Abstract: The present disclosure provides devices and uses thereof. A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.

Abstract: A wearable optical device is described for optically detecting parameters of interest within muscle, such as during physical activity or when at rest. The parameters of interest include oxygenation level and/or hemoglobin concentrations in some situations. The detected parameters, such as oxygenation level, may be used to assess physical performance, such as the extent to which the muscle is utilizing aerobic or anaerobic processes. Methods for determining the parameters of interest, such as oxygenation level, from the detected optical signals are also described, and feedback may be provided to a user.

Abstract: Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Abstract: A cross-modal interface includes a multi-modal sensor configured to concurrently receive multiple input signals with each input signal being provided from a different imaging modality and in response thereto providing a single cross-modal output signal to processing circuitry which processes the single cross-modal output signal provided thereto and generates an output comprising information obtained or otherwise derived from each of or a combination of the different imaging modalities.

Abstract: Methods for creating a haptic effect script for an application and producing haptic effects in response to an event occurring in an application are described Creating the haptic script includes launching an application, launching a scripting engine, monitoring a dynamic memory footprint for the application, receiving an indication of an event occurrence in the application, and determining changes to one or more values stored within the dynamic memory footprint that indicate the event occurrence. To produce the haptic effects, during execution and running of the application the dynamic memory footprint is monitored for value changes associated with an event occurrence as defined by the haptic event script and, if it is determined an event has occurred, the haptic script is executed to product a haptic effect signal.

Abstract: Embodiments of the present invention provide methods of implementing a private but traceable primary transaction implementing a transfer of an asset from an originator to a recipient using a third party, using a distributed network of computers implementing a distributed ledger. The methods use a third party to accept a transaction request from an originator. The third party then separates the transaction into a plurality of secondary transactions, characterized by various steps to make reconstruction of the original transaction difficult. The secondary transactions are recorded on the distributed ledger, accomplishing the original transaction without having any single transaction on the publicly accessible distributed ledger that directly corresponds to the original transaction, ary transactions.

Abstract: A load control system may be commissioned using beacons. The load control system may include control devices that each include a beacon transmitting circuit configured to transmit a beacon that comprises an identifier associated with the control device. A network device, such as a mobile device, may discover a control device based on the beacon received from the control device. In response to discovery of the control device, the control device may be added to a temporary group of control devices for being collectively configured and/or controlled. Control devices may be discovered based on the signal strength at which the beacons are received. The control devices may provide feedback to a user in response to confirmation messages to indicate to a user that the lighting control device has been added to the temporary group. The control devices may stop providing the feedback after they are removed from the temporary group.

Abstract: A load control system may be commissioned using beacons. The load control system may include control devices that each include a beacon transmitting circuit configured to transmit a beacon that comprises an identifier associated with the control device. A network device, such as a mobile device, may discover a control device based on the beacon received from the control device. In response to discovery of the control device, the control device may be added to a temporary group of control devices for being collectively configured and/or controlled. Control devices may be discovered based on the signal strength at which the beacons are received. The control devices may provide feedback to a user in response to confirmation messages to indicate to a user that the lighting control device has been added to the temporary group. The control devices may stop providing the feedback after they are removed from the temporary group.

Abstract: Low density particles that have an exterior surface coated with a thin polymeric coating of an aminoplast can be used in aerospace sealants to reduce the specific gravity of a sealant.

Abstract: A heat shield includes an outer jacket including a fluid inlet port and a fluid outlet port, and an inner jacket nested within the outer jacket and spaced apart therefrom to define a fluid passageway therebetween. The fluid passageway is in fluid communication with the fluid inlet port and the fluid outlet port for directing a cooling fluid from the fluid inlet port to the fluid outlet port through the fluid passageway. The inner jacket at least partially defines a main cavity configured to at least partially protect a turbocharger of the marine engine.

Abstract: An air intake and exhaust system for a marine engine having an intake manifold and an exhaust manifold includes an air compressor configured to compress ambient air into compressed air and a catalytic converter assembly configured to convert pollutants in an exhaust gas stream received from the exhaust manifold. The air compressor is configured to be fluidly coupled to the intake manifold of the engine for directing at least a first portion of the compressed air to the intake manifold of the engine. The air compressor is also selectively fluidly coupled to the catalytic converter assembly for selectively directing a second portion of the compressed air into the exhaust gas stream at a secondary air injection location at or upstream of the catalytic converter assembly.

Abstract: Zwitterionic polymers or biocompatible polymers with improved properties for cell encapsulation, coating of devices, or a combination thereof are described. The biocompatible polymer contains a zwitterionic monomer, a monomer with a reactive side chain, and optionally another hydrophobic monomer or a neutral hydrophilic monomer. The zwitterionic polymers are cross-linked with a cross-linker via covalent bond to form a zwitterionic hydrogel in the presence of cells. Also provided, are methods of making and using the zwitterionic polymers.

Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.

Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.

Abstract: A composition containing biocompatible hydrogel encapsulating mammalian cells and anti-inflammatory drugs is disclosed. The encapsulated cells have reduced fibrotic overgrowth after implantation in a subject. The compositions contain a biocompatible hydrogel having encapsulated therein mammalian cells and anti-inflammatory drugs or polymeric particles loaded with anti-inflammatory drugs. The anti-inflammatory drugs are released from the composition after transplantation in an amount effective to inhibit fibrosis of the composition for at least ten days. Methods for identifying and selecting suitable anti-inflammatory drug-loaded particles to prevent fibrosis of encapsulated cells are also described. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Abstract: Some embodiments of the present invention provide a method of recording transactions using a T1 distributed ledger in a distributed database over a first distributed network of computers, and a plurality of T2 distributed ledgers each in a distributed database over a corresponding distributed network of computers, wherein each T2 distributed ledger has associated with it a corresponding plurality of wallets that are not also associated with any other T2 distributed ledger, comprising: (a) recording transactions identifying an originating wallet in the T2 distributed ledger associated with the originating wallet; (b) for any transactions that identify a recipient wallet that is not associated with the same T2 distributed ledger as the originating wallet, after recording the transaction in the associated T2 distributed ledger then recording the transaction in the T1 distributed ledger, and then recording the transaction in the T2 distributed ledger associated with the recipient wallet.

Abstract: Disclosed herein are methods, techniques, and processes for enhancing the purity of a mixed rare earth solution. In one embodiment the rare earth mixture may include Lanthanum, Cerium, Praseodymium, Neodymium, Promethium, Samarium, Europium, Gadolinium, Terbium, Dysprosium, Holmium, Erbium, Thulium, Ytterbium, Lutetium, Scandium, and/or Yttrium. In one embodiment, the resin is a chelating resin that interacts poorly with one or more rare earth elements. In one embodiment a rare earth is selectively excluded for example, Lanthanum (sometimes considered a transition metal), Cerium, Praseodymium, Neodymium, Promethium, Samarium, Europium, Gadolinium, Terbium, Dysprosium, Holmium, Erbium, Thulium, Ytterbium, Lutetium, Scandium, and/or Yttrium. In one embodiment, yttrium is selectively excluded from the column.

Abstract: Provided herein are methods and systems for detecting genetic variants from sequencing data. The methods and systems provided herein can be useful for identifying the presence or absence of clinically actionable variants from a sequencing data set and reporting the clinically actionable variants to a user of the methods and systems.

Abstract: An electronic device may have a pixel array. A light source may illuminate the pixel array to produce image light. The image light may pass through a multi-element lens and may be coupled into a waveguide using an input coupler such as a prism. An output coupler such as a diffraction grating may couple the image light out of the waveguide and towards a user. The user may view the image light and may observe real-world objects through the waveguide. The waveguide may have locally modified portions that define an aperture stop at a distance from an exit surface of the multi-element lens. The multi-element lens may have first and second achromatic doublets and first and second singlets between the first and second achromatic doublets. The lens elements of the multi-element lens may include lens elements with aspheric surfaces.

Abstract: Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.