Abstract: Techniques for virtual machines include receiving virtual machine (VM) requests, and finding one or more VM requests of the VM requests that optimize available resources of a candidate host machine while seeking to minimize differences between the one or more VM requests and the candidate host machine. The one or more VM requests are allocated to the candidate host machine.

Abstract: Techniques for virtual machines include receiving virtual machine (VM) requests, and finding one or more VM requests of the VM requests that optimize available resources of a candidate host machine while seeking to minimize differences between the one or more VM requests and the candidate host machine. The one or more VM requests are allocated to the candidate host machine.

Abstract: A method of forming a stamped part includes forming a tailor welded blank by friction stir welding (FSW) a first blank to a second blank, removing a FSW start spot and a FSW stop spot from the tailor welded blank using a machining process such that a finished tailor welded blank is formed and stamping the finished tailor welded blank into the stamped part such that a weld formed by FSW the first blank to the second blank is plastically deformed. The first blank and the second blank can be aluminum alloy blanks and a predetermined amount of material is machined from the FSW start spot and the FSW stop spot, the predetermined amount of material being equal to or greater than a thickness of the first blank and the second blank.

Abstract: The present application relates to a field of smart searching technology, and provides a method and an apparatus for searching a multimedia content, a device, and a storage medium. The method includes: acquiring a query vector of query information; determining, from a search library, a first category matching the query vector, wherein the search library comprises a plurality of categories, each of the categories comprises a plurality of vectors, and each of the vectors is associated with a corresponding multimedia content; and inquiring, in the first category, a target vector matching the query vector, and acquiring the multimedia content corresponding to the target vector.

Abstract: Compounds of Formula (I) or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising these compounds, the use of these compounds and compositions in the treatment of diseases in which LRRK-2 kinase is involved.

Abstract: Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Disclosed are substituted fused pyrazoles, for example substituted indazoles, that inhibit LRRK2 kinase activity, pharmaceutical compositions containing them and their use in the treatment of Parkinson's disease.

Abstract: A method of evaluating a sheet metal stamping simulation is provided. The method may include defining elements of a finite-element mesh representing a stamped panel, operating on the elements to simulate deformation of the panel during stamping to generate, for each of the elements, incremental differential major and minor plastic strain values, applying a weighting factor to temporally adjacent pairs of the values to generate smoothed values, deriving, from the smoothed values and for each of the elements, a plurality of plastic strain incremental ratios representing plastic flow direction of the elements during the deformation, and altering colors of a map based on the ratios to represent changes in severity of plastic deformation of the stamped panel.

Abstract: The present invention relates to novel compounds that inhibit LRRK2 kinase activity, to processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Dies for forming components, such as sheet components, and methods of producing the dies are disclosed. The die may include a bulk material and a forming surface. A solid conductor may be formed in the bulk material. The solid conductor may be spaced from and extend adjacent to the forming surface and have a melting point that is greater than a melting point of the bulk material. The solid conductor may be configured to absorb heat from the forming surface. There may multiple solid conductors within the bulk material, for example spaced apart and extending along an axis. The solid conductor may be a bundle of carbon fibers, which may be pitch-based. The solid conductor may be conformal to the forming surface, for example, having a constant spacing therefrom. The solid conductor may be cast-in to the die during its production.

Abstract: A resistance regulating device for a wheel of a training device is disclosed. The resistance regulating device comprises a rotary mechanism pivotally connected with a stationary mechanism and a motor with other components to rotate the rotary mechanism and hence a distance between magnets of the rotary mechanism and the wheel is changed. In addition, an optical detection device may be used to detect and define a minimum resistance and a maximum resistance and hence to adjust a resistance in a stepless manner. An emergency brake mechanism may be further employed.

Abstract: Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: The present invention provides novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Compounds of Formula (I) or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising these compounds, the use of these compounds and compositions in the treatment of diseases in which LRRK-2 kinase is involved.

Abstract: A method of quenching a press hardenable steel (PHS) is provided. The method includes preparing a die having a material with a thermal conductivity of at least 40W/(m·K) and placing a blank within the die and simultaneously hot stamping and quenching the blank at a heat transfer coefficient of at least 2,950W/(m2·K). In one form, the step of hot stamping the blank is carried out with greater than 20 MPa of contact pressure between the die and the blank. In another form, the step of hot stamping the blank is carried out with 31 MPa of contact pressure between the die and the blank.

Abstract: A resistance regulating device for a wheel of a training device is disclosed. The resistance regulating device comprises a rotary mechanism pivotally connected with a stationary mechanism and a motor with other components to rotate the rotary mechanism and hence a distance between magnets of the rotary mechanism and the wheel is changed. In addition, an optical detection device may be used to detect and define a minimum resistance and a maximum resistance and hence to adjust a resistance in a stepless manner An emergency brake mechanism may be further employed.

Abstract: A method of evaluating a sheet metal stamping simulation is provided. The method may include defining elements of a finite-element mesh representing a stamped panel, operating on the elements to simulate deformation of the panel during stamping to generate, for each of the elements, incremental differential major and minor plastic strain values, applying a weighting factor to temporally adjacent pairs of the values to generate smoothed values, deriving, from the smoothed values and for each of the elements, a plurality of plastic strain incremental ratios representing plastic flow direction of the elements during the deformation, and altering colors of a map based on the ratios to represent changes in severity of plastic deformation of the stamped panel.