Abstract: The present disclosure provides a pharmaceutical composition of fused tricyclic gamma-amino acid derivatives and the use thereof. The pharmaceutical composition includes: (i) a compound having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof, as an active material, in an amount of 1% to 45% by weight; (ii) optionally one or more fillers in an amount of 50% to 95% by weight; (iii) optionally one or more lubricating agents in an amount of 0.1% to 5.5% by weight; and the sum of weight percentages of the all components is 100%, wherein the pharmaceutically acceptable salt of the compound of formula (I) has a structure as follows.

Abstract: The present invention is directed to 4?-substituted nucleoside derivatives of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC. The present invention also provides processes for the preparation of 4?-substituted nucleoside derivatives of Formula I and derivatives thereof.

Abstract: Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-iso-propyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one embodiment, the overall yield from the starting material 2-isopropylphenol to Compound A citrate salt is greater than 50%. In another embodiment, the overall yield is greater than 60%. Also disclosed herein are novel salts and solvates of Compound A.

Abstract: A lid body for a pressure cooker includes a pot lid, an inner lid mounted at an outer side of the pot lid, a top lid mounted at an outer side of the inner lid, and a solenoid exhaust valve. The pot lid includes a mounting cavity and a limiting rib protruding inward from a side wall of the mounting cavity. The solenoid exhaust valve includes a valve seat mounted in the mounting cavity and including a mounting hole, a valve core inserted in the mounting hole, and a valve cover matingly connected with a top of the valve core and being movable with respect to the valve core. A bottom end of the valve seat abuts against an upper end face of the limiting rib, and a lower end face of the limiting rib abuts against the pot lid or the inner lid.

Abstract: Disclosed is a continuous process for the purification of steviol glycosides extracted from the dried stevia leaves using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.

Abstract: A forming method for curved glass has been provided. The method comprises: placing a flat glass plate in a pattern die, and placing the pattern die in a forming apparatus; and subjecting the pattern die successively to staged heating, staged forming and staged cooling, so as to obtain the curved glass, wherein the staged heating is performed over stages which are different from each other in temperature, the staged forming is performed over stages which are different from each other in temperature, and during at least one of the stages, a varying pressure which varies from low pressure to high pressure is applied to the pattern die, the staged cooling is performed by cooling the glass plate in the pattern die over stages which are different from each other in temperature. The glass product could be used as front and rear covers of electronic products including notebook computers, mobile phones, tablet computers and smart watches.

Abstract: A lid body and a cooker. The lid body is provided with a lid body wireless transmission device. The lid body wireless transmission device comprises a circuit board (3). The lid body is provided with a mounting cavity (21) for mounting the circuit board (3), one side of the mounting cavity (21) being open. The circuit board (3) is fixedly mounted in the mounting cavity (21); moreover, the mounting cavity (21) is potted by means of a potting adhesive and the opening is sealed. The circuit board (3) is potted in the mounting cavity (21) by means of the potting adhesive, so that the circuit board (3) is completely isolated from a cavity in the lid body to ensure that the circuit board (3) does not contact high-temperature steam in the lid body, thereby preventing the occurrence of excessive temperature rise of a component due to that the circuit board (3) contacts high-temperature steam and the occurrence of damages to the circuit board (3).

Abstract: The present invention discloses a method for preparing ?-caprolactone. The method comprises the steps of: adding cyclohexanone, a co-oxidant and a certain amount of catalyst into a certain amount of organic solvent, using molecular oxygen as an oxidant, implementing a reaction with stirring for 0.1 to 24 hours under a pressure of 0.1 to 2 MPa and at a temperature of 60° C. to 100° C., wherein the co-oxidant is acrolein, and the catalyst is a carbon material. The present invention has the advantages of high-efficiency co-oxidant, easily available and recovered catalyst, environmental-friendly oxidant, simple operation and low cost.

Abstract: The present disclosure provides a float valve motion detection device, a pot cover assembly and a pressure cooking appliance, the float valve motion detection device comprising: a float valve, a hollow inductance coil (3) and a detection circuit. A valve core (2) of the float valve is made of materials having permeability unequal to that of air. When the valve core (2) is pushed by the pressure in a pot from a first position to a second position, the volume of the valve core (2) in the hollow inductance coil (3) changes, which changes the inductance of the hollow inductance coil (3). A detection circuit determines the position of the valve core (2) by means of detecting the change in the inductance of the hollow inductance coil (3) so as to determine whether it is safe to uncover at the current time.

Abstract: Provided are a polymer containing S,S-dioxide-dibenzothiophene in backbone chain with content-adjustable triarylamine end groups, and a preparation method and an application thereof. Triarylamines hole-transport small molecules are introduced into the polymer end group, and a content of the triarylamine end groups can be adjusted by controlling a polymer molecular weight, so that the polymer has better electron-transport and hole-transport capabilities, and charge carrier transport can be balanced, so that more exciton recombination takes place effectively, thus improving the luminous efficiency and stability of the polymer. The polymer is prepared by a Suzuki polymerization reaction and does not require synthesis of new monomers. The polymer material is used for preparing highly effective and stable monolayer devices, and is dissolved directly in an organic solvent, then spin-coated, ink-jet printed, or printed to form a film.

Abstract: A system for managing online group chat and methods for making and using same. A server computer can create a topic in a chat group and receive a request from a user device for a member of the chat group to join the topic. The request can be in response to activation of a user interface for the topic on the user device. The member can be permitted in real time to join a topic subgroup associated with the topic upon determination that a membership of the topic subgroup is less than a maximum participant number. The maximum participant number can be at least partially based on a messaging service capacity of the server. A publish-subscribe messaging service can be offered for the topic subgroup. Advantageously, the topic subgroup can be dynamically updated based on operation on the user device to reduce server workload and improve user experience.

Abstract: Disclosed is a split-type electric pressure cooker. The cooker comprises a cooker body and a cooker lid, the cooker body being provided with a power supply device. The split-type electric pressure cooker further comprises: a mechanical vent valve, comprising a valve seat and a valve cover, wherein the valve seat is fixedly mounted on the cooker lid, and the valve cover can be movably mounted on the valve seat; a power transmitting device mounted on the cooker body and able to be electrically connected to the power supply device; a power receiving device mounted on the cooker lid; and a motor driving device mounted on the cooker lid and electrically connected to the power receiving device, the motor driving device being used for driving the valve cover to move so as to open or close the mechanical vent valve. With the cooperation of the power transmitting device and the power receiving device, the power transmission is realized between the cooker body and the cooker lid.

Abstract: A device for detecting thickness and thickness variation of a sheetlike object, includes at least a first guiding component, a plurality of second guiding components, a plurality of detection units and a position sensor. An up-down displacement occurs between the first guiding component and the second guiding components while the sheetlike object passed through the first guiding component and those second guiding components. The detection units are configured relatively to second guiding components, each of the detection units further comprises a detecting block, a first elastic member, a second elastic member and a fixing member, the first elastic member and a second elastic member connect with the second guiding component via the detecting block, while the displacement occurs at the second guiding component, a sensing face to detected of the first elastic member is having a parallel displacement relative to the position sensor.

Abstract: Provided is a method for detecting respirable participles in a bulk material comprising particles. The method comprises: analyzing morphology of the particles; analyzing chemical composition of the particles; creating a profile of the particles, wherein each particle in the profile is characterized by its shape, size and chemical composition; selecting particles from the profile which match the size and chemical composition of a respirable particle; and calculating a percentage of the respirable particles in the bulk material.

Abstract: The present invention discloses a method for preparing ?-caprolactone. The method comprises the steps of: adding cyclohexanone, a co-oxidant and a certain amount of catalyst into a certain amount of organic solvent, using molecular oxygen as an oxidant, implementing a reaction with stirring for 0.1 to 24 hours under a pressure of 0.1 to 2 MPa and at a temperature of 60° C. to 100° C., wherein the co-oxidant is acrolein, and the catalyst is a carbon material. The present invention has the advantages of high-efficiency co-oxidant, easily available and recovered catalyst, environmental-friendly oxidant, simple operation and low cost.

Abstract: This disclosure provides a package substrate and its fabrication method. The package substrate comprises: a first dielectric material layer have an opening; a first conductive unit including a first part in the opening of the first dielectric material layer and a second part on the first dielectric material layer; and a second dielectric material layer covering the first conductive unit and the first dielectric material layer; wherein a height of the first conductive unit is larger than a thickness of the first dielectric material layer; wherein a cross-section of the second part is larger than that of the first part in the first conductive unit.

Abstract: Disclosed is a continuous process for the purification of steviol glycosides extracted from the dried stevia leaves using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.

Abstract: A method, including determining a length of a to-be-downloaded streaming media file fragment, splitting the to-be-downloaded streaming media file fragment into at least two subfragments when the length of the to-be-downloaded streaming media file fragment is greater than a preset length, where a length of each subfragment is not greater than the preset length, and separately downloading each subfragment. The to-be-downloaded streaming media file fragment is split based on the preset length and the subfragments obtained after splitting are downloaded in parallel when a network environment is relatively poor and the to-be-downloaded streaming media file fragment is relatively long.

Abstract: Disclosed is a continuous process for the purification of steviol glycosides extracted from the dried stevia leaves using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.