Patents by Inventor Fumihisa Kitawaki
Fumihisa Kitawaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11959873Abstract: The present invention forms a detection layer in an embedded biosensor probe by using a phenazine derivative as a redox mediator in which a phenazine group is covalently bonded to a high molecular weight polymer having a carboxyl group or an amino group, such as polyamino acid, polyimine, or polyallylamine; and the distance between the phenazine group and the high molecular weight polymer main chain is increased by using a polyethylene glycol chain.Type: GrantFiled: January 28, 2019Date of Patent: April 16, 2024Assignee: PHC HOLDINGS CORPORATIONInventors: Keigo Haneda, Kazuaki Edagawa, Fumihisa Kitawaki
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Publication number: 20220322978Abstract: The present disclosure provides a means for preventing or suppressing the leaching of a redox mediator constituting a reagent layer in a probe of an embedded biosensor, in particular, a means capable of improving preservation stability (durability) while maintaining glucose measurement sensitivity. The high molecular weight redox polymer according to the present disclosure is represented by general formula (A1), wherein X? represents an anionic species; L represents a linker; Poly represents a high molecular weight polymer; and R1 to R8 each independently represent a hydrogen atom or a substituent. The biosensor according to the present disclosure has a working electrode, a counter electrode, a reagent layer disposed on the working electrode, and a protective film covering at least the reagent layer, and the reagent layer contains an oxidoreductase that oxidizes or dehydrogenates the analyte and at least one high molecular weight redox polymer represented by general formula (A1).Type: ApplicationFiled: September 30, 2019Publication date: October 13, 2022Applicant: PHC Holdings CorporationInventors: Keigo HANEDA, Kazuaki EDAGAWA, Fumihisa KITAWAKI
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Publication number: 20210025843Abstract: The present invention forms a detection layer in an embedded biosensor probe by using a phenazine derivative as a redox mediator in which a phenazine group is covalently bonded to a high molecular weight polymer having a carboxyl group or an amino group, such as polyamino acid, polyimine, or polyallylamine; and the distance between the phenazine group and the high molecular weight polymer main chain is increased by using a polyethylene glycol chain.Type: ApplicationFiled: January 28, 2019Publication date: January 28, 2021Applicant: PHC Holdings CorporationInventors: Keigo HANEDA, Kazuaki EDAGAWA, Fumihisa KITAWAKI
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Patent number: 10023897Abstract: A biosensor chip is placed in a biosensor device and is rotated while a biochemical analysis specimen is measured, the biosensor chip comprising a main body, a holding chamber, a dispensing chamber, a plurality of quantification chambers, and a plurality of measurement chambers. The main body has an inlet into which the specimen is poured. The holding chamber holds the poured specimen inside the main body. The dispensing chamber is connected to the holding chamber via a first channel and dispenses the specimen. The quantification chambers are connected to the dispensing chamber, hold a specific amount of the dispensed specimen, and are disposed at positions located away from a rotational center of a rotary motion according to a distance from the first channel. The measurement chambers are connected to the quantification chambers via a second channel and react the specimen with a biochemical analysis reagent.Type: GrantFiled: September 30, 2014Date of Patent: July 17, 2018Assignee: PHC HOLDINGS CORPORATIONInventors: Kazuyoshi Mori, Masahiro Kouge, Fumihisa Kitawaki, Takako Matsumura, Seiji Onishi
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Patent number: 9151765Abstract: Hemoglobin in a sample solution is quickly and reliably denatured; at the same time, quick and accurate measurement of hemoglobin and a hemoglobin derivative is realized. In a method for measuring hemoglobin and a hemoglobin derivative, and a reagent composition, a measurement kit, an analysis device, and an analysis system used in the method, a sample solution containing a blood component is treated with a nonionic surfactant, an oxidizing agent, and a metal salt to denature hemoglobin in the sample solution to measure the hemoglobin, and thereafter the amount of a hemoglobin derivative in the sample is measured by an immunological method using an antibody specifically binding to a denatured site of the denatured hemoglobin derivative.Type: GrantFiled: September 12, 2013Date of Patent: October 6, 2015Assignee: Panasonic Healthcare Holdings Co., Ltd.Inventors: Hirotaka Tanaka, Masanori Tanaka, Chizu Asahara, Fumihisa Kitawaki
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Publication number: 20150024477Abstract: This biosensor chip is placed in a biosensor device and is rotated while a specimen is measured, the biosensor chip comprising a main body, a holding chamber, a dispensing chamber, a plurality of quantification chambers, and a plurality of measurement chambers. The main body has an inlet into which a biochemical analysis specimen is poured. The holding chamber holds the poured specimen inside the main body. The dispensing chamber is connected to the holding chamber via a first channel and dispenses the specimen. The plurality of quantification chambers are connected to the dispensing chamber, hold a specific amount of dispensed specimen, and are disposed at positions located away from the rotational center of the rotary motion according to the distance from the first channel. The plurality of measurement chambers are connected to the quantification chambers via a second channel and react the specimen with a biochemical analysis reagent.Type: ApplicationFiled: September 30, 2014Publication date: January 22, 2015Inventors: Kazuyoshi MORI, Masahiro KOUGE, Fumihisa KITAWAKI, Takako MATSUMURA, Seiji ONISHI
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Patent number: 8921052Abstract: A sample solution including blood components is processed with a denaturalization reagent comprising a nonionic surface-activating agent and an oxidizing agent to denaturalize a hemoglobin derivative in the sample solution, and thereafter, an immunoassay is performing utilizing an antibody that is specific to a denaturalized site of the hemoglobin derivative to measure the amount of the hemoglobin derivative in the sample. Therefore, when performing assay of hemoglobin derivative, denaturalization of hemoglobin can be performed speedily and reliably while minimizing adverse effects of the denaturalization reagent on immune reaction.Type: GrantFiled: April 12, 2006Date of Patent: December 30, 2014Assignee: Panasonic Healthcare Co., Ltd.Inventors: Hirotaka Tanaka, Masanori Tanaka, Fumihisa Kitawaki
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Publication number: 20140017814Abstract: Hemoglobin in a sample solution is quickly and reliably denatured; at the same time, quick and accurate measurement of hemoglobin and a hemoglobin derivative is realized. In a method for measuring hemoglobin and a hemoglobin derivative, and a reagent composition, a measurement kit, an analysis device, and an analysis system used in the method, a sample solution containing a blood component is treated with a nonionic surfactant, an oxidizing agent, and a metal salt to denature hemoglobin in the sample solution to measure the hemoglobin, and thereafter the amount of a hemoglobin derivative in the sample is measured by an immunological method using an antibody specifically binding to a denatured site of the denatured hemoglobin derivative.Type: ApplicationFiled: September 12, 2013Publication date: January 16, 2014Applicant: Panasonic CorporationInventors: Hirotaka TANAKA, Masanori TANAKA, Chizu ASAHARA, Fumihisa KITAWAKI
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Publication number: 20130231588Abstract: Provided is a biological tissue collecting tool capable of reducing a variation in the amount of collected biological tissue at the time of collecting the biological tissue from a biological aperture. A biological tissue collecting tool 10 according to the present invention includes: an exterior body 3 having first space formed therein and having a first collection opening 2 formed in a wall thereof, the exterior body 3 having such a shape as to be insertable in a biological aperture; a collecting portion 15 disposed in the first space such that the collecting portion 15 is movable in the first space, the collecting portion 15 being configured to collect a part of biological tissue that protrudes into the first space through the first collection opening 2; and an operating portion 7 connected to the collecting portion 15, the operating portion 7 allowing the collecting portion 15 to be operated from outside of the exterior body 3.Type: ApplicationFiled: April 4, 2012Publication date: September 5, 2013Applicant: PANASONIC CORPORATIONInventors: Takaomi Fukuhara, Toshifumi Nanjo, Fumihisa Kitawaki
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Patent number: 7998752Abstract: According to the biosensor and the blood component analytical method of the present invention, in a biosensor that is made of a single layer or plural layers of a porous material as shown in FIG. 1, having a reagent holding part and utilizing chromatography, a cell shrinkage reagent is carried on at least part of the reagent holding part, or at least part of a chromatographically developed part that is upstream of the reagent holding part. According to the biosensor having the above-mentioned structure and the blood component analytical method, even when whole blood is a sample, a high-accuracy blood component analysis cart be performed easily and quickly with less cost.Type: GrantFiled: December 5, 2007Date of Patent: August 16, 2011Assignee: Panasonic CorporationInventors: Mie Takahashi, Masataka Nadaoka, Hirotaka Tanaka, Fumihisa Kitawaki
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Patent number: 7915051Abstract: According to the biosensor and the blood component analytical method of the present invention, in a biosensor that is made of a single layer or plural layers of a porous material as shown in FIG. 1, having a reagent holding part and utilizing chromatography, a cell shrinkage reagent is carried on at least part of the reagent holding part, or at least part of a chromatographically developed part that is upstream of the reagent holding part. According to the biosensor having the above-mentioned structure and the blood component analytical method, even when whole blood is a sample, a high-accuracy blood component analysis cart be performed easily and quickly with less cost.Type: GrantFiled: December 5, 2007Date of Patent: March 29, 2011Assignee: Panasonic CorporationInventors: Mie Takahashi, Masataka Nadaoka, Hirotaka Tanaka, Fumihisa Kitawaki
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Publication number: 20100267048Abstract: Hemoglobin in a sample solution is quickly and reliably denatured; at the same time, quick and accurate measurement of hemoglobin and a hemoglobin derivative is realized. In a method for measuring hemoglobin and a hemoglobin derivative, and a reagent composition, a measurement kit, an analysis device, and an analysis system used in the method, a sample solution containing a blood component is treated with a nonionic surfactant, an oxidizing agent, and a metal salt to denature hemoglobin in the sample solution to measure the hemoglobin, and thereafter the amount of a hemoglobin derivative in the sample is measured by an immunological method using an antibody specifically binding to a denatured site of the denatured hemoglobin derivative.Type: ApplicationFiled: October 29, 2008Publication date: October 21, 2010Applicant: PANASONIC CORPORATIONInventors: Hirotaka Tanaka, Masanori Tanaka, Chizu Asahara, Fumihisa Kitawaki
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Patent number: 7790470Abstract: A method capable of stirring a liquid sample and a reagent promptly and easily includes the following steps (A) and (B). In step (A), using a cell including: a liquid sample retaining section having a plurality of particles; and a liquid sample supply inlet, a liquid sample containing an analyte is supplied from the liquid sample supply inlet to the liquid sample retaining section. In step (B), the liquid sample and a specific binding substance capable of specifically binding to the analyte are stirred by the movement of the particles caused by the flow of the liquid sample in the cell resulting from the supply of the liquid sample, to obtain a liquid mixture. The electric charge of at least the surface of the particles and the electric charge of the specific binding substance have the same polarity in the liquid mixture.Type: GrantFiled: March 23, 2005Date of Patent: September 7, 2010Assignee: Panasonic CorporationInventors: Akihito Kamei, Fumihisa Kitawaki, Tatsurou Kawamura, Hiroshi Nakayama, Nobuyuki Shigetou
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Patent number: 7790439Abstract: In a biosensor having a developing layer for developing a sample solution, including a reagent part immobilized to a portion of the developing layer and a marked reagent part which is held in a dry state by a portion of the developing layer, and is dissolvable by developing the sample solution, and qualitatively or quantitatively analyzing an analyte in the sample solution by measuring the amount of the marker reagent bound to the reagent immobilization part; wherein plural reagent immobilization parts exist, and the respective reagent immobilization parts have different affinities for the analyte in the sample solution or the marker reagent, whereby a prozone phenomenon can be detected. Further, a biosensor with a high precision of measurement, which has a wider dynamic range for the concentration of the analyte in the sample solution, can be provided.Type: GrantFiled: August 9, 2002Date of Patent: September 7, 2010Assignee: Panasonic CorporationInventors: Masataka Nadaoka, Mie Takahashi, Hirotaka Tanaka, Fumihisa Kitawaki
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Patent number: 7754151Abstract: Herein disclosed is a liquid homogenizer for mixing two or more liquids, comprising: a rotator (1) rotatable around a rotation axis; at least two liquid-mixing chambers (6, 10) formed in the rotator, and being different from each other in distance from the rotation axis; and at least two channels (8) through which one of the liquid-mixing chambers is communicated with the other of the liquid-mixing chambers (6, 10), wherein the liquid-mixing chambers (6, 10) include an outer liquid-mixing chamber (10) and an inner liquid-mixing chamber (6) close to the rotation axis in comparison with the outer liquid-mixing chamber, when the rotator (1) is rotating around the rotation axis, the liquids are shifted by a centrifugal force to the outer liquid-mixing chamber from the inner liquid-mixing chamber through the channels (8), and agitated to be mixed by turbulent flows in the outer liquid-mixing chamber.Type: GrantFiled: March 24, 2006Date of Patent: July 13, 2010Assignee: Panasonic CorporationInventors: Fumihisa Kitawaki, Hirotaka Tanaka, Kenji Watanabe
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Publication number: 20100096276Abstract: A multicomponent analysis sensor for measuring two or more kinds of the subjects to be measured by using redox reactions, which is a multicomponent analysis sensor comprising a liquid sample inlet from which a liquid sample containing two or more kinds of the subjects to be measured is introduced, a first measurement chamber, a second measurement chamber, a first channel connecting the above-described liquid sample inlet to the above-described first measurement chamber and a second channel connecting the above-described first measurement chamber to the second measurement chamber, wherein the above-described first measurement chamber and the above-described second measurement chamber respectively have a working electrode and a counter electrode. A first reagent layer containing an enzyme and an electron transfer substance is provided in the first channel or the first chamber, while another reagent layer containing an enzyme is provided in the second channel or the second chamber.Type: ApplicationFiled: October 1, 2007Publication date: April 22, 2010Applicant: PANASONIC CORPORATIONInventors: Shinki Kojima, Tomohiro Yamamoto, Fumihisa Kitawaki, Tetsuo Yukimasa
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Patent number: 7691255Abstract: A sensor capable of measuring a plurality of measuring items quickly and accurately, a measuring device, and a measuring method are provided. The sensor includes a sample-holding unit for holding a sample containing an analyte; a sample-supplying port for supplying the sample to the sample-holding unit; a detecting unit for carrying out an electrochemical measurement, the unit being provided in the sample-holding unit; an optical measuring unit for carrying out an optical measurement, the unit being provided in the sample-holding unit; and a reagent-holding unit for holding a reagent for the optical measurement, the unit being provided in the sample-holding unit; wherein in the flowing direction of the sample supplied from the sample-supplying port in sample-holding unit, the sample-supplying port, the detecting unit, and the reagent-holding unit are positioned in the order recited.Type: GrantFiled: April 22, 2005Date of Patent: April 6, 2010Assignee: Panasonic CorporationInventors: Fumihisa Kitawaki, Akihito Kamei, Tatsurou Kawamura
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Publication number: 20100062414Abstract: A sample liquid analytical chip that whilst being of simple structure, has a reaction region and a detection region isolated from each other and further has liquid feed control means for a sample liquid, thereby realizing speedy reliable analysis. The sample liquid analytical chip comprises a tubular sample liquid transfer channel with its both ends open, a reaction reagent layer disposed on the internal wall surface of the sample liquid transfer channel and a detection region for detecting any physical or chemical change of the sample liquid. In the sample liquid analytical chip, the sample liquid transfer channel at an area of its wall surface is provided an opening and a lid fitted to the opening. Portion of the lid forms a hinge in cooperation with the wall surface.Type: ApplicationFiled: April 4, 2008Publication date: March 11, 2010Applicant: PANASONIC CORPORATIONInventors: Tomohiro Yamamoto, Tetsuo Yukimasa, Ryou Hamada, Fumihisa Kitawaki, Nobuhiko Ozaki
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Patent number: 7598090Abstract: A biosensor is provided with an area in which a reagent having bleaching action is carried in a state where it can be dissolved, at least in a part of a sample application area to which an inspection target solution is applied or the downstream of the sample application area in the direction of the inspection target solution permeating, in a development layer. In the so-constituted biosensor, a colored component in the inspection target solution can be faded by the bleaching reagent, so that the color in parts other than a reactive area is reduced in consequence, whereby a visual judgment is possible and a more accurate measurement result in which a reading error by a measuring device is extremely suppressed can be obtained.Type: GrantFiled: July 24, 2006Date of Patent: October 6, 2009Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Mie Takahashi, Masataka Nadaoka, Hirotaka Tanaka, Fumihisa Kitawaki
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Patent number: 7575915Abstract: A biosensor is provided with a development layer for developing an inspection target solution, that has a reagent immobilization part where an antibody for a measurement target in the inspection target solution is immobilized and a reagent holding part which marks in a dry state and holds an antibody which can be eluted by development of the inspection target solution in parts of the development layer. The biosensor measures a bonding amount of the marker reagent bonded to the reagent immobilization part, thereby qualitatively or quantitatively measuring components to be measured in the inspection target solution, and is further provided with a space forming material that forms a cavity part, which is a space into which the inspection target solution flows, between the development layer for developing the inspection target solution and the space forming material.Type: GrantFiled: May 25, 2001Date of Patent: August 18, 2009Assignee: Panasonic CorporationInventors: Masataka Nadaoka, Mie Takahashi, Hirotaka Tanaka, Fumihisa Kitawaki