Abstract: The invention provides an in vivo individualized systemic immunotherapeutic method and device. The method includes, in a non-sequential manner: (1) increasing release amount of tumor antigens at a tumor site; (2) at the tumor site, increasing level of proteins capable of adhering to and/or wrapping the tumor antigens; (3) at the tumor site, increasing level of dedicated antigen-presenting cells involved in immunity, and establishing, between the dedicated antigen-presenting cells and immune effector cells, a close connection capable of activating the immune effector cells; and (4) at the tumor site, increasing level and improving function of the immune effector cells. The steps (1)-(4) each reaches a maximum value at a respective time which overlaps with each other maximally, as well as at a respective site which overlaps with each other maximally. The invention combines oncolytic therapy and immunotherapy, in individualized systemic immunotherapy, and provides significantly improved therapeutic effect.

Abstract: Techniques for concurrently upgrading one or more software applications hosted by one or multiple hosts. Checkpoint data associated with the upgrade processes executing on the multiple hosts may be generated during the overall upgrade operation. The checkpoint data may be stored in a shared storage that can be accessed by the upgrade processes. A reporting tool may generate a timing report using the checkpoint data. The timing report may indicate execution timing data of all hosts executing the upgrade processes such as the total time spent for each upgrade process, when an upgrade process started execution, when an upgrade process stopped and/or completed execution, and the like.

Abstract: Techniques for managing an upgrade operation comprising multiple upgrade process executing on multiple host machines (or hosts) for upgrading software applications on the multiple hosts. Techniques are disclosed for managing notifications that are generated by the multiple upgrade processes during execution, and more particular, techniques for reducing the number of notifications that are sent to a user. The techniques include: only sending a subset of the generated notifications to a user, the subset being selected at the host machines based upon notifications level criteria specified by the user for the host machines; consolidating multiple generated notifications into a fewer number of consolidated notifications and only sending consolidated notifications to the user; combination of criteria-based selection and notifications consolidation.

Abstract: In an upgrade infrastructure performing an overall upgrade operation comprising multiple upgrade processes being executed, possibly concurrently, on multiple hosts for upgrading one or more software applications hosted by hosts, automated hang detection mechanisms are disclosed for quickly, efficiently, and automatically detecting when one or more of the upgrade process are in a hang state. Different hang detection techniques are described including a metadata-driven hang detection mechanism and a code-driven hang detection mechanism.

Abstract: Embodiments provide techniques for concurrently upgrading one or more software applications hosted by one or multiple hosts. Checkpoint data associated with the upgrade processes executing on the multiple hosts may be generated during the upgrade. The checkpoint data may be stored in a shared storage that can be accessed by the upgrade processes. Each upgrade process running on a host may be adapted to read checkpoint data from the shared storage and write checkpoint data only to a dedicated location on the shared storage. Checkpoint data written by a first upgrade process may be read by a second upgrade process to determine the status and/or progress of the first upgrade process on a given host. In this manner, the checkpoint data enable the multiple upgrade processes to synchronize with each other.

Abstract: A breathing apparatus according to embodiments of the invention includes a facemask portion sized to cover a lower portion of a wearer's face. The facemask portion includes a flow chamber. The flow chamber includes a first opening disposed near a first end of the flow chamber, a second opening disposed near a second end of the flow chamber, and a serpentine passage disposed between the first opening and the second opening. At least one light emitting diode configured to emit light having a peak wavelength in the ultraviolet range is disposed in the serpentine passage. The at least one light emitting diode is disposed off center relative to a centerline oriented along a direction of air flow through the serpentine passage.

Abstract: The present disclosure provides a method, system and device for processing the release failure of a PDN. The method includes: a UE, when the UE determines that it currently connects with at least two PDNs, sends a PDN release request message to an EPC and then receives a release rejection message from the EPC, wherein a rejection reason is that the last PDN connection is not allowed to be released; and the UE releases each PDN connection with the EPC and then resets up a PDN connection with the EPC. Through the technical solution, the PDN connection information of the UE and that of the EPC are kept consistent, so that resources are saved and the reliability of data transmission is improved.

Abstract: In a process of making a liquid cleaning composition, adding a gel breaker upstream of an anionic surfactant addition in the recirculatory loop of a recirculatory batch processor mitigates the viscous hexagonal phase whilst providing maximum flexibility in formulating various ingredients in the composition.

Abstract: A clutch mechanism with overload protection provided between a power input shaft and a power output shaft of an actuator includes a magnet set including at least a first magnet and a second magnet that are arranged as magnetically attractive to each other and are attached to the power input shaft and the power output shaft, respectively; and a friction assembly including a first friction member and a second friction member arranged adjacent to each other and between the first magnet and the second magnet, so as to provide a constant friction between the magnets. The magnet set and the friction assembly jointly set a limit of a torque between the power input shaft and the power output shaft. When the torque exceeds the limit, the power input shaft and the power output shaft are disconnected, so as to achieve overload protection.

Abstract: The present disclosure provides a method, system and device for processing the release failure of a PDN. The method includes: a UE, when the UE determines that it currently connects with at least two PDNs, sends a PDN release request message to an EPC and then receives a release rejection message from the EPC, wherein a rejection reason is that the last PDN connection is not allowed to be released; and the UE releases each PDN connection with the EPC and then resets up a PDN connection with the EPC. Through the technical solution, the PDN connection information of the UE and that of the EPC are kept consistent, so that resources are saved and the reliability of data transmission is improved.

Abstract: A clutch mechanism with overload protection provided between a power input shaft and a power output shaft of an actuator includes a magnet set including at least a first magnet and a second magnet that are arranged as magnetically attractive to each other and are attached to the power input shaft and the power output shaft, respectively; and a friction assembly including a first friction member and a second friction member arranged adjacent to each other and between the first magnet and the second magnet, so as to provide a constant friction between the magnets. The magnet set and the friction assembly jointly set a limit of a torque between the power input shaft and the power output shaft. When the torque exceeds the limit, the power input shaft and the power output shaft are disconnected, so as to achieve overload protection.

Abstract: An actuator having a load weighting mechanism is disclosed. The actuator has a screw and a nut mounted around the screw and connected with a driving shaft. The driving shaft supports a load. When moving along the screw, the nut displaces the driving shaft forward and backward. The screw has a pair of thrust bearings for bearing the load, and at least one load weighting unit installed between the pair of thrust bearings for weighting the load.

Abstract: The present invention relates to compositions and methods for ablating tumor cells in a subject having at least one tumor site. More specifically, the method comprises contacting the tumor cells in at least one tumor with a lytic agent in vivo, under lytic conditions, forming a treated tumor; and applying a sufficient in vivo stimulus to the treated tumor forming a stimulated tumor. Compositions and methods are included for shrinking a local tumor or a distal metastatic tumor, or both in a subject. In a preferred embodiment, the method for shrinking a tumor in a subject comprises: contacting a stimulated tumor cells in vivo with a lytic agent. The stimulus directed toward the tumor cells is capable of increasing the level of chaperone proteins in the tumor cells. The combination of lytic agents and tumor cell stimulus leads to shrinkage of the tumors that were treated directly, wherein the stimulus is either applied simultaneously or sequentially.

Abstract: Pharmaceutical compositions containing taxanes having about 5 to about 75% phospholipid, about 0.01 to about 50% of a surfactant of an HLB value greater than 10, about 0.01 to about 50% alcohol and about 0.01 to about 40% taxane(s) or a derivative thereof.

Abstract: The present invention discloses the combination use of arsenic-containing pharmaceutical composition and radiation therapy on cutaneous metastases.

Abstract: The invention relates to a pharmaceutical composition for the treatment of skin neoplasm, which comprises a therapeutically effective amount of arsenic trioxide and a pharmaceutically acceptable carrier. Furthermore, the invention also relates to a method of treating skin neoplasm in a human by administering to a human in need thereof a therapeutically effective amount of a pharmaceutical composition comprising arsenic trioxide.

Abstract: The present application relates to a concentrated emulsion formulation for water-insoluble silatecan comprising silatecan of 0.01-1.0% (W/W), phospholipid of 4.79-75% (W/W); propylene glycol of 24.79˜95% (W/W); optional ethanol of 0.1-40% (W/W); optional surfactant of 0.1-10% (W/W), especially Tween® 80. The present application also relates to a method for manufacturing the concentrated emulsion formulation.

Abstract: A process for the large scale production of a liposome suspension, in which three selected lipid compounds in a predetermined ratio are dissolved in an alcohol solvent to form a mixture, which, in turn, is directly admixed with an aqueous ammonium sulfate solution in a predetermined ratio. The resultant mixture is subjected to a pore-extrusion treatment, followed by dialyzing the pore-extruded mixture with a 5% to 15% sucrose aqueous solution, such that a liposome suspension containing liposome particles suspended in the liposome suspension is obtained. The thus obtained liposome suspension can be used to encapsulate a selected drug, in particular doxorubicin.

Abstract: A belt reel for fastening goods on a truck includes an axle extending through a main frame and a lever to pivotally mount the main frame and the lever to each other. The axle includes two opposite ends each having a ratchet wheel mounted thereto between the main frame and the lever and rotated with the axle. A slot is diametrically defined in the axle for allowing a belt extending through the axle. The main frame has a stop plate slidably mounted therein and selectively engaged to the ratchet, and the lever has a pawl slidably mounted therein. The pawl is engaged to the ratchet for driving the axle to reel the belt and separated from the ratchet for releasing the strain of the strained belt.