Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences, including multiplex lateral flow diagnostic devices and methods of use, including for detection of cancer markers, are provided.

Abstract: Disclosed is a non-oriented electrical steel sheet with low magnetic anisotropy, which comprises the following chemical elements in mass percentage: 0<C?0.005%; Si: 2.0-3.5%; Mn: 0.1-2.0%; at least one of Sn and Sb: 0.003-0.2%; Al: 0.2-1.8%; the balance being Fe and inevitable impurities. Further disclosed is a manufacturing method for the above non-oriented electrical steel sheet with low magnetic anisotropy, which includes the following steps: (1) smelting and casting; (2) hot rolling; (3) normalizing; (4) cold rolling; (5) continuous annealing: rapidly heating a cold-rolled steel sheet from an initial temperature of 350° C.-750° C. to a soaking temperature at a heating rate of 50-800° C./s, and performing soaking and heat preservation; and (6) applying an insulating coating to obtain a finished non-oriented electrical steel sheet. The non-oriented electrical steel sheet is characterized by low iron loss and low magnetic anisotropy at high frequency.

Abstract: The embodiments of the present disclosure provide a display panel. The display panel includes a first substrate, a second substrate disposed opposite to the first substrate, and a liquid crystal layer between the first substrate and the second substrate, a plurality of first electrodes disposed on a side, close to the second substrate, of the first substrate and spaced apart at intervals, a first dielectric layer for planarizing the plurality of first electrodes, a second dielectric layer disposed on a side, close to the liquid crystal layer, of the first dielectric layer, a light shielding portion disposed on the side, close to the liquid crystal layer, of the second substrate, and a control circuit configured to apply a voltage between the first electrode and the second electrode so that the liquid crystal layer is in a first state or a second state.

Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.

Abstract: A gas pressure regulator includes a valve body and a valve cover. The valve cover is covered on the valve body. The valve body is provided with a valve cavity, and the valve cavity is connected to an air inlet channel and an air outlet channel. The valve cavity includes a primary pressure regulating cavity and a secondary pressure regulating cavity, and the primary pressure regulating cavity and the secondary pressure regulating cavity are communicated with each other through a valve port. The primary pressure regulating cavity is communicated with the air inlet channel, and a valve core pressure regulating assembly is disposed between the primary pressure regulating cavity and the air inlet channel. The secondary pressure regulating cavity is communicated with the air outlet channel. A lever pressure regulating assembly is disposed between the valve port and the secondary pressure regulating cavity.

Abstract: Provided are a display panel and a preparation method thereof, and a display apparatus. The display panel includes a first substrate and a second substrate which are aligned and combined into a cell, wherein the first substrate includes a backlight structure layer and an array structure layer arranged on a side of the backlight structure layer facing the second substrate, the backlight structure layer includes a light guide plate, a grating layer arranged on a side of the light guide plate facing the array structure layer and a refractive layer covering the grating layer, the grating layer includes a plurality of grating units, the array structure layer includes a plurality of pixel electrodes, and the grating units are in one-to-one correspondence with the pixel electrodes.

Abstract: Methods and compositions for inducing a plurality of mutations in transgenic Cas9 eukaryotes to model a neuronal disease or disorder. The invention further comprehends testing putative treatments with such models, e.g., testing putative chemical compounds that may be pharmaceutically relevant for treatment or gene therapy that may be relevant for treatment, or combinations thereof. The invention allows for the study of genetic diseases and putative treatments to better understand and alleviate a genetic disease or a condition, e.g., autism, autism-spectrum disease or disorder, obsessive-compulsive disorder, or psychiatric disorders.

Abstract: A wet processing device includes a first channel, a nozzle, a second channel, and a sensor. The nozzle includes a spout communicated with the first channel. Negative pressure is formed in the second channel. The second channel includes an opening, the spout is located in the second channel, and the opening is located below the spout. The sensor is configured to detect whether there is liquid in the nozzle.

Abstract: Provided is a display substrate, which includes a base substrate, a circuit structure layer disposed on the base substrate, multiple ultrasonic sensing elements and multiple micro light-emitting elements. The multiple ultrasonic sensing elements are disposed on a side of the circuit structure layer away from the base substrate, and are electrically connected to the circuit structure layer, and the multiple light-emitting elements are disposed on the side of the circuit structure layer away from the base substrate, and are electrically connected to the circuit structure layer. An orthographic projection of the multiple ultrasonic sensing elements on the base substrate does not overlap with an orthographic projection of the multiple micro light-emitting elements on the base substrate.

Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.

Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.

Abstract: The present disclosure relates to systems and methods for a handover. The methods may include establishing a connection between a vehicle terminal and a first macro evolved Node B (MeNB) and a connection between the vehicle terminal and a secondary evolved Node B (SeNB), the vehicle terminal in a dual connectivity mode with the first MeNB and the SeNB; receiving, by the vehicle terminal, a handover command from the first MeNB; and disconnecting, based on the handover command, the vehicle terminal from the first MeNB and establishing synchronization between the vehicle terminal and a second MeNB, wherein the connection between the vehicle terminal and the SeNB is maintained. The SeNB is a secondary vehicle terminal meeting a preset condition or an SeNB installed at a fixed location.

Abstract: A big data processing method based on direct computation of compressed data. The method includes 1) compressing, based on a modified Sequitur compression method, original input data according to a smallest compression granularity given by an user, and transforming them into a directed acyclic graph, DAG, consisting of digits; and 2) determining an optimal traversal pattern, and performing a top-downward traversal or a bottom-upward traversal on the DAG in the step 1) based on the determined optimal traversal pattern so as to enable direct processing of the compressed data. By providing a modified Sequitur algorithm and top-downward and bottom-upward traversal strategies in the disclosure, direct processing of compressed data is enabled, significant improvement in time and space has been gained with broad applicability, and certain representations with respect to more advanced document analytics can still be derived on the basis of these.

Abstract: A production line for producing components to a high standard of cleanliness and sealed and protected in that state includes a loading device, a cleaning device, a detecting device, a pasting device, a heat-sealing device, a packing device, and transfer devices of the production line. The production line automatically processes the components for obtaining components with the high cleanliness. By the processes of protective film pasting, heat-sealing, and packing, the components may be further protected from subsequent pollution. A method for producing components with a high cleanliness applied to the production line is also disclosed.

Abstract: A fingerprint identification module, a manufacturing method thereof and an electronic device are disclosed. In the fingerprint identification module, an auxiliary structure is at least partially located on a functional substrate, and a plurality of first driving electrodes are on a side, away from the functional substrate, of the piezoelectric material and the auxiliary structure; each first driving electrode extends along a first direction and exceeds a first edge of the piezoelectric material layer in the first direction; the plurality of first driving electrodes are arranged at intervals along a second direction; the auxiliary structure is at least in contact with the first edge; the auxiliary structure includes a slope portion; and a thickness of the slope portion in a direction perpendicular to the functional substrate gradually decreases in a direction from the first edge to a position away from a center of the piezoelectric material layer.

Abstract: Methods, apparatus and systems for wireless sleep monitoring are disclosed. In one embodiment, a described sleep monitoring system comprises: at least one sensor in a venue, wherein the at least one sensor comprises a wireless non-contact sensor having no physical contact with the user; a processor communicatively coupled to the at least one sensor; a memory communicatively coupled to the processor; and a set of instructions stored in the memory. The set of instructions, when executed by the processor, causes the processor to perform: obtaining, based on the at least one sensor, a plurality of time series of sensing features (TSSF) associated with a sleep motion of a user in the venue, and monitoring the sleep motion of the user jointly based on the plurality of TSSF.

Abstract: Methods, apparatus and systems for wireless sensing are described. In one embodiment, a described presentation system comprises: a presentation device with a user-interface; a processor communicatively coupled to the presentation device; a memory communicatively coupled to the processor; and a set of instructions stored in the memory. The set of instructions, when executed by the processor, causes the processor to perform: determining a plurality of time series of analytics (TSA) associated with a lifelog of a living object, determining a common time axis for the plurality of TSA, and generating a presentation that presents the plurality of TSA synchronously and jointly in a hybrid manner based on the common time axis. The presentation is presented on the user-interface of the presentation device.

Abstract: The present application discloses display substrate having a base substrate; an insulating layer on the base substrate; and an electrode layer on a side of the insulating layer distal to the base substrate and having a plurality of electrode blocks. The insulating layer has a first side distal to the base substrate and a second side opposite to the first side and proximal to the base substrate. Each of the plurality of electrode blocks has a third side distal to the base substrate and a fourth side opposite to the third side and proximal to the base substrate. The first side of the insulating layer in the inter-electrode block region has a first height relative to a surface of the base substrate greater than a second height of the fourth side of an adjacent electrode of the plurality of electrode blocks relative to the surface of the base substrate.

Abstract: Aspects of the invention include receiving, from a first client, a first object, determining a first file format for the first object, wherein the first file format is operable to run on a first platform, generating a catalog for the first object, wherein the catalog comprises data associated with the first object, and wherein the catalog for the first object is stored on a first server, receiving, from a second client, a request to access the data associated with the first object, determining a second platform operated by the second client, converting, on a second server, the first file format for the first object to a second file format, the second file format operable to run on the second platform, and transmitting the first object in the second file format to the second client.

Abstract: A method of fabricating a display panel includes forming a first conductive layer on a base substrate, wherein the first conductive layer is formed in an encapsulated area and a peripheral area of the display panel; forming an organic insulating layer on a side of the first conductive layer away from the base substrate, wherein the organic insulating layer is formed to be limited in the encapsulated area; forming a first inorganic insulating layer on a side of the organic insulating layer away from the base substrate; forming a second conductive layer on a side of the organic insulating layer and the first inorganic insulating layer away from the base substrate, wherein the second conductive layer is formed in the encapsulated area and the peripheral area; and forming a second inorganic insulating layer, the second inorganic insulating layer formed between the organic insulating layer and the first conductive layer.