Abstract: A heat exchanger having: a first heat exchanger core including a first sub-heat exchanger core and a second sub-heat exchanger core, wherein the first sub-heat exchanger core and the second sub-heat exchanger core includes heat exchange tubes, the heat exchange tubes of the first sub-heat exchanger core and the second sub-heat exchanger core are connected to each other, and orthographic projections of the first sub-heat exchanger core and the second sub-heat exchanger core on a plane where the second sub-heat exchanger core is located at least overlap partially; and a second heat exchanger core including a heat exchange tube, wherein the heat exchange tube of the second heat exchanger core is connected to the heat exchange tubes of the first sub-heat exchanger core and the second sub-heat exchanger core is disclosed.

Abstract: Provided are a display panel and a preparation method thereof, and a display apparatus. The display panel includes a first display region, and the first display region includes multiple sub-display regions and a first light transmittance region located between adjacent sub-display regions. Each first sub-display region of the multiple sub-display regions includes a first light-emitting element and a first filter unit disposed in a first light-emergence direction of the first light-emitting element. Each second sub-display region in the multiple sub-display regions includes a first collimating light extraction element disposed in a second light-emergence direction of the first light-emitting element and a second filter unit disposed in a light-emergence direction of the first collimating light extraction element.

Abstract: The present invention discloses a non-oriented electrical steel plate, comprising the following chemical elements in percentage by mass: 0<C?0.003%; Si: 1.6-3.4%; Mn: 0.1-1.2%; S?0.003%; Al: 0.1-3.0%; Sn: 0.005-0.2%; Ca: 0.0005-0.01%; O?0.003%; N?0.003%; and the balance being Fe and inevitable impurities. In addition, the present invention further discloses a manufacturing method for the above non-oriented electrical steel plate, including the steps of: smelting and casting; hot rolling; intermediate annealing; cold rolling; continuous annealing; and applying an insulation coating to obtain a finished non-oriented electrical steel plate. The non-oriented electrical steel plate is excellent in magnetic property.

Abstract: Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: Systems, methods and compositions for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising IscB polypeptides, novel IscB nucleases and reprogrammable targeting nucleic acid components and methods and application of use are provided.

Abstract: Authentication management by receiving a request to initiate an authentication from a computing device of a user, directing the request to a selected authentication service of a plurality of authentication services, wherein the selected authentication service is determined dynamically based on respective authentication metrics of the plurality of authentication services, receiving authentication information via the selected authentication service, and authenticating the user based on the received authentication information.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. The novel nucleic acid targeting systems can comprise components of one or more transposases, one or more components of a CRISPR-Cas system, and a transposable element.

Abstract: A method for sleep monitoring is provided, including: detecting whether a sleep assistance command is received; lighting up a breathing light at a preset frequency in response to receiving the sleep assistance command; monitoring physical sign information of a user in response to receiving a monitoring command; detecting whether the user enters into a sleep state according to the physical sign information; gradually reducing a brightness of the breathing light within a first preset duration until the breathing light is extinguished in a case where the user enters into the sleep state, and determining sleep quality information of the user according to the physical sign information of the user. The physical sign information includes at least breathing information, which is determined according to at least one of: oronasal airflow information, thoracoabdominal motion information, or pressure sensing information.

Abstract: Systems, methods, and compositions for targeting polynucleotides. More particularly, the disclosure provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting nucleic acid-guided nuclease and at least one targeting nucleic acid component like a guide RNA.

Abstract: A display panel and a display device are provided, the display panel include a substrate, an EL display unit group and a filter layer. The EL display unit group is disposed on one side of the substrate, the EL display units includes a plurality of EL display units for emitting light of different colors; the filter layer is disposed on a light emitting side of the EL display unit, the filter layer includes a plurality of filters allowing lights of different colors to pass through, a light emitted from the EL display unit has a color same as a color of a light allowed to pass through the filter disposed on the light emitting side of the EL display unit.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: Compositions, systems and methods for targeted gene modification, insertion and perturbation of gene transcripts and nucleic acid editing are provided. In particular, helitron-mediated gene targeting systems and methods of their use are detailed and provided herein.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a SIN CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing SIN CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.