Abstract: Provided herein is a class of a rapidly metabolized lipid compound, and particularly relates to compounds represented by formula (I), or pharmaceutically acceptable salts, isotopic variants, tautomers, or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids.

Abstract: A fully automatic medicine testing instrument and an automatic testing method are provided. The fully automatic medicine testing instrument includes an outer housing. A shaking mechanism, a heating mechanism, a reagent reservoir configured to store test samples and test reagents, an optical detection mechanism configured to test absorbance of test samples, a moving mechanism configured to move microplate and pipettes, a pipette holder, and a microplate holder configured to hold microplate for treating test samples are arranged inside the outer housing. The reagent reservoir is located in middle of bottom of the outer housing, the pipette holder and the microplate holder are respectively located on two sides of the reagent reservoir, the optical detection mechanism and the shaking mechanism are respectively located on the other two sides of the reagent reservoir, and the heating mechanism is located on one side, close to the microplate holder, of the shaking mechanism.

Abstract: A spiral magnetorheological polishing method for mid-frequency error control is provided, relating to the technical field of optical polishing. The method includes: scanning along a polishing path by using a magnetorheological polishing method, and removing a material in a spiral manner with a polishing tool to achieve spiral magnetorheological polishing of a workpiece. An angle between a scanning direction and a workpiece material removal direction is changed in real time during scanning, to alter a spatial posture of a removal function on a polishing surface in a spiral manner, thereby reducing mid-frequency errors. The method further includes: during scanning, randomly changing a processing line spacing in real time to further achieve suppression of mid-frequency ripple errors. A scanning strategy employs raster scanning processing; when the scanning strategy employs raster scanning processing, the processing line spacing is a raster scanning spacing.

Abstract: A method of providing improved mouthfeel in consumables having a fat content of about 20% or less is provided. The method includes the step of adding to a consumable composition base from about 0.02 parts per billion to about 25 parts per million based on the total weight of the consumable composition of an Amadori compound, without any subsequent heating. The Amadori compound is a reaction product of glucose with proline.

Abstract: Provided herein is a class of a rapidly metabolized lipid compound, and particularly relates to compounds represented by formula (I), or pharmaceutically acceptable salts, isotopic variants, tautomers, or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids.

Abstract: The present application provides a low-modulus supramolecular coating and a fluid self-assembly method, which are applied to micro devices and assembly substrate. The modulus of the low-modulus supramolecular coating is 10 MPa or less, and the surface thereof has fluidity; and the low-modulus supramolecular coating is applied to the surfaces of micro devices and the surface of an assembly substrate, and the low-modulus supramolecular coating applied to the surfaces of the micro devices and the low-modulus supramolecular coating applied to assembly positions on the assembly substrate contain complementary supramolecular functional groups. The present application solves the problems in existing fluid self-assemble whereby the transfer efficiency is low, the structure of an assembly substrate is complex, subsequent repairing is difficult, and it is difficult to realize simultaneous classification and assembly of various micro devices.

Abstract: A chip based on a low-modulus supramolecular coating material includes a chip body and a low-modulus supramolecular coating provided on one side of the chip away from a growth substrate, wherein the chip body is of a cylindrical or columnar structure, the low-modulus supramolecular coating is completely or partially coated on a surface of the chip, and an area of the low-modulus supramolecular coating is less than or equal to an area of the chip body. The transfer substrate includes a substrate and a low-modulus supramolecular coating, wherein the low-modulus supramolecular coating is patterned and modified on a surface of the substrate to form a plurality of transfer sites, and a position and a size of each transfer site correspond to distribution and sizes of the transferred chips. The present application addresses problems such as complicated structures, relatively low transfer efficiency, poor precision and vulnerability of the transferred chips.

Abstract: A method for automatically marking a U-turn lane line includes: obtaining information about an intersection entry point, information about an intersection exit point, and information about an obstacle at a to-be-marked intersection; and marking a U-turn lane line with a first depth. The first depth is determined based on a second depth of the obstacle. The first depth of the U-turn lane line is determined based on the second depth of the obstacle, so that a marked U-turn lane line does not collide with the obstacle, to mark a more proper U-turn lane line.

Abstract: A flavor composition is provided. The composition includes a dihydrochalcone selected from the group consisting of hesperetin dihydrochalcone, hesperetin dihydrochalcone 4?-beta-D-glucoside, and combinations thereof, and an aroma ingredient selected from the group consisting of furonol, ethyl furanone, maltol, furfural, 5-methyl furfural, vanillin, benzaldehyde, and combinations thereof.

Abstract: A flavor composition is provided. The composition includes a dihydrochalcone selected from the group consisting of hesperetin dihydrochalcone, hesperetin dihydrochalcone 4?-beta-D-glucoside, and combinations thereof, and an aroma ingredient selected from the group consisting of furonol, ethyl furanone, maltol, furfural, 5-methyl furfural, vanillin, benzaldehyde, and combinations thereof.

Abstract: A consumable is provided. The consumable includes (a) at least one sweetener, and (b) a sweetness modifier comprising an extract or fraction from Gnaphalium affine or at least one flavonoid compound. The at least one sweetener is present is a sweetening amount.

Abstract: A consumable is provided. The consumable includes (a) at least one sweetener, and (b) a sweetness modifier comprising an extract or fraction from Viscum articulatum or at least one flavan or flavanone compound. The at least one sweetener is present is a sweetening amount.

Abstract: Provided is a method for training a content moderation mode. The method includes extracting part of image data of a sample video file as sample image data; positioning a time point of the sample image data in the sample video file in the case that the sample image data contains offensive content; extracting salient image region data from the image data around the time point; and training the content moderation model based on the image region data and the sample image data.

Abstract: A spiral magnetorheological polishing method for mid-frequency error control is provided, relating to the technical field of optical polishing. The method includes: scanning along a polishing path by using a magnetorheological polishing method, and removing a material in a spiral manner with a polishing tool to achieve spiral magnetorheological polishing of a workpiece. An angle between a scanning direction and a workpiece material removal direction is changed in real time during scanning, to alter a spatial posture of a removal function on a polishing surface in a spiral manner, thereby reducing mid-frequency errors. The method further includes: during scanning, randomly changing a processing line spacing in real time to further achieve suppression of mid-frequency ripple errors. A scanning strategy employs raster scanning processing; when the scanning strategy employs raster scanning processing, the processing line spacing is a raster scanning spacing.

Abstract: A flavor composition is provided. The composition includes brazzein; and at least one aroma ingredient selected from the group consisting of furonol, ethyl furanone, maltol, furfural, 5-methyl furfural, vanillin and combinations thereof.

Abstract: Provided are a tin borate microwave dielectric ceramic with a near-zero temperature coefficient and a preparation method thereof. The tin borate microwave dielectric ceramic with the near-zero temperature coefficient has a chemical formula of (1?x)BaSn(BO3)2?xTiO2, x being in a range of 0.05 to 0.25; where a principal crystalline phase of the tin borate microwave dielectric ceramic with the near-zero temperature coefficient has a chemical formula of BaSn(BO3)2.

Abstract: Modified immune cells are provided, the modified immune cells expressing a heterologous polynucleotide comprising a nucleotide sequence encoding a function (e.g., at least one of persistence, proliferation, or cytotoxicity) booster, e.g., an apoptosis inhibitor. In one aspect, the modified T cells further comprise a chimeric antigen receptor. Methods, kits, and components for making and using the modified immune cells are also provided.

Abstract: Disclosed is a method for preparing an organic carboxylic ester by using a combined catalyst of an aryl bidentate phosphine ligand. The method includes subjecting a terminal olefin, carbon monoxide, and an alcohol to a hydroesterification reaction in the presence of a combined catalyst of a palladium compound, an aryl bidentate phosphine ligand, and an acidic additive, to generate an organic carboxylic ester having one more carbon atom than the terminal olefin.

Abstract: A flavor composition is provided. The composition includes aromadendrin 3-acetate; and at least one sweetness modifier selected from the group consisting of steviol glycosides, mogrosides, dihydrochalcones, sweet proteins and combinations thereof.

Abstract: The present disclosure relates to a bisphenol A preparation process and device thereof. Each stage of reaction system includes a cooler and reactors, each with four sections, the reactors are filled with bisphenol A synthetic resin catalysts before startup operation, and filling proportions of the catalysts are as follows: ? of the catalysts for the first-section reactor, ? for the second-section reactor, the full amount for the third-section reactor and the full amount for the fourth-section reactor. The three reactors operate in series connection through valves, the reactor with the deactivated catalyst is cut out and the reactor to be used is cut in to maintain the three reactors operating in series every time the system operates ? of the service life of the catalyst, and the process can provide a larger air speed, which is beneficial to eliminating the influence of external diffusion, thereby obtaining higher product benefits.