Abstract: Disclosed is a photoplethysmography-based non-invasive diabetes prediction system, comprising an optical signal transmitter, a driving circuit, a receiving circuit and a processor module. The optical signal transmitter, when driven by the driving circuit, obtains and emits an optical signal of a fixed wavelength and intensity. The receiving circuit converts a received optical signal of photoplethysmography into an electrical signal of photoplethysmography, performs amplification, filtering, digital-analog conversion, and sends the digital photoplethysmography signal to the processor module. The processor module performs signal processing, feature extraction, modeling and prediction on the digital photoplethysmographic signal, and visually displays same. The photoplethysmography-based non-invasive diabetes prediction system and method can achieve non-invasive, real-time and convenient diabetes screening and disease risk prediction.

Abstract: A method is provided to automatically create road and lane geometry from images representing map geometry within a geographical area using object detection. Methods may include: receiving a rasterized image representative of map geometry within a geographic area, where each pixel of the rasterized image includes a property representing at least one component of the map geometry; applying an object detection model to the rasterized image; generating a list of the bounding boxes together with classes of objects within the bounding boxes based on the object detection model; generating map data from the list of bounding boxes and the classes of objects within the bounding boxes; and updating a map in a map database with the map data.

Abstract: The present disclosure provides a synthesis method of a g-C3N4/C composite material based on a hollyhock stalk, including the following steps: (1) pretreatment of hollyhock stalks; and (2) fabrication of the g-C3N4/C composite material. In this method, with the hollyhock stalk as a carbon skeleton, g-C3N4 is spread on a template surface to form a laminated layer, and a composite system with a special structure is constructed. Compared with pure phase g-C3N4, the composite material substantially increases specific surface area and has a clear interface; the carbon skeleton not only functions as a rigid support, but also increases the electron transfer efficiency of the composite material, thereby improving the separation efficiency of photogenerated carriers and the utilization rate of visible light.

Abstract: A method for manufacturing a stator for a rotary electric machine including: a process of abutting, on each other, tip end parts of one coil piece and an other one coil piece for forming a stator coil of a rotary electric machine; and a welding process of irradiating a welding target location regarding the tip end part having been abutted with a laser beam having a wavelength of 0.6 ?m or less, in which in the welding process, the laser beam is generated for every pulse oscillation in a laser oscillator in a mode of having a laser output of 3.0 kW or more, and in at least a part of a period during one pulse oscillation, the laser beam is moved so that an irradiation position changes linearly parallel to an abutment surface of the tip end part.

Abstract: A method for manufacturing a stator for a rotary electric machine including: a first disposing process of disposing one workpiece for stator in a first station (ST1); a first welding process of completing welding of a first part of stator coil in the one workpiece in ST1; a second disposing process of disposing an other one workpiece for stator in a second station (ST2); and a second welding process of completing welding of a second part of stator coil in other one workpiece in ST2, wherein first welding process includes first irradiation process of irradiating first part with a laser beam for welding, second welding process includes second irradiation process of irradiating second part with a laser beam for welding, first and second irradiation processes have a time difference, and laser beam used in each of the first and second irradiation processes are generated based on the same oscillator.

Abstract: There is disclosed a method for manufacturing a stator for a rotary electric machine including: a process of abutting, on each other, tip end parts (40 of one coil piece (52) and an other one coil piece (52) for forming a stator coil (24) of a rotary electric machine (1); and a welding process of irradiating a welding target location regarding the tip end part having been abutted with a laser beam (110) having a wavelength of 0.6 µm or less, in which an output distribution at a focal point of the laser beam has a flat center part.

Abstract: An apparatus including an assembly associated with a downhole tool configured to thermally isolate a thermally sensitive component. Components of the assembly include an external isolating vessel; a passive thermal barrier encased in the external isolating vessel; at least one electronic component housed within the downhole tool for monitoring geothermal well properties; and at least one thermally sensitive electronics carrier package positioned within the passive thermal barrier comprising thermally sensitive electronic components. The passive thermal barrier ideally comprises an additively manufactured layered labyrinthine shell structure, a plurality of polarly phased centralizers between shell layers and minimal centralizing contact points on its exterior shell, to minimize known heat transfer modes associated with the external isolating vessel.

Abstract: A 25-hydroxycholecalciferol monohydrate crystal, a preparation method thereof, and a microemulsion using the 25-hydroxycholecalciferol monohydrate crystal. The X-ray powder diffraction spectrum of the 25-hydroxycholecalciferol monohydrate crystal of the present disclosure shows characteristic peaks at 2? of 10.035°, 11.623°, 14.631°, 15.054°, 15.551°, 16.471°, 17.198°, 19.002°, 19.628°, 20.109°, 21.886°, 23.113°, 23.661°, 24.701°, 25.220°, 25.440°, and 28.527°. The 25-hydroxycholecalciferol monohydrate crystal can effectively enhance the stability of 25-hydroxycholecalciferol, and is more beneficial to the production and storage of related preparations, and thus biological characteristics of 25-hydroxycholecalciferol can be effectively utilized.

Abstract: This method of manufacturing a stator includes a step of removing insulating coatings on first surfaces of lead wire portions that are surfaces to be welded, and a step of welding together the first surfaces by a green laser with the insulating coatings on the first surfaces being removed and with insulating coatings on second surfaces opposite the first surfaces being unremoved.

Abstract: This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.

Abstract: This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.

Abstract: This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.

Abstract: A high temperature-resistant wheel, comprising: an elastic hub assembly (1), which has a thermal insulation layer integrated therewith so as to insulate the elastic hub assembly (1) from exterior high temperatures; and a rigid wheel barbed ring (2), which has the elastic hub assembly (1) fastened inside and rotates together with the elastic hub assembly (1). A robot, which comprises the high temperature-resistant wheel.

Abstract: The present invention relates to a crystal of cephalosporin intermediate 7?-methoxy cephalothin (I) and a method for preparing same. The crystal of 7?-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2?; the crystal of 7?-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.34°±0.20°, 12.71°±0.20°, 14.25°±0.20°, 14.68°±0.20°, 16.52°±0.20°, 17.99°±0.20°, 19.98°±0.20°, and 22.69°±0.20°. The crystal of 7?-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7?-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7?-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.

Abstract: The present invention relates to compositions of anti-CTLA-4 antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for the reduction of autoimmune side effects compared to other immunotherapeutic agents.

Abstract: This invention relates to anti-CTLA-4 antibody compositions that bind to the human CTLA-4 molecule, and the use of the compositions in cancer immunotherapy and for reducing autoimmune side effects compared to other immunotherapeutic agents.

Abstract: A 25-hydroxycholecalciferol monohydrate crystal, a preparation method thereof, and a microemulsion using the 25-hydroxycholecalciferol monohydrate crystal. The X-ray powder diffraction spectrum of the 25-hydroxycholecalciferol monohydrate crystal of the present disclosure shows characteristic peaks at 2? of 10.035°, 11.623°, 14.631°, 15.054°, 15.551°, 16.471°, 17.198°, 19.002°, 19.628°, 20.109°, 21.886°, 23.113°, 23.661°, 24.701°, 25.220°, 25.440°, and 28.527°. The 25-hydroxycholecalciferol monohydrate crystal can effectively enhance the stability of 25-hydroxycholecalciferol, and is more beneficial to the production and storage of related preparations, and thus biological characteristics of 25-hydroxycholecalciferol can be effectively utilized.

Abstract: The present invention discloses a universal non-invasive blood glucose estimation method based on time series analysis, which comprises 5 steps, i.e., data input and preprocessing, features screening, establishment of single-feature model based on time series analysis, multi-feature fusion, and non-invasive blood glucose estimation. During non-invasive blood glucose estimation, new non-invasive test data is inputted, and the blood glucose estimation series is calculated using related feature information obtained through modeling, single-feature model, and multi-feature fusion model. The estimation method provided in the present invention is easy to execute, and can overcome the delay between changes of physiological parameters of human body and changes of blood glucose, and thereby can obtain more accurate non-invasive blood glucose test results. The estimation method is universal and is applicable to different non-invasive blood glucose monitoring methods.