Abstract: An orbital atherectomy system includes a handheld driver having a motor. An elongate flexible driveshaft has a proximal end portion and a distal end portion. The proximal end portion is drivably coupled to the motor. The distal end portion defines a rotational axis. An abrasive element is fixedly disposed on the distal end portion of the elongate flexible driveshaft. The abrasive element includes a first flat side, a second flat side, a leading tapered end portion having a leading end, and a trailing tapered end portion having a trailing end. The first flat side and the second flat side are on opposite sides of the rotational axis.

Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.

Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Abstract: A computer implemented method of processing a financial transaction executed by first person includes determining an automatic savings amount from the financial transaction by rounding up the amount of the financial transaction to the nearest dollar. The method further includes debiting the calculated savings amount from an account of the first person and crediting the savings amount to an account of a second person.

Abstract: A method, system and computer-usable medium for performing cognitive computing operations comprising receiving streams of data from a plurality of data sources; processing the streams of data from the plurality of data sources, the processing the streams of data from the plurality of data sources performing data enriching for incorporation into a cognitive graph; defining a cognitive persona within the cognitive graph, the cognitive persona corresponding to an archetype user model, the cognitive persona comprising a set of nodes in the cognitive graph; associating a user with the cognitive persona; and, performing a cognitive computing operation based upon the cognitive persona associated with the user.

Abstract: Systems and method for improved consumer and portable consumer device authentication are disclosed. Such systems and methods may include using dynamic verification values, challenge questions, and consumer notification as ways to prevent fraudulent transactions from being conducted.

Abstract: A computer system may be configured to access a rule including one or more conditions, providing a user interface configured for user input of a modification to a condition of the rule, receive from a user, via the user interface, a modification to a first condition of the rule constituting a first changed condition, wherein the first changed condition is associated with a modified rule, determine an output data set, based on an input data set including a plurality of past data samples, and the first changed condition of the modified rule, and update the user interface to include a visualization indicating at least some of the output data set.

Abstract: The present disclosure provides compositions for and methods of monitoring the progression of and treating gastrointestinal infections in a subject, particularly those involving Clostridioides difficile.

Abstract: Zr-based metal-organic frameworks (Zr-MOFs) independently comprising the following formula and/or structure: Zr6O4(OH)4(polycarboxylate)6, and methods of making and using same. In various examples, a method produces a Zr-MOF or Zr-MOFs. In various examples, a Zr-MOF is a hydrogen sulfide (H2S)-loaded Zr-MOF. In various examples, a method produces a (H2S)-loaded Zr-MOF or (H2S)-loaded Zr-MOF. In various examples, a Zr-MOF or Zr-MOFs is/are used to deliver H2S to an aqueous environment, a solvent, or the like. In various examples, a Zr-MOF or Zr-MOFs is/are used to deliver H2S to an aqueous environment, a solvent, or the like. In various examples, a Zr-MOF or Zr-MOFs is/are used to deliver H2S to an individual, such as, for example, an individual suffering from or at risk of an ischemia-reperfusion injury, inflammation, a wound, or the like, or any combination thereof.

Abstract: An animal collar defining a cavity to enhance visibility of information and identification tags. The collar includes a strap having an attachment point positioned thereon. At least one receiver is defined by the strap. The receiver includes a cavity configured to receive and retain information tag.

Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.

Abstract: The disclosure provides a method for treating a subject afflicted with a tumor, e.g., lung cancer, having a high tumor mutation burden (TMB) status comprising administering to the subject an immunotherapy, e.g., an anti-PD-1 antibody or antigen-binding portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: A method and system employing deep learning techniques improves processing speed and spatial resolution of acoustic wavenumber spectroscopy (ASSESS) techniques by performing semantic segmentation on simulated ultrasonic wavefield images of a steady-state, select-tone excitation of a structural or mechanical component. One or more embodiments may employ a convolutional neural network (CNN), pre-trained on openly-available datasets, and trained by transfer learning on an augmented wavefield dataset, to localize and characterize defects or damage from inspection measurements of components.

Abstract: A system and related method are provided to receive user streaming interaction data (USID) and determine a context of the interaction. Processed stream data is stored, and emotion information (EI) is created by analyzing the processed stream data, producing an EI-tagged interaction record. An overall first EI value (EIV) reflects a value of an EI at a first time, and an overall second EIV reflects a value of an EI at a second time. Indicators related to the EIs are provided on a device of a service representative (SR). When the second EIV is more negative than the first EIV, the system communicates a recommended action to the service representative that is dependent upon on the context of the interaction and the EI.

Abstract: A method for the use of electronic transactional tokens includes: generating a plurality of transactional tokens including a first token; associating each of the transactional tokens with a plurality of users, the first token associated with a first user; monitoring usage of the transactional tokens in a plurality of transactions in a local region or network; and in response to receiving transactional data for the first transaction, updating the first token from a first state to a second state (e.g., to provide a benefit when the token is applied in the local region or network). The tokens may be generated and monitored using a token processing system, which uses transaction data received by a transaction handler that is handling transaction processing for the transactions.

Abstract: The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).

Abstract: An apparatus includes an analyte sensor, a memory, and a processor. The processor monitors, using the analyte sensor, an analyte of a patient during a time period to obtain measured analyte data for the analyte and monitors other measured sensor data indicative of a physiological state of the patient during the time period. The processor also determines, based on the physiological state of the patient during the time period, expected analyte data for the analyte and determines a correction factor based on the expected analyte data and the measured analyte data. The correction factor is indicative of an error in calibration of the analyte sensor. The processor also determines whether recalibration of the analyte sensor is possible. If recalibration is possible, the processor recalibrates the analyte sensor based on the correction factor, and if recalibration is not possible, the processor recommends, to the patient, to replace the analyte sensor.

Abstract: One embodiment of the present disclosure sets forth a technique for analyzing network vulnerabilities. The technique includes determining an address for each target device included in a plurality of target devices; for each target device, assigning a port scanning task to an associated port scanning service, the port scanning task being associated with the target device via the address of the target device; for each port scanning task, receiving a port scanning result from the port scanning service assigned to the port scanning task, the port scanning result including a list of open ports for the target device associated with the port scanning task; for each open port included in each port scanning result, assigning a vulnerability scanning task to an associated vulnerability service; receiving a vulnerability scanning result for each vulnerability scanning task; and generating a report based on the port scanning results or the vulnerability scanning results.

Abstract: Various examples are directed to systems and methods for interfacing between a user and a computing device. The computing device may receive data describing a projected periodic savings amount and first expense data describing a first expense of the user. The first expense data may indicate an amount of the first expense and a first expense time when the first expense will be incurred. The computing device may display a graphical user interface at a display. The graphical user interface may comprise a savings shape having a size based at least in part on the projected periodic savings amount and a first expense shape having a size based at least in part on the first amount. The computing device may receive an instruction to place the first expense shape in the savings shape and may determine that the projected periodic savings amount is sufficient to fund the first expense at the first time.