Patents by Inventor Fabrice Piu

Fabrice Piu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VARIANT ADENO-ASSOCIATED VIRUS (AAV) CAPSID POLYPEPTIDES AND GENE THERAPEUTICS THEREOF FOR TREATMENT OF HEARING LOSS
    Publication number: 20240226330
    Abstract: Described herein are variant adeno-associated virus (AAV) capsid polypeptides and gene therapeutics thereof for use in the treatment or prevention of hearing loss.
    Type: Application
    Filed: May 5, 2023
    Publication date: July 11, 2024
    Inventors: Steven Pennock, Adrian M. Timmers, Mark Shearman, Christopher Bartolome, Wang Xiaobo, Prahav Dinesh Mathur, Phillip M. Uribe, Stephanie Szobota, Bonnie E. Jacques, Alan C. Foster, Fabrice Piu
  • Auris formulations for treating otic diseases and conditions
    Patent number: 11969501
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: April 30, 2024
    Assignees: DOMPÉ FARMACEUTICI S.P.A., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Michael Christopher Scaife, Benedikt Vollrath, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • VARIANT ADENO-ASSOCIATED VIRUS (AAV) CAPSID POLYPEPTIDES AND GENE THERAPEUTICS THEREOF FOR TREATMENT OF HEARING LOSS
    Publication number: 20240131189
    Abstract: Described herein are variant adeno-associated virus (AAV) capsid polypeptides and gene therapeutics thereof for use in the treatment or prevention of hearing loss.
    Type: Application
    Filed: May 4, 2023
    Publication date: April 25, 2024
    Inventors: Steven Pennock, Adrian M. Timmers, Mark Shearman, Christopher Bartolome, Wang Xiaobo, Prahav Dinesh Mathur, Phillip M. Uribe, Stephanie Szobota, Bonnie E. Jacques, Alan C. Foster, Fabrice Piu
  • Triglyceride otic formulations and uses thereof
    Patent number: 11918653
    Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: March 5, 2024
    Assignee: DOMPÉ FARMACEUTICI S.P.A.
    Inventors: Robert Savel, Zhanpeng Zhang, Scott Coleman, Fabrice Piu, Hong Qi, Martha Pastuszka
  • OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY
    Publication number: 20230293524
    Abstract: Provided herein are methods for preventing and/or reducing the severity of drug induced ototoxicity. Provided herein are methods for recovery from hearing loss due to drug-induced ototoxicity.
    Type: Application
    Filed: October 30, 2020
    Publication date: September 21, 2023
    Inventors: Alan FOSTER, Fabrice PIU, Bonnie Elizabeth JACQUES, Phillip Michael URIBE, Stephanie SZOBOTA, Pranav Dinesh MATHUR
  • GROWTH FACTOR FORMULATION FOR CONDITION ASSOCIATED WITH OTIC EVENT
    Publication number: 20230122991
    Abstract: Disclosed herein are otic formulations and compositions comprising growth factors. These otic formulations and compositions allow for the delivery of the growth factor to the outer, middle, and/or inner ear for the treatment of otic diseases and disorders.
    Type: Application
    Filed: January 22, 2021
    Publication date: April 20, 2023
    Inventors: Alan FOSTER, Bonnie Elizabeth JACQUES, Fabrice PIU
  • Controlled release antimicrobial compositions and methods for the treatment of otic disorders
    Patent number: 11369566
    Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: June 28, 2022
    Assignees: ALK-ABELLÓ, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS
    Publication number: 20220040096
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
    Type: Application
    Filed: August 18, 2021
    Publication date: February 10, 2022
    Inventors: Jay LICHTER, Andrew M. TRAMMEL, Fabrice PIU, Qiang YE, Michael Christopher SCAIFE, Benedikt VOLLRATH, Sergio G. DURON, Luis A. DELLAMARY, Carl LEBEL, Jeffrey P. HARRIS
  • AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS
    Publication number: 20220040095
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
    Type: Application
    Filed: August 18, 2021
    Publication date: February 10, 2022
    Inventors: Jay LICHTER, Andrew M. TRAMMEL, Fabrice PIU, Qiang YE, Michael Christopher SCAIFE, Benedikt VOLLRATH, Sergio G. DURON, Luis A. DELLAMARY, Carl LEBEL, Jeffrey P. HARRIS
  • Auris formulations for treating OTIC diseases and conditions
    Patent number: 11123285
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: September 21, 2021
    Assignees: Otonomy, Inc., The Regents of the University of California
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • Auris formulations for treating otic diseases and conditions
    Patent number: 11123286
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: September 21, 2021
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • CONTROLLED-RELEASE CNS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS
    Publication number: 20210220263
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
    Type: Application
    Filed: January 12, 2021
    Publication date: July 22, 2021
    Inventors: Jay LICHTER, Andrew M. TRAMMEL, Fabrice PIU, Qiang YE, Michael Christopher SCAIFE, Benedikt VOLLRATH, Sergio G. DURON, Luis A. DELLAMARY, Carl LEBEL, Jeffrey P. HARRIS
  • Treatment using truncated Trk B and Trk C antagonists
    Patent number: 11034961
    Abstract: Disclosed herein are methods, compositions, vectors, and kits comprising an antagonist of a truncated TrkC or a truncated TrkB. Also described herein are methods of treating and/or preventing an otic disease or condition associated with an elevated expression level of a truncated TrkC or truncated TrkB isoform.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: June 15, 2021
    Assignee: OTONOMY, INC.
    Inventors: Horacio Uri Saragovi, Fabrice Piu
  • TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF
    Publication number: 20210138069
    Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 13, 2021
    Inventors: Robert SAVEL, Zhanpeng ZHANG, Scott COLEMAN, Fabrice PIU, Hong QI, Martha PASTUSZKA
  • Controlled-release CNS modulating compositions and methods for the treatment of otic disorders
    Patent number: 10918594
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: February 16, 2021
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Michael Christopher Scaife, Benedikt Vollrath, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF
    Publication number: 20200397907
    Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.
    Type: Application
    Filed: September 3, 2020
    Publication date: December 24, 2020
    Inventors: Robert SAVEL, Zhanpeng ZHANG, Scott COLEMAN, Fabrice PIU, Hong QI
  • Triglyceride otic formulations and uses thereof
    Patent number: 10821185
    Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: November 3, 2020
    Assignee: Otonomy Inc.
    Inventors: Robert Savel, Zhanpeng Zhang, Scott Coleman, Fabrice Piu, Hong Qi
  • Controlled release antimicrobial compositions and methods for the treatment of otic disorders
    Patent number: 10772828
    Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: September 15, 2020
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • Auris formulations for treating otic diseases and conditions
    Patent number: 10751281
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: August 25, 2020
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS
    Publication number: 20200230051
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
    Type: Application
    Filed: March 19, 2020
    Publication date: July 23, 2020
    Inventors: Jay LICHTER, Andrew M. TRAMMEL, Fabrice PIU, Qiang YE, Michael Christopher SCAIFE, Benedikt VOLLRATH, Sergio G. DURON, Luis A. DELLAMARY, Carl LEBEL, Jeffrey P. HARRIS