Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: An application of a prokaryotic Argonaute protein with only a cleavage activity of a target ribonucleic acid (RNA) in RNA editing is provided. The Argonaute protein is derived from a mesophilic prokaryotes Verrucomimicrobia bacterium, and its amino acid sequence is shown in SEQ ID NO: 1 or a protein with high similarity to SEQ ID NO: 1 and the same function. This protein has binding activity to a single-stranded guide DNA and nuclease activity only to the target RNA complementarily paired with the single-stranded guide DNA. Therefore, the protein can be utilized for in vitro and in vivo targeted RNA editing, providing a new powerful tool for RNA editing.

Abstract: The present invention discloses a bacterium and an obtaining method and application thereof. The bacterium has a property of coproducing 1,3-propanediol and D-lactic acid. Further, the bacterium is Klebsiella oxytoca, including Klebsiella oxytoca PDL-5 CCTCC M 2016185. The obtaining method of the bacterium may be to obtain the bacterium by directly screening wild bacteria that satisfy conditions from the environment or performing gene engineering modification to wild bacteria. The present invention has the advantages that the bacteria can coproduce 1,3-propanediol and D-lactic acid through fermentation, the molar conversion rate and the concentration of the two products are very high, the types of byproducts are few, the concentration is low, the product extraction process is simplified, the high-efficiency biological production of 1,3-propanediol and D-lactic acid can be realized, and the industrial application prospect is very great.

Abstract: A circuit board assembly is applied to the field of electronic communications technologies to resolve a prior-art heat dissipation problem of a circuit board. The circuit board assembly combines, on a second circuit board, low-speed signals transmitted between a plurality of I/O modules and an IC chip, and then transmits the combined low-speed signals to the IC chip by using a low-speed cable. A low-speed signal sent by the IC chip to the plurality of I/O modules is extended to a plurality of low-speed signals on the second circuit board, and then the plurality of low-speed signals are separately sent to the plurality of I/O modules. This may be applied to a scenario in which a relatively large quantity of electronic components need to be disposed on a circuit board.

Abstract: A silicon-based anode material for secondary batteries, a preparation method thereof and a secondary battery are provided. The silicon-based anode material includes: an inner core including an Si particle and silicon oxide SiOx1, where 0<x1<2, a first shell layer including a compound of the general formula MySiOz (0<y?4, 0<z?5, and z?x1) and a C particle, wherein the first shell layer covers the inner core, and the contents of M and C in the first shell layer gradually increase from a side thereof close to the inner core to another side thereof far away from the inner core; and a second shell layer including a carbon film layer or a composite film layer formed by a carbon film layer and a conductive additive, the second shell layer covers the first shell layer. The first charge-discharge cycle capability of the silicon-based anode material is improved, and the manufacturing cost is reduced.

Abstract: An array substrate and a display panel are provided. By allowing a gate electrode layer between a first active layer and a second active layer to overlap the first active layer and the second active layer at least partially, respectively, an area occupied by the first active layer, the second active layer, and the gate electrode layer can be reduced, and a design area of sub-pixels can be increased, thereby improving an aperture ratio.

Abstract: The present disclosure provides a display panel and a display device. The display panel includes a thin film transistor; and further includes a substrate,; a first metal layer disposed on the substrate and including a gate of the thin film transistor; an active layer disposed on a side of the first metal layer away from the substrate and including an active portion of the thin film transistor; a spacer layer disposed on a side of the active layer away from the first metal layer and including a plurality of contact holes; a second metal layer disposed on a side of the spacer layer away from the active layer and including a source and a drain of the thin film transistor; an orthographic projection of the gate electrode on the substrate covers an orthographic projection of at least part of the contact holes on the substrate.

Abstract: An equalization time configuration method is applied to a processor system in which a Peripheral Component Interconnect Express (PCIe) bus or a Cache Coherent Interconnect for Accelerators (CCIX) bus is used. The equalization time configuration method includes determining a working physical layer (PHY) type of a master chip and a working PHY type of a slave chip, determining an equalization time of the slave chip in a fourth phase of equalization based on the working PHY type of the master chip, and determining an equalization time of the master chip in a third phase of the equalization based on the working PHY type of the slave chip.

Abstract: An airborne short message communication method, apparatus, device and system, and a readable storage medium. In the technical solution provided in the present invention, the method comprises: an airborne short message communication device acquiring a message control command; by means of the message control command, selecting a target message type from among selectable message types and determining a sending frequency; generating a target message corresponding to the target message type; and sending the target message according to the determined sending frequency. According to the technical solution provided in the present invention, the problems of delayed communication and large consumption caused by an unchanging message type and message sending frequency can be avoided, and in an emergency state, the message type and the message sending frequency can be changed, such that an important message can be sent in a timely manner.

Abstract: An electric power system emulator apparatus includes a plurality of nodes arrayed in first and second dimensions and a plurality of transmission path emulator circuits, respective ones of which are configured to be connected between adjacent ones of the nodes in the first and second dimensions. The apparatus further includes a control circuit configured to control the transmission path emulator circuits to emulate transmission paths of an electric power system. The control circuit may be configured to control the transmission path emulator circuits to emulate transmission lines and/or transformers. The transmission path emulator circuits may include respective power electronics converter circuits. The apparatus may further include source/load emulator circuits configured to be coupled to the nodes.

Abstract: A full-face shaft tunnel boring machine system includes a tunnel boring machine cutterhead device for tunneling downwards in a shaft; a full-hydraulic formwork device for supporting and walling in a wellbore; and an upper muck-discharge system for vertically conveying rock mucks generated by tunneling. The tunnel boring machine cutterhead device comprises a vertical guide frame, a cutter-expanded boring head and an advanced cutterhead that are fixedly connected in a vertical order from top to bottom so as to form an integrated structure. The vertical guide frame is a hollow cylindrical structure and driven to rotate around an axis of the vertical guide frame by a power mechanism, and an outer wall of the vertical guide frame is provided with multiple sets of first guide rollers.

Abstract: A full-face shaft tunnel boring machine system includes a tunnel boring machine cutterhead device for tunneling downwards in a shaft; a full-hydraulic formwork device for supporting and walling in a wellbore; and an upper muck-discharge system for vertically conveying rock mucks generated by tunneling. The tunnel boring machine cutterhead device comprises a vertical guide frame, a cutter-expanded boring head and an advanced cutterhead that are fixedly connected in a vertical order from top to bottom so as to form an integrated structure. The vertical guide frame is a hollow cylindrical structure and driven to rotate around an axis of the vertical guide frame by a power mechanism, and an outer wall of the vertical guide frame is provided with multiple sets of first guide rollers.

Abstract: Provided are a composite coating, a piston, an engine, and a vehicle. The composite coating comprises a metal bonding layer, a transition layer, a ceramic layer, and a sealing layer which are sequentially laminated, wherein the metal bonding layer is configured to be bonded with a piston basic body, the metal bonding layer is a rare earth metal modified bonding layer, and the transition layer is a rare earth metal modified zirconia layer.

Abstract: A silicon-based anode material for secondary batteries, a preparation method thereof and a secondary battery are provided. The silicon-based anode material includes: an inner core including an Si particle and silicon oxide SiOx1, where 0<x1<2, a first shell layer including a compound of the general formula MySiOz (0<y?4, 0<z?5, and z?x1) and a C particle, wherein the first shell layer covers the inner core, and the contents of M and C in the first shell layer gradually increase from a side thereof close to the inner core to another side thereof far away from the inner core; and a second shell layer including a carbon film layer or a composite film layer formed by a carbon film layer and a conductive additive, the second shell layer covers the first shell layer. The first charge-discharge cycle capability of the silicon-based anode material is improved, and the manufacturing cost is reduced.

Abstract: The present disclosure provides a data collection system and method. The data collection system includes a microcontroller module, a switch and a storage module. The microcontroller module sends protocol information to the switch, configures a port of the switch, and sends control instruction to the switch. The switch receives the control instruction and transmits data to the microcontroller module according to the control instruction. The microcontroller module processes the data transmitted by the switch and transmits processed data to the storage module. The storage module receives the processed data and save the processed data. The data collection system is easy to deploy, improves production efficiency, simplifies the operation steps of data collection, and reduces the technical threshold of users.

Abstract: A salty taste enhancing peptide derived from dry-cured ham is provided, and the amino acid sequences thereof are Asp-Leu; Phe-Met-Ser-Ala-Leu-Phe, as shown in SEQ ID NO: 1; and His-Val-Arg-Arg-Lys, as shown in SEQ ID NO: 2. The salty taste enhancing peptide in the present disclosure is of small molecular weight, features easy separation and purification, has strong salty taste enhancing effect and simple sequences, and is easy to synthesize, therefore, the salty taste enhancing peptide can be applied to the fields of food, health products, medicine and biology, and is expected to replace salt substitute products currently available on the market.

Abstract: The application provides a silicon-based lithium storage material and a preparation method thereof, wherein the silicon-based lithium storage material includes: an inner core, including silicon elements with a valence of 0-4; a first shell layer coating or partially coating the inner core, the first shell layer comprises a fluorocarbon layer, and the fluorocarbon layer comprises a fluorocarbon. According to the technical scheme of the present application, the silicon-based lithium storage material may improve the characteristics of the silicon-based lithium storage material as an active material of a lithium ion secondary battery under high-temperature storage conditions, and simultaneously improve the cycle characteristics and initial charge-discharge coulombic efficiency of the secondary battery.

Abstract: A circuit board assembly is applied to the field of electronic communications technologies to resolve a prior-art heat dissipation problem of a circuit board. The circuit board assembly combines, on a second circuit board, low-speed signals transmitted between a plurality of I/O modules and an IC chip, and then transmits the combined low-speed signals to the IC chip by using a low-speed cable. A low-speed signal sent by the IC chip to the plurality of I/O modules is extended to a plurality of low-speed signals on the second circuit board, and then the plurality of low-speed signals are separately sent to the plurality of I/O modules. This may be applied to a scenario in which a relatively large quantity of electronic components need to be disposed on a circuit board.

Abstract: A semiconductor device has a semiconductor material in a substrate. The semiconductor device has an MOS transistor. A trench in the substrate extends from a top surface of the substrate) into the semiconductor material. A shield is disposed in the trench. The shield has a contact portion which extends toward a top surface of the trench. A gate of the MOS transistor is disposed in the trench over the shield. The gate is electrically isolated from the shield. The gate is electrically isolated from the contact portion of the shield by a shield isolation layer which covers an angled surface of the contact portion extending toward the top of the trench. Methods of forming the semiconductor device are disclosed.

Abstract: An engine piston is provided. A first sealing structure, including a first sealing rubber ring and a first annular groove, is provided at a head of the engine piston. The first sealing rubber ring has a U-shaped section with a reserved space at the top of the first sealing rubber ring, and a gap for circulating hydraulic oil is provided between a ring bank, above the first sealing rubber ring, of the engine piston and a simulated cylinder liner of a fatigue testing apparatus for an engine piston. In a case that the hydraulic oil is introduced into the fatigue testing apparatus for the engine piston to simulate pressure loading under a high-explosion pressure, when the hydraulic oil enters into the reserved space from the gap for circulating the hydraulic oil, an inner wall of the reserved space is squeezed and the first sealing rubber ring is deformed.