Abstract: The present disclosure relates to a bisphenol A preparation process and device thereof. Each stage of reaction system includes a cooler and reactors, each with four sections, the reactors are filled with bisphenol A synthetic resin catalysts before startup operation, and filling proportions of the catalysts are as follows: ? of the catalysts for the first-section reactor, ? for the second-section reactor, the full amount for the third-section reactor and the full amount for the fourth-section reactor. The three reactors operate in series connection through valves, the reactor with the deactivated catalyst is cut out and the reactor to be used is cut in to maintain the three reactors operating in series every time the system operates ? of the service life of the catalyst, and the process can provide a larger air speed, which is beneficial to eliminating the influence of external diffusion, thereby obtaining higher product benefits.

Abstract: The present disclosure relates to a bisphenol A preparation process and device thereof. Each stage of reaction system includes a cooler and reactors, each with four sections, the reactors are filled with bisphenol A synthetic resin catalysts before startup operation, and filling proportions of the catalysts are as follows: ? of the catalysts for the first-section reactor, ? for the second-section reactor, the full amount for the third-section reactor and the full amount for the fourth-section reactor. The three reactors operate in series connection through valves, the reactor with the deactivated catalyst is cut out and the reactor to be used is cut in to maintain the three reactors operating in series every time the system operates ? of the service life of the catalyst, and the process can provide a larger air speed, which is beneficial to eliminating the influence of external diffusion, thereby obtaining higher product benefits.

Abstract: A compressor for an aircraft engine. A rotor includes blades rotatable about an axis. Blade tips extend between leading and trailing edges. A shroud surrounds the rotor, with an inner surface surrounding the tips. Grooves are defined in the shroud inner surface adjacent the tips. The grooves extend circumferentially about the shroud and radially from inlet openings to closed end surfaces. Groove sidewalls extend circumferentially about the axis. The grooves are axially spaced-apart, the most upstream inlet opening having an upstream end disposed upstream of the leading edges of the blades. The grooves have a swept angle from the inner surface, with a center of the inlet openings is axially offset of a center of the closed-end surfaces. The grooves span an overall axial distance corresponding to 30% or more of the blades' chord length. The grooves have circumferential interruptions defined by baffles, and extend non-continuously around a shroud circumference.

Abstract: Provided herein is a class of a rapidly metabolized lipid compound, and particularly relates to compounds represented by formula (I?), or pharmaceutically acceptable salts, isotopic variants, tautomers, or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids.

Abstract: A jet polishing device capable of stably forming a Gaussian removal function includes: an auxiliary mounting mechanism; a jet machining mechanism. The jet machining mechanism is connected with the auxiliary mounting mechanism, the jet machining mechanism includes a rotation driving assembly, a positioning assembly and a jet machining assembly, the positioning assembly includes a linear guide rail, a slide mass, a first laser and a second laser, the rotation driving assembly is connected with the linear guide rail, the slide mass is slidably connected to the linear guide rail, the first laser is fixedly arranged relative to the linear guide rail, the jet machining assembly includes a mounting bracket fixedly connected with the slide mass, a nozzle mounting body rotatably connected to the mounting bracket and a nozzle arranged on the nozzle mounting body, and the second laser is connected with the nozzle mounting body.

Abstract: The present disclosure relates to a production process and device for synthesizing bisphenol A by a resin method, including a condensation reaction unit for performing a catalytic condensation reaction between phenol and acetone to generate bisphenol A, a first-stage adduct crystallization unit for mixing a concentrated solution with adduct crystals recycled after melting and then performing adduct crystallization, a liquid-phase dephenolization unit for melting an adduct to yield a bisphenol A product, a secondary adduct crystallization unit for recycling phenol and bisphenol A from a mother solution, a solvent recycling unit for recycling unreacted phenol and unreacted acetone, and discharging phenol-containing process water for sewage treatment, and a cracking and rearrangement unit for recycling the phenol from the mother solution, and convert bisphenol A, 2,4-bisphenol A and the like therein in the mother solution into the bisphenol A.

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

Abstract: Provided are an endovascular-stent-based electrode array, a method for manufacturing the same, and an electrical stimulation system. The endovascular-stent-based electrode array includes a stent woven from stent woven wires. The stent woven wires include at least one first metal woven wire, each respective first metal woven wire includes an insulated segment and a conductive segment axially arranged, the insulated segment is electrically insulated from other stent woven wires and a human tissue, and the conductive segment is configured to perform at least one of: delivering a stimulation pulse to a nerve surrounding the human tissue, and sensing an electrical signal from the nerve surrounding the human tissue. A proximal end of the respective first metal woven wire is configured to be electrically connected to an external device, and a distal terminal end of the respective first metal woven wire is electrically insulated from the human tissue.

Abstract: Provided herein is a class of a rapidly metabolized lipid compound, and particularly relates to compounds represented by formula (I), or pharmaceutically acceptable salts, isotopic variants, tautomers, or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids.

Abstract: A system may receive, from a first user device, a request to create an account for an application that monitors a second user device, and may receive an indication that the second user device is not associated with an account. The system may cause an account to be created for the second user device, and may provide, to the first user device, an indication that the account is created. The system may receive, from the first user device, a request to associate the second user device with the account, and may receive an indication that the second user device is eligible for the account. The system may receive, from the first user device, a request to onboard the second user device for the account, and may onboard the second user device for the account. The system may perform actions based on the second user device being onboarded.

Abstract: A system may receive, from a first user device, a request to create an account for an application that monitors a second user device, and may receive an indication that the second user device is not associated with an account. The system may cause an account to be created for the second user device, and may provide, to the first user device, an indication that the account is created. The system may receive, from the first user device, a request to associate the second user device with the account, and may receive an indication that the second user device is eligible for the account. The system may receive, from the first user device, a request to onboard the second user device for the account, and may onboard the second user device for the account. The system may perform actions based on the second user device being onboarded.

Abstract: A method of making an electrical connector includes the steps of: molding a first insulator and a separate second insulator with an upper row of contacts and molding an insulator with a lower row of contacts, respectively; bending the upper row of contacts along a region thereof situated between the first insulator and the separate second insulator; bending the lower row of contacts; securing the first insulator and the separate second insulator to the insulator molded with the lower row of contacts; and molding an insulator with the upper and the lower rows of contacts while exposing respective upper and lower contacting portions of the upper and the lower rows of contacts.

Abstract: Provided compounds of Formula I and I?, pharmaceutical compositions comprising the compounds, and methods of using the same, in treating, for example, the diseases, disorders, or conditions mediated by the degradation of a protein kinase, such as Hematopoietic progenitor kinase 1 (HPK1).

Abstract: The present disclosure provides compounds of Formula I?, compositions comprising the compound of Formula I?, and methods of using the same, in treating diseases, disorders, or conditions mediated by the inhibition of certain kinases, such as hematopoietic progenitor kinase 1 (HPK1) and/or Fms related receptor tyrosine kinases (FLTs), such as FLT3.

Abstract: The disclosure relates to a permanent magnet-electromagnet hybrid array type magnetorheological polishing device, comprising a polishing mechanism, a main excitation device arranged on the polishing mechanism, and auxiliary permanent magnet sets used for driving magnetorheological liquid to be recycled. The main excitation device is a permanent magnet-electromagnet hybrid array comprising main excitation permanent magnets and fine-adjustment electromagnetic excitation devices connected with the main excitation permanent magnets. Each fine-adjustment electromagnetic excitation device comprises a coil and a coil retaining pile. The main excitation device further comprises a permanent magnet-electromagnet device connecting plate made from a non-magnetically conductive material.

Abstract: The present application provides novel fusion proteins for dephosphorylating proteins that regulate T cell activation through the TCR signaling pathway, nucleic acids encoding said proteins, vectors comprising said nucleic acids, compositions comprising said nucleic acids or vectors, host cells comprising said nucleic acids, vectors or compositions or related pharmaceutical compositions. The present application also provides methods for dephosphorylation of proteins that regulate T cell activation through the TCR signaling pathway of a cell, methods of producing a cell having dephosphorylated proteins that regulate T cell activation through the TCR signaling pathway (e.g. a CAR T cell having dephosphorylated Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) of endogenous CD3), methods of treating a disease, and methods of reducing or preventing GvHD in a subject associated with the administration of one or more CAR T-cells to the subject.

Abstract: The disclosure provides at compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating diseases, disorders of conditions mediated by the signaling of formyl peptide receptor 1 (FPR1).

Abstract: A system and method for registering images to each other or registering images to templates to generate geometric or nonlinear registration transformation mappings is disclosed. The method includes obtaining a first image from an imaging device, and obtaining either a reference image from the imaging device, or a template, comprising a partial or full representation of contents of the first image. The reference image or the template is in a second modality, and the first image is in a first modality. At least one mapping function is applied to one of the reference image or template, or both the first image and the reference image or template by mapping pixel data of the template or reference image to the first image to generate an estimation of a parametric registration transformation. Output data comprising one or more parameters of the parametric registration transformation is provided.

Abstract: Disclosed are a borate MWDC with a low dielectric constant and a preparation method thereof by cold sintering. The method for preparing a borate MWDC with a low dielectric constant by cold sintering, including: subjecting a boron source and a metal source to first mixing to obtain a first mixture; subjecting the first mixture to presintering to obtain a presintered material; subjecting the presintered material and a boron oxide solution to second mixing to obtain a second mixture; and subjecting the second mixture to cold sintering to obtain the borate MWDC with the low dielectric constant.

Abstract: The present disclosure relates to a thermal coupling method for preparing ethylene by ethanol dehydration and device thereof. The device includes an ethanol dehydration reaction system, a quenching compression system, an alkaline washing system, a molecular sieve drying system and an ethylene purification and propylene refrigeration cycle system; ethanol dehydration reaction products in the ethanol dehydration reaction system serve as a heat source for preheating, vaporization and superheating of a raw material of ethanol; tower bottoms of an evaporation tower in the quenching compression system serve as a heat source for preheating of a feed stream of the evaporation tower and heating of an overhead gas of a quenching tower; products of ethylene in the alkaline washing system serve as a cold source for cooling of crude ethylene.