Abstract: An SGT MOSFET comprising a substrate, an epitaxial layer, a masking dielectric layer, an interlayer dielectric layer, a source lead-out contact hole, and a source conductive layer and a method for manufacturing the SGT MOSFET are provided. The epitaxial layer is on an upper surface of the substrate and comprises a cellular trench structure, a terminal lead-out structure, a source lead-out structure, a body region, and a source region. The source lead-out structure comprises a source lead-out conductive layer. The masking dielectric layer and the interlayer dielectric layer are sequentially stacked above the epitaxial layer. The source lead-out contact hole penetrates the interlayer dielectric layer and the masking dielectric layer and extends into the source lead-out conductive layer, The source conductive layer fills the source lead-out contact hole. The masking dielectric layer is formed between the interlayer dielectric layer and the epitaxial layer and masks the third dielectric layer.

Abstract: This disclosure relates to methods, uses, and compositions (e.g., articles of manufacture and kits) comprising an anti-OSMR? antibody, such as vixarelimab, for the treatment of inflammatory gastrointestinal diseases associated with the oncostatin M (OSM) pathway (e.g., inflammatory bowel disease (IBD) (e.g., ulcerative colitis (UC (e.g., moderate to severe UC)) and Crohn's disease (CD)).

Abstract: The present invention relates to the technical field of power electronics converters and discloses a grid-forming energy storage converter on/off-grid switching control method and system, where the method includes the following steps: S1: using a single-loop power control strategy in an off-grid state when an on-grid relay of target energy storage drops out; S2: using a parallel virtual impedance loop-based power control strategy in a transient on-grid state when the on-grid relay of target energy storage pulls in; and S3: using a cascaded dual-loop power control strategy with a virtual admittance voltage loop and an inner current loop when a stable on-grid state is established. The present invention solves the problems of large current impact and unstable switching process state in the existing working strategy for on/off-grid switching in the prior art.

Abstract: The present invention discloses use of Bifidobacterium animalis subsp.lactis in promoting efficacy exertion of a Ginseng Radix Et Rhizoma extract in alleviating liver injuries. According to the present invention, Bifidobacterium animalis subsp.lactis CCFM1274 may grow in a fermentation base rich in a Ginseng Radix Et Rhizoma extract, and a fermentation broth of the Ginseng Radix Et Rhizoma extract fermented with this strain can increase the content of active substances such as aglycone flavonoids and short-chain fatty acids, promote the efficacy exertion of the Ginseng Radix Et Rhizoma extract, including improving the ability of the Ginseng Radix Et Rhizoma extract to alleviate a non-alcoholic liver injury, and reduce the fat accumulation in liver cells. This strain and the Ginseng Radix Et Rhizoma extract may be used to prepare a product for promoting the efficacy of alleviating the non-alcoholic liver injury.

Abstract: The present invention relates to a compound represented by general formula (I) or a stereoisomer, deuterated compound, solvate, prodrug, metabolite, pharmaceutically acceptable salt or eutectic crystal thereof, and an intermediate thereof, and use thereof in IRAK4-related diseases such as an autoimmune disease, an inflammatory disease or cancer.

Abstract: The present disclosure discloses a bionic cuttlefish-typed underwater detection robot, including a bionic “cuttlefish”-typed body structure, a piezoelectric energy capture device, a circuit rectification and storage assembly and a power control assembly. The bionic “cuttlefish”-typed body structure includes a head and a main body; the piezoelectric energy capture device includes piezoelectric ceramic elements arranged around the main body and PVDF floating belts, and an end of each piezoelectric ceramic element is connected to a spherical spoiler component, the PVDF floating belts are evenly distributed at a tail end of the main body. The present disclosure adopts piezoelectric ceramic elements with spoiler components and PVDF floating belts to generate electricity, converts wave energy and ocean current energy into electric energy, powers the power control assembly of the detection robot.

Abstract: A device and a method of whole lifecycle multi-indicator synchronous detection of yarns or fabrics are provided. The device includes a hairiness detection unit, a first guide unit, a tension adjustment unit, and a friction unit. The device is used for circularly rubbing a closed-loop object to be detected with a preset length on the friction unit, and collecting hairiness data in real time through the hairiness detection unit. The tension adjustment unit is a free-falling tension adjustment unit used to automatically adjust tension of the object to be detected in real time to ensure the stability of friction and transmission of the object to be detected. By arranging the circulating friction closed-loop circuit and arranging the free-falling tension adjustment unit on the circuit, the friction stability is improved. The synchronous and rapid detection of multiple indicators of the object to be detected can be realized.

Abstract: The present disclosure provides a data processing method, a device, a computer apparatus and a storage medium, wherein the method includes: in response to a target disk receiving at least one write request within a preset time period, determining a size threshold value for classifying a data update type according to a size of write data respectively indicated by each write request; determining a data update type corresponding to each write request according to a size of each write request and the size threshold value; dividing write data of the write request to obtain a data block according to a preset data block size, and caching the data block in a cache region of the target disk corresponding to the data update type, the target disk has multiple types of cache regions configured therein, different cache regions are configured to support caching of data with different update frequencies.

Abstract: An optical system includes an objective lens module, an image inverting module, and an eyepiece module. The objective lens module includes a first lens group, a second lens group, a third lens group, a fourth lens group, and a fifth lens group. The optical system satisfies at least one of the following conditions: 0.45?LG4D/LG1D?0.8; 0.015 mm?1?1/fG3?0.045 mm?1; 0.045 mm?1?|1/fG4|?0.07 mm?1; 0.35?|fG4/fG3|?0.75; 0.15?fG1/f?1.6; wherein LG4D is an effective optical diameter of the fourth lens group, LG1D is an effective optical diameter of the first lens group, fG1 is an effective focal length of the first lens group, fG3 is an effective focal length of the third lens group, fG4 is an effective focal length of the fourth lens group, and f is an effective focal length of the objective lens module.

Abstract: This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.

Abstract: A powertrain and a vehicle. The powertrain includes an enclosure, a separator, a motor, a first liquid return channel, and a second liquid return channel. The separator separates an interior of the enclosure into a first cavity and a second cavity. The motor is located in the first cavity. The first liquid return channel is located on an outer side of the enclosure and communicates with the first cavity and the second cavity. The second liquid return channel is located on the outer side of the enclosure and communicates with the first cavity and the second cavity. In the embodiments, with two liquid return channels provided, a liquid return requirement can be met when the powertrain is installed or disposed at any angle or used on a slope, improving adaptability and safety of the powertrain.

Abstract: This invention relates to anti-CTLA-4 antibody compositions that bind to the human CTLA-4 molecule, and the use of the compositions in cancer immunotherapy and for reducing autoimmune side effects compared to other immunotherapeutic agents.

Abstract: The present disclosure provides a data processing system and method, a computer device and a storage medium. The method includes: reading first data from a first memory space of a target memory space and splitting the first data to obtain multiple segments of second data; determining check information corresponding to each segment of the second data, and storing the check information of each segment of the second data as third data in a second memory space of the target memory space; generating a data assembly instruction based on a data assembly order for the second data and the third data; and sending the data assembly instruction to a storage acceleration module, enabling the storage acceleration module to write the fourth data into the hard disk based on read data and the target data structure.

Abstract: A method of performing state estimation for a microgrid system includes: obtaining a general quantum state estimation model for swing-bus-contained microgrid systems; establishing a state estimation formulation through quantum language; assigning quantum registers used during a quantum state estimation iteration; generating a quantum-circuit-based state estimation solver for performing quantum phase estimation, controlled rotation, and inverse quantum phase estimation; generating a preconditioned quantum linear solver for an ill-conditioned state estimation iteration; iteratively optimizing voltage and residual vectors while iteratively updating preconditioned errors by the state estimation solver, the optimizing and updating iterations continuing until the linear solver reaches convergence; obtaining a quantum state estimation model for hierarchical-based microgrid systems including droop and/or secondary control modes; establishing an enhanced quantum state estimation framework including the state estimatio

Abstract: The present disclosure provides a method for allocating memory, computer device and storage medium. The method can achieve allocation of hard disk memory to a target application through use of free memory information of the hard disk memory and size information written into a first storage space. In addition, the free memory information of the hard disk memory is stored in system memory, and during allocation for the hard disk memory, the free memory information of the hard disk memory is directly read from the system memory.

Abstract: The present invention provides a method of treating targeted abnormal cells that are resistant, refractory, insensitive, non-responsive, or inadequately responsive to an ingredient, as well as cytotoxic cells used therein, comprising administering an effective amount of the ingredient-complexed cytotoxic cells to a subject with the disease.

Abstract: The present disclosure provides an auto-focus spectrometer, including: a grating element configured to split light; an imaging element configured to converge a light beam; a controller configured to move the imaging element to realize autofocus, and connected to the imaging element; and a detector; and an incident light is diffracted through the grating to the imaging element, and then converged to the detector through the imaging element to obtain spectrogram information. The present disclosure automatically adjusts the imaging element position according to the configuration and operation state of the spectrometer, so that the spectrometer can be automatically kept at an optimal imaging position and exert the best performance thereof.

Abstract: This invention relates to anti-CTLA-4 antibody compositions that bind to the human CTLA-4 molecule, and the use of the compositions in cancer immunotherapy and for reducing autoimmune side effects compared to other immunotherapeutic agents.

Abstract: An apparatus including an assembly associated with a downhole tool configured to thermally isolate a thermally sensitive component. Components of the assembly include an external isolating vessel; a passive thermal barrier encased in the external isolating vessel; at least one electronic component housed within the downhole tool for monitoring geothermal well properties; and at least one thermally sensitive electronics carrier package positioned within the passive thermal barrier comprising thermally sensitive electronic components. The passive thermal barrier ideally comprises an additively manufactured layered labyrinthine shell structure, a plurality of polarly phased centralizers between shell layers and minimal centralizing contact points on its exterior shell, to minimize known heat transfer modes associated with the external isolating vessel.

Abstract: A high temperature-resistant fire extinguishing robot, comprising: a high temperature-resistant robot chassis system and a high temperature-resistant turret system. The high temperature-resistant robot chassis system carries the high temperature-resistant turret system to perform movements and obstacle avoidance, provides the high temperature-resistant turret system with energy, and further comprises: a high temperature-resistant tract drive system, a thermal protection system, and a control and sensor system, the high temperature-resistant track drive system being arranged outside of the thermal protection system, and the control and sensor system being arranged within the thermal protection system.