Abstract: Provided is a sulfonamide derivate represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing said derivative, and the use thereof as a therapeutic agent, especially as a Lysine Acetyl Transferase (KAT) inhibitor and the use of same in the preparation of a medicament for the treatment and/or prevention of cancer.

Abstract: The present disclosure provides a method and a system for adaptively dividing a graph network comprising a plurality of nodes, each of the plurality of nodes being connected to at least one other node of the plurality of nodes, the method comprising: for each pair of subnetworks from a plurality of subnetworks within the graph network, calculating an association score based on a first accuracy metric in predicting a first latent attribute of at least one first node of a first subnetwork of the each pair of subnetworks using parameters optimized for accurately predicting a second latent attribute of at least one second node of a second subnetwork of the each pair of subnetworks; and forming one of a plurality of new subnetworks within the graph network from each pair of a pair set of subnetworks from the plurality of subnetworks based on a result of determining a sum of the association scores of the pair set of subnetworks is higher than that of another pair set of subnetworks from the plurality of subnetworks

Abstract: An electronic atomization device includes: a heating element for atomizing an aerosol-forming material: an electromagnetic heating circuit with an inverse class-E characteristic; a power supply circuit connected to the electromagnetic heating circuit so as to supply power to the electromagnetic heating circuit; and a drive circuit connected to the electromagnetic heating circuit so as to generate a drive signal. The electromagnetic heating circuit controls, based on a change of the drive signal, the heating element to atomize the aerosol-forming material.

Abstract: A thermal-power power electronic direct-hung energy-storage plant backup power system includes a thermal-power grid connection startup/standby unit, a power electronic energy-storage switching unit and a thermal-power plant unit. The thermal-power grid connection startup/standby unit is connected to the power electronic energy-storage switching unit and the thermal-power plant unit, respectively. The power electronic energy-storage switching unit is connected to the thermal-power plant unit.

Abstract: A chimeric compound for targeted degradation of androgen receptor protein, a preparation method therefor, and a medical use thereof. Specifically, the present invention relates to a spiro compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the spiro compound, and uses thereof as a therapeutic agent, in particular a use as an androgen receptor degradation agent and a use in the preparation of a drug for treating and/or preventing androgen receptor mediated or dependent diseases or conditions.

Abstract: The present application provides an information transmission method and device, storage medium and processor. The method includes: a network side transmits request configuration information of other system information to a terminal, the request configuration information of the other system information including a transmission configuration for request information of the other system information, the request information of the other system information being information transmitted to the network side when the terminal requests to acquire the other system information; and the network side transmits the other system information on the downlink transmission port indicated by the request information of the other system information.

Abstract: Provided are a display panel and a preparation method thereof, and a display device. The display panel includes a base substrate; a first transistor, a second transistor, a third transistor; and a pixel circuit supplying a drive current to a display element, and a driver circuit supplying a drive signal to the pixel circuit; where the driver circuit includes the first transistor, and the pixel circuit includes the second transistor and the third transistor; and the subthreshold swing of the first transistor is SS1, and the subthreshold swing of the second transistor is SS2, where SS1<SS2.

Abstract: The present disclosure relates to a nitrogen-containing tetracyclic compound, a preparation method therefor, and a medical use thereof. In particular, the present disclosure relates to the nitrogen-containing tetracyclic compound represented by general formula (IM), a preparation method therefor, a pharmaceutical composition containing said compound, the use thereof as a therapeutic agent, especially as a KRAS G12C inhibitor, and the use thereof in the preparation of medicaments for the treatment and/or prevention of tumors.

Abstract: Provided are a method and system for detecting an oil abrasive particle size. The method includes: acquiring a voltage signal of an oil abrasive particle in real time, where the voltage signal is generated in real time in a process that the oil abrasive particle passes through an electromagnetic abrasive particle sensor; establishing a voltage curve coordinate system with an amplitude of the voltage signal as a Y-axis and a time of the voltage signal as an X-axis, and obtaining a voltage curve; performing feature extraction on the voltage curve, and obtaining an area S defined by a voltage curve within a half voltage signal cycle T and the X-axis and a maximum absolute value A of a voltage signal value according to the voltage curve coordinate system; and inputting S and A to a trained back propagation neural network for prediction to obtain a predicted oil abrasive particle size.

Abstract: A display panel and a display device are disclosed. The display panel includes a first substrate, a second substrate, and a liquid crystal layer disposed therebetween. The first substrate includes a first base and a planarization layer disposed on a side of the first substrate adjacent to the liquid crystal layer. A side of the planarization layer adjacent to the liquid crystal layer includes a textured structure, which includes at least one groove path. The first substrate further includes a bottom edge. An extending direction of the at least one groove path forms an included angle with the bottom edge, the included angle being greater than or equal to 45 degrees and less than or equal to 135 degrees. A liquid crystal material in the liquid crystal layer diffuses along the extending direction of the groove path through the groove path based on capillary phenomenon.

Abstract: A thin film transistor, a manufacturing method thereof, a display substrate, and a display device are provided. The thin film transistor includes: a substrate, an active layer, a gate, a source and a drain. The active layer is arranged on the substrate and formed as a grid, including silicon nanowires extending along a first direction, the active layer includes source and drain regions oppositely arranged along the first direction, and a channel region located therebetween. The gate is arranged on the substrate, and an orthographic projection of the gate onto the substrate overlaps with orthographic projections for silicon nanowires in the channel region onto the substrate. The source and drain are arranged on the substrate, the source contacts silicon nanowires in the source region, and the drain contacts silicon nanowires in the drain region.

Abstract: The present disclosure provides a battery module, battery pack and vehicle. The battery module comprises: two battery blocks opposite each other, each of the battery blocks comprising a plurality of battery cells arranged along a first direction; and a circuit board disposed between the two battery blocks, the circuit board comprising a substrate and a plurality of electrical connectors passing through the substrate and arranged along the first direction, and the plurality of electrical connectors alternately connecting the plurality of battery cells of the two battery blocks in series; wherein each of the battery cells of one battery block is staggered and opposite to a corresponding battery cell of the other battery block, a tail-end electrode of a battery cell of the one battery block is aligned with a head-end electrode of a battery cell of the other battery block, and the tail-end electrode is connected to the head-end electrode by the electrical connector.

Abstract: A stop valve is provided. A stop valve includes a valve body, a valve core and a connecting block. The valve body is provided with a first opening and a second opening. The valve core is movable in the valve body to communicate the first opening with the second opening and cut off a communication therebetween. One end of the connecting block is located outside the valve body, the other end thereof is fixedly connected to an end of the valve body. A part of the valve core extends into the connecting block and is in threaded fit with the connecting block. The connecting block extends towards the valve body to define a seal portion along an axis of the valve core. When the stop valve is in a fully opened state, the valve core is capable of abutting against the seal portion and forming a linear seal therewith.

Abstract: A ratchet structure is provided. The ratchet structure comprises a housing having at least one pair of racks slidably overlapped with each other. Further, a cover coupled to the housing, having a cavity. Further, a ratchet gear detachably secured within the cavity, and comprising a plurality of elastic ribs having one or more grooves. Further, a knob having a plurality of driving ribs configured to be received within the one or more grooves of the plurality of elastic ribs. Therefore, the plurality of driving ribs facilitates the movement of the plurality of elastic ribs of the ratchet gear to slide the at least one pair of racks.

Abstract: Systems and methods for generating and processing modeling workflows are disclosed. In some examples, a reference distribution of scores generated by a model is determined. The reference distribution of scores is recorded in a structured database. One or more unexpected scores are detected during execution of the model. To detect the one or more unexpected scores, a production distribution of scores is compared with the reference distribution of scores recorded in the structured database. The production distribution of scores is generated by the model for a production input data set. An alert is then provided to an external system, when an alert condition is determined to be satisfied based on the comparison. The alert indicates detection of the one or more unexpected scores.

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Abstract: The present disclosure relates to a tetrahydronaphthalene compound, and a preparation method therefor and the use thereof in medicine. Specifically, the present disclosure relates to a tetrahydronaphthalene compound as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof as a therapeutic agent, in particular the use thereof as an estrogen receptor degrader, the use in the preparation of a drug for treating and/or preventing estrogen receptor-mediated or dependent diseases or conditions and the use in the preparation of a drug for treating and/or preventing diseases or conditions by means of degrading a target protein.

Abstract: Provided are an electron detection device and a scanning electron microscope. The electron detection device includes: a reflective energy analyzer including first and second control electrodes that are sequentially arranged in an incidence direction of an electron beam; a first detector disposed at a side of the second control electrode away from the first control electrode; a second detector disposed at a side of the first control electrode away from the second control electrode; and a conductive shielding tube penetrating the first and second control electrodes in the incidence direction and configured to shield an electric field generated by the reflective energy analyzer, allowing the electron beam to pass through and be incident on the target sample. First control electrode is configured to generate a first electric field between the first and second control electrodes. The first electric field is configured to guide the secondary electron to the first detector.

Abstract: This application provides a pre-connector and a communications device. The pre-connector includes a connector component and an outdoor component. The connector component includes a ferrule base and a ferrule that is slidable relative to the ferrule base. The ferrule base is configured to fasten the optical cable, and the ferrule is connected to an optical fiber that is of the optical cable and that is inserted into the ferrule base. In this way, the optical fiber can be connected to the communications device by using the ferrule. The outdoor component includes: a spindle that is sleeved on the ferrule base and that is fastened to the ferrule base; and a handle sleeve sleeved on the spindle. The outdoor component is used as a connecting piece to be detachably fastened and connected to the communications device, so as to provide a locking force used when the communications device is connected.

Abstract: Provided in the present disclosure is an antibody or fragment thereof against a human growth and differentiation factor 15 (GDF15). Further provided in the present disclosure is the use of the antibody or fragment thereof in the preparation of a drug for treating diseases or conditions. The antibody or fragment thereof provided in the present disclosure can bind to human GDF15 with high affinity and specificity, blocks the interaction of GDF15 with receptor GFRAL thereof, and has a longer half-life period in vivo in comparison with antibodies of the same kind.