Patents by Inventor Feng Zhang

Feng Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230091690
    Abstract: Described herein are guided excision-transposition systems, methods of making, and uses thereof.
    Type: Application
    Filed: December 30, 2020
    Publication date: March 23, 2023
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Guilhem Faure, Daniel Strebinger, Makoto Saito
  • Publication number: 20230087228
    Abstract: The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides novel class 1, Type IV and novel class I, Type I Cas proteins and their use in modifying target sequences.
    Type: Application
    Filed: February 24, 2021
    Publication date: March 23, 2023
    Inventors: Feng Zhang, Han Altae-Tran, Soumya Kannan
  • Patent number: 11607663
    Abstract: A strengthening oxidation system of the external micro-interfacial unit for producing PTA with PX is provided, including: a reactor, a circulating heat exchange device and a micro-interfacial unit. The reactor includes an outer casing and an inner cylinder disposed concentrically inside the outer casing. The circulating heat exchange device is disposed at an exterior of the reactor, and is connected with the outer casing and the inner cylinder respectively, for regulating reaction temperatures of the first reaction zone, the second reaction zone and the third reaction zone inside the reactor in a reaction process of producing PTA with PX.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: March 21, 2023
    Assignee: NANJING YANCHANG REACTION TECHNOLOGY RESEARCH INSTITUTE CO., LTD.
    Inventors: Zhibing Zhang, Zheng Zhou, Feng Zhang, Lei Li, Weimin Meng, Baorong Wang, Gaodong Yang, Huaxun Luo, Guoqiang Yang, Hongzhou Tian, Yu Cao
  • Publication number: 20230081215
    Abstract: The disclosure provides a connector and an electronic device using the connector. The connector is connected with a conductive element. The connector includes a terminal support component, a multiple of gold fingers and an electric conversion component. The terminal support component includes a first surface and a second surface. The first surface is opposite to the second surface or the first surface and the second surface are arranged at intervals. The multiple of gold fingers symmetrically arranged on the first surface and the second surface. The electric conversion component includes a main electric unit and two auxiliary conductive units. The main electric unit is electrically connected the two auxiliary conductive units and the conductive element. The two auxiliary conductive units are electrically connected with the gold fingers that respectively arranged on the first surface and the second surface of the terminal support component.
    Type: Application
    Filed: February 10, 2022
    Publication date: March 16, 2023
    Inventor: FENG ZHANG
  • Publication number: 20230081278
    Abstract: The disclosure provides a connector and an electronic device using the connector. The connector subassembly includes two connectors that plug into each other, the connector includes a terminal support component, the terminal support component includes a first surface and a second surface, the first surface is opposite to the second surface or the first surface and the second surface are arranged at intervals; a multiple of gold fingers are symmetrically arranged on the first surface and the second surface; an electric conversion component includes a main electric unit and two auxiliary conductive units, the main electric unit is electrically connected the two auxiliary conductive units and a conductive element; the two auxiliary conductive units are electrically connected with the gold fingers. The gold fingers are respectively arranged on the first surface and the second surface of the terminal support component.
    Type: Application
    Filed: February 11, 2022
    Publication date: March 16, 2023
    Inventor: FENG ZHANG
  • Publication number: 20230074840
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
    Type: Application
    Filed: December 17, 2021
    Publication date: March 9, 2023
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng ZHANG, Bernd ZETSCHE, Johnathan S. GOOTENBERG, Omar O. ABUDAYYEH, Ian SLAYMAKER
  • Publication number: 20230074893
    Abstract: An electronic device receives an indication of a number of physical resource blocks and subcarrier spacing of at least a portion of a transmission channel and determines a dynamic transmission bandwidth, or receives an indication of a modulation coding scheme of the transmission channel and determines a modulation order. The electronic device transmits, using a transmitter, a signal over at least the portion of the transmission channel based on the dynamic transmission bandwidth being less than or equal to a threshold bandwidth, or the modulation order not corresponding to an additional power backoff, using a first power based on a maximum output power capacity of the electronic device and a maximum power reduction. Otherwise, the electronic device transmits the signal over at least the portion of the transmission channel at a second power based on the maximum output power capacity, the maximum power reduction and the additional power backoff.
    Type: Application
    Filed: June 14, 2022
    Publication date: March 9, 2023
    Inventors: Lijie Zhang, Hailong Yang, Kexin Ma, Alex Yee Kit Ho, Feng Zhang, SR., Bing Zhao, Ying Zhang, Zhiwei Wang, Qiang Miao
  • Patent number: 11597949
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: March 7, 2023
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Patrick Hsu, Chie-Yu Lin, Fei Ran
  • Patent number: 11597919
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: March 7, 2023
    Assignees: THE BROAD INSTITUTE INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, UNIVERSITY OF TOKYO
    Inventors: Silvana Konermann, Alexandro Trevino, Mark Brigham, Fei Ran, Patrick Hsu, Chie-yu Lin, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani, Feng Zhang
  • Publication number: 20230064759
    Abstract: Disclosed are a display apparatus, a drive chip, and an electronic device. When determining that a disconnected signal line exists, the drive chip sends a control signal to a signal line repair module, so that when a shift output end of the first shift unit corresponding to the disconnected signal line outputs an enable signal, a selector switch corresponding to the shift output end is turned on, and then a connection control unit keeps outputting a turn-on signal to a control end of a corresponding connection switch.
    Type: Application
    Filed: September 22, 2021
    Publication date: March 2, 2023
    Inventors: Pengming Chen, Jide Liang, Ruiliang Li, Feng Zhang, Jiandong Deng, Muyao Li
  • Patent number: 11591601
    Abstract: The application relates to methods for compositions for identifying lncRNA loci associated with target genotypes or phenotypes, including desirable plant genotypes or phenotype. The application also relates to regulatory regions and genes associated with drug resistance, such as resistance to BRAF-inhibitors. Such regulatory regions and genes form the basis for methods for identifying resistance to BRAF-inhibitors, which is useful for improving disease prognosis, treatment, and likely outcomes. The regulatory regions and genes are also suitable targets for therapy in melanoma that is resistant to BRAF-inhibitors.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: February 28, 2023
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Julia Joung, Jesse Engreitz, Eric S. Lander, Feng Zhang
  • Patent number: 11591581
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a SIN CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing SIN CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: February 28, 2023
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Feng Zhang, Beverly Davidson, Chie-Yu Lin, Edgardo Rodriguez
  • Publication number: 20230056577
    Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.
    Type: Application
    Filed: May 12, 2022
    Publication date: February 23, 2023
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Strecker, Alim Ladha
  • Publication number: 20230056698
    Abstract: The present disclosure relates to the technical field of wafer cleaning, and in particular to a wafer cleaning device and a wafer cleaning system. The wafer cleaning device includes a liquid inlet pipe, a first liquid discharge pipe, a first valve and a liquid supply device, wherein the liquid inlet pipe has an inlet terminal and an outlet terminal; a wall of the liquid inlet pipe is protruded outward to form a protrusion, the protrusion having a cavity; one terminal of the first liquid discharge pipe is communicated with the cavity, while the other terminal thereof is communicated with a container; the first valve is arranged on the liquid inlet pipe and located between the protrusion and the outlet terminal; and, the liquid supply device is communicated with the inlet terminal of the liquid inlet pipe to import cleaning solution into the liquid inlet pipe.
    Type: Application
    Filed: June 8, 2021
    Publication date: February 23, 2023
    Inventor: Feng ZHANG
  • Publication number: 20230049737
    Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems, reverse transcriptase, pegRNAs, paired pegRNAs or modified pegRNAs, DNA processing proteins, recombinases, proteins for inhibiting nucleases, and proteins for promoting ssDNA annealing.
    Type: Application
    Filed: December 30, 2020
    Publication date: February 16, 2023
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Strecker, David Li
  • Patent number: 11578312
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: February 14, 2023
    Assignees: THE BROAD INSTITUTE INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, UNIVERSITY OF TOKYO
    Inventors: Feng Zhang, Winston Yan, Osamu Nureki, Kaijie Zheng, Le Cong, Hiroshi Nishimasu, Fei Ran, Yinqing Li
  • Patent number: 11576317
    Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: February 14, 2023
    Assignees: CELLECTIS SA, MEDICAGO INC.
    Inventors: Luc Mathis, Daniel F. Voytas, Jin Li, Feng Zhang, Thomas Stoddard, Marc-Andre D'Aoust
  • Publication number: 20230040216
    Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and non-LTR retrotransposon elements.
    Type: Application
    Filed: November 18, 2020
    Publication date: February 9, 2023
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Michael Segel, Alim Ladha
  • Patent number: D980689
    Type: Grant
    Filed: June 1, 2022
    Date of Patent: March 14, 2023
    Inventor: Feng Zhang
  • Patent number: D980785
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: March 14, 2023
    Assignee: Shenzhen Zhadao Vehicle Industry Co., Ltd.
    Inventor: Feng Zhang