Abstract: The stamping of a metal sheet within a stamping die is simulated. The die includes a drawbead running perpendicular to a draw direction. A plurality of successive states are generated for iteratively representing the metal sheet from a blank shape to a final stamped shape. The drawbead is represented as a two-dimensional flat band within a model of the stamping die. Forces acting on the metal sheet are calculated at each successive state to define a next successive state. The calculating step includes a restraining force of the drawbead acting on the metal sheet calculated in response to a predetermined function of a length of the metal sheet engaged in the flat band in respective states. The particular width and location of the flat band achieve improved accuracy of estimating the restraining force.

Abstract: The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

Abstract: A system and method for incrementally forming a workpiece. A first manipulator is configured to move a first tool in multiple directions along a first surface of a workpiece. A second manipulator is configured to move a second tool in multiple directions along a second surface of the workpiece. The first and second tools move along first and second predetermined paths of motion and exert force to form the workpiece.

Abstract: Oxadiazole substituted indazole derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.

Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: 1,2,4-Oxadiazol derivatives represented by formula (I) useful as sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated via S1P1 receptor are disclosed.

Abstract: 5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.

Abstract: 5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.

Abstract: Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptor are disclosed.

Abstract: A method of incrementally forming a workpiece. The method may include incrementally forming a stiffening feature on the workpiece and incrementally forming a part on the workpiece. A gap between forming tools may be decreased to reform the part.

Abstract: A method of incrementally forming a workpiece. The method includes incrementally forming a first monotonic wrap surface in a first direction and incrementally forming a second wrap surface in a second direction disposed opposite the first direction.

Abstract: The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof; where R1-R5, Y, m, n, and p are defined herein. Compounds and compositions of the present invention are useful the treatment of atherosclerosis.

Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: A system and method for incrementally forming a workpiece. A first manipulator is configured to move a first tool in multiple directions along a first surface of a workpiece. A second manipulator is configured to move a second tool in multiple directions along a second surface of the workpiece. The first and second tools move along first and second predetermined paths of motion and exert force to form the workpiece.

Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: A method for simulating a hydroforming process includes modeling a virtual hydroforming die and a virtual tubular workpiece. The virtual workpiece is placed within the die after the die has been expanded. The die is then contracted to a finished size while the workpiece is deformed into a non-circular cross section in contact with the virtual die. The workpiece is subsequently pressurized to simulate production of a finished part.

Abstract: A method for determining compensated addendum and binder surfaces as part of a springback compensated stamping die for producing a stamped part includes modeling of the existing addendum surface and binder surface of the stamping die. The addendum and binder surfaces are modified according to a number of compensatory surface displacements and in-plane rotations required for springback compensation of the finished stamped part. Following this modification, the stamped part may be separated from the addendum and binder without a loss of dimensional accuracy.