Abstract: The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to largescale production of therapeutic molecules containing such variant Fc. Described herein are compositions and methods to improve glycosylation maturation of and to minimize the culture process-dependent effects of Fc-containing molecules, e.g., Fc-fusion molecules and antibodies. Creating single and multiple amino acid substitutions within the Fc domain with the aim to improve high mannose processing and glycosylation maturation.

Abstract: An indazole derivative, a preparation method therefor, and a pharmaceutical application thereof. In particular, the present invention relates to an indazole derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and a use of the derivative as an estrogen receptor modulator in the prevention and/or treatment of an estrogen receptor mediated or dependent disease or condition, the disease being particularly preferably breast cancer. The definition of each substituent in the general formula (I) is the same as that in the description.

Abstract: An ultrathin glass article has a thickness of less than or equal to 0.5 mm. The glass has a low TTV and a large threshold diffusivity. The glass has a working point T4 of more than 1100° C. and a linear thermal expansion coefficient CTE of more than 6*10-6/° C. in the temperature range between 25° C. and 300° C. A method for producing the article as well as the use of the article is also provided. The glass article can be chemically strengthened and forms surface compressive stress layers on surfaces and center tension layer in the center. The toughened ultrathin glass sheet is more flexible and has extraordinary thermal shock resistance which makes it easier to handle for processing.

Abstract: Disclosed is a method for preparing a benzofuran derivative. In particular, provided is a method for preparing a benzofuran derivative, wherein according to the method provided, reaction steps required to synthesize the benzofuran substance in the prior art can be effectively shortened.

Abstract: Provided are a thienoheterocyclic derivative, a preparation method therefor and the medical use thereof. In particular, provided are a thienoheterocyclic derivative represented by formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, the use of same as a therapeutic agent, particularly as an ERK inhibitor, and the use of same in the preparation of a drug for treating or preventing cancers, inflammation or other proliferative diseases, wherein each substituent of formula (I) is the same as defined in the description.

Abstract: The present application relates to a substituted fused bicyclic derivative, a preparation method therefor, and an application thereof in medicines. Specifically, the present application relates to a novel substituted fused bicyclic derivative as represented by formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, an application thereof as a therapeutic agent, in particular, as an ERK inhibitor, and an application thereof in preparation of medicines for treatment and/or prevention of cancer, inflammation, or other proliferative diseases, wherein the definitions of the substituents in formula (I) are the same as those in the description.

Abstract: A fume collecting assembly, a range hood, a side suction range hood, a range hood for two-sided fume collection and central air intake, a range hood with partition, and a central fume purification device are provided. The fume collecting assembly includes a fume collecting panel having curved recessed portion and an air deflector, which has curved protruding portion and is connected to the fume collecting panel, and the curved protruding portion is opposite the curved recessed portion, forming first air inlet and second air inlet spaced apart. The fume collecting panel includes a fume collecting port for discharging fumes into a duct of range hood. The first air inlet and the second air inlet both communicate with the fume collecting port. The range hood, the side suction range hood, the range hood for two-sided fume collection and central air intake, and the range hood with partition include the fume collecting assembly.

Abstract: The present application provides a pyrroloheterocyclic derivative, a preparation method therefor, and an application thereof in medicine. Specifically, the present application provides a novel pyrroloheterocyclic derivative as represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and an application of the derivative as a therapeutic agent, particularly as an ERK inhibitor, wherein substituents in the formula have the same definitions as those in the description.

Abstract: Described herein is a method of producing a drimane sesquiterpene, such as an albicanol compound and/or derivatives thereof, by contacting at least one polypeptide with farnesyl diphosphate (FPP) with a polypeptide of the Haloacid dehalogenase-like (HAD-like) hydrolase superfamily as obtainable from plants of the genus Dryopteris, in particular of the species Dryopteris fragrans. The method may be performed in vitro or in vivo. Also described herein are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. Also described herein are host cells or organisms genetically modified to express the polypeptides and useful to produce a drimane sesquiterpene such as an albicanol compound.

Abstract: Specifically, the present invention relates to the 6-oxo-1,6-dihydropyridazine prodrug derivative shown in general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, a use thereof as a NaV inhibitor, and a use thereof in the preparation of a drug for the treatment and/or prevention of pain and pain-related diseases.

Abstract: This application discloses CD73 inhibitors represented by the general formula (I) and analogs thereof, pharmaceutical compositions containing these compounds, methods of preparing them, and use of these compounds as therapeutic agents for the treatment of diseases or conditions associated with CD73 activity, such as various cancers.

Abstract: A heteroaryl[4,3-c]pyrimidin-5-amine derivative, a preparation method therefor, and medical uses thereof are provided. Specifically, a heteroaryl[4,3-c]pyrimidin-5-amine derivative of formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and uses thereof as therapeutic agents are provided. In particular, the provided compounds can be used as A2a receptor antagonists and for treatment of conditions or symptoms that are ameliorated by inhibiting the A2a receptor. The various substituent groups in the formula (I) have the meanings as described in the specification.

Abstract: The present invention provides a crystal form of a 1,2,3-triazolo[1,5-a]pyrazines derivative and a preparation method for the crystal form. Specifically, the present invention provides a crystal form of a compound (S)-N5-(3,4-difluorophenyl)-6-methyl-N3-((R)-1,1,1-trifluoropropan-2-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-c]pyrazine-3,5(4H)-dimethylformamide and a preparation method for the crystal form. The prepared crystal form has good stability and clinical application value.

Abstract: A 6-oxo-1,6-dihydropyridazine derivative, a preparation method therefor and medical use thereof, in particular, a 6-oxo-1,6-dihydropyridazine derivative represented by general formula (I), a preparation method therefor, and a pharmaceutical composition containing the derivative, and use thereof as a Nav inhibitor and use thereof in the preparation of a drug for the treatment and/or prevention of pain and pain-related diseases. Each substituent in general formula (I) is the same as defined in the description.

Abstract: A method for producing a structured glass disk is provided that includes the steps of: providing a glass disk having a thickness of at most 400 ?m; directing and focusing a laser beam onto the glass disk such that the laser beam produces an elongated focus within the glass disk with an intensity sufficient to produce damage within the glass disk along the elongated focus; moving the laser beam and the glass disk relative to one another to insert damage zones along a ring-shaped path so that a workpiece is defined in the glass disk with the ring-shaped path encompassing the workpiece and with the workpiece remaining connected to the glass disc; exposing the glass disk to an etchant so that the etchant intrudes into the damage zones; and chemically toughening the glass disk with the workpiece.

Abstract: Compounds of formula (I) useful as agonists of stimulator of interferon genes (STING), the preparation method therefor, pharmaceutical compositions comprising the compounds, and the pharmaceutical uses for the treatment of STING-mediated diseases or disorders are disclosed.

Abstract: The present disclosure relates to bendable elements. The bendable elements can be used in display covers for electronic devices such as smart phones. The elements have reduced delayed elastic deformation or creep when released from the influence of persistent mechanical stresses, e.g. unfolded from a folded position. The present disclosure also relates to covers for color filters, filter printed electronics, sensors for touch control panels, fingerprint sensors, mobile electronic devices, bendable/foldable displays that include the bendable elements as substrates, or other applications where a combination of high chemical stability, temperature stability, low gas permeability, flexibility, high strength, low thickness and premium cosmetic appearance is necessary. Besides consumer and industrial electronics the present disclosure could also be used for protection applications in industrial production or metrology.

Abstract: The present invention relates to a piperazine heteroaryl derivative, a preparation method therefor and the use of same in medicine. In particular, the present invention relates to the piperazine heteroaryl derivative as shown in the general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and the use of same as a capsid protein inhibitor, in particular in the prevention and/or treatment of diseases such as hepatitis B, influenza, herpes, AIDS, etc. The definitions of each group in the general formula (I) are the same as those defined in the description.

Abstract: The present invention relates to an indole macrocyclic derivative, a preparation method therefor and an application thereof in medicine. Specifically, the present invention relates to an indole macrocyclic derivative represented by general formula (IM), a preparation method therefor, a pharmaceutical composition containing the derivative, and a use thereof as a therapeutic agent, especially as an MCL-1 inhibitor. Each substituent of general formula (IM) is the same as those defined in the description.

Abstract: Technical solutions for video event recognition relate to the fields of knowledge graphs, deep learning and computer vision. A video event graph is constructed, and each event in the video event graph includes: M argument roles of the event and respective arguments of the argument roles, with M being a positive integer greater than one. For a to-be-recognized video, respective arguments of the M argument roles of a to-be-recognized event corresponding to the video are acquired. According to the arguments acquired, an event is selected from the video event graph as a recognized event corresponding to the video.