Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.

Abstract: A toy has one or more LED light sources positioned on the toy so the light source illuminates beyond the toy. A toy to be worn on the human finger comprises a body includes an anchoring portion for receiving or locating a finger or fingers. A LED or other light source is operated on the toy to interact with photo-luminescent ink and other inks pre-printed or included in a decoration on the surface of another item such as a book or other toy. The toy is a reading tool or a light source or an enhancement of other toys or writings. The LED light sources include a black light and/or other LED lights of other colors. The lights are connected to a circuit board and an integrated power source, which are connected to a switch encased on the toy.

Abstract: A reusable container for transporting, inspecting, and/or storing a fuel cell or other item may include a crate or box lined with plurality of cushioning inserts to protect a fuel cell placed within the container, and a plurality of straps that extend inwardly from walls of the container and couplable to the fuel cell. The straps are tensionable to suspend at least a portion of the weight of the fuel cell from the walls of the container while a portion of the fuel cell may rest on top of cushioning inserts at the floor of the container.

Abstract: Disclosed aspects include a semiconductor die including a substrate having a semiconductor surface including circuitry. A top metal layer is above the semiconductor surface including top metal lines that are electrically connected through a metal stack including metal interconnects that electrically connect to the circuitry. The top metal lines are configured in a primary orientation that collectively represents at least 50% of a total length of the top metal lines in a first direction. The top metal layer includes bond pads exposed from a passivation layer. The metal features are positioned lateral to and not directly electrically connected to the top metal layer and/or are positioned on the passivation layer. At least a majority of a total area of the metal features is not over metal interconnects. The metal features have a length direction oriented in a second direction that is at least essentially perpendicular relative to the primary orientation.

Abstract: The present invention relates to compositions for preventing or treating hypercholesterolemia, comprising an extract obtained from Ananas comosus, said extract comprising a therapeutically effective amount of N1, N10-Diferuloylspermidine, and preparation methods thereof. The invention provides for a natural product exhibiting HMG-CoA reductase and lipase enzyme inhibition that may be as effective as synthetic cholesterol-lowering drugs available in the market.

Abstract: The present invention is directed to a platform used to support a person's leg during shaving. The platform includes a plurality of anti-slip feet used to stabilize the platform in a wet environment, such as a shower. The platform includes a plurality of telescoping legs pivotably attached to a base, such that the platform is able to be collapsed for ease of portability and storage and is adjustable to the height of a user. The platform further includes an upper surface having a recessed compartment for storing supplies related to shaving and/or other shower supplies. The platform includes a plurality of holes for facilitating water runoff and at least one cutout for receiving a user's hand for carrying purposes.

Abstract: Provided are systems and methods for producing seamless woven materials that are variable in each of their 3 dimensions. The systems and methods generally operate by altering heddle positions independently to impart three dimensional structure to a woven fabric. Weft yarn is woven into a set of warp yarns that have been individually raised or lowered along a particular cross section, essentially locking the weave into an intended 3 dimensional form.

Abstract: In order to make it more difficult to obtain numbers that can be used to conduct fraudulent transactions, a portion of a real account number is encrypted. The encrypted portion of the account number is used to generate a new account number, a new expiration date, and a new verification value. This information can be determined using processor that may reside in a point of sale terminal, a smart card, or a computer operated by a user. The new account number, the new expiration date, and the new verification value can be used in a payment transaction. A server computer in a central payment processing network may determine that the new account information is not the real account information, and may subsequently generate a modified authorization request message using the real account information and may send it to an issuer for approval. The transmission of data is more secure, since real account information is not sent from the merchant to the payment processing network.

Abstract: A data processing method includes receiving input data associated with a plurality of transactions; generating, based on the input data, a plurality of wavelets corresponding to the plurality of transactions; storing the plurality of wavelets and corresponding keys associated with the wavelets in a key-value database; and outputting, based on the plurality of wavelets, one or more indicators.

Abstract: A method for training a control system model includes introducing a simulated fault into a software simulation of a physical system and generating emulated sensor data based on the simulated fault, where the emulated sensor data emulates output from one or more sensors of the physical system. The method further includes obtaining output data from a test control system provided with the emulated sensor data, where the test control system emulates a control system of the physical system and tagging the output data with the simulated fault to create training data. The method further includes utilizing the training data to train the control system model, where the control system model is a machine learning model for use with the control system of the physical system during operation of the physical system.

Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Abstract: There is provided a card or token for use in financial transactions. The financial transaction token or card has an onboard energy storage device that enables onboard electronics to operate when the card is not in the proximity of a merchant Point-Of-Service (POS) terminal. In one implementation, the onboard energy storage device includes a capacitor such as a thin-film capacitor that stores sufficient energy to power onboard electronics without the need for an onboard battery. The card may be incorporated within various conventional apparatus such as a see-through and/or protective substrate, an item of clothing, an item of jewelry, a cell phone, a Personal Digital Assistant (PDA), a credit card, an identification card, a money holder, a wallet, a personal organizer, a keychain payment tag, and like personality.

Abstract: Semiconductor packages with cavities and methods of making such semiconductor packages are described. The semiconductor package includes a semiconductor die including an interface region where various components configured to interact with an environment surrounding the package can be located. Such components include a humidity sensor, a temperature sensor, a light emitting diode, a solid-state laser, a photodiode, or the like. The semiconductor package includes an opening above the interface region to facilitate proper and adequate operations of the components. The semiconductor package also includes a polymer structure surrounding the interface region, thereby forming the opening. The polymer structure has an uneven inner sidewall profile formed by multiple layers of a polymer material.

Abstract: A computer implemented method of processing a financial transaction executed by first person includes determining an automatic savings amount from the financial transaction by rounding up the amount of the financial transaction to the nearest dollar. The method further includes debiting the calculated savings amount from an account of the first person and crediting the savings amount to an account of a second person.

Abstract: The present invention relates to compounds that target monocytes, macrophages and other cells (such as dendritic cells) that express CD-206, particularly those cells at are assembled at a site of disease, using a target moiety coupled to a glucan backbone. The compounds disclosed here preferably comprise a glucan backbone, a targeting moiety, a targeting moiety linker, a payload and optionally a payload linker. The present invention also provides methods of making such compounds and compositions. The present invention also provides diagnostic methods and methods of treatment using compounds comprising a target moiety coupled to a glucan backbone.

Abstract: Provided herein are compositions, systems, methods, and kits for peptide analysis, including peptide sequencing. Aspects of the present disclosure provide bifunctional reagents which may selectively couple to amino acids and selectively couple to detectable species. Aspects of the present disclosure further provide methods for using these bifunctional reagents to sequence and analyze peptides.

Abstract: The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: Disclosed aspects include a semiconductor die including a substrate having a semiconductor surface including circuitry. A top metal layer is above the semiconductor surface including top metal lines that are electrically connected through a metal stack including metal interconnects that electrically connect to the circuitry. The top metal lines are configured in a primary orientation that collectively represents at least 50% of a total length of the top metal lines in a first direction. The top metal layer includes bond pads exposed from a passivation layer. The metal features are positioned lateral to and not directly electrically connected to the top metal layer and/or are positioned on the passivation layer. At least a majority of a total area of the metal features is not over metal interconnects. The metal features have a length direction oriented in a second direction that is at least essentially perpendicular relative to the primary orientation.

Abstract: A method for calibrating a direct flow simulation of a rock sample involves providing a 3D image of a rock sample and generating a segmented structural image of the rock sample from the 3D image by selecting voxels to represent either a pore space or a solid material. Fluid flow is simulated on the segmented structural image with a direct flow simulation. A 3D spatially-resolved fluid velocity map is generated for one or more fluid phases at a pore-scale resolution using pulsed field gradient nuclear magnetic resonance imaging. The simulated fluid flow and the 3D spatially-resolved fluid velocity map are compared to calibrate the direct flow simulation across the rock sample.

Abstract: An orbital atherectomy system includes a handheld driver having a motor. An elongate flexible driveshaft has a proximal end portion and a distal end portion. The proximal end portion is drivably coupled to the motor. The distal end portion defines a rotational axis. An abrasive element is fixedly disposed on the distal end portion of the elongate flexible driveshaft. The abrasive element includes a first flat side, a second flat side, a leading tapered end portion having a leading end, and a trailing tapered end portion having a trailing end. The first flat side and the second flat side are on opposite sides of the rotational axis.