Patents by Inventor Evan C. Unger

Evan C. Unger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized nanoparticle formulations of camptotheca derivatives
    Publication number: 20030059465
    Abstract: Pharmaceutical formulations are provided that increase the systemic bioavailability of camptotheca derivatives; preferably, the camptothecin derivative is 7-ethyl-10-hydroxyl camptothecin, SN-38. The drug is complexed with a stabilizing agent, but is not covalently bound thereto. Anionic or neutral lipids and/or polymers are used as the stabilizing agent, and secondary stabilizing agents and/or other excipients may be incorporated into the formulation as well. Therapeutic methods are also provided, wherein a formulation of the invention is administered to a patient to treat a condition, disorder, or disease that is responsive to camptothecin derivatives. Generally, administration is oral or parenteral.
    Type: Application
    Filed: June 6, 2002
    Publication date: March 27, 2003
    Inventors: Evan C. Unger, Marek J. Romanowski, VaradaRajan Ramaswami
  • Oxygen delivery agents and uses for the same
    Patent number: 6537246
    Abstract: The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery agents or blood substitutes.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: March 25, 2003
    Assignee: IMARX Therapeutics, Inc.
    Inventors: Evan C. Unger, Thomas McCreery, Yunqiu Wu
  • Contrast agent comprising low density microspheres
    Publication number: 20030053953
    Abstract: Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.
    Type: Application
    Filed: October 25, 2002
    Publication date: March 20, 2003
    Inventor: Evan C. Unger
  • Charged lipids and uses for the same
    Publication number: 20030054027
    Abstract: The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.
    Type: Application
    Filed: January 15, 2002
    Publication date: March 20, 2003
    Applicant: ImaRx Therapeutics, Inc.
    Inventor: Evan C. Unger
  • Low density microspheres and their use as contrast agents for computed tomography and in other applications
    Patent number: 6528039
    Abstract: Substantially homogeneous aqueous suspensions of low density microspheres are presented as contrast media for imaging the gastrointestinal tract and other body cavities using computed tomography. In one embodiment, the low density microspheres are gas-filled. With computed tomography, the contrast media serve to change the relative density of certain areas within the gastrointestinal tract and other body cavities, and improve the overall diagnostic efficacy of this imaging method.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: March 4, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventor: Evan C. Unger
  • Novel therapeutic delivery systems
    Publication number: 20030039613
    Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided.
    Type: Application
    Filed: March 26, 2002
    Publication date: February 27, 2003
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Methods of imaging and treatment with targeted compositions
    Patent number: 6521211
    Abstract: Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.
    Type: Grant
    Filed: February 3, 1999
    Date of Patent: February 18, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Yunqiu Wu
  • Methods for diagnostic imaging by regulating the administration rate of contrast agent
    Publication number: 20030012735
    Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.
    Type: Application
    Filed: August 6, 2002
    Publication date: January 16, 2003
    Inventors: Evan C. Unger, Terry Matsunaga, Thomas A. Fritz, Varadarajan Ramaswami
  • Methods of preparing gaseous precursor-filled microspheres
    Publication number: 20030003055
    Abstract: Methods of and apparatus for preparing gas-filled microspheres are described. Gas-filled microspheres prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Application
    Filed: August 6, 2002
    Publication date: January 2, 2003
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Method of preparing gas and gaseous precursor-filled microspheres
    Patent number: 6479034
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: November 12, 2002
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Novel targeted compositions for diagnostic and therapeutic use
    Publication number: 20020159951
    Abstract: Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise lipid, protein or polymer gas-filled vesicles which further comprise novel compounds of the general formula L-P-T, wherein L comprises a hydrophobic compound, P comprises a hydrophilic polymer, and T comprises a targeting ligand which targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The compositions can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.
    Type: Application
    Filed: January 23, 2002
    Publication date: October 31, 2002
    Inventors: Evan C. Unger, Thomas P. McCreery
  • Novel acoustically active drug delivery systems
    Publication number: 20020159952
    Abstract: The present invention is directed to targeted therapeutic delivery systems comprising a gas or gaseous precursor filled microsphere wherein said gas or gaseous precursor filled microsphere comprises an oil, a surfactant, and a therapeutic compound. Methods of preparing the targeted therapeutic delivery systems are also embodied by the present invention which comprise processing a solution comprising an oil and a surfactant in the presence of a gaseous precursor, at a temperature below the gel to liquid crystalline phase transition temperature of the surfactant to form gas or gaseous precursor filled microsphere, and adding to said microspheres a therapeutic compound resulting in a targeted therapeutic delivery system, wherein said processing is selected from the group consisting of controlled agitation, controlled drying, and a combination thereof.
    Type: Application
    Filed: February 27, 2002
    Publication date: October 31, 2002
    Inventor: Evan C. Unger
  • Ultrasound imaging and treatment
    Publication number: 20020150539
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Application
    Filed: April 2, 2002
    Publication date: October 17, 2002
    Inventor: Evan C. Unger
  • Method of magnetic resonance focused surgical and therapeutic ultrasound
    Patent number: 6461586
    Abstract: A novel method for the controlled delivery of therapeutic compounds to a region of a patient, using magnetic resonance focused therapeutic ultrasound, is disclosed.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: October 8, 2002
    Assignee: Imarx Therapeutics, Inc.
    Inventor: Evan C. Unger
  • Lipid soluble steroid prodrugs
    Patent number: 6444660
    Abstract: The present invention is directed to novel lipid soluble steroid prodrugs, compositions comprising steroid prodrugs, and uses of the same.
    Type: Grant
    Filed: February 3, 2000
    Date of Patent: September 3, 2002
    Assignee: Imarx Therapeutics, Inc.
    Inventors: Evan C. Unger, DeKang Shen
  • Therapeutic delivery systems
    Patent number: 6443898
    Abstract: Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 3, 2002
    Assignee: Imarx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Transmembrane transport apparatus and method
    Publication number: 20020099356
    Abstract: A drug delivery device and method comprising first creating channels or pores across a biological membrane and secondly creating a driving force to propel drugs across or withdraw biological fluids through the membrane.
    Type: Application
    Filed: January 19, 2001
    Publication date: July 25, 2002
    Inventors: Evan C. Unger, Yunqiu Wu
  • Acoustically active drug delivery systems
    Patent number: 6416740
    Abstract: The present invention is directed to targeted therapeutic delivery systems comprising a gas or gaseous precursor filled microsphere wherein said gas or gaseous precursor filled microsphere comprises an oil, a surfactant, and a therapeutic compound. Methods of preparing the targeted therapeutic delivery systems are also embodied by the present invention which comprise processing a solution comprising an oil and a surfactant in the presence of a gaseous precursor, at a temperature below the gel to liquid crystalline phase transition temperature of the surfactant to form gas or gaseous precursor filled microsphere, and adding to said microspheres a therapeutic compound resulting in a targeted therapeutic delivery system, wherein said processing is selected from the group consisting of controlled agitation, controlled drying, and a combination thereof.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: July 9, 2002
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventor: Evan C. Unger
  • Silicon amphiphilic compounds and the use thereof
    Patent number: 6414139
    Abstract: Novel silicon amphiphilic compounds which comprise a silicon residue. The silicon amphiphilic compounds are particularly suitable for use in compositions for diagnostic imaging, such as ultrasound. Compositions of the silicon amphiphilic compounds comprise a gas or gaseous precursor, and may take the form of vesicle compositions, such as micelles or liposomes.
    Type: Grant
    Filed: September 3, 1996
    Date of Patent: July 2, 2002
    Assignee: Imarx Therapeutics, Inc.
    Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
  • Method for delivering bioactive agents using cochleates
    Patent number: 6403056
    Abstract: The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: June 11, 2002
    Assignee: Imarx Therapeutics, Inc.
    Inventor: Evan C. Unger