Abstract: The present disclosure provides an isolated recombinant oncolytic adenovirus, a pharmaceutical composition, and uses thereof for drugs for treatment of tumors and/or cancers. The recombinant oncolytic adenovirus is a selectively replicating oncolytic adenovirus, and the genome of the recombinant oncolytic adenovirus is integrated with a coding sequence of exogenous shRNA capable of inhibiting PDL1 expression in tumor cells. The replication capability of the virus in normal primary cells is much lower than the replication capability of the virus in tumor cells. Moreover, the expressed shPDL1 can significantly reduce the level of PDL1 protein highly expressed in tumor cells. Thus, the oncolytic killing effect of the oncolytic virus and the anti-tumor immunostimulatory effect of immune cells produce a synergistic effect.

Abstract: Provided is the use of selectively replicating oncolytic viruses in the preparation of immunostimulants for treatment of tumors and/or cancers, wherein the oncolytic viruses do not carry exogenous immunoregulatory genes.

Abstract: The present disclosure provides therapeutic agents comprising oncolytic vaccinia viruses and NK cells, and uses thereof for preparation of drugs for treatment of tumors and/or cancers. The active ingredients of the therapeutic agents comprise an oncolytic vaccinia virus and NK cells, wherein the oncolytic vaccinia virus can selectively replicate in tumor cells.

Abstract: The present disclosure provides therapeutic agents and uses thereof for drugs for treatment of tumors and/or cancers. The active ingredients of the therapeutic agents comprise an oncolytic virus that selectively replicate in tumor cells and comprise NK cells.

Abstract: In an upgrade infrastructure performing an overall upgrade operation comprising multiple upgrade processes being executed, possibly concurrently, on multiple hosts for upgrading one or more software applications hosted by hosts, automated hang detection mechanisms are disclosed for quickly, efficiently, and automatically detecting when one or more of the upgrade process are in a hang state. Different hang detection techniques are described including a metadata-driven hang detection mechanism and a code-driven hang detection mechanism.

Abstract: Disclosed are a regenerative medical material for promoting the repair of soft and hard tissues, a preparation method therefor, and the use thereof. The regenerative medical material has a three-dimensional network structure and is a composite material composed of inorganics and organics, wherein the mass ratio of the inorganics to the organics is 2:1-4:1. Based on the total mass of the inorganics, the inorganics contain 12-38% SiO2, 3-5% Na2O, 15-29% CaO, 10-32.5% P2O5, 1-5% inositol hexaphosphate, 1-5% cyclohexanhexol phosphate, and the balance of impurities, with the content of impurities being less than 0.5%. Based on the total mass of the organics, the organics contain 30-60% carboxymethyl chitosan and 30-60% sodium hyaluronate. The regenerative medical material has a composition and properties better suited to the human body and plays a key role in cell repair and bonding, cell proliferation, and promoting the growth of hair follicles.

Abstract: Techniques for managing an upgrade operation comprising multiple upgrade process executing on multiple host machines (or hosts) for upgrading software applications on the multiple hosts. Techniques are disclosed for managing notifications that are generated by the multiple upgrade processes during execution, and more particular, techniques for reducing the number of notifications that are sent to a user. The techniques include: only sending a subset of the generated notifications to a user, the subset being selected at the host machines based upon notifications level criteria specified by the user for the host machines; consolidating multiple generated notifications into a fewer number of consolidated notifications and only sending consolidated notifications to the user; combination of criteria-based selection and notifications consolidation.

Abstract: A breathing apparatus according to embodiments of the invention includes a facemask portion sized to cover a lower portion of a wearer's face. The facemask portion includes a flow chamber. The flow chamber includes a first opening disposed near a first end of the flow chamber, a second opening disposed near a second end of the flow chamber, and a serpentine passage disposed between the first opening and the second opening. At least one light emitting diode configured to emit light having a peak wavelength in the ultraviolet range is disposed in the serpentine passage. The at least one light emitting diode is disposed off center relative to a centerline oriented along a direction of air flow through the serpentine passage.

Abstract: An electrical connector includes an insulating body having a base, and multiple upper row terminals and multiple lower row terminals fixed in the insulating body. Each terminal has a soldering portion respectively extending out of the base. The upper row terminals include at least one upper row signal terminal, and the lower row terminals include at least one lower row signal terminal. The soldering portion of the upper row signal terminal is in contact with the soldering portion of the lower row signal terminal. By means of contact between the soldering portions of the upper row and lower row signal terminals, a transmission signal of the upper row signal terminal and a transmission signal of the lower row signal terminal are directly combined, and the signals do not need to be combined by other means. The transmission current is larger due to more conducted parts in the electrical connector.

Abstract: A method for implementing redundancy protection applied in a first router includes: providing a first protection group comprising one active interface and any number of inactive interfaces selected from interfaces of the first router, wherein all interfaces in the first protection group serve to distribute or receive multicast traffic; activating Bidirectional Forwarding Detection BFD protocol only at the active interface in the first protection group, so as to enable the active interface in the first protection group to establish interaction with an active interface in a second protection, wherein a second router determines a status of the active interface in the first protection group through the active interface in the second protection group; and stopping all interfaces in the first protection group to distribute or receive the multicast traffic when failure occurs at the active interface in the first protection group.

Abstract: An electrical connector includes an insulating body having a base, and multiple upper row terminals and multiple lower row terminals fixed in the insulating body. Each terminal has a soldering portion respectively extending out of the base. The upper row terminals include at least one upper row signal terminal, and the lower row terminals include at least one lower row signal terminal. The soldering portion of the upper row signal terminal is in contact with the soldering portion of the lower row signal terminal. By means of contact between the soldering portions of the upper row and lower row signal terminals, a transmission signal of the upper row signal terminal and a transmission signal of the lower row signal terminal are directly combined, and the signals do not need to be combined by other means. The transmission current is larger due to more conducted parts in the electrical connector.

Abstract: Techniques for managing an upgrade operation comprising multiple upgrade process executing on multiple host machines (or hosts) for upgrading software applications on the multiple hosts. Techniques are disclosed for managing notifications that are generated by the multiple upgrade processes during execution, and more particular, techniques for reducing the number of notifications that are sent to a user. The techniques include: only sending a subset of the generated notifications to a user, the subset being selected at the host machines based upon notifications level criteria specified by the user for the host machines; consolidating multiple generated notifications into a fewer number of consolidated notifications and only sending consolidated notifications to the user; combination of criteria-based selection and notifications consolidation.

Abstract: Techniques for managing an upgrade operation comprising multiple upgrade process executing on multiple host machines (or hosts) for upgrading software applications on the multiple hosts. Techniques are disclosed for managing notifications that are generated by the multiple upgrade processes during execution, and more particular, techniques for reducing the number of notifications that are sent to a user. The techniques include: only sending a subset of the generated notifications to a user, the subset being selected at the host machines based upon notifications level criteria specified by the user for the host machines; consolidating multiple generated notifications into a fewer number of consolidated notifications and only sending consolidated notifications to the user; combination of criteria-based selection and notifications consolidation.

Abstract: In an upgrade infrastructure performing an overall upgrade operation comprising multiple upgrade processes being executed, possibly concurrently, on multiple hosts for upgrading one or more software applications hosted by hosts, automated hang detection mechanisms are disclosed for quickly, efficiently, and automatically detecting when one or more of the upgrade process are in a hang state. Different hang detection techniques are described including a metadata-driven hang detection mechanism and a code-driven hang detection mechanism.

Abstract: Embodiments provide techniques for concurrently upgrading one or more software applications hosted by one or multiple hosts. Checkpoint data associated with the upgrade processes executing on the multiple hosts may be generated during the upgrade. The checkpoint data may be stored in a shared storage that can be accessed by the upgrade processes. Each upgrade process running on a host may be adapted to read checkpoint data from the shared storage and write checkpoint data only to a dedicated location on the shared storage. Checkpoint data written by a first upgrade process may be read by a second upgrade process to determine the status and/or progress of the first upgrade process on a given host. In this manner, the checkpoint data enable the multiple upgrade processes to synchronize with each other.

Abstract: In a process of making a liquid cleaning composition, adding a gel breaker upstream of an anionic surfactant addition in the recirculatory loop of a recirculatory batch processor mitigates the viscous hexagonal phase whilst providing maximum flexibility in formulating various ingredients in the composition.

Abstract: Techniques for concurrently upgrading one or more software applications hosted by one or multiple hosts. Checkpoint data associated with the upgrade processes executing on the multiple hosts may be generated during the overall upgrade operation. The checkpoint data may be stored in a shared storage that can be accessed by the upgrade processes. A reporting tool may generate a timing report using the checkpoint data. The timing report may indicate execution timing data of all hosts executing the upgrade processes such as the total time spent for each upgrade process, when an upgrade process started execution, when an upgrade process stopped and/or completed execution, and the like.

Abstract: In an upgrade infrastructure performing an overall upgrade operation comprising multiple upgrade processes being executed, possibly concurrently, on multiple hosts for upgrading one or more software applications hosted by hosts, automated hang detection mechanisms are disclosed for quickly, efficiently, and automatically detecting when one or more of the upgrade process are in a hang state. Different hang detection techniques are described including a metadata-driven hang detection mechanism and a code-driven hang detection mechanism.

Abstract: A method for implementing redundancy protection applied in a first router includes: providing a first protection group comprising one active interface and any number of inactive interfaces selected from interfaces of the first router, wherein all of interfaces in the first protection group serve to distribute or receive multicast traffic; activating bidirectional forwarding detection BFD protocol only at the active interface in the first protection group, so as to enable the active interface in the first protection group to establish interaction with an active interface in a second protection, such that a second router can determine a status of the active interface in the first protection group through the active interface in the second protection group; and stopping the all of interfaces in the first protection group to distribute or receive the multicast traffic when failure occurs at the active interface in the first protection group.

Abstract: A method of making a patterned article includes: forming a shielding layer on a substrate; patterning the shielding layer and the substrate to form a cavity that extends through the shielding layer into the substrate so as to form a recess in the substrate, the recess being defined by a recess-defining surface of the substrate; forming a color layer on the recess-defining surface of the substrate so that the color layer is defined with an indentation; and removing the shielding layer after forming the color layer.