Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

Abstract: A stamped part includes a first blank, a second blank, and a weld joining the first blank to the second blank. The weld includes opposing ends. At least one of the opposing ends of the weld is recessed from adjacent edges of the first and second blanks.

Abstract: The embodiment of the present invention discloses an anti-drowning safety alarm method and device for swimming pools. Acquiring images taken by multiple cameras; inputting the images into a target detection model to detect human bodies and heads, so as to obtain human body target detection boxes and human head target detection boxes; calculating the relationship between the human heads and the human bodies according to these boxes; performing multi-camera fusion on the human body target detection boxes and the human head target detection boxes to obtain the human body boxes and head boxes; determining the relative position relationship between the human bodies or the human heads and the water surface; calculating the correlation between the bounding box sequence at the current moment and that at the previous moment to obtain the human tracking trajectory; updating the state database; generating alarm information according to the state database.

Abstract: Protection of a kernel from a sniff and code reuse attack. A kernel mode page table in initialized in a kernel. The kernel page entries in the kernel mode page table are set from s-pages to u-pages. Supervisor mode access prevention is enabled in the u-pages. Code contained in the kernel page entries in the u-pages is executed, the kernel page entries in the u-pages are capable of execution but are not capable of being accessed and read directly.

Abstract: The disclosure provides for compounds and methods for modulating or inhibiting glutaminyl-peptide cyclotransferase-like protein (QPCTL). In one aspect, described herein are compounds of Formulas (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), and (IIbb), stereoisomer thereof, or salts or solvates thereof. Further provided herein are methods of treating a disease or a condition comprising administering a compound of Formula (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), or (IIbb), a stereoisomer thereof, or a salt or solvate thereof.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.

Abstract: The present application relates to a field of smart searching technology, and provides a method and an apparatus for searching a multimedia content, a device, and a storage medium. The method includes: acquiring a query vector of query information; determining, from a search library, a first category matching the query vector, wherein the search library comprises a plurality of categories, each of the categories comprises a plurality of vectors, and each of the vectors is associated with a corresponding multimedia content; and inquiring, in the first category, a target vector matching the query vector, and acquiring the multimedia content corresponding to the target vector.

Abstract: A method of forming a stamped part includes forming a tailor welded blank by friction stir welding (FSW) a first blank to a second blank, removing a FSW start spot and a FSW stop spot from the tailor welded blank using a machining process such that a finished tailor welded blank is formed and stamping the finished tailor welded blank into the stamped part such that a weld formed by FSW the first blank to the second blank is plastically deformed. The first blank and the second blank can be aluminum alloy blanks and a predetermined amount of material is machined from the FSW start spot and the FSW stop spot, the predetermined amount of material being equal to or greater than a thickness of the first blank and the second blank.

Abstract: According to embodiments of the present disclosure, there is provided a method, system, apparatus, electronic device, storage medium and program product for data exchange. The method described herein comprises: obtaining original data to be exchanged by a target application between a first platform and a second platform; obtaining normalized data corresponding to a type of the original data by processing the original data based on the type; determining a satisfaction of a data exchange constraint from the normalized data. In this way, the embodiments of the present disclosure may simplify and promote the determination of the data exchange constraint and accelerate the data exchange process.

Abstract: A novel type of pyrrolopyrazole derivatives shown in general formula (I), a preparation method thereof and application thereof or a pharmaceutical composition containing same as a therapeutic agent, particularly as a gastric acid secretion inhibitor and a potassium-competitive acid blocker (P-CABs) in biomedicine.

Abstract: A forming die includes a first die component with a male bead and a second die component with a female bead. The male bead and the female bead form a bead with a reverse bead geometry with the male bead having a groove and the female bead having a protrusion complimentary with the groove such that the protrusion is aligned with the groove when the male bead extends into the female bead. The male bead includes a push surface, a pair of sidewalls extending from the push surface to a main surface of the first die component, and the groove extends inwardly into the rib. And the female bead includes a stop surface and a pair of sidewalls extending from the stop surface to a main surface of the second die component, and the protrusion extends outwardly from the stop surface into the female bead.

Abstract: A method of quenching a press hardenable steel (PHS) is provided. The method includes preparing a die having a material with a thermal conductivity of at least 40W/(m·K) and placing a blank within the die and simultaneously hot stamping and quenching the blank at a heat transfer coefficient of at least 2,950W/(m2·K). In one form, the step of hot stamping the blank is carried out with greater than 20 MPa of contact pressure between the die and the blank. In another form, the step of hot stamping the blank is carried out with 31 MPa of contact pressure between the die and the blank.

Abstract: Disclosed are a pyrrolopyrazole derivative, a preparation method therefor, and the medical use thereof. In particular, disclosed are a novel class of pyrrolopyrazole derivatives represented by general formula (I), a preparation method therefor, and the use of the pyrrolopyrazole derivatives or pharmaceutical compositions containing the pyrrolopyrazole derivatives in biomedicine as therapeutic agents, particularly as gastric acid secretion inhibitors and potassium ion competitive acid blochers (P-CABs). The definitions of various substituent (R1, R2, R3, R4) and the group (X) in general formula (I) are the same as the definitions in the description.

Abstract: The present invention relates to pyrrolo-pyrazol derivatives, a preparation method thereof and application thereof in medicine, and particularly to a novel category of pyrrolo-pyrazol derinatives respesented by formula (I), a preparation method thereof and a bio-pharmaceutical use thereof or of pharmaceutical compositions containing the same as therapeutic agents, especially as gastric acid secretion inhibitors and potassium-competitive acid blockers (P-CABs). Substituent groups (Ar and R1) in formula(I) are defined identically as in description.

Abstract: The present invention relates to pyrrolo-pyrazol derivatives, a preparation method thereof and application thereof in medicine, and particularly to a novel category of pyrrolo-pyrazol derivatives represented by formula (I), a preparation method thereof and a bio-pharmaceutical use thereof or of pharmaceutical compositions containing the same as therapeutic agents, especially as gastric acid secretion inhibitors and potassium-competitive acid blockers (P-CABs).

Abstract: A class of pyrrolopyrazole derivatives represented by general formula (I), a preparation method thereof, and the applications of said derivatives or of pharmaceutical compositions containing said class of derivatives as therapeutic agents, especially the application as gastric acid secretion inhibitors and potassium ion competitive acid blockers (P-CABs) in biomedicine.

Abstract: Techniques for virtual machines include receiving virtual machine (VM) requests, and finding one or more VM requests of the VM requests that optimize available resources of a candidate host machine while seeking to minimize differences between the one or more VM requests and the candidate host machine. The one or more VM requests are allocated to the candidate host machine.

Abstract: Techniques for virtual machines include receiving virtual machine (VM) requests, and finding one or more VM requests of the VM requests that optimize available resources of a candidate host machine while seeking to minimize differences between the one or more VM requests and the candidate host machine. The one or more VM requests are allocated to the candidate host machine.