Abstract: A display panel and a display device are disclosed. The display panel includes a first substrate, a second substrate, and a liquid crystal layer disposed therebetween. The first substrate includes a first base and a planarization layer disposed on a side of the first substrate adjacent to the liquid crystal layer. A side of the planarization layer adjacent to the liquid crystal layer includes a textured structure, which includes at least one groove path. The first substrate further includes a bottom edge. An extending direction of the at least one groove path forms an included angle with the bottom edge, the included angle being greater than or equal to 45 degrees and less than or equal to 135 degrees. A liquid crystal material in the liquid crystal layer diffuses along the extending direction of the groove path through the groove path based on capillary phenomenon.

Abstract: A thin film transistor, a manufacturing method thereof, a display substrate, and a display device are provided. The thin film transistor includes: a substrate, an active layer, a gate, a source and a drain. The active layer is arranged on the substrate and formed as a grid, including silicon nanowires extending along a first direction, the active layer includes source and drain regions oppositely arranged along the first direction, and a channel region located therebetween. The gate is arranged on the substrate, and an orthographic projection of the gate onto the substrate overlaps with orthographic projections for silicon nanowires in the channel region onto the substrate. The source and drain are arranged on the substrate, the source contacts silicon nanowires in the source region, and the drain contacts silicon nanowires in the drain region.

Abstract: The present disclosure provides a battery module, battery pack and vehicle. The battery module comprises: two battery blocks opposite each other, each of the battery blocks comprising a plurality of battery cells arranged along a first direction; and a circuit board disposed between the two battery blocks, the circuit board comprising a substrate and a plurality of electrical connectors passing through the substrate and arranged along the first direction, and the plurality of electrical connectors alternately connecting the plurality of battery cells of the two battery blocks in series; wherein each of the battery cells of one battery block is staggered and opposite to a corresponding battery cell of the other battery block, a tail-end electrode of a battery cell of the one battery block is aligned with a head-end electrode of a battery cell of the other battery block, and the tail-end electrode is connected to the head-end electrode by the electrical connector.

Abstract: A ratchet structure is provided. The ratchet structure comprises a housing having at least one pair of racks slidably overlapped with each other. Further, a cover coupled to the housing, having a cavity. Further, a ratchet gear detachably secured within the cavity, and comprising a plurality of elastic ribs having one or more grooves. Further, a knob having a plurality of driving ribs configured to be received within the one or more grooves of the plurality of elastic ribs. Therefore, the plurality of driving ribs facilitates the movement of the plurality of elastic ribs of the ratchet gear to slide the at least one pair of racks.

Abstract: A stop valve is provided. A stop valve includes a valve body, a valve core and a connecting block. The valve body is provided with a first opening and a second opening. The valve core is movable in the valve body to communicate the first opening with the second opening and cut off a communication therebetween. One end of the connecting block is located outside the valve body, the other end thereof is fixedly connected to an end of the valve body. A part of the valve core extends into the connecting block and is in threaded fit with the connecting block. The connecting block extends towards the valve body to define a seal portion along an axis of the valve core. When the stop valve is in a fully opened state, the valve core is capable of abutting against the seal portion and forming a linear seal therewith.

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Abstract: Systems and methods for generating and processing modeling workflows are disclosed. In some examples, a reference distribution of scores generated by a model is determined. The reference distribution of scores is recorded in a structured database. One or more unexpected scores are detected during execution of the model. To detect the one or more unexpected scores, a production distribution of scores is compared with the reference distribution of scores recorded in the structured database. The production distribution of scores is generated by the model for a production input data set. An alert is then provided to an external system, when an alert condition is determined to be satisfied based on the comparison. The alert indicates detection of the one or more unexpected scores.

Abstract: The present disclosure relates to a tetrahydronaphthalene compound, and a preparation method therefor and the use thereof in medicine. Specifically, the present disclosure relates to a tetrahydronaphthalene compound as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof as a therapeutic agent, in particular the use thereof as an estrogen receptor degrader, the use in the preparation of a drug for treating and/or preventing estrogen receptor-mediated or dependent diseases or conditions and the use in the preparation of a drug for treating and/or preventing diseases or conditions by means of degrading a target protein.

Abstract: Provided are an electron detection device and a scanning electron microscope. The electron detection device includes: a reflective energy analyzer including first and second control electrodes that are sequentially arranged in an incidence direction of an electron beam; a first detector disposed at a side of the second control electrode away from the first control electrode; a second detector disposed at a side of the first control electrode away from the second control electrode; and a conductive shielding tube penetrating the first and second control electrodes in the incidence direction and configured to shield an electric field generated by the reflective energy analyzer, allowing the electron beam to pass through and be incident on the target sample. First control electrode is configured to generate a first electric field between the first and second control electrodes. The first electric field is configured to guide the secondary electron to the first detector.

Abstract: This application provides a pre-connector and a communications device. The pre-connector includes a connector component and an outdoor component. The connector component includes a ferrule base and a ferrule that is slidable relative to the ferrule base. The ferrule base is configured to fasten the optical cable, and the ferrule is connected to an optical fiber that is of the optical cable and that is inserted into the ferrule base. In this way, the optical fiber can be connected to the communications device by using the ferrule. The outdoor component includes: a spindle that is sleeved on the ferrule base and that is fastened to the ferrule base; and a handle sleeve sleeved on the spindle. The outdoor component is used as a connecting piece to be detachably fastened and connected to the communications device, so as to provide a locking force used when the communications device is connected.

Abstract: Provided in the present disclosure is an antibody or fragment thereof against a human growth and differentiation factor 15 (GDF15). Further provided in the present disclosure is the use of the antibody or fragment thereof in the preparation of a drug for treating diseases or conditions. The antibody or fragment thereof provided in the present disclosure can bind to human GDF15 with high affinity and specificity, blocks the interaction of GDF15 with receptor GFRAL thereof, and has a longer half-life period in vivo in comparison with antibodies of the same kind.

Abstract: A resource management configuration may receive an API request from an API server. The API request specifies task information from a plurality of tenants. The configuration transmits status information of a plurality of VMs to the API server to assign tasks to one or more VMs based on the task information and the status information. Tasks assigned to a VM of the plurality of VMs are for one tenant of the plurality of tenants. The configuration configures on an untrusted network, network security groups for managing communications of tenants such that a network security group configured for a tenant permits communications between VMs assigned to the same tenant but prevents communications between VMs assigned to different tenants. The configuration pins each assigned VM of the one or more assigned VMs to perform the task based on the task information of the corresponding tenant.

Abstract: A single molecule detection method based on grating scanning recognition, in which a large number of capture beads are scattered on a bead retaining plate (or a detection chip). At least part of the capture beads are specifically bound with an analyte, and each analyte is bound with a luminescent substance. Grating ports of a grating detection device are used to scan the capture beads column by column from the capture beads arranged at one end. The number of the capture beads bound with a marker is synchronously counted. The capture beads on the whole bead retaining plate are scanned through transverse relative movement between the grating ports and the capture beads. The total number of analytes can be obtained after scanning is completed.

Abstract: A connector includes a shielding shell having a plurality of sockets and a plurality of terminal modules respectively inserted into the sockets. The terminal modules include a signal terminal module for transmitting signals and a power terminal module for transmitting power. The signal terminal module includes a signal terminal holder and a signal terminal provided in the signal terminal holder. The power terminal module includes a power terminal holder and a power terminal provided in the power terminal holder.

Abstract: An unsingulated semiconductor package includes multiple integrated circuits provided on a single substrate segment and encapsulated by a single cover. The unsingulated semiconductor package is mounted on a PCB of a computing component to increase the capacity and performance capabilities of the computing component without occupying additional space on the PCB.

Abstract: A connector terminal module includes a retaining body having a terminal hole, a terminal disposed in the terminal hole of the retaining body, a cable having a conductor core electrically connected to the terminal, and a shielding shell including a front shell part fitted onto the retaining body and a rear shell part crimped onto an end of the cable. The front shell part and the rear shell part of the shielding shell are opposite to each other in a longitudinal direction of the shielding shell. The shielding shell is an integral stamped piece.

Abstract: An open-pit mine truck automatic dispatching system and method, which comprises a digital twin creation module and a driver terminal; the digital twin creation module creates the dispatcher digital twin, the dispatcher digital twin receives the production plan, and creates the loader digital twin, the unloading point digital twin, the truck digital twin and the transportation path digital twin according to the production plan. The driver terminal obtains the available information of loaders and trucks and sends the available information to the dispatcher digital twin; the dispatcher digital twin generates dispatching commands based on available information, schedules the loader digital twin and the truck digital twin based on the dispatching command, and updates the property information of the loader digital twin, the unloading point digital twin, the truck digital twin and the transportation path digital twin. The invention realizes the automatic dispatching of open-pit mine trucks.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for jointly training an encoder that generates a watermark and a decoder that decodes a data item encoded within the watermark. The training comprises obtaining a plurality of training images and data items. For each training image, a first watermark is generated using an encoder and a subsequent second watermark is generated by tiling two or more first watermarks. The training image is watermarked using the second watermark to generate a first error value and distortions are added to the watermarked image. A distortion detector predicts the distortions based on which the distorted image is modified. The modified image is decoded by the decoder to generate a predicted data item and a second error value. The training parameters of the encoder and decoder are adjusted based on the first and the second error value.

Abstract: A method for mixing immunoassay reagent in immunoassay analysis device and an immunoassay analysis device are provided. The method disperses aggregated magnetic beads in a reagent tray of the immunoassay analysis device by keeping an immunoassay reagent tube containing the immunoassay reagent in a variable speed state during rotation and/or by exerting an impact force on the immunoassay reagent tube during rotation of the immunoassay reagent tube, so as to keep the immunoassay reagent in a mixed state. The method can mix the immunoassay reagent, avoid the phenomenon of magnetic beads' aggregation and ensure the accuracy of the testing results.

Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.