Abstract: The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

Abstract: A method for performing a maintenance function of a system under diagnosis includes a step for hierarchical decomposition of the system under diagnosis into sub-systems based on the model of the system and, for each sub-system, steps for determination of a model of the sub-system starting from the model of the system, and allocation of a diagnostic method depending on the processing and memory resources of said sub-system. The method allocated is a first diagnostic method based on the model of the system or a second diagnostic method based on predefined logical relationships. The method further includes calculation of the logical relationships for the sub-systems implementing the second diagnostic method, and the transfer of the logical relationships to the sub-systems implementing the second method and the transfer of the model to the sub-systems implementing the first method.

Abstract: A rapidly installable and rapidly removable set of equipment (1-6, 11) which can be replaced by standard exchanges, furnished with individual electronic circuits for monitoring proper operation (1a-6a, 20a-23a, 30a-32a, 1 1a) assuming, at their level, a BITE function (Build [sic] In Test Equipment) for testing, for fault diagnosis and for issuing fault messages sent by data transmission to a central maintenance computer (7) itself formulating a report regarding the overall state of operation of the set of equipment. It relates more especially to the hardware parts of the electronic circuits for monitoring proper operation which are integral with the equipment (1-6) or with equipment parts (20-23, 30-32) and which are furnished with a nonvolatile memory (405) and by means of detection, selection and capture (403, 413, 423) into their nonvolatile memories (405), of the report formulated by the central maintenance computer (7).

Abstract: The invention relates to a device for system diagnosis of an aircraft. The device includes: means for the monitoring of equipment of the system, the means for emitting messages of observations on the basis of effects produced by equipment; means for the determination of a set of observations on the basis of the messages of observations arising from the monitoring of a log of the messages of observations and of a model representing a current state of the system; means for the determination of indictments on the basis of observations of the set of observations and of a behavioural model of the system, the indictments being logical relations between operating modes of equipment having produced effects; and means for the determination of maintenance operations on the basis of the indictments.

Abstract: A method for generating electronic documentation (DOC) for the maintenance of a set of equipment (EQPT), in particular of an aircraft, is provided. The method is beneficial in allowing the automatic generation of electronic documentation (DOC) updated dynamically in tandem with the progress in a maintenance operation on the set of equipment (EQPT). Utilization of particular schemes for constructing dynamic models (ABS) associated with sets of equipment (EQPT) is advantageously accomplished.

Abstract: Substituted 2-naphthoic acids of structural formula are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.

Abstract: A centralized maintenance system for aircraft which includes line replacement units (LRUs). The system includes at least one digital database whose data are information relating to the LRUs; and a device for updating the data of the database. The lifetime information for the LRUs is known and contained in the digital database. The database includes a mean time between failure (MTBF) data of each LRU. The MTBF data is able to be modified and updated, according to at least one event modifying the failure probabilities for at least one LRU.

Abstract: The present invention relates to the field of aiding ground maintenance of an aircraft. More particularly, the invention consists of a portable access terminal intended to aid maintenance, commonly designated by the acronym PMAT for Portable Maintenance Access Terminal. The invention exhibits the advantage of allowing the consideration of human factors in the design of maintenance strategies and procedures in the field of aeronautics. The implementation of portable access terminals according to the invention in the heart of a system for aiding maintenance is aimed at limiting the risks of human errors within the framework of aircraft maintenance operations and, optionally, the adaptation of the maintenance strategies and procedures to particular profiles of maintenance personnel.

Abstract: The method of identifying a flight profile of an aircraft, the aircraft including a centralized maintenance system and an item of equipment including a component designed to measure the environmental conditions, comprises: a first step of collecting data measured by a sensor of the component; a second step of comparing values measured by at least one sensor with predefined threshold values so as to store in a resource the values that exceed the threshold values; a third step of comparing at least one set of stored values with at least one predefined flight profile, a flight profile representing a trend of values measured by a sensor according to at least one item of information defining a flight context; a fourth step of identifying the flight profile that is closest to the set of values stored for a sensor.

Abstract: The invention relates to a method for aiding the maintenance of a system, the system comprising a set of networked elements, the system being accompanied by indications defining subsets of networked elements Ei, each subset of networked elements Ei being associated with a probability of failure Pi, the including the steps of calculating a first value Ti for each subset of networked elements Ei, the first value Ti including an estimation of the maintenance time related to the repair of the subset of networked elements Ei, calculating a second value Fi for each subset of networked elements Ei, the second value Fi including a representation of a compromise between the estimation of the maintenance time Ti related to the repair of the subset of networked elements Ei and the probability of failure Pi of the subsets of networked elements Ei, and sorting the designated sets of items of equipment Ei in order of decreasing second value Fi.

Abstract: The invention relates to a method and a device for locating a fault in a system. The system includes a set of elements. The elements are connected in a network. Each element is associated with an operational status and a probability of failure. The method according to an embodiment of the invention includes, for each of the elements having a status indicating a malfunction, denoted as a defective element, the creation, from the system topology, of an expression comprising terms corresponding to functional elements connected to said defective element. If several expressions have been created in the preceding step, then merge expressions having at least one term in common. For each expression, delete terms in the expression corresponding to elements having a “healthy” status. Calculate a minimal expression from the preceding expression. Calculate failure probabilities for selected members of the minimal expression based on failure probabilities of the corresponding elements.

Abstract: The present invention relates to a new paper making composition useful for reducing linting and dusting in paper, a method for reducing paper linting and dusting wherein certain phosphate esters are added to a fiber pulp during the paper making process and the novel additive composition for reducing linting and dusting in paper comprising the phosphate ester.

Abstract: The invention relates to a maintenance system for a set of equipment of an aircraft, forming a physical network (106) configured by configuration files (101). The maintenance system according to the invention comprises a model M (104) of the set of equipment of the physical network, taking into account the topology of the physical network and the interactions between the various equipment items. This model M is constructed and updated in real time from data (including, for example, the configuration tables) concerning the physical network and the equipment items themselves.

Abstract: The present invention relates to a fault validation method and system for aerodynes. The method includes at least a configuration step associating with each detectable fault equipment units for which a copy of memory segments is to be made. Verification tests to be performed include a step for copying memory segments and a step for verifying equipment units.

Abstract: A method of preventive maintenance is disclosed for an aircraft. The aircraft includes components, including items of equipment of the aircraft and/or electronic modules and/or physical links. The lifetime information for the components is known. The aircraft also includes means for monitoring the components, a centralized maintenance system, and means for estimating the life time of the components. The aircraft carries out a set of functions, each being ensured by a chain of components. The method comprises several steps including, a first step of locating the degradations of the items of equipment, a second step making it possible to allocate the located degradations to the various functions of the aircraft, a third step of estimating the lifetime of the functions identified in the second step, and a fourth step of formulating the maintenance message constructed on the basis of the previous steps.

Abstract: A centralized maintenance system is disclosed for aircraft. The aircraft includes line replacement units having components termed LRUs. The LRUs comprise items of equipment and/or electronic modules of the aircraft and/or physical links. The system comprises at least one first digital database whose data are information relating to the LRUs. Means are provided for updating the data of the database. The lifetime information for the LRUs is known and contained in the digital database. The latter comprises the mean time between failure (MTBF) data of each LRU. The MTBF data being able to be modified and updated, according to at least one event modifying the failure probabilities for at least one LRU.

Abstract: The subject of the invention is a device for managing equipment maintenance. It relates to a device for managing maintenance of a number N of items of equipment EQi built into a system, i designating an index identifying the item of equipment EQi and lying between 1 and N, the system furthermore comprising a main computer RC, the equipment EQi exchanging data with the main computer RC through a communication network, the equipment EQi being capable of being built into the system or of being removed from the system, each item of equipment EQi being protected by a protective housing BPi, the communication node Nj occupying a position internal to the housing BPi and being devised to exchange data with the radio tag ETi, the radio tag ETi being fixed securely to the housing BPi and being devised to deliver data through a contactless link.

Abstract: The invention relates to the maintenance of a rapidly installable and rapidly removable set of equipment (1-6, 11) which can be replaced by standard exchanges, furnished with individual electronic circuits for monitoring proper operation (1a-6a, 20a-23a, 30a-32a, 11a) assuming, at their level, a BITE function (Build [sic] In Test Equipment) for testing, for fault diagnosis and for issuing fault messages sent by data transmission to a central maintenance computer (7) itself formulating a report regarding the overall state of operation of the set of equipment. It relates more especially to the hardware parts of the electronic circuits for monitoring proper operation which are integral with the equipment (1-6) or with equipment parts (20-23, 30-32) and which are furnished with a nonvolatile memory (405) and with means of detection, selection and capture (403, 413, 423) into their nonvolatile memories (405), of the report formulated by the central maintenance computer (7).

Abstract: A large round baler is equipped with an enveloping arrangement that moves a run of enveloping material to the circumferential surface of a bale with a pivot arm including a driver having projections in the form of teeth that can be caused to penetrate the enveloping material to cause a positive locking with the run of enveloping material so that the enveloping material may be selectively inserted into the baling chamber at the beginning of a wrapping cycle and engaged with a contact plate to effect separation of the enveloping material once a predetermined number of wraps have been applied to the circumference of the bale.