Abstract: The invention relates to novel mTOR inhibitor compounds having the formula (I) or a pharmaceutically acceptable salt thereof, compositions comprising the mTOR inhibitor compounds, methods for producing the same, and the use thereof.

Abstract: The invention relates to novel mTOR inhibitor compounds having the general formula (I), to compositions comprising said mTOR inhibitor compounds, methods for producing same, and the use thereof in compositions as a drug.

Abstract: A method for managing an electronic logbook of an aircraft, comprises the steps of agreeing or refusing a read and/or write request by a client post as a function of predefined criteria comprising criteria associated with predefined time intervals and network connectivity criteria. Developments describe the management of a degraded mode (for example in case of interruption and/or of the restoral of network connectivity, e.g. with notification of the client posts and/or local backup saves), criteria further dependent on that part of the electronic logbook designated by the read and/or write request, security levels and/or priority levels. Encryption, integrity verification, network quality of service and distributed database aspects are described. Software and system aspects are described.

Abstract: The invention relates to novel mTOR inhibitor compounds. The invention is characterized in that the mTOR inhibitor compounds have general formula (I). The invention also relates to compositions comprising said mTOR inhibitor compounds, methods for producing same, and the use thereof in compositions as a drug.

Abstract: The invention relates to novel mTOR inhibitor compounds. The invention is characterized in that the mTOR inhibitor compounds have general formula (I). The invention also relates to compositions comprising said mTOR inhibitor compounds, methods for producing same, and the use thereof in compositions as a drug.

Abstract: A bale wrapper and a round baler with such a device are described. The bale wrapper comprises a supply device, extending along the width of a bale chamber of a round baler, for the introduction of wrapping material. The supply device comprises a shielding layer, located on its upper side, for the upper-side shielding of a free end of the wrapping material, to be introduced into the bale chamber. In order to improve the supply operation of wrapping material into the bale chamber, the shielding layer comprises several shielding lips, located parallel to one another along the width of the bale chamber, which extend in the direction of an interior of the bale chamber.

Abstract: The present disclosure provides a system and method for recycling intermediate product streams of at least gasoline from the MTP plant to the steam cracker plant for processing with the feedstock of the steam cracker plant to generate a higher percentage of ethylene and propylene. The steam cracker feedstock can be ethane.

Abstract: The invention relates to novel heterocyclic compounds of general formula (I), as well as their pharmaceutically acceptable salts, and their enantiomers. The invention also relates to the use thereof as a medicinal product, preferably in the prevention and/or treatment of inflammatory diseases with a neurogenic component or use thereof as a cosmetic. The compounds of the present invention act as antagonists of the CGRP-R receptor.

Abstract: A computer implemented method of computing performance for an aircraft, comprises the steps of collecting data from a plurality of data sources comprising data sources of avionics type and external data sources of non-avionics type; processing the data collected in an electronic device of EFB or electronic flight bag type; and undertaking the performance computation. Developments describe the extraction of data from images or audio streams; the manipulation of data of alarm, INOP, aircraft status, air conditioning and anti-ice, runway, ATIS, meteorological and/or NOTAM type; the interfaces with an FPS or flight planning system and/or a CMS or centralized maintenance system. System aspects and software aspects are described.

Abstract: A method for managing an electronic logbook of an aircraft, comprises the steps of agreeing or refusing a read and/or write request by a client post as a function of predefined criteria comprising criteria associated with predefined time intervals and network connectivity criteria. Developments describe the management of a degraded mode (for example in case of interruption and/or of the restoral of network connectivity, e.g. with notification of the client posts and/or local backup saves), criteria further dependent on that part of the electronic logbook designated by the read and/or write request, security levels and/or priority levels. Encryption, integrity verification, network quality of service and distributed database aspects are described. Software and system aspects are described.

Abstract: The invention relates to novel heterocyclic compounds of general formula (I), as well as their pharmaceutically acceptable salts, and their enantiomers. The invention also relates to the use thereof as a medicinal product, preferably in the prevention and/or treatment of inflammatory diseases with a neurogenic component or use thereof as a cosmetic. The compounds of the present invention act as antagonists of the CGRP-R receptor.

Abstract: The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

Abstract: The present disclosure provides a system and method for recycling intermediate product streams of at least gasoline from the MTP plant to the steam cracker plant for processing with the feedstock of the steam cracker plant to generate a higher percentage of ethylene and propylene. The steam cracker feedstock can be ethane.

Abstract: A method implemented by a computer for managing meteorological data for managing the flight of an aircraft, comprises the steps of receiving a cartographic background and selections of meteorological products; receiving meteorological data associated with the flight plan of the aircraft, according to a first space scale; determining one or more types of graphic symbols; as a function of a second space scale, determining one or more graphic declinations of the types of graphic symbols, the graphic superimpositions predefined; and displaying the cartographic background and the determined graphic declinations. Developments describe the management of the visual density of the display, the taking into account of the flight context and/or of the physiology of the pilot, the deactivation on request of the adjustments of the display. Software and system aspects (e.g. electronic flight bag, gaze monitoring) are also described.

Abstract: A method implemented by a computer for managing meteorological data for the management of the flight of an aircraft, comprises the steps of receiving a cartographic background and meteorological data associated with the flight plan, selecting one or more meteorological events; displaying graphic representations associated with the meteorological events selected on a strip representing the flight plan; based on the updating of the meteorological data, refreshing the display of the meteorological data. Developments notably describe the re-refreshing of the display corresponding to a revision of the flight plan, taking into account of the severity of the meteorological events, the emission of alerts and/or selectable notifications, the distinction between meteorology of regulatory type and of non-regulatory type. Software and system aspects are described (e.g. electronic flight bag EFB).

Abstract: A computer implemented method for managing alarm and maintenance messages of an aircraft, comprises collecting information relating to the alarm, aircraft status and maintenance messages; transmitting the information collected to an electronic device of EFB or electronic flight bag type, the electronic device being able to correlate the alarm messages with the maintenance messages and to associate the descriptions of the alarms with links and electronic maintenance documents. Developments describe notably the extracting of data from images or audio streams; listening to the communications on an avionics bus between the centralized maintenance system CMS and the printing service Printer and/or ground equipment of AGARS or VHF type; and the establishing of links with the electronic documentation and the use of an electronic flight bag EFB.

Abstract: The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

Abstract: A web wrap device is provided for a round baler. The device has a web carrier for pulling the web from a roll of web to a bale chamber. In a leading portion the web carrier has two elements at least one of which being moveable towards the other. The moveable element has a leading edge, which engages the web and is pulled by the tensioned web onto the other element, which increases the clamping effect. In addition a guard is provided to cover a knife during the wrapping mode, but to expose the knife to the web, when it should be cut.

Abstract: The invention provides certain substituted phenyl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

Abstract: A computer-implemented method for managing the data of an aircraft flight plan comprises collecting initial data of an operational flight plan from a flight planning system FPS by an electronic device of electronic flight bag EFB type; converting the initial data and communicating the converted data to the avionics system of the flight management system FMS, the FMS being able to compute an avionic flight plan on the basis of the converted data; and retrieving the avionic flight plan data such as processed by the flight management system FMS. Developments describe notably the verification of the security and/or of the integrity of the converted initial data by means of predefined compliance rules; the emulation of avionics protocols and the use of the encipherment of the data. System aspects and software aspects are described.