Abstract: Disclosed are a compound as represented by general formula (I) or a stereoisomer, deuterated compound, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, and an intermediate thereof, and the use thereof in AR or AR splicing mutant-related diseases such as cancer.

Abstract: This invention relates to anti-CTLA-4 antibody compositions that bind to the human CTLA-4 molecule, and the use of the compositions in cancer immunotherapy and for reducing autoimmune side effects compared to other immunotherapeutic agents.

Abstract: A head-up display screen, a head-up display assembly, and a vehicle are provided. The head-up display screen is attached to an inner side of an attachment surface of a windshield and configured to reflect image light emitted towards the windshield. The head-up display screen includes a functional layer, a reflective layer, and a protective layer that are sequentially arranged in a direction from the windshield to a driving position. The functional layer includes prism microstructures protruding from the inner side of the attachment surface of the windshield. The reflective layer is at least attached to lower inclined surfaces of the prism microstructures and is configured to reflect the image light towards the driving position. The protective layer covers the reflective layer and the functional layer.

Abstract: Disclosed are a compound preparation for neuranagenesis, and a preparation method therefor and the use thereof. The compound preparation for neuranagenesis comprises the raw medicinal materials in parts by weight: 10-20 parts of raw Astragali radix, 10-20 parts of Rehmaimiae Radix praeparata, 10-20 parts of Actyranthes bidentata, 6-15 parts of Jujubae fructus, 6-15 parts of Lycii fructus, 6-15 parts of parched Ziziphi spinosae semen, 6-12 parts of Angelicae smensis radix, 3-9 parts of Carthami flos, 6-15 parts of Poria, 6-15 parts of parched Atractylodis macrocephalae rhizoma and 10-20 parts of Zaocys. The compound preparation can be used for preparing drugs to treat nerve damage diseases, and can be prepared into oral liquids, granules, dissolved granules and tablets.

Abstract: The present application provides a projection screen and a projection system. The projection screen includes an optical structure layer and a reflective layer, where the optical structure layer includes a plurality of microstructure units; each of the plurality of microstructure units include a first sidewall and second sidewalls; the reflective layer covers at least part of the first sidewall to form a first working surface, and the reflective layer covers at least part of the second sidewalls to form second working surfaces, respectively; the first working surface deflects an input image beam, and at least part of the input image beam is transmitted to viewer's field and the second working surfaces; and the second working surfaces deflect an input image beam came from the first working surface, and the input image beam came from the first working surface is transmitted to the viewer's field. The present application improves the brightness evenness of the projection screen.

Abstract: An apparatus including an assembly associated with a downhole tool configured to thermally isolate a thermally sensitive component. Components of the assembly include an external isolating vessel; a passive thermal barrier encased in the external isolating vessel; at least one electronic component housed within the downhole tool for monitoring geothermal well properties; and at least one thermally sensitive electronics carrier package positioned within the passive thermal barrier comprising thermally sensitive electronic components. The passive thermal barrier ideally comprises an additively manufactured layered labyrinthine shell structure, a plurality of polarly phased centralizers between shell layers and minimal centralizing contact points on its exterior shell, to minimize known heat transfer modes associated with the external isolating vessel.

Abstract: A method for controlling a game character, comprising following steps: in response to a sliding operation started from an initial position of the skill button, locking the virtual joystick for disabling control of the skill release direction of the game character; monitoring a track of the sliding operation, obtaining a current position P2 of a touch point of the sliding operation, and calculating a vector a; determining whether the vector a meets the condition of |a|>a preset threshold L; if yes, generating a first operating instruction to release a skill in the direction of the vector a; and unlocking the virtual joystick; if no, determining whether the sliding operation has been released; if yes, generating a second operating instruction to release the skill, wherein a release direction is a current orientation of the game character; and unlocking the virtual joystick. The method may effectively reduce a misoperation rate.

Abstract: A display device is provided. The display device includes a display panel (20) and a flexible circuit board electrically connected with the display panel (20). The flexible circuit board includes a first circuit board (11), a second circuit board (22) and a conductive portion; the first circuit board (11) includes a first substrate (100), and a main contact pad, a first wire (501) and a second wire (502) provided on the first substrate (100); the second circuit board (22) includes a second substrate (200), a relay contact pad and a third wire (210) provided on the second substrate (200); and the conductive portion is configured for electrically connecting the main contact pad and the relay contact pad.

Abstract: A battery shell includes a shell body internally provided with an accommodating cavity. At least one face of a shell body facing and/or facing away from the accommodating cavity is provided with heat dissipation recesses, so that the face has a non-penetrating “skylight” structure. The heat dissipation recesses extend in a thickness direction of the shell body without penetrating the shell body. A plurality of heat dissipation recesses are provided in the at least one face of the shell body. All the heat dissipation recesses are arranged at intervals.

Abstract: A genetically engineered bacterium and a preparation method and use thereof are disclosed. The genetically engineered bacteria contain a gene encoding ?-1,2-fucosyltransferase, and a gene encoding a protein tag is connected to the gene encoding ?-1,2-fucosyltransferase; the protein tag is MBP, SUMO1, SUMO2 or TrxA, the amino acid sequence of the MBP is shown in SEQ ID NO: 2, the amino acid sequence of the SUMO1 is shown in SEQ ID NO: 3, the amino acid sequence of the SUMO2 is shown in SEQ ID NO: 4, the amino acid sequence of the TrxA is shown in SEQ ID NO: 5. Fermentation with the genetically engineered bacteria can greatly increase the yield of 2?-fucosyllactose compared to the genetically engineered bacteria that only expresses ?-1,2-fucosyltransferase exogenously, and the yield can be more than doubled in a preferred case.

Abstract: The invention discloses a genetically engineered bacterium and its application in the preparation of sialyllactose. The genetically engineered bacterium has an N-acetylneuraminic acid biosynthesis pathway, includes multiple copies of a gene neuB for encoding sialic acid synthase, and the gene neuB is initiated for expression by a strong promoter. Using the genetically engineered bacteria of the invention to produce sialyllactose has the advantages of high yield and low overall cost.

Abstract: The present invention relates to the technical field of n-type semiconductor materials. Disclosed are an n-type conjugated polymer, a preparation method therefor, and a use thereof. In the method, using a solvent as a reaction medium, a reaction monomer is reacted under the action of a substance having oxidability to obtain an n-type conjugated polymer. The n-type conjugated polymer comprises one or more polymerization units, and the polymerization unit are of a structure of formula (I) and/or a structure of formula (II), and/or in an enol-type transformation form corresponding thereto. According to the present invention, an aromatic diketone substance having active methylene is a raw material, and is subjected to a direct polymerization reaction by means of the substance having the oxidability.

Abstract: A high temperature-resistant fire extinguishing robot, comprising: a high temperature-resistant robot chassis system and a high temperature-resistant turret system. The high temperature-resistant robot chassis system carries the high temperature-resistant turret system to perform movements and obstacle avoidance, provides the high temperature-resistant turret system with energy, and further comprises: a high temperature-resistant tract drive system, a thermal protection system, and a control and sensor system, the high temperature-resistant track drive system being arranged outside of the thermal protection system, and the control and sensor system being arranged within the thermal protection system.

Abstract: The present disclosure discloses a busbar-side voltage transformer cabinet including a busbar chamber configured to install a busbar therein; an inflation chamber arranged below the busbar chamber and configured to install an electrical device therein, and filled with insulating gas; and a cable chamber arranged below the inflation chamber and configured to install a feeder therein, the cable chamber is installed with a voltage transformer, the inflation chamber is provided with an isolation device to switch the voltage transformer between on state and grounded state. According to the present disclosure, there is no need to add an additional isolation switch cabinet to control grounding and connection of the voltage transformer; the voltage transformer is installed in the cable chamber at the bottom, so there is no need for additional small gas box, which saves space and the height of the cabinet is the same as that of other cabinets.

Abstract: A semiconductor device includes an N-type semiconductor substrate, a drift layer, a semiconductor layer, a first trench located in the semiconductor layer, a gate located in the first trench, a P-well, a source region, and an N-type second semiconductor region that are located in the semiconductor layer, a source, and a drain. The drift layer includes an N-type column region and a P-type column region that are disposed in parallel and alternately. In the semiconductor device, an electrode is further disposed below the gate, a P-type first semiconductor region is disposed at the bottom of the first trench, the first semiconductor region is in contact with the electrode and the P-type column region located below the gate, and the electrode is electrically connected to the source.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-? signaling with the compounds and compositions of the disclosure.

Abstract: Disclosed are a polypropylene composite material capable of blasting at a low temperature, and a preparation method therefor and application thereof. The polypropylene composite material comprises the following components in parts by weight: 35-75 parts of special polypropylene A, 3-10 parts of special polypropylene B, 15-30 parts of a filler, 2-10 parts of a special toughening agent, 15-25 parts of a toughening agent, 0.1-0.3 part of a lubricant, 0.1-0.3 part of a photostabilizer, and 0.2-0.6 part of an antioxidant, wherein the special toughening agent comprises ultrahigh molecular weight polyethylene and a metallocene ethylene-propylene copolymer. The polypropylene composite material that is capable of blasting at a low temperature and has good rigidity is prepared by using the special polypropylene A, the special polypropylene B, and the special toughening agent in combination with the normal filler and the normal toughening agent, and the polypropylene composite material has a wide application prospect.

Abstract: Provided are the compound shown in general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt, or co-crystal thereof, an intermediate thereof, and a use thereof in EGFR-related diseases such as cancer.

Abstract: An intratumor turbulent flow device, comprising: a turbulent flow disc of a double-layer metal wire braided structure, a developing mark is provided in the center of the turbulent flow disc, and metal wires in the center of the turbulent flow disc are fixed in the developing mark; a distal end of a release portion is connected to the developing mark; a pushing guide wire is connected to the turbulent flow disc through the release portion; and a microcatheter for transporting the turbulent flow disc. The pushing guide wire pushes, into a tumor cavity of an aneurysm along the microcatheter. The turbulent flow disc expands in the tumor cavity and is fitted to the inner wall of the tumor cavity. The release portion is broken restoring the center of the turbulent flow disc, and the developing mark is prevented from forming an embolism in the blood vessel.

Abstract: A computer-implemented method for defect analysis is provided. The computer-implemented method includes calculating a plurality of weight-of-evidence (WOE) scores respectively for a plurality of device operations with respect to defects occurred during a fabrication period, a higher WOE score indicating a higher correlation between a defect and a device operation; and ranking the plurality of WOE scores to obtain a list of selected device operations highly correlated with the defects occurred during the fabrication period, device operations in the list of selected device operations having a WOE score greater than a first threshold score. A respective one of the plurality of device operations is a respective device defined by a respective operation site at which the respective device perform a respective operation.