Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: The disclosure provides a multi-type hydrate formation simulation system and a method thereof. The simulation system comprises a hydrate generator, a gas source device and a cryogenic cooler. The hydrate generator comprises a reactor, in which a formation simulation space is provided and can be selectively filled with a loose formation skeleton or a consolidated formation skeleton. The gas source device is configured to introduce natural gas at a preset pressure into the formation simulation space. The cryogenic cooler comprises a temperature-adjustable thermotank, in which the hydrate generator is arranged. The simulation system and method provided can be used to study the influence of consolidated hydrate formation structures and loose hydrate formation structures and particle contact modes on the physical properties of hydrate rock, and are of great significance to the interpretation of hydrate formation exploration data and the estimation of hydrate saturation.

Abstract: Authentication management by receiving a request to initiate an authentication from a computing device of a user, directing the request to a selected authentication service of a plurality of authentication services, wherein the selected authentication service is determined dynamically based on respective authentication metrics of the plurality of authentication services, receiving authentication information via the selected authentication service, and authenticating the user based on the received authentication information.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.

Abstract: Methods, apparatus and systems for improving accuracy and efficiency of wireless monitoring are described. In one example, a described method comprises: transmitting a first wireless signal from a first wireless device with transmit antennas through a wireless multipath channel of a venue; receiving a second wireless signal by a second wireless device with receive antennas through the wireless multipath channel, wherein the second wireless signal differs from the first wireless signal due to the wireless multipath channel that is impacted by a motion of an object in the venue; obtaining a number of time series of channel information (TSCI) of the wireless multipath channel based on the second wireless signal, wherein each TSCI is associated with a respective one of the transmit antennas and a respective one of the receive antennas; preprocessing the number of TSCI; and monitoring the motion of the object based on the number of preprocessed TSCI.

Abstract: This application relates to the field of terminal technologies, and provides a Bluetooth communication method, a wearable device, and a system, to avoid always maintaining an HFP connection, so as to avoid an unnecessary delay or a call error caused when an electronic device processes a voice message. The Bluetooth communications system includes an electronic device and a wearable device, and an HFP connection is established between the electronic device and the wearable device. When the electronic device meets a preset condition, the HFP connection is automatically disconnected. The electronic device sends a first notification to the wearable device after receiving an incoming call, to reestablish the HFP connection. In this case, the electronic device may answer the incoming call by using the wearable device.

Abstract: This disclosure provides an anti-interference method for a new radio network, to reduce intra-frequency interference caused by a long term evolution (LTE) cell to a neighboring new radio (NR) cell. In the method, a base station obtains network configuration information of at least one LTE cell neighboring to an NR cell, based thereon determines anti-interference configuration information that includes an anti-interference pattern having a plurality of strip areas, in which at least one first area and at least one second area are distributed in spacing, the first area is used to carry a service signal of the NR cell, and the second area is used to carry an interference signal of the at least one LTE cell. The base station sends the anti-interference configuration information to a target user equipment for selecting the at least one first area to carry the service signal of the NR cell.

Abstract: The present disclosure provides an electrode plate, a microfluidic chip, and a method of manufacturing the electrode plate. In one embodiment, an electrode plate includes: a substrate, an electrode and a surface contact layer stacked in sequence, and a droplet inlet hole passing through the substrate, the electrode and the surface contact layer. The surface contact layer comprises a super-hydrophobic region and a hydrophilic region, and the droplet inlet hole is disposed in the hydrophilic region. The microfluidic chip includes: a first electrode plate formed by the abovementioned electrode plate, and a second electrode plate provided on a side of the first electrode plate close to the surface contact layer. The first electrode plate is provided opposite to the second electrode plate and a liquid channel is formed between the first electrode plate and the second electrode plate.

Abstract: A method of identifying and characterizing novel Cas protein and guide RNAs with desired activity and specificity. The disclosure further comprises compositions and systems comprising engineered Cas protein and guide RNAs with desired activity and specificity.

Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRJSPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CR.ISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.

Abstract: A big data processing method based on direct computation of compressed data. The method includes 1) compressing, based on a modified Sequitur compression method, original input data according to a smallest compression granularity given by an user, and transforming them into a directed acyclic graph, DAG, consisting of digits; and 2) determining an optimal traversal pattern, and performing a top-downward traversal or a bottom-upward traversal on the DAG in the step 1) based on the determined optimal traversal pattern so as to enable direct processing of the compressed data. By providing a modified Sequitur algorithm and top-downward and bottom-upward traversal strategies in the disclosure, direct processing of compressed data is enabled, significant improvement in time and space has been gained with broad applicability, and certain representations with respect to more advanced document analytics can still be derived on the basis of these.

Abstract: A heat exchanger includes: a header, having a first end and a second end which are opposite each other, and further having an inner cavity; a plurality of heat exchange tubes arranged in an axial direction of the header, with ends of the plurality of heat exchange tubes being connected to the header; and a connecting tube, the connecting tube having a connecting part and a supply part which is connected to the connecting part and also connected to the first end of the header, the supply part being configured such that a flow direction of a heat exchange medium supplied to a predetermined number of heat exchange tubes through the inner cavity of the header is not parallel to an axis of the header, the predetermined number of heat exchange tubes being a predetermined number of heat exchange tubes counted from the first end of the header. By using the heat exchanger according to the embodiments of the present disclosure, heat exchanger performance can be improved.

Abstract: An R-tree index merging and updating method and apparatus based on a Hilbert curve, and a medium. The method comprises: S1, acquiring a first R-tree to be merged and a second R-tree into which the first R-tree is to be inserted; S2, querying a node for insertion, for each merged leaf node in a leaf node level of the first R-tree by means of a “top to bottom” hierarchical query algorithm; S3, inserting, according to an order of the Hilbert values, spatial objects included in each leaf node in the first R-tree into the node for insertion that is determined in S2, thereby merging the two R-trees; and S4, for the second R-tree after merging, updating information stored in each node level by level according to an order from a leaf node to a root node.

Abstract: Provided are a spin orbit torque magnetic random access memory cell, a spin orbit torque magnetic random access memory array and a method for calculating a Hamming distance, wherein the spin orbit torque magnetic random access memory cell includes a magnetic tunnel junction; a first transistor, a drain terminal of the first transistor being connected to a bottom of the magnetic tunnel junction; and a second transistor, a drain terminal of the second transistor being connected to a top of the magnetic tunnel junction.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas13b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.

Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.

Abstract: A system and method for computing a metric indicating a user operation of an application is described. The system accesses online activity data of a user operation of the application. The system filters the online activity data based on a preset time range. An after-hours activity score is calculated based on a type of activity or a duration of an activity from the filtered online activity data, and a weight assigned to the type of activity or the duration of the activity. The system computes an after-hours metric based on the after-hours activity score. A configuration setting for the application based on the after-hours metric is applied to the application.

Abstract: The present disclosure relates to systems and methods for a handover. The methods may include establishing a connection between a vehicle terminal and a first macro evolved Node B (MeNB) and a connection between the vehicle terminal and a secondary evolved Node B (SeNB), the vehicle terminal in a dual connectivity mode with the first MeNB and the SeNB; receiving, by the vehicle terminal, a handover command from the first MeNB; and disconnecting, based on the handover command, the vehicle terminal from the first MeNB and establishing synchronization between the vehicle terminal and a second MeNB, wherein the connection between the vehicle terminal and the SeNB is maintained. The SeNB is a secondary vehicle terminal meeting a preset condition or an SeNB installed at a fixed location.

Abstract: A management and distribution device for insect breeding includes a main body, an upper cover, and a lower cover. The upper cover is clamped to a top portion of the main body, and the lower cover is clamped to a lower end of the main body. Three partition plates for insects to climb are clamped in an inner portion of the main body, and the three partition plates are wave-shaped. A notch is defined at a lower middle portion of each of the three partition plates, a plurality of through holes for insect faeces to pass through are defined on a bottom of the main body, an insertion opening is defined at a lower end of an outer wall of the main body, and a hinge door is rotatably disposed at the lower end of the outer wall of the main body.

Abstract: A transducer, a method of manufacturing a transducer, and a transducing device are provided. The transducer includes a receiving unit and a transmitting unit. The receiving unit includes a first receiving electrode, a first piezoelectric film, and a second receiving electrode which are sequentially stacked, and the receiving unit is configured to convert a first acoustic wave signal into an electrical signal by using a piezoelectric effect of the first piezoelectric film. The transmitting unit is configured to receive a control signal, which is based on the electrical signal, to transmit a second acoustic wave signal.