Patents by Inventor Fabrice Piu

Fabrice Piu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Controlled-Release CNS Modulating Compositions and Methods for the Treatment of Otic Disorders
    Publication number: 20190350845
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
    Type: Application
    Filed: June 20, 2019
    Publication date: November 21, 2019
    Inventors: Jay LICHTER, Andrew M. TRAMMEL, Fabrice PIU, Qiang YE, Michael Christopher SCAIFE, Benedikt VOLLRATH, Sergio G. DURON, Luis A. DELLAMARY, Carl LEBEL, Jeffrey P. HARRIS
  • AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS
    Publication number: 20190307678
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
    Type: Application
    Filed: April 19, 2019
    Publication date: October 10, 2019
    Inventors: Jay LICHTER, Andrew M. TRAMMEL, Fabrice PIU, Qiang YE, Michael Christopher SCAIFE, Benedikt VOLLRATH, Sergio G. DURON, Luis A. DELLAMARY, Carl LEBEL, Jeffrey P. HARRIS
  • CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS
    Publication number: 20190298799
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with anti-apoptotic agent or pro-apoptotic agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
    Type: Application
    Filed: April 17, 2019
    Publication date: October 3, 2019
    Inventors: Jay LICHTER, Andrew M. TRAMMEL, Fabrice PIU, Qiang YE, Michael Christopher SCAIFE, Benedikt VOLLRATH, Sergio G. DURON, Luis A. DELLAMARY, Carl LEBEL, Jeffrey P. HARRIS
  • CONTROLLED RELEASE DELIVERY DEVICES FOR THE TREATMENT OF OTIC DISORDERS
    Publication number: 20190192425
    Abstract: Disclosed herein are delivery devices for use in the treatment of otic disorders wherein the delivery device is administered locally to an individual afflicted with an otic disorder, through direct application or via perfusion into the targeted auris structure(s).
    Type: Application
    Filed: February 27, 2019
    Publication date: June 27, 2019
    Inventors: Jay LICHTER, Andrew M. TRAMMEL, Fabrice PIU, Qiang YE, Michael Christopher SCAIFE, Benedikt VOLLRATH, Sergio G. DURON, Luis A. DELLAMARY, Carl LEBEL, Jeffrey P. HARRIS
  • Auris formulations for treating otic diseases and conditions
    Patent number: 10272034
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: April 30, 2019
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris, Benedikt Vollrath, Sergio G. Duron, Michael Christopher Scaife
  • Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders
    Patent number: 10232044
    Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: March 19, 2019
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Michael Christopher Scaife, Benedikt Vollrath, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • TREATMENT USING TRUNCATED TRK B AND TRK C ANTAGONISTS
    Publication number: 20190017053
    Abstract: Disclosed herein are methods, compositions, vectors, and kits comprising an antagonist of a truncated TrkC or a truncated TrkB. Also described herein are methods of treating and/or preventing an otic disease or condition associated with an elevated expression level of a truncated TrkC or truncated TrkB isoform.
    Type: Application
    Filed: July 20, 2018
    Publication date: January 17, 2019
    Inventors: Horacio Uri SARAGOVI, Fabrice PIU
  • Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
    Patent number: 10092580
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: October 9, 2018
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Benedikt Vollrath, Sergio G. Duron, Carl Lebel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Andrew M. Trammel, Michael Christopher Scaife, Jeffrey P. Harris
  • Treatment using truncated Trk B and Trk C antagonists
    Patent number: 10066229
    Abstract: Disclosed herein are methods, compositions, vectors, and kits comprising an antagonist of a truncated TrkC or a truncated TrkB. Also described herein are methods of treating and/or preventing an otic disease or condition associated with an elevated expression level of a truncated TrkC or truncated TrkB isoform.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: September 4, 2018
    Assignee: OTONOMY, INC.
    Inventors: Horacio Uri Saragovi, Fabrice Piu
  • CONTROLLED RELEASE ANTIMICROBIAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS
    Publication number: 20180161271
    Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Application
    Filed: September 20, 2017
    Publication date: June 14, 2018
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • MODULATION OF GEL TEMPERATURE OF POLOXAMER-CONTAINING FORMULATIONS
    Publication number: 20180125781
    Abstract: Disclosed herein are methods for modulation of gel temperature of poloxamer-containing formulations. Also described herein are sustained release pharmaceutical formulations that gel upon contact with the body and are administered by direct application of these compositions and formulations onto or via perfusion into the targeted structure(s).
    Type: Application
    Filed: June 14, 2017
    Publication date: May 10, 2018
    Inventors: Qiang Ye, Luis A. Dellamary, Fabrice Piu
  • CONTROLLED RELEASE CORTICOSTEROID COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS
    Publication number: 20180110727
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Application
    Filed: June 2, 2017
    Publication date: April 26, 2018
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Michael Christopher Scaife, Benedikt Vollrath, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • PREVENTION OF AND RECOVERY FROM DRUG-INDUCED OTOTOXICITY
    Publication number: 20180036231
    Abstract: Provided herein are methods for preventing and/or reducing the severity of drug induced ototoxicity. Provided herein are methods for recovery from hearing loss due to drug-induced ototoxicity.
    Type: Application
    Filed: October 19, 2017
    Publication date: February 8, 2018
    Inventors: Fabrice Piu, Qiang Ye, Luis Dellamary, Carl Lebel
  • Controlled release antimicrobial compositions and methods for the treatment of otic disorders
    Patent number: 9867778
    Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: January 16, 2018
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF
    Publication number: 20180000950
    Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.
    Type: Application
    Filed: June 29, 2017
    Publication date: January 4, 2018
    Inventors: Robert Savel, Zhanpeng Zhang, Scott Coleman, Fabrice Piu, Hong Qi
  • Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
    Patent number: 9808460
    Abstract: Disclosed herein are auris acceptable gel compositions containing a multiparticulate glutamate receptor antagonist, and methods for the treatment of otic diseases or conditions through intratympanic administration of the composition to an individual afflicted with an otic disease or condition.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: November 7, 2017
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Benedikt Vollrath, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • Controlled release corticosteroid compositions and methods for the treatment of otic disorders
    Patent number: 9744126
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: August 29, 2017
    Assignees: Otonomy, Inc., The Regents of the University of California
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • Controlled release antimicrobial compositions and methods for the treatment of otic disorders
    Patent number: 9603796
    Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: March 28, 2017
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • TREATMENT USING TRUNCATED TRK B AND TRK C ANTAGONISTS
    Publication number: 20170029822
    Abstract: Disclosed herein are methods, compositions, vectors, and kits comprising an antagonist of a truncated TrkC or a truncated TrkB. Also described herein are methods of treating and/or preventing an otic disease or condition associated with an elevated expression level of a truncated TrkC or truncated TrkB isoform.
    Type: Application
    Filed: July 28, 2016
    Publication date: February 2, 2017
    Inventors: Horacio Uri Saragovi, Fabrice Piu
  • METHODS FOR THE TREATMENT OF PEDIATRIC OTIC DISORDERS
    Publication number: 20170027930
    Abstract: Disclosed herein are methods for the treatment of pediatric otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Application
    Filed: September 13, 2016
    Publication date: February 2, 2017
    Inventors: Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel