Abstract: A gas pressure regulator includes a valve body and a valve cover. The valve cover is covered on the valve body. The valve body is provided with a valve cavity, and the valve cavity is connected to an air inlet channel and an air outlet channel. The valve cavity includes a primary pressure regulating cavity and a secondary pressure regulating cavity, and the primary pressure regulating cavity and the secondary pressure regulating cavity are communicated with each other through a valve port. The primary pressure regulating cavity is communicated with the air inlet channel, and a valve core pressure regulating assembly is disposed between the primary pressure regulating cavity and the air inlet channel. The secondary pressure regulating cavity is communicated with the air outlet channel. A lever pressure regulating assembly is disposed between the valve port and the secondary pressure regulating cavity.

Abstract: The invention provides a built-in micro-interface oxidation system for preparing terephthalic acid from p-xylene. The oxidation system includes a first reactor, a rectifying tower and a second reactor which are sequentially connected. A first outlet is disposed on a side wall of the first reactor; a first inlet is disposed on a side wall of the second reactor; a material inlet is disposed on a side wall of the rectifying tower; and a material outlet is disposed at a bottom of the rectifying tower. The first outlet is connected with the material inlet of the rectifying tower; the first inlet is connected with the material outlet of the rectifying tower. Micro-interface units are arranged in the first reactor and the second reactor for dispersing and crushing air into bubbles. Through disposing micro-interface units in reactors, problems of high energy consumption, high raw material consumption and low reaction efficiency are solved.

Abstract: A method for evaluating the reliability of a sealing structure in a multi-failure mode based on an Adaboost algorithm. The Adaboost algorithm is adopted to carry out a classification iterative training on the seal ring failure related data of a small sample until a classification error of set classifier meets a precision requirement; then the failure probability of the sealing structure is calculated under the fluctuation condition of related parameters by adopting the important sampling method, and further the reliability of the sealing structure is evaluated in the multi-failure mode. The present invention solves the problems of long time consumption and complex calculation process of reliability evaluation in multi-failure mode of the complex structure.

Abstract: The disclosure relates to etoricoxib solvates and a preparation method thereof. A solvent is a hydrogen bond donor solvent with a polarity value ?* ranging from 60 to 100 or a hydrogen bond acceptor solvent with a polarity value ?* ranging from 92 to 100. Solvents with a polarity value ?* within the above range all can form corresponding etoricoxib solvates with etoricoxib. The etoricoxib solvate can be prepared by cooling crystallization or suspension crystallization. A 1,2-propanediol solvate of etoricoxib and a dimethyl sulfoxide (DMSO) solvate of etoricoxib provided in the present disclosure have high thermal stability, unique crystal form, large size, concentrated distribution, and prominent flowability and is safe, pharmaceutically acceptable, and not easy to agglomerate. Compared with etoricoxib, the etoricoxib solvates exhibit significantly improved solubility.

Abstract: Technologies are disclosed for resource mapping during URL changes in multi-tenant distributed computing systems. The distributed computing system may resolve a URL by using a tenant and/or site name extracted from the URL to retrieve an entry in a site map table. The entry includes an address to a database that contains the requested content. After a tenant or site name has been changed, or if the tenant or site have been moved, the distributed computing system will resolve pre-existing URLs to the old entry, resulting in a file not found error. In some embodiments, during an operation that changes a tenant or site name, a redirect URL containing the new tenant and/or site name is added to the old entry. When a request addressed to a URL containing the old tenant and/or site names is received, the distributed system sends a redirect response that includes the redirect URL.

Abstract: The disclosure provides a displaying substrate, a manufacturing method thereof, and a display panel, and relates to the technical field of display. The displaying substrate comprises a first supporting base (1), plurality of vibrating element modules (2), and a display module (3). The display module (3) comprises display units (31), connecting units (32) and hollowed-out units (33). Each connecting unit (32) is located between two adjacent display units (31). Each hollowed-out unit (33) is located between two adjacent display units (31) except an area where the corresponding connecting unit (32) is located. The hollowed-out units (33) are provided with cavities (40) corresponding to the vibrating element modules (2). Orthographic projections of the hollowed-out units (33) on a reference plane cover orthographic projections of the vibrating element modules (2) on the reference plane. The vibrating element modules (2) and the cavities (40) form a transducer.

Abstract: Provided herein are methods and kits for parallel detection one or more target sequences across multiple samples, comprising separating a set of samples into one or more pooled sets, wherein each sample may comprise an initial amplicon comprising one or more target sequences and at least one barcode; conducting an amplification reaction on the one or more pooled sets to further amplify the amplicons, and optionally further adding an additional barcode to the amplicon; sequencing the amplicons; identifying individual samples from the pooled sample set that are positive for the one or more target sequences based on sequencing of the amplicons, wherein identification is based, at least in part, on detection of the unique combination of barcodes.

Abstract: The present disclosure discloses a method for reconstructing geostationary ocean color satellite data based on Data INterpolating Empirical Orthogonal Functions. The method includes steps of: 1) for an original ocean color remote sensing area, using concentration detection and edge detection to eliminate abnormal image elements; 2) in the Data INterpolating Empirical Orthogonal Functions, using Laplace smoothing filter to smoothly filter a time covariance matrix; 3) for temporal modes value obtained by the Data INterpolating Empirical Orthogonal Functions, first decomposing it into sub-temporal mode, then adopting empirical modal decomposition, and finally performing interpolation, to obtain an ocean color remote sensing reanalysis data set that maintains its original accuracy and full coverage of time and space.

Abstract: A treatment system and method for cephalosporin wastewater are disclosed. The treatment system includes: a flocculation and sedimentation device, an alkali reaction tank, a PAC reaction tank, a PAM reaction tank, a wastewater heat exchanger, a wastewater heater and an oxidation reactor that are connected with each other in sequence, wherein the wastewater heat exchanger is provided with a material inlet, a material outlet, a heat source inlet and a heat source outlet. An oxidized water from the oxidation reactor enters the wastewater heat exchanger from the heat source inlet, the heat source outlet is connected with a product canister, the product canister is connected with a membrane filtration device to realize concentration treatment of a landfill leachate, the material inlet is connected with the PAM reaction tank, and the material outlet is connected with the wastewater heater.

Abstract: The embodiments of the present disclosure provide a display panel. The display panel includes a first substrate, a second substrate disposed opposite to the first substrate, and a liquid crystal layer between the first substrate and the second substrate, a plurality of first electrodes disposed on a side, close to the second substrate, of the first substrate and spaced apart at intervals, a first dielectric layer for planarizing the plurality of first electrodes, a second dielectric layer disposed on a side, close to the liquid crystal layer, of the first dielectric layer, a light shielding portion disposed on the side, close to the liquid crystal layer, of the second substrate, and a control circuit configured to apply a voltage between the first electrode and the second electrode so that the liquid crystal layer is in a first state or a second state.

Abstract: The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

Abstract: A signal processing method is applied to an RFID electronic tag, and includes: coding a digital baseband signal to obtain a coded signal; performing phase-shift keying modulation on the coded signal to obtain a first modulated signal; performing OFDM modulation on the first modulated signal to obtain a second modulated signal; and sending the second modulated signal to an RFID reader, by means of which the OFDM demodulation, phase-shift keying demodulation, and decoding are performed sequentially on the second modulated signal. According to the signal processing method and device, and the RFID system of one or more embodiments of present disclosure, the RFID system can be caused to effectively utilize bandwidth, thereby achieving high-speed transmission of signals and significantly reducing a bit error ratio of signal transmission.

Abstract: The present application provides a display panel and a display device. The display panel comprises: a base substrate; an insulating layer arranged on the base substrate, the insulating layer being provided with recesses spaced from each other; metal lines arranged on one side of the insulating layer away from the base substrate, portions of the metal lines corresponding to the recesses being located in the recesses, the metal lines having a corrugated longitudinal cross-section in an extending direction of the metal lines to reduce a risk of the metal lines breaking during bending and improve flexibility of the display panel.

Abstract: Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.

Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.

Abstract: Provided herein is a lateral flow diagnostic device and methods of using thereof. The device comprises a substrate and a first end, wherein the first end comprises a sample loading portion. The first end may further comprise a first region loaded with a detectable ligand, a CRISPR effector system, a detection construct, a first test band comprising a biotin ligand, and a second test band comprising a capture molecule for the detectable ligand. The detection construct may comprise an RNA oligonucleotide, having a first molecule such as FITC on a first end and a second molecule such as FAM on a second end. Contacting the sample loading portion with a sample causes the sample to flow from the sample loading portion of the substrate towards the first and second capture regions, thereby generating a detectable signal, which may be indicative of a disease state.

Abstract: The present invention provides a silicon-based micro display screen and method for manufacturing the same. The method includes following steps: providing a silicon substrate, defining a number of sub-pixel regions on the silicon substrate, and sequentially and respectively preparing an anode layer, an OLED layer, a cathode layer and a first protective layer in each sub-pixel region on the silicon substrate; plasma bombarding and removing the exposed OLED layer; forming a second protective layer on sides of the etched cathode layer, the protective layer and the OLED layer; sequentially performing other sub-pixels; and processing and forming a silicon-based micro-display screen based on the results of the above steps. In present invention, the etching and coating processes are carried out in a vacuum environment to prevent the OLED layer from being invaded by water vapor and oxygen, and prolong the service life of the silicon-based micro display screen.