ticlopidine and clopidogrel having high blood platelet aggregation inhibitory and anti-thrombotic activities are simply prepared by reacting a substituted thiophene derivative with a 2-chlorobenzylamine derivative.

Abstract: Provided is a method and apparatus for configuring and managing an overlay multicast data delivery tree in a transmission network having a SM (session manager) and at least one MA (multicast agent).

Abstract: Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.

Abstract: It is possible to filter spam of diversified Internet protocol (IP) multimedia applications, since it is possible to provide spam filtering services suitable for various processing methods of calls of the IP multimedia applications and media features in an application server layer without changing a structure of IP multimedia service network by classifying calls of IP multimedia application services based on service features, checking policy information of the calls classified based on the service features, filtering spam so as to determine whether the call is spam through dynamic filtering mechanism for each application service, and transmitting the call to a lower network by determining a suitable processing method based on the checking result of the policy information or the filtering result, so as to filter IP multimedia spam in an application server in a network for providing various real-time IP multimedia application services.

Abstract: The present invention relates to a nail grinder which enables a more clean nail grinding work by preventing grinding efficiency from being reduced and preventing nail powders from being scattered in such a manner that ground nail powders are prevented from being stacked on the surface of an abrasive cloth by wiping nail powders generated in grinding nails right away in its grinding process by arranging abrasive clothes having a different roughness surface to thus gradually perform a nail grinding work and attaching a fabric paper having adsorptivity at one side of a base.