Patents by Inventor Evan C. Unger

Evan C. Unger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition comprising low density microspheres
    Patent number: 6998107
    Abstract: Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: February 14, 2006
    Assignee: Bristol-Myers Squibb Pharma Comapany
    Inventor: Evan C. Unger
  • Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
    Patent number: 6884407
    Abstract: Improved methods for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combination with a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: April 26, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventor: Evan C. Unger
  • Non-invasive intravascular thrombolysis using modified ultrasound techniques
    Publication number: 20040265393
    Abstract: A non-invasive method for disrupting a blood clot within the vasculature of a patient using new ultrasound techniques is provided. Lipid vesicles containing a gas or gaseous precursor are administered intravascularly to the patient and ultrasound having a power greater than about 0.5 Watts/cm2 to about 20 Watts/cm2 for about 10% to about 80% of the duty cycle is applied to the patient for a period of time sufficient to induce rupture of the vesicles adjacent to the site of the blood clot, thereby disrupting the blood clot. Administration of thrombolytic biological agents is not required. Optionally, progress of clot disruption can be monitored using magnetic resonance imaging.
    Type: Application
    Filed: June 10, 2004
    Publication date: December 30, 2004
    Inventors: Evan C. Unger, Reena Zutshi, Terry O. Matsunaga
  • Composition comprising low density microspheres
    Publication number: 20040223914
    Abstract: Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.
    Type: Application
    Filed: June 10, 2004
    Publication date: November 11, 2004
    Applicant: Bristol-Myers Squibb Medical Imaging Inc.
    Inventor: Evan C. Unger
  • Charged lipids and uses for the same
    Patent number: 6808720
    Abstract: The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: October 26, 2004
    Assignee: ImaRx Therapeutics, Inc.
    Inventor: Evan C. Unger
  • Methods for delivering compounds into a cell
    Publication number: 20040176473
    Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.
    Type: Application
    Filed: March 18, 2004
    Publication date: September 9, 2004
    Applicant: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas McCreery
  • Contrast agent comprising low density microspheres
    Patent number: 6773696
    Abstract: Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: August 10, 2004
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventor: Evan C. Unger
  • Methods for delivering compounds into a cell
    Patent number: 6743779
    Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: June 1, 2004
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas McCreery
  • Solid matrix therapeutic compositions
    Publication number: 20040091541
    Abstract: The present invention is directed to a solid porous matrix comprising a surfactant in combination with a bioactive agent. The solid porous matrix may be prepared by combining a surfactant and a therapeutic, together with a solvent, to form an emulsion containing random aggregates of the surfactant and the therapeutic, and processing the emulsion by controlled drying, or controlled agitation and controlled drying to form the solid porous matrix.
    Type: Application
    Filed: July 16, 2003
    Publication date: May 13, 2004
    Inventor: Evan C. Unger
  • Methods of ultrasound treatment using gas or gaseous precursor-filled compositions
    Patent number: 6716412
    Abstract: The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous precursor prior to their in vivo administration to a patient. Further optimization of contrast enhancement is achieved by administering the gaseous precursor filled compositions to a patient as an infusion. Enhanced effectiveness is also achieved for ultrasound mediated targeting and drug delivery.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: April 6, 2004
    Assignee: Imarx Therapeutics, Inc.
    Inventor: Evan C. Unger
  • Method and apparatus for vascular neuromuscular blockade
    Publication number: 20030211975
    Abstract: Method and apparatus of vascular neuromuscular blockade including percutaneous delivery of a quantity of neurotransmitter inhibiting agent to an affected region of a vessel.
    Type: Application
    Filed: June 16, 2003
    Publication date: November 13, 2003
    Applicant: IMARX THERAPEUTICS INC
    Inventor: Evan C. Unger
  • Methods for delivering compounds into a cell
    Patent number: 6638767
    Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: October 28, 2003
    Assignee: ImaRx Pharmaceutical Corporation
    Inventors: Evan C. Unger, Thomas McCreery
  • Methods and systems for applying multi-mode energy to biological samples
    Patent number: 6627421
    Abstract: A system for applying energy to cells so as to elicit the formation of pores, to enhance transfection, and/or cell transformation, includes a computer, a plurality of acoustic probes for controllably applying acoustic energy to batches of cells, and a robot operatively for effecting relative movement between the probes and the batches of cells. Preferably, the acoustic energy comprises ultrasonic energy, which is applied in combination with optical or electrical energy to enhance the formation of pores in surface membranes of the cells.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: September 30, 2003
    Assignee: ImaRx Therapeutics, Inc.
    Inventors: Evan C. Unger, Yunqiu Wu, Thomas McCreery
  • Novel methods of imaging and treatment with targeted compositions
    Publication number: 20030157025
    Abstract: Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.
    Type: Application
    Filed: January 13, 2003
    Publication date: August 21, 2003
    Inventors: Evan C. Unger, Yunqiu Wu
  • Oxygen delivery agents and uses for the same
    Publication number: 20030120204
    Abstract: The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery agents or blood substitutes.
    Type: Application
    Filed: January 6, 2003
    Publication date: June 26, 2003
    Inventors: Evan C. Unger, Thomas McCreery, Yunqiu Wu
  • Method and apparatus for vascular neuromuscular blockade
    Patent number: 6579847
    Abstract: Method and apparatus of vascular neuromuscular blockade including percutaneous delivery of a quantity of neurotransmitter inhibiting agent to an affected region of a vessel.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: June 17, 2003
    Assignee: Imarx Therapeutics Inc.
    Inventor: Evan C. Unger
  • Non-invasive methods for surgery in the vasculature
    Patent number: 6576220
    Abstract: Novel methods of non-invasive intravascular surgery are disclosed, which include the intravascular administration of a composition comprising gas or gaseous precursor filled vesicles, followed by application of ultrasound in an amount sufficient to induce activation or rupture of the vesicles. The methods optionally also include the step of scanning the patient with diagnostic imaging to determine the presence of the vesicles in the region.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: June 10, 2003
    Assignee: ImaRx Therapeutics, Inc.
    Inventor: Evan C. Unger
  • NON-INVASIVE METHODS FOR SURGERY IN THE VASCULATURE
    Publication number: 20030088176
    Abstract: Novel methods of non-invasive intravascular surgery are disclosed.
    Type: Application
    Filed: May 10, 2001
    Publication date: May 8, 2003
    Applicant: ImaRx Therapeutics, Inc.
    Inventor: Evan C. Unger
  • Container with multi-phase composition for use in diagnostic and therapeutic applications
    Patent number: 6551576
    Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: April 22, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Terry Matsunaga, David Yellowhair
  • Thermal preactivation of gaseous precursor filled compositions
    Patent number: 6548047
    Abstract: The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous precursor prior to their in vivo administration to a patient. Further optimization of contrast enhancement is achieved by administering the gaseous precursor filled compositions to a patient as an infusion. Enhanced effectiveness is also achieved for ultrasound mediated targeting and drug delivery.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: April 15, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventor: Evan C. Unger