Patents by Inventor Felix Hermann

Felix Hermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220033779
    Abstract: A genetically modified mesenchymal stem cell including an exogenous nucleic acid including a Klotho encoding region operably linked to a promoter or promoter/enhancer combination, wherein the genetically modified mesenchymal stem cell exhibits increased Klotho expression compared to an unmodified mesenchymal stem cell. Also disclosed are methods of treating a patient including administering a therapeutically effective number of the genetically modified mesenchymal stem cells to the patient. The methods of treatment include treating the patient for a neurodegenerative disease; cancer; organ fibrosis; renal disease; age-related changes of organs or organ systems; to slow, reverse and/or inhibit aging; arteriosclerosis; dementia; diabetes mellitus; erectile dysfunction; autoimmune diseases or autoimmune-related diseases; an inflammatory disease of the lung and sepsis.
    Type: Application
    Filed: September 17, 2021
    Publication date: February 3, 2022
    Inventors: Christine Günther, Manfred Stangl, Felix Hermann
  • Publication number: 20220011682
    Abstract: The present application relates to an apparatus and to a method for removing at least a single particulate from a substrate, especially an optical element for extreme ultraviolet (EUV) photolithography, wherein the apparatus comprises: (a) an analysis unit designed to determine at least one constituent of a material composition of the at least one single particulate; and (b) at least one gas injection system designed to provide a gas matched to the particular constituent in an environment of the at least one single particulate; (c) wherein the matched gas contributes to removing the at least one single particulate from the substrate.
    Type: Application
    Filed: July 7, 2021
    Publication date: January 13, 2022
    Inventors: Klaus Edinger, Christian Felix Hermanns, Tilo Sielaff, Jens Oster, Christof Baur, Maksym Kompaniiets
  • Patent number: 11104390
    Abstract: A motor vehicle has a body; an air-guide, fastenable to the body; a drive to adjust the air-guide when the air-guide is fastened to the body; and connectors that connect the drive to the body. The connectors include first fastening elements and second fastening elements. The first fastening elements are insertable through cutouts in the body into the second fastening elements via a first position up to a second position. An orientation of the drive relative to the body is possible in the first position, and the second fastening elements exert a clamping force on the first fastening elements in the second position.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: August 31, 2021
    Assignee: Dr. Ing. h.c. F. Porsche Aktiengesellschaft
    Inventor: Felix Hermann
  • Publication number: 20200282078
    Abstract: A method for treating a subject having a medical conditions associated with inflammation and/or an unwanted immune response, and said subject does not have an alpha1-antitrypsin (AAT) deficiency, wherein the method includes administering genetically modified mesenchymal stem cells to the subject, wherein said genetically modified mesenchymal stem cells include an exogenous nucleic acid including (i) an Alpha-1 antitrypsin (AAT) encoding region operably linked to (ii) a promoter or promoter/enhancer combination.
    Type: Application
    Filed: February 25, 2020
    Publication date: September 10, 2020
    Inventors: Christine GÜNTHER, Sabine GEIGER-SCHREDELSEKER, Felix HERMANN, Ralf HUSS, Daria Larissa FORSTER
  • Publication number: 20200268802
    Abstract: A method of treating a tumor in a subject including administering a genetically modified mesenchymal stem cell (MSC), wherein the MSC includes one or more exogenous nucleic acid molecule(s), wherein the one or more exogenous nucleic acid molecule(s) includes one or more regions encoding two or more immune response-stimulating cytokines operably linked to one or more promoters or promoter/enhancer combinations, wherein the two or more immune response-stimulating cytokines include at least IL-7, and at least one of IL-12 or IL-21.
    Type: Application
    Filed: January 28, 2020
    Publication date: August 27, 2020
    Inventors: Christine Günther, Stefanos Theoharis, Felix Hermann, Ralf Huss
  • Publication number: 20190382062
    Abstract: A motor vehicle has a body; an air-guide, fastenable to the body; a drive to adjust the air-guide when the air-guide is fastened to the body; and connectors that connect the drive to the body. The connectors include first fastening elements and second fastening elements. The first fastening elements are insertable through cutouts in the body into the second fastening elements via a first position up to a second position. An orientation of the drive relative to the body is possible in the first position, and the second fastening elements exert a clamping force on the first fastening elements in the second position.
    Type: Application
    Filed: June 13, 2019
    Publication date: December 19, 2019
    Inventor: Felix Hermann
  • Patent number: 10442476
    Abstract: A spoiler system for a vehicle includes a spoiler body having a spoiler surface for influencing an air flow around the vehicle; and a spoiler receptacle having a sealing device with a seal configured to provide sealing between the sealing device and a sealing surface of the spoiler body during an extension movement of the spoiler body from a retracted position into an extended position. The spoiler body is movably mounted on the spoiler receptacle between the retracted position in which the spoiler body is received at least partially in the spoiler receptacle and the extended position in which the spoiler body is extended at least partially out of the spoiler receptacle.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: October 15, 2019
    Assignee: DR. ING. H.C. F. PORSCHE AKTIENGESELLSCHAFT
    Inventors: Felix Hermann, Sebastian Collet
  • Patent number: 10435086
    Abstract: A spoiler arrangement of a motor vehicle includes a spoiler blade, a body portion to which the spoiler blade attaches, a displacement device for the spoiler blade, the displacement device being configured to move the spoiler blade relative to the body portion between a retracted position and an extended position; and a cover configured to attach to the spoiler blade and to at least partially close a rear gap which is formed, in the extended position of the spoiler blade, between a rear edge of the spoiler blade and an adjoining assembly of the body portion.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: October 8, 2019
    Assignee: DR. ING. H.C. F. PORSCHE AKTIENGESELLSCHAFT
    Inventors: Felix Hermann, Sebastian Collet
  • Publication number: 20190030152
    Abstract: A tumor or a malignant disease can be treated by the combined administration of mesenchymal stem cells (MSCs) with an anti-tumor immunotherapy. The MSCs need not be genetically modified, and do not include exogenous nucleic acids that encode immune response-stimulating cytokines. The anti-tumor immunotherapy can be a cellular immunotherapy, such as administration of chimeric antigen receptor (CAR) T cells, in which the T cell receptor binds specifically to a tumor-associated antigen.
    Type: Application
    Filed: March 31, 2017
    Publication date: January 31, 2019
    Inventors: Felix Hermann, Christine Günther, Ulf Geumann
  • Publication number: 20180215422
    Abstract: A spoiler system for a vehicle includes a spoiler body having a spoiler surface for influencing an air flow around the vehicle; and a spoiler receptacle having a sealing device with a seal configured to provide sealing between the sealing device and a sealing surface of the spoiler body during an extension movement of the spoiler body from a retracted position into an extended position. The spoiler body is movably mounted on the spoiler receptacle between the retracted position in which the spoiler body is received at least partially in the spoiler receptacle and the extended position in which the spoiler body is extended at least partially out of the spoiler receptacle.
    Type: Application
    Filed: January 15, 2018
    Publication date: August 2, 2018
    Inventors: Felix Hermann, Sebastian Collet
  • Publication number: 20180215423
    Abstract: A spoiler arrangement of a motor vehicle includes a spoiler blade, a body portion to which the spoiler blade attaches, a displacement device for the spoiler blade, the displacement device being configured to move the spoiler blade relative to the body portion between a retracted position and an extended position; and a cover configured to attach to the spoiler blade and to at least partially close a rear gap which is formed, in the extended position of the spoiler blade, between a rear edge of the spoiler blade and an adjoining assembly of the body portion.
    Type: Application
    Filed: January 15, 2018
    Publication date: August 2, 2018
    Inventors: Felix Hermann, Sebastian Collet
  • Publication number: 20180037868
    Abstract: A genetically modified mesenchymal stem cell (MSC) includes an exogenous nucleic acid that includes a Klotho encoding region operably linked to a promoter or promoter/enhancer combination. The MSCs can be used for the treatment of cancer, organ fibrosis, renal failure, age-related changes of organs or organ systems, arteriosclerosis, and neurodegenerative diseases, such as Alzheimer's disease (AD), Multiple sclerosis (MS), Huntington's disease, Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease, and Schizophrenia, as well as dementia, diabetes mellitus, sepsis and autoimmune diseases and autoimmune-related diseases.
    Type: Application
    Filed: February 26, 2016
    Publication date: February 8, 2018
    Inventors: Christine Günther, Manfred Stangl, Felix Hermann
  • Publication number: 20180000969
    Abstract: Genetically modified mesenchymal stem cells can be used as a medicament in the treatment of medical conditions associated with inflammation and/or an unwanted immune response in subjects without an alpha1-antitrypsin (AAT) deficiency. The stem cells include an exogenous nucleic acid, which includes (i) an Alpha-1 antitrypsin (AAT) encoding region operably linked to (ii) a promoter or promoter/enhancer combination.
    Type: Application
    Filed: January 8, 2016
    Publication date: January 4, 2018
    Inventors: Christine GÜNTHER, Sabine GEIGER-SCHREDELSEKER, Felix HERMANN, Ralf HUSS, Daria Larissa FORSTER
  • Publication number: 20170239297
    Abstract: A genetically modified mesenchymal stem cell (MSC) and medical use thereof in the treatment of tumors, the MSC including one or more exogenous nucleic acid molecule(s), wherein the exogenous nucleic acid molecule(s) include a region encoding one or more immune response-stimulating or immune response-modulating cytokine(s) operably linked to a promoter or promoter/enhancer combination. The invention encompasses the use of the cells in modulating the tumor microenvironment in order to attract immune effector cells and facilitate their activation and/or adoption of a memory phenotype.
    Type: Application
    Filed: August 18, 2015
    Publication date: August 24, 2017
    Inventors: Christine Günther, Stefanos Theoharis, Felix Hermann, Ralf Huss
  • Patent number: 7934765
    Abstract: A top for a convertible, which has a rear window frame with a rear window and, in the closed state, at least one roof section situated in front of the rear window frame in the direction of travel. When there are two roof sections which are adjacent to each other when the top is closed, a respective extension, which is extended to the rear or front, is formed on the lateral border regions of one of the roof sections. The extension being configured as a seal carrier.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: May 3, 2011
    Assignee: Dr. Ing. h.c. F. Porsche Aktiengesellschaft
    Inventors: Felix Hermann, Dominik Beierl, Lars Schulz
  • Patent number: 7832787
    Abstract: A convertible has a top which can be opened and can be put away and which has a rear window frame and, when the top is closed, at least one surface bow situated in front of said rear window frame in the direction of travel. A coupling linkage for carrying out a relative movement of the surface bow with respect to the rear window frame is arranged between the rear window frame and the surface bow. It is essential for the invention that at least two surface bows which are situated in front of the rear window frame in the direction of travel are provided, which surface bows, when the top is closed, form a continuous roof contour together with the rear window frame. Furthermore, the coupling linkage is designed in such a manner that, at the beginning of the opening of the top, the second surface bow can be moved downward relative to the adjacent first surface bow and relative to the rear window frame out of the roof contour.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: November 16, 2010
    Assignee: Dr. Ing. h.c. F. Porsche Aktiengesellschaft
    Inventors: Dominik Beierl, Lars Schulz, Felix Hermann, Kristian Franz
  • Patent number: 7802837
    Abstract: A vehicle roof has at least two roof segments which, in the closed position of the roof, support a flexible roof skin at least in some regions and can be shifted via at least two pairs of links in a positively controlled manner from a closed position G of the top into a fixed storage position A of the top and vice-versa. One pair of links is thereby drivable by motor in order to move all of the roof parts. In the storage position A of the top, the driven pair of links can be supported by a first vehicle-body-side stop on each side of the vehicle in order to fix all of the roof parts with defined distances being maintained at least between the at least two pairs of links.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: September 28, 2010
    Assignee: Dr. Ing h.c. F. Porsche AG
    Inventors: Lars Schulz, Felix Hermann, Dominik Beierl
  • Patent number: 7798554
    Abstract: A motor vehicle roof configuration which can be put away has at least two shaping sections, which are movable relative to one another and can be put away together, for lateral convertible top cloth strips. The shaping sections lie in a row next to one another in a closed position of the roof configuration and have water channels which run approximately parallel to each convertible top cloth strip and in the longitudinal direction of the vehicle and also adjacent to the convertible top cloth strips. It is provided that, at least in a closed position of the roof configuration, an inner edge of each convertible top cloth strip together with at least one sealing configuration forms a leakproof covering for the adjacent water channel.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: September 21, 2010
    Assignee: Dr. Ing. h.c. F. Porsche AG
    Inventors: Dominik Beierl, Felix Hermann, Harald Neidlein, Angelo Bronda
  • Patent number: 7775579
    Abstract: A top drive for a flexible vehicle roof which can be transferred from a closed position into a storage position and vice versa. At least one roof link is movable via a linear drive, the roof link and a fixed end of the linear drive being fastened to a main bearing of the top, wherein an actuating end of the linear drive is fastened pivotably to a throw-over lever which is fastened to the main bearing of the top and at the free end of which there is arranged a drive connecting rod which is fastened at a first end in an articulated manner to the free end of the throw-over lever and at a second end in an articulated manner to a section of the roof link, which section is spaced apart from the pivot point on the main bearing of the top, as a result of which a driving movement of the linear drive can be transmitted to the roof link.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: August 17, 2010
    Assignee: Dr. Ing. h.c. F. Porsche AG
    Inventors: Lars Schulz, Felix Hermann, Dominik Beierl
  • Patent number: 7651152
    Abstract: A top for a convertible has a rear window frame, at least one roof section placed in front of it in the direction of travel when the top is closed, and a lateral top linkage. When the top is closed, a further roof section which is connected to the top linkage in an articulated manner and can be driven by the latter is provided between a front roof section and the rear window frame.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: January 26, 2010
    Assignee: Dr. Ing. h.c. F. Porsche AG
    Inventors: Dominik Beierl, Felix Hermann, Lars Schulz, Reiner Armbruster