Patents by Inventor Evan C. Unger

Evan C. Unger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxygen delivery agents and uses for the same
    Publication number: 20030120204
    Abstract: The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery agents or blood substitutes.
    Type: Application
    Filed: January 6, 2003
    Publication date: June 26, 2003
    Inventors: Evan C. Unger, Thomas McCreery, Yunqiu Wu
  • Method and apparatus for vascular neuromuscular blockade
    Patent number: 6579847
    Abstract: Method and apparatus of vascular neuromuscular blockade including percutaneous delivery of a quantity of neurotransmitter inhibiting agent to an affected region of a vessel.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: June 17, 2003
    Assignee: Imarx Therapeutics Inc.
    Inventor: Evan C. Unger
  • Non-invasive methods for surgery in the vasculature
    Patent number: 6576220
    Abstract: Novel methods of non-invasive intravascular surgery are disclosed, which include the intravascular administration of a composition comprising gas or gaseous precursor filled vesicles, followed by application of ultrasound in an amount sufficient to induce activation or rupture of the vesicles. The methods optionally also include the step of scanning the patient with diagnostic imaging to determine the presence of the vesicles in the region.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: June 10, 2003
    Assignee: ImaRx Therapeutics, Inc.
    Inventor: Evan C. Unger
  • NON-INVASIVE METHODS FOR SURGERY IN THE VASCULATURE
    Publication number: 20030088176
    Abstract: Novel methods of non-invasive intravascular surgery are disclosed.
    Type: Application
    Filed: May 10, 2001
    Publication date: May 8, 2003
    Applicant: ImaRx Therapeutics, Inc.
    Inventor: Evan C. Unger
  • Container with multi-phase composition for use in diagnostic and therapeutic applications
    Patent number: 6551576
    Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: April 22, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Terry Matsunaga, David Yellowhair
  • Thermal preactivation of gaseous precursor filled compositions
    Patent number: 6548047
    Abstract: The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous precursor prior to their in vivo administration to a patient. Further optimization of contrast enhancement is achieved by administering the gaseous precursor filled compositions to a patient as an infusion. Enhanced effectiveness is also achieved for ultrasound mediated targeting and drug delivery.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: April 15, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventor: Evan C. Unger
  • Stabilized nanoparticle formulations of camptotheca derivatives
    Publication number: 20030059465
    Abstract: Pharmaceutical formulations are provided that increase the systemic bioavailability of camptotheca derivatives; preferably, the camptothecin derivative is 7-ethyl-10-hydroxyl camptothecin, SN-38. The drug is complexed with a stabilizing agent, but is not covalently bound thereto. Anionic or neutral lipids and/or polymers are used as the stabilizing agent, and secondary stabilizing agents and/or other excipients may be incorporated into the formulation as well. Therapeutic methods are also provided, wherein a formulation of the invention is administered to a patient to treat a condition, disorder, or disease that is responsive to camptothecin derivatives. Generally, administration is oral or parenteral.
    Type: Application
    Filed: June 6, 2002
    Publication date: March 27, 2003
    Inventors: Evan C. Unger, Marek J. Romanowski, VaradaRajan Ramaswami
  • Oxygen delivery agents and uses for the same
    Patent number: 6537246
    Abstract: The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery agents or blood substitutes.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: March 25, 2003
    Assignee: IMARX Therapeutics, Inc.
    Inventors: Evan C. Unger, Thomas McCreery, Yunqiu Wu
  • Charged lipids and uses for the same
    Publication number: 20030054027
    Abstract: The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.
    Type: Application
    Filed: January 15, 2002
    Publication date: March 20, 2003
    Applicant: ImaRx Therapeutics, Inc.
    Inventor: Evan C. Unger
  • Contrast agent comprising low density microspheres
    Publication number: 20030053953
    Abstract: Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.
    Type: Application
    Filed: October 25, 2002
    Publication date: March 20, 2003
    Inventor: Evan C. Unger
  • Low density microspheres and their use as contrast agents for computed tomography and in other applications
    Patent number: 6528039
    Abstract: Substantially homogeneous aqueous suspensions of low density microspheres are presented as contrast media for imaging the gastrointestinal tract and other body cavities using computed tomography. In one embodiment, the low density microspheres are gas-filled. With computed tomography, the contrast media serve to change the relative density of certain areas within the gastrointestinal tract and other body cavities, and improve the overall diagnostic efficacy of this imaging method.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: March 4, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventor: Evan C. Unger
  • Novel therapeutic delivery systems
    Publication number: 20030039613
    Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided.
    Type: Application
    Filed: March 26, 2002
    Publication date: February 27, 2003
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Methods of imaging and treatment with targeted compositions
    Patent number: 6521211
    Abstract: Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.
    Type: Grant
    Filed: February 3, 1999
    Date of Patent: February 18, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Yunqiu Wu
  • Methods for diagnostic imaging by regulating the administration rate of contrast agent
    Publication number: 20030012735
    Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.
    Type: Application
    Filed: August 6, 2002
    Publication date: January 16, 2003
    Inventors: Evan C. Unger, Terry Matsunaga, Thomas A. Fritz, Varadarajan Ramaswami
  • Methods of preparing gaseous precursor-filled microspheres
    Publication number: 20030003055
    Abstract: Methods of and apparatus for preparing gas-filled microspheres are described. Gas-filled microspheres prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Application
    Filed: August 6, 2002
    Publication date: January 2, 2003
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Method of preparing gas and gaseous precursor-filled microspheres
    Patent number: 6479034
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: November 12, 2002
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Novel acoustically active drug delivery systems
    Publication number: 20020159952
    Abstract: The present invention is directed to targeted therapeutic delivery systems comprising a gas or gaseous precursor filled microsphere wherein said gas or gaseous precursor filled microsphere comprises an oil, a surfactant, and a therapeutic compound. Methods of preparing the targeted therapeutic delivery systems are also embodied by the present invention which comprise processing a solution comprising an oil and a surfactant in the presence of a gaseous precursor, at a temperature below the gel to liquid crystalline phase transition temperature of the surfactant to form gas or gaseous precursor filled microsphere, and adding to said microspheres a therapeutic compound resulting in a targeted therapeutic delivery system, wherein said processing is selected from the group consisting of controlled agitation, controlled drying, and a combination thereof.
    Type: Application
    Filed: February 27, 2002
    Publication date: October 31, 2002
    Inventor: Evan C. Unger
  • Novel targeted compositions for diagnostic and therapeutic use
    Publication number: 20020159951
    Abstract: Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise lipid, protein or polymer gas-filled vesicles which further comprise novel compounds of the general formula L-P-T, wherein L comprises a hydrophobic compound, P comprises a hydrophilic polymer, and T comprises a targeting ligand which targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The compositions can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.
    Type: Application
    Filed: January 23, 2002
    Publication date: October 31, 2002
    Inventors: Evan C. Unger, Thomas P. McCreery
  • Ultrasound imaging and treatment
    Publication number: 20020150539
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Application
    Filed: April 2, 2002
    Publication date: October 17, 2002
    Inventor: Evan C. Unger
  • Method of magnetic resonance focused surgical and therapeutic ultrasound
    Patent number: 6461586
    Abstract: A novel method for the controlled delivery of therapeutic compounds to a region of a patient, using magnetic resonance focused therapeutic ultrasound, is disclosed.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: October 8, 2002
    Assignee: Imarx Therapeutics, Inc.
    Inventor: Evan C. Unger