Patents by Inventor Evan C. Unger

Evan C. Unger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cationic lipids and the use thereof
    Patent number: 5830430
    Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: November 3, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
  • Sunscreen agents from natural sources
    Patent number: 5824312
    Abstract: Photoabsorptive compounds are disclosed which comprise a purified extract of a plant or plant part, wherein said plant is indigenous to an arid region of the world, especially where said arid region is located between 35.degree. north latitude and 35.degree. south latitude. The photoabsorptive compounds in many cases are capable of absorbing solar radiation from about 190 nm to about 500 nm, comprising ultraviolet A, ultraviolet B, and high energy visible light. In particular embodiments, the plant part is pollen, and the plant is mesquite, Prosopis juliflora; Mexican palo verde, Parkinsonia aculeata; blue palo verde, Cercidium floridum; or foothills palo verde, Cercidium microphyllum.
    Type: Grant
    Filed: December 15, 1995
    Date of Patent: October 20, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas P. Mc Creery
  • Method of preparing gas-filled microspheres using a lyophilized lipids
    Patent number: 5776429
    Abstract: Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: July 7, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Container with multi-phase composition for use in diagnostic and therapeutic applications
    Patent number: 5773024
    Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: June 30, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Terry Matsunaga, David Yellowhair
  • Gas filled liposomes and stabilized gas bubbles and their use as ultrasonic contrast agents
    Patent number: 5769080
    Abstract: Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: June 23, 1998
    Assignee: DuPont Merck Pharmaceutical Company
    Inventors: Evan C. Unger, Guanli Wu
  • Therapeutic drug delivery systems
    Patent number: 5770222
    Abstract: Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 23, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Liposoluble compounds useful as magnetic resonance imaging agents
    Patent number: 5762910
    Abstract: Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: June 9, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, DeKang Shen
  • Stabilized homogenous suspensions as computed tomography contrast agents
    Patent number: 5736121
    Abstract: Novel stabilized suspensions of a gas as diagnostic contrast agents, including computed tomography (CT) and magnetic resonance (MR) contrast agents. In preferred embodiments, the suspensions comprise stabilized gas filled microspheres. Also in some preferred embodiments, at least a portion of the gas is derived from a gaseous precursor.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: April 7, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventor: Evan C. Unger
  • Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
    Patent number: 5733572
    Abstract: Gas and gaseous precursor filled microspheres, and foams thereof, provide novel topical and subcutaneous delivery vehicles for various active ingredients, including drugs and cosmetics.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: March 31, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Terry O. Matsunaga, David Yellowhair
  • Methods of preparing gas-filled liposomes
    Patent number: 5715824
    Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 10, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Contrast media for ultrasonic imaging
    Patent number: 5714528
    Abstract: Novel contrast media for use in ultrasonic imaging are described. Such contrast media may be comprised of an aqueous solution of one or more biocompatible polymers, wherein said biocompatible polymers are coated with and/or in admixture with at least one silicon containing compound. Alternatively, the contrast media may be comprised of an aqueous solution of one or more biocompatible synthetic polymers, or an aqueous solution of cellulose. The contrast media maybe employed, if desired, with anti-gas agents and/or suspending agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 3, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Guanli Wu
  • Contrast media for ultrasonic imaging
    Patent number: 5714529
    Abstract: Novel contrast media for use in ultrasonic imaging are described. Such contrast media may be comprised of an aqueous solution of one or more biocompatible polymers, wherein said biocompatible polymers are coated with and/or in admixture with at least one silicon containing compound. Alternatively, the contrast media may be comprised of an aqueous solution of one or more biocompatible synthetic polymers, or an aqueous solution of cellulose. The contrast media may be employed, if desired, with anti-gas agents and/or suspending agents.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 3, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Guanli Wu
  • Compositions of lipids and stabilizing materials
    Patent number: 5705187
    Abstract: Compositions comprising, in an aqueous carrier, a lipid and a material which is capable of stabilizing the composition. The stabilizing material is associated non-covalently with said lipid and is present in an amount sufficient to coat the lipid but insufficient to raise the viscosity of the composition. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: January 6, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventor: Evan C. Unger
  • Compositions comprising a biocompatible gas and a polymer for magnetic resonance imaging
    Patent number: 5681542
    Abstract: Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents such as paramagnetic, superparamagnetic or proton density contrast agents. Additionally, the polymers or polymer and contrast agent admixtures may be mixed with one or more biocompatible gases to increase the relaxivity of the resultant preparation, and/or with other components. In a preferable embodiment, the contrast medium is hypoosmotic.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 28, 1997
    Assignee: ImaRx Pharmaceutical Corp.
    Inventor: Evan C. Unger
  • Non cross-linked synthetic polymers as contrast media for magnetic resonance imaging
    Patent number: 5658550
    Abstract: Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents such as paramagnetic, superparamagnetic or proton density contrast agents. Additionally, the polymers or polymer and contrast agent admixtures may be mixed with one or more biocompatible gases to increase the relaxivity of the resultant preparation, and/or with other components. In a preferable embodiment, the contrast medium is hypoosmotic.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: August 19, 1997
    Assignee: ImaR.sub.x Pharmaceutical Corp.
    Inventor: Evan C. Unger
  • Synthetic polyuronic and hypoosmotic polymer compositions in admixture with proteinaceously bound contrast agents for MRI
    Patent number: 5645816
    Abstract: Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents such as paramagnetic, superparamagnetic or proton density contrast agents. Additionally, the polymers or polymer and contrast agent admixtures may be mixed with one or more biocompatible gases to increase the relaxivity of the resultant preparation, and/or with other components. In a preferable embodiment, the contrast medium is hypoosmotic.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 8, 1997
    Assignee: ImaRx Pharmaceutical Corp.
    Inventor: Evan C. Unger
  • Contrast media for ultrasonic imaging
    Patent number: 5639442
    Abstract: Novel contrast media for use in ultrasonic imaging are described. Such contrast media may be comprised of an aqueous solution of one or more biocompatible polymers, wherein said biocompatible polymers are coated with and/or in admixture with at least one silicon containing compound. Alternatively, the contrast media may be comprised of an aqueous solution of one or more biocompatible synthetic polymers, or an aqueous solution of cellulose. The contrast media may be employed, if desired, with anti-gas agents and/or suspending agents.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: June 17, 1997
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Guanli Wu
  • Liposoluble heterocyclic compounds useful as magnetic resonance imaging agents
    Patent number: 5624662
    Abstract: Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 29, 1997
    Assignee: ImaRx Pharmaceutical Corporation
    Inventors: Evan C. Unger, DeKang Shen
  • Hypoosmotic compositions comprising a polymer and a complexed contrast agent for MRI
    Patent number: 5624661
    Abstract: Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents such as paramagnetic, superparamagnetic or proton density contrast agents. Additionally, the polymers or polymer and contrast agent admixtures may be mixed with one or more biocompatible gases to increase the relaxivity of the resultant preparation, and/or with other components. In a preferable embodiment, the contrast medium is hypoosmotic.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 29, 1997
    Inventor: Evan C. Unger
  • Method of preparing gas and gaseous precursor-filled microspheres
    Patent number: 5585112
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: November 30, 1993
    Date of Patent: December 17, 1996
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu